Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 44, 2014 - Issue 6
332
Views
5
CrossRef citations to date
0
Altmetric
Research Article

Changes in pharmacokinetic profiles of acetaminophen and its glucuronide after pretreatment with combinations of N-acetylcysteine and either glycyrrhizin, silibinin or spironolactone in rat

, , , , &
Pages 541-546 | Received 02 Sep 2013, Accepted 21 Oct 2013, Published online: 19 Nov 2013

References

  • Aleksunes LM, Slitt AL, Maher JM, et al. (2008). Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2. Toxicol Appl Pharmacol 226:74–83
  • Bohnenstengel F, Kroemer HK, Sperker B. (1999). In vitro cleavage of paracetamol glucuronide by human liver and kidney beta-glucuronidase: determination of paracetamol by capillary electrophoresis. J Chromatogr B Biomed Sci Appl 721:295–9
  • Chen C, Hennig GE, Manautou JE. (2003). Hepatobiliary excretion of acetaminophen glutathione conjugate and its derivatives in transport-deficient (TR-) hyperbilirubinemic rats. Drug Metab Dispos 31:798–804
  • Crocenzi FA, Roma MG. (2006). Silymarin as a new hepatoprotective agent in experimental cholestasis: new possibilities for an ancient medication. Curr Med Chem 13:1055–74
  • Ezhilarasan D, Karthikeyan S, Vivekanandan P. (2012). Ameliorative effect of silibinin against N-nitrosodimethylamine-induced hepatic fibrosis in rats. Environ Toxicol Pharmacol 34:1004–13
  • Ghanem CI, Ruiz ML, Villanueva SS, et al. (2005). Shift from biliary to urinary elimination of acetaminophen-glucuronide in acetaminophen-pretreated rats. J Pharmacol Exp Ther 315:987–95
  • Hau DK, Wong RS, Cheng GY, et al. (2010). Novel use of silymarin as delayed therapy for acetaminophen-induced acute hepatic injury. Forsch Komplementmed 17:209–13
  • Horikawa M, Kato Y, Tyson CA, Sugiyama Y. (2002). The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites. Drug Metab Pharmacokinet 17:23–33
  • Howie D, Adriaenssens PI, Prescott LF. (1977). Paracetamol metabolism following overdosage: application of high performance liquid chromatography. J Pharm Pharmacol 29:235–7
  • Jaeschke H. (2005). Role of inflammation in the mechanism of acetaminophen-induced hepatotoxicity. Expert Opin Drug Metab Toxicol 1:389–97
  • Jaeschke H, Bajt ML. (2006). Intracellular signaling mechanisms of acetaminophen-induced liver cell death. Toxicol Sci 89:31–41
  • Jaeschke H, Knight TR, Bajt ML. (2003). The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity. Toxicol Lett 144:279–88
  • Kim SW, Jin Y, Shin JH, et al. (2012). Glycyrrhizic acid affords robust neuroprotection in the postischemic brain via anti-inflammatory effect by inhibiting HMGB1 phosphorylation and secretion. Neurobiol Dis 46:147–56
  • Lauterburg BH, Corcoran GB, Mitchell JR. (1983). Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo. J Clin Invest 71:980–91
  • Lickteig AJ, Fisher CD, Augustine LM, et al. (2007). Efflux transporter expression and acetaminophen metabolite excretion are altered in rodent models of nonalcoholic fatty liver disease. Drug Metab Dispos 35:1970–8
  • Liu J, Liu Y, Mao Q, Klaassen CD. (1994). The effects of 10 triterpenoid compounds on experimental liver injury in mice. Fundam Appl Toxicol 22:34–40
  • Mitchell JR, Jollow DJ, Potter WZ, et al. (1973). Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J Pharmacol Exp Ther 187:211–17
  • Moldeus P. (1978). Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse. Biochem Pharmacol 27:2859–63
  • Ni YF, Kuai JK, Lu ZF, et al. (2011). Glycyrrhizin treatment is associated with attenuation of lipopolysaccharide-induced acute lung injury by inhibiting cyclooxygenase-2 and inducible nitric oxide synthase expression. J Surg Res 165:e29–35
  • Ochs HR, Greenblatt DJ, Bodem G, Smith TW. (1978). Spironolactone. Am Heart J 96:389–400
  • Rowden AK, Norvell J, Eldridge DL, Kirk MA. (2006). Acetaminophen poisoning. Clin Lab Med 26:49–65, viii
  • Ruiz ML, Villanueva SS, Luquita MG, et al. (2007). Beneficial effect of spironolactone administration on ethynylestradiol-induced cholestasis in the rat: involvement of up-regulation of multidrug resistance-associated protein 2. Drug Metab Dispos 35:2060–6
  • Shen C, Zhang G, Qiu H, Meng Q. (2006). Acetaminophen-induced hepatotoxicity of gel entrapped rat hepatocytes in hollow fibers. Chem Biol Interact 162:53–61
  • Souza CO, Peracoli MT, Weel IC, et al. (2012). Hepatoprotective and anti-inflammatory effects of silibinin on experimental preeclampsia induced by L-NAME in rats. Life Sci 91:159–65
  • Wan XY, Luo M, Li XD, He P. (2009). Hepatoprotective and anti-hepatocarcinogenic effects of glycyrrhizin and matrine. Chem Biol Interact 181:15–19
  • Williams CD, Farhood A, Jaeschke H. (2010). Role of caspase-1 and interleukin-1beta in acetaminophen-induced hepatic inflammation and liver injury. Toxicol Appl Pharmacol 247:169–78
  • Xu R, Zhang X, Yang J, et al. (2012). Effects of glycyrrhizin on biliary transport and hepatic levels of glutathione in rats. Biopharm Drug Dispos 33:235–45

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.