Xenobiotica, Volume 44, Issue 6 (2014)

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Xenobiotica, Volume 44, Issue 6 (2014)

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General Xenobiochemistry

Article
Hepatobiliary and intestinal elimination of darunavir in an integrated preclinical rat model
Jef Stappaerts, Sarinj Fattah, Pieter Annaert & Patrick Augustijns
Pages: 489-497
Published online: 26 Nov 2013
AbstractforHepatobiliary and intestinal elimination of darunavir in an integrated preclinical rat model | Full Text | References | PDF (407.6 KB)
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Research Article

Article
High-resolution mass spectrometric investigation of the phase I and II metabolites of finasteride in pig plasma, urine and bile
Anna Lundahl, Annica Tevell Åberg, Ulf Bondesson, Hans Lennernäs & Mikael Hedeland
Pages: 498-510
Published online: 09 Dec 2013
AbstractforHigh-resolution mass spectrometric investigation of the phase I and II metabolites of finasteride in pig plasma, urine and bile | Full Text | References | PDF (2.3 MB)
  • 232 Views
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Article
Comparison of intestinal metabolism of CYP3A substrates between rats and humans: application of portal–systemic concentration difference method
Keitaro Kadono, Akiko Koakutsu, Yoichi Naritomi, Shigeyuki Terashita, Kenji Tabata & Toshio Teramura
Pages: 511-521
Published online: 12 Dec 2013
AbstractforComparison of intestinal metabolism of CYP3A substrates between rats and humans: application of portal–systemic concentration difference method | Full Text | References | PDF (569.5 KB)
  • 675 Views
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Clinical Pharmacokinetics and Metabolism

Article
Absorption, metabolism and excretion of [14C]gemigliptin, a novel dipeptidyl peptidase 4 inhibitor, in humans
Namtae Kim, Lorna Patrick, Stuart Mair, Lloyd Stevens, Gill Ford, Vicky Birks & Sung-Hack Lee
Pages: 522-530
Published online: 04 Dec 2013
AbstractforAbsorption, metabolism and excretion of [14C]gemigliptin, a novel dipeptidyl peptidase 4 inhibitor, in humans | Full Text | References | PDF (688.6 KB)
  • 502 Views
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Animal Pharmacokinetics and Metabolism

Article
Metabolism and disposition of ABT-894, a novel α4β2 neuronal acetylcholine receptor agonist, in mice and monkeys
Hong Liu, Wentao Fu, Jill Wetter, Hongyu Xu, Zhiwen Guan & Patricia Stuart
Pages: 531-540
Published online: 30 Jan 2014
AbstractforMetabolism and disposition of ABT-894, a novel α4β2 neuronal acetylcholine receptor agonist, in mice and monkeys | Full Text | References | PDF (251.8 KB)
  • 237 Views
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Research Article

Article
Changes in pharmacokinetic profiles of acetaminophen and its glucuronide after pretreatment with combinations of N-acetylcysteine and either glycyrrhizin, silibinin or spironolactone in rat
Ruijuan Xu, Qian Wang, Jing Zhang, Min Zang, Xiaoquan Liu & Jin Yang
Pages: 541-546
Published online: 19 Nov 2013
AbstractforChanges in pharmacokinetic profiles of acetaminophen and its glucuronide after pretreatment with combinations of N-acetylcysteine and either glycyrrhizin, silibinin or spironolactone in rat | Full Text | References | PDF (912 KB)
  • 332 Views
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Article
Pharmacokinetics of macrolactin A and 7-O-succinyl macrolactin A in mice
Ji Won Jung, Ju Myung Kim, Mi Hye Kwon, Dong Hee Kim & Hee Eun Kang
Pages: 547-554
Published online: 26 Nov 2013
AbstractforPharmacokinetics of macrolactin A and 7-O-succinyl macrolactin A in mice | Full Text | References | PDF (280.1 KB)
  • 179 Views
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Article
Application of a liquid chromatography–tandem mass spectrometry method to the pharmacokinetics, bioavailability and tissue distribution of neohesperidin dihydrochalcone in rats
Xianqin Wang, Yu Pan, Ma Jianshe, Shaohua Shi, Xiaoyong Zheng & Zheng Xiang
Pages: 555-561
Published online: 25 Nov 2013
AbstractforApplication of a liquid chromatography–tandem mass spectrometry method to the pharmacokinetics, bioavailability and tissue distribution of neohesperidin dihydrochalcone in rats | Full Text | References | PDF (517.3 KB)
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Article
In vitro cytotoxicity, pharmacokinetics and tissue distribution in rats of MXN-004, a novel conjugate of polyethylene glycol and SN38
Sufeng Zhou, Ning Li, Xin Wang, Cuiyun Li, Fengjie Tian, Shuangxia Ren, Yuehua Zhang, Yuanping He, Zhixia Qiu, Di Zhao & Xijing Chen
Pages: 562-569
Published online: 06 Dec 2013
AbstractforIn vitro cytotoxicity, pharmacokinetics and tissue distribution in rats of MXN-004, a novel conjugate of polyethylene glycol and SN38 | Full Text | References | PDF (502.2 KB)
  • 371 Views
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Molecular Toxicology

Article
The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease
Mohammad A. Aminzadeh, Scott A. Reisman, Nosratola D. Vaziri, Mahyar Khazaeli, Jun Yuan & Colin J. Meyer
Pages: 570-578
Published online: 06 Nov 2013
AbstractforThe synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease | Full Text | References | PDF (1.4 MB)
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Open Access

Pharmacogenetics

Article
Frequency and genotype distribution of ABCB1 gene polymorphisms among Maharashtrian population of Central India
Sreemanta Pramanik, Subin T. Surendran, Saravana Devi, Kannan Krishnamurthi & Tapan Chakrabarti
Pages: 579-582
Published online: 06 Dec 2013
AbstractforFrequency and genotype distribution of ABCB1 gene polymorphisms among Maharashtrian population of Central India | Full Text | References | PDF (106.3 KB)
  • 141 Views
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