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Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 2
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Original Article

Evidence that epichlorohydrin is not a toxic metabolite of 1,2-dibromo-3-chloropropane

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Pages 229-240 | Received 01 Dec 1985, Published online: 30 Sep 2009

References

  • Beatty P. W., Mueller R. L., Page A. C. In vitro metabolism of [14C]-epichlorohydrin in hepatic and extrahepatic microsomes from F-344 rats. The Toxicologist 1983; 3: 5
  • Beatty P. W., Mueller R. L., Page A. C., Dzidic I., Cocchiara J. P., Gingell R. Identification of 1,2-dibromo-3-chloropropane metabolites from in vitro incubations with rat hepatic microsomes. The Pharmacologist 1984; 26: 168
  • Fakhouri G., Jones A. R. Epichlorohydrin: metabolism and toxicity in the rat. Australian Journal of Pharmaceutical Science 1979; 8: 11–14
  • Gingell R., Mitschke H. R., Beatty P. W., Sawin V. L., Page A. C. Disposition and metabolism of [2-14C]-epichlorohydrin after oral administration to rats. Drug Metab. Disp. 1985; 13: 333–341
  • Gontovnick L. S., Bellward G. D. A comparative study of benzo(a)pyrene hydroxylase and epoxide hydrolase derived from isolated rat nuclei and microsomes. Drug Metabolism Disposition 1981; 9: 265–269
  • Jones A. R., Fakhouri G., Gadiel P. The metabolism of the soil fumigant 1,2-dibromo-3-chloropropane in the rat. Experientia 1979; 35: 1432–1434
  • Kato Y., Sato K., Harada T., Maki S., Matano O., Goto S. Correlation Between Macromolecular Binding of DBCP Metabolites and Pathology of Necrosis. Journal of Pesticide Science 1980; 5: 81–88
  • Kluwe W. M., Gupta B. N., Lamb J. C. The comparative effects of 1,2-dibromo-3-chloropropane (DBCP) and its metabolites, 3-chloro-1,2-propaneoxide (epichlorohydrin), 3-chloro-1,2-propanediol (alphachlorohydrin) and oxalic acid on the urogenital system of male rats. Toxicology and Applied Pharmacology 1983; 70: 67–86
  • Layne E. Spectrophotometric and turbidometric methods for measuring protein. Methods of Enzymology, S. Colowick, N. Kaplan, 1957; 3: 447
  • Marsden P. J., Casida J. E. 2-Haloacrylic acids as indicators of mutagenic 2-haloacrolein intermediates in mammalian metabolism of selected promutagens and carcinogens. Journal of Agricultural and Food Chemistry 1982; 30: 627–631
  • Nachtomi E. Metabolism of ethylene dibromide in the rat. Biochemical Pharmacology 1970; 19: 2853–2860
  • Rossi A. M., Migliore L., Loprieno N., Romano M., Salmona M. Microsomal epoxide hydrolase-dependent deactivation of ECH mutagenicity in, Schizosaccharomyces pombe in vitro. Mutation Research 1983; 109: 41–52
  • Presented in part at the Society of Toxicology Annual Meeting. March, 1985, Toxicologist 5 Abstract no. 308)

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