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Xenobiotica
the fate of foreign compounds in biological systems
Volume 46, 2016 - Issue 6
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Xenobiotic Transporters

ATP-binding cassette proteins BCRP, MRP1 and P-gp expression and localization in the human umbilical cord

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Pages 548-556 | Received 31 Aug 2015, Accepted 02 Sep 2015, Published online: 25 Sep 2015

References

  • Ahmed F, Arseni N, Glimm H, et al. (2008). Constitutive expression of the ATP-binding cassette transporter ABCG2 enhances the growth potential of early human hematopoietic progenitors. Stem Cells 26:810–8
  • Alt R, Wilhelm F, Pelz-Ackermann O, et al. (2009). ABCG2 expression is correlated neither to side population nor to hematopoietic progenitor function in human umbilical cord blood. Exp Hematol 37:294–301
  • Azzaroli F, Mennone A, Feletti V, et al. (2007). Clinical trial: modulation of human placental multidrug resistance proteins in cholestasis of pregnancy by ursodeoxycholic acid. Aliment Pharmacol Ther 26:1139–46
  • Beghin D, Delongeas J, Claude N, et al. (2010). Comparative effects of drugs on P-glycoprotein expression and activity using rat and human trophoblast models. Toxicol in Vitro 24:630–7
  • Benirschke K, Kaufmann P. (2000). Pathology of the human placenta. New York: Springer
  • Borst P, Elferink R. (2002). Mammalian ABC transporters in health and disease. Ann Rev Biochem 71:531–92
  • Buyl K, Kock JD, Najar M, et al. (2014). Characterization of hepatic markers in human Wharton’s Jelly-derived mesenchymal stem cells. Toxicol in Vitro 28:113–19
  • Collier A, Ganley N, Tingle M, et al. (2002a). UDP-glucuronosyltransferase activity, expression and cellular localization in human placenta at term. Biochem Pharmacol 63:409–19
  • Collier A, Tingle M, Paxton J, et al. (2002b). Metabolizing enzyme localization and activities in the first trimester human placenta: the effect of maternal and gestational age, smoking and alcohol consumption. Hum Reprod 17:2564–72
  • Cui T, Liu Y, Men V, et al. (2009). Bile acid transport correlative protein mRNA expression profile in human placenta with intrahepatic cholestasis of pregnancy. Saudi Med J 30:1406–10
  • Dauchy S, Miller F, Couraud P, et al. (2009). Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells. Biochem Pharmacol 77:897–909
  • Dutheil F, Dauchy S, Diry M, et al. (2009). Xenobiotic-metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function. Drug Metab Dispos 37:1528–38
  • Evseenko D, Paxton J, Keelan J. (2006). ABC drug transporter expression and functional activity in trophoblast-like cell lines and differentiating primary trophoblast. Am J Physiol Regul Integr Comp Physiol 290:R1357–65
  • Evseenko D, Paxton J, Keelan J. (2007). Independent regulation of apical and basolateral drug transporter expression and function in placental trophoblasts by cytokines, steroids, and growth factors. Drug Metab Dispos 35:595–601
  • Feinshtein V, Holcberg G, Amash A, et al. (2010). Nitrofurantoin transport by placental choriocarcinoma JAr cells: involvement of BCRP, OATP2B1 and other MDR transporters. Arch Gynecol Obstet 281:1037–44
  • Gedeon C, Anger G, Piquette-Miller M, Koren G. (2008). Breast cancer resistance protein: mediating the trans-placental transfer of glyburide across the human placenta. Placenta 29:39–43
  • Gil S, Saura R, Forestier F, Farinotti R. (2005). P-glycoprotein expression of the human placenta during pregnancy. Placenta 26:268–70
  • Hemauer S, Patrikeeva S, Wang X, et al. (2010). Role of transporter-mediated efflux in the placental biodisposition of bupropion and its metabolite, OH-bupropion. Biochem Pharmacol 80:1080–6
  • Hodyl N, Stark M, Butler M, Clifton V. (2013). Placental P-glycoprotein is unaffected by timing of antenatal glucocorticoid therapy but reduced in SGA preterm infants. Placenta 34:325–30
  • Ikeda K, Yamasaki K, Homemoto M, et al. (2012). Efflux transporter mRNA expression profiles in differentiating JEG-3 human choriocarcinoma cells as a placental transport model. Pharmazie 67:86–90
  • Iqbal M, Audette MC, Petropoulos S, et al. (2012). Placental drug transporters and their role in fetal protection. Placenta 33:137–42
  • Iwahana M, Utoguchi N, Mayumi T, et al. (1998). Drug resistance and P-glycoprotein expression in endothelial cells of newly formed capillaries induced by tumors. Anticancer Res 18:2977–80
  • Jin H, Audus K. (2005). Effect of bisphenol A on drug efflux in BeWo, a human trophoblast-like cell line. Placenta 26:S96–103
  • Jones J, Jones M, Jones B, et al. (2015). Detection of codeine, morphine, 6-monoacetylmorphine, and meconin in human umbilical cord tissue: method validation and evidence of in utero heroin exposure. Ther Drug Monit 37:45–52
  • Kolwankar D, Glover D, Ware J, Tracy T. (2005). Expression and function of ABCB1 and ABCG2 in human placental tissue. Drug Metab Dispos 33:524–9
  • Kummu M, Sieppi E, Wallin K, et al. (2012). Cadmium inhibits ABCG2 transporter function in BeWo choriocarcinoma cells and MCF-7 cells overexpressing ABCG2. Placenta 33:859–65
  • Langmann T, Mauerer R, Zahn A, et al. (2003). Real-time reverse transcription-PCR expression profiling of the complete human ATP-binding cassette transporter superfamily in various tissues. Clin Chem 49:230–8
  • MacFarland A, Abramovich D, Ewen S, Pearson C. (1994). Stage-specific distribution of P-glycoprotein in first-trimester and full-term human placenta. Histochem J 26:417–23
  • Manceau S, Giraud C, Declèves X, et al. (2012). ABC drug transporter and nuclear receptor expression in human cytotrophoblasts: influence of spontaneous syncytialization and induction by glucocorticoids. Placenta 33:927–32
  • Mao Q, Unadkat JD. (2015). Role of the breast cancer resistance protein (BCRP/ABCG2) in drug transport–an update. AAPS J 17:65–82
  • Mitra P, Audus K. (2010). MRP isoforms and BCRP mediate sulfate conjugate efflux out of BeWo cells. Int J Pharmaceut 384:15–23
  • Montanucci P, Basta G, Pescara T, et al. (2011). New simple and rapid method for purification of mesenchymal stem cells from the human umbilical cord Wharton jelly. Tissue Eng Part a 17:2651–61
  • Myllynen P, Immonen E, Kummu M, Vähäkangas K. (2009). Developmental expression of drug metabolizing enzymes and transporter proteins in human placenta and fetal tissues. Expert Opin Drug Metab Toxicol 5:1483–99
  • Nagashige M, Ushigome F, Koyabu N, et al. (2003). Basal membrane localization of MRP1 in human placental trophoblast. Placenta 24:951–8
  • Natarajan K, Xie Y, Baer MR, Ross DD. (2012). Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance. Biochem Pharmacol 83:1084–103
  • Pascolo L, Fernetti C, Garcia-Mediavilla M, et al. (2001). Mechanisms for the transport of unconjugated bilirubin in human trophoblastic BeWo cells. FEBS Lett 495:94–9
  • Pascolo L, Fernetti C, Pirulli D, et al. (2003). Effects of maturation on RNA transcription and protein expression of four MRP genes in human placenta and in BeWo cells. Biochem Biophys Res Commun 303:259–65
  • Pollex E, Anger G, Hutson J, et al. (2010). Breast cancer resistance protein (BCRP)-mediated glyburide transport: effect of the C421A/Q141K BCRP single-nucleotide polymorphism. Drug Metab Dispos 38:740–4
  • Rankin J, Stock M, Anderson D. (1980). Fetal heart rate and umbilical blood flow. J Dev Physiol 2:11–16
  • Richard K, Hume R, Kaptein E, et al. (2001). Sulfation of thyroid hormone and dopamine during human development: ontogeny of phenol sulfotransferases and arylsulfatase in liver, lung, and brain. J Clin Endocrinol Metab 86:2734–42
  • Ridano M, Racca A, Flores-Martín J, et al. (2012). Chlorpyrifos modifies the expression of genes involved in human placental function. Reprod Toxicol 33:331–8
  • Seo Y, Yang S, Jee M, et al. (2011). Human umbilical cord blood-derived mesenchymal stem cells protect against neuronal cell death and ameliorate motor deficits in Niemann Pick type C1 mice. Cell Transplantation 20:1033–47
  • Snodgrass R, Collier AC, Coon AE, Pritsos CA. (2010). Mitomycin C inhibits ribosomal RNA: a novel cytotoxic mechanism for bioreductive drugs. J Biol Chem 285:19068–75
  • Snyder N, Revello S, Liu X, et al. (2013). Cellular uptake and antiproliferative effects of 11-oxo-eicosatetraenoic acid. J Lipid Res 54:3070–7
  • Sugawara I, Kataoka I, Morishita Y, et al. (1988). Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16. Cancer Res 48:1926–9
  • Sun M, Kingdom J, Baczyk D, et al. (2006). Expression of the multidrug resistance P-glycoprotein, (ABCB1 glycoprotein) in the human placenta decreases with advancing gestation. Placenta 27:602–9
  • Wagner-Souza K, Diamond H, Ornellas M, et al. (2008). Rhodamine 123 efflux in human subpopulations of hematopoietic stem cells: comparison between bone marrow, umbilical cord blood and mobilized peripheral blood CD34 + cells. Int J Mol Med 22:237–42
  • Wang H, Unadkat J, Mao Q. (2008). Hormonal regulation of BCRP expression in human placental BeWo cells. Pharm Res 25:444–52
  • Wright TE, Milam K, Rougee LR, et al. (2011). Agreement of umbilical cord drug and cotinine levels with maternal self-report of drug use and smoking during pregnancy. J Perinatol 31:324–9
  • Yasuda S, Itagaki S, Hirano T, Iseki K. (2006). Effects of sex hormones on regulation of ABCG2 expression in the placental cell line BeWo. J Pharm Pharm Sci 9:133–9
  • Yeboah D, Sun M, Kingdom J, et al. (2006). Expression of breast cancer resistance protein (BCRP/ABCG2) in human placenta throughout gestation and at term before and after labor. Can J Physiol Pharmacol 84:1251–8
  • Zhang H, Wen Z, Lan S, et al. (2007). The AFT024 stromal cell line improves MDR1 gene transfer to CD34 + cells derived from human umbilical cord blood. Neoplasma 54:21–8

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