Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 2
246
Views
1
CrossRef citations to date
0
Altmetric
Animal Pharmacokinetics and Metabolism

Pharmacokinetic characterization of the novel TAZ modulator TM-25659 using a multicompartment kinetic model in rats and a possibility of its drug–drug interactions in humans

, , , , , , , , , , , & show all
Pages 193-200 | Received 05 Jun 2012, Accepted 04 Jul 2012, Published online: 03 Aug 2012

References

  • Beubler E, Lembeck F. (1979). Inhibition of stimulated fluid secretion in the rat small and large intestine by opiate agonists. Naunyn Schmiedebergs Arch Pharmacol 306:113–118.
  • Chan SW, Lim CJ, Guo K, Ng CP, Lee I, Hunziker W, Zeng Q, Hong W. (2008). A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells. Cancer Res 68:2592–2598.
  • Choi SH, Lee KR, Woo JC, Kim NJ, Moon DC, Hwang ES, Ahn SH, Bae MA, Kim MS. (2012). Determination of a novel TAZ modulator, 2-butyl-5-methyl-6-(pyridine-3-yl)-3-[2′-(1H-tetrazole-5-yl)-biphenyl-4-ylmethyl]-3H imidazo[4,5-b]pyridine] (TM-25659) in rat plasma by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal 63:47–52.
  • Cui CB, Cooper LF, Yang X, Karsenty G, Aukhil I. (2003). Transcriptional coactivation of bone-specific transcription factor Cbfa1 by TAZ. Mol Cell Biol 23:1004–1013.
  • FDA US. (2001). Guidance for industry: bioanalytical method validation. Rockville, MD: CDER.
  • Fu H, Subramanian RR, Masters SC. (2000). 14-3-3 proteins: structure, function, and regulation. Annu Rev Pharmacol Toxicol 40:617–647.
  • Harada S, Rodan GA. (2003). Control of osteoblast function and regulation of bone mass. Nature 423:349–355.
  • Hong JH, Hwang ES, McManus MT, Amsterdam A, Tian Y, Kalmukova R, Mueller E, Benjamin T, Spiegelman BM, Sharp PA, Hopkins N, Yaffe MB. (2005). TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science 309:1074–1078.
  • Hong JH, Yaffe MB. (2006). TAZ: a beta-catenin-like molecule that regulates mesenchymal stem cell differentiation. Cell Cycle 5:176–179.
  • Jang EJ, Jeong H, Kang JO, Kim NJ, Kim MS, Choi SH, Yoo SE, Hong JH, Bae MA, Hwang ES. (2012). TM-25659 enhances osteogenic differentiation and suppresses adipogenic differentiation by modulating the transcriptional co-activator TAZ. Br J Pharmacol 165:1584–1594.
  • Kanai F, Marignani PA, Sarbassova D, Yagi R, Hall RA, Donowitz M, Hisaminato A, Fujiwara T, Ito Y, Cantley LC, Yaffe MB. (2000). TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J 19:6778–6791.
  • Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao YH, Inada M, Sato M, Okamoto R, Kitamura Y, Yoshiki S, Kishimoto T. (1997). Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89:755–764.
  • Lee KR, Chae YJ, Maeng HJ, Lee J, Kim DD, Chong S, Shim CK, Chung SJ. (2011). Physiologically based pharmacokinetic modeling of SNU-0039, an anti-Alzheimer’s agent, in rats. J Pharmacokinet Pharmacodyn 38:637–651.
  • Mahoney WM Jr, Hong JH, Yaffe MB, Farrance IK. (2005). The transcriptional co-activator TAZ interacts differentially with transcriptional enhancer factor-1 (TEF-1) family members. Biochem J 388:217–225.
  • Murakami M, Nakagawa M, Olson EN, Nakagawa O. (2005). A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome. Proc Natl Acad Sci USA 102:18034–18039.
  • Murakami M, Tominaga J, Makita R, Uchijima Y, Kurihara Y, Nakagawa O, Asano T, Kurihara H. (2006). Transcriptional activity of Pax3 is co-activated by TAZ. Biochem Biophys Res Commun 339:533–539.
  • Otto F, Thornell AP, Crompton T, Denzel A, Gilmour KC, Rosewell IR, Stamp GW, Beddington RS, Mundlos S, Olsen BR, Selby PB, Owen MJ. (1997). Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89:765–771.
  • Park KS, Whitsett JA, Di Palma T, Hong JH, Yaffe MB, Zannini M. (2004). TAZ interacts with TTF-1 and regulates expression of surfactant protein-C. J Biol Chem 279:17384–17390.
  • Song JS, Chae JW, Lee KR, Lee BH, Choi EJ, Ahn SH, Kwon KI, Bae MA. (2011). Pharmacokinetic characterization of decursinol derived from Angelica gigas Nakai in rats. Xenobiotica 41:895–902.
  • Tian Y, Li D, Dahl J, You J, Benjamin T. (2004). Identification of TAZ as a binding partner of the polyomavirus T antigens. J Virol 78:12657–12664.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.