The impact of raised BMI on the outcome of assisted reproduction: Current concepts

References

• Asimakopoulos B, Koster F, Felberbaum R, Tripsiannis G, Caglar GS, Nikolettos N . 2009. Intrafollicular and circulating concentrations of leptin do not predict the outcome in IVF-ICSI cycles reproductive sciences. Fertility and Sterility 16:113–119.
   Google Scholar
• Agarwal SK, Judd HL, Magoffin DA. 1996. A mechanism for the suppression of estrogen production in polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 81:3686–3691.
   PubMed Web of Science ®Google Scholar
• Balen AH, Anderson RA; Policy and Practice Committee of the BFS. 2007. Impact of obesity on female reproductive health: British Fertility Society, Policy and Practice Guidelines. Human Fertility (Cambridge) 10:195–206.
   PubMedGoogle Scholar
• Bellver J, Rossal LP, Bosch E, Zuniga A, Corona JT, Melendez F . 2003. Obesity and the risk of spontaneous abortion after oocyte donation. Fertility and Sterility 79:1136–1140.
   PubMed Web of Science ®Google Scholar
• Bellver J, Melo MAB, Bosch E, Serra V, Remohi J, Pellicer A. 2007. Obesity and poor reproductive outcome: the potential role of the endometrium. Fertility and Sterility 88:446–451.
   PubMed Web of Science ®Google Scholar
• Bellver J, Ayllon Y, Ferrando M, Melo M, Goyri E, Pellicer A . 2010. Female obesity impairs in vitro fertilization outcome without affecting embryo quality. Fertility and Sterility 93:447–454.
   PubMed Web of Science ®Google Scholar
• Brannian JD, Schmidt SM, Kreger DO, Hansen KA. 2001. Baseline non-fasting serum leptin concentration to body mass index ratio is predictive of IVF outcomes. Human Reproduction 16:1819–1826.
   PubMed Web of Science ®Google Scholar
• Brannian JD, Hansen KA. 2002. Leptin and ovarian folliculogenesis: implications for ovulation induction and ART outcomes. Seminars in Reproductive Medicine 20:103–112.
   PubMed Web of Science ®Google Scholar
• Brewer CJ, Balen AH. 2010. The adverse effects of obesity on conception and implantation. Reproduction 140:347–364.
   PubMed Web of Science ®Google Scholar
• Brunn JM, Pederson SB, Kristensen K, Richelsen B. 2002. Opposite regulation of interleukin 8 and tumour necrosis factor-alpha by weight loss. Obesity Research 10:499–506.
   PubMedGoogle Scholar
• Butzow TL, Lehtovirta M, Siegberg R, Hovatta O, Koistinen R, Seppala M and Apter D. 2000. The decrease in leuteinizing hormone in response to weight reduction is inversely related to the severity of insulin resistance in overweight women. Journal of Clinical Endocrinology and Metabolism 85:3271–3275.
   PubMed Web of Science ®Google Scholar
• Carrell DT, Jones KP, Peterson CM, Aoki V, Emery BR, Campbell BR. 2001. Body mass index is inversely related to intrafollicular HCG concentration, embryo quality and IVF outcome. Reproductive Biomedicine Online 3:109–111.
   PubMedGoogle Scholar
• Castellucci M, De Matteis R, Meisser A, Cancello R, Monsurro V, Islami D . 2000. Leptin modulates extracellular matrix molecules and metalloproteinases: possible implications for trophoblast invasion. Molecular Human Reproduction 6:951–958.
   PubMed Web of Science ®Google Scholar
• De Placido G, Alviggi C, Clarizia R, Mollo A, Alviggi E, Strina I . 2006. Intra-follicular leptin concentration as a predictive factor for in vitro oocyte fertilization in assisted reproductive techniques. Journal of Endocrinological Investigation 29:719–726.
   PubMed Web of Science ®Google Scholar
• DeUgarte DA, DeUgarte CM, Sahakian V. 2010. Surrogate obesity negatively impacts pregnancy rates in third-party reproduction. Fertility and Sterility 93:1008–1010.
   PubMed Web of Science ®Google Scholar
• Dokras A, Baredziak L, Blaine J, Syrop C, VanVoorhis BJ, Sparks A. 2006. Obstetric outcomes after in vitro fertilization in obese and morbidly obese women. Obstetrics and Gynaecology 108:61–69.
   PubMed Web of Science ®Google Scholar
• Dumesic DA, Padmanabhan V, Abbott DH. 2008a. Polycystic ovary syndrome and oocyte developmental competence. Obstetrical and Gynecological Survey 63:39–48.
   PubMed Web of Science ®Google Scholar
• Dumesic DA, Lesnick TG, Abbott DH. 2008b. Increased adiposity enhances intrafollicular estradiol levels in normoandrogenic ovulatory women receiving gonadotropin-releasing hormone analog/recombinant human follicle-stimulating hormone therapy for in vitro fertilization. Journal of Clinical Endocrinology and Metabolism 92:1438–1441.
   Web of Science ®Google Scholar
• Dyck DJ, Heigenhauser GJ, Bruce CR. 2006. The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity. Acta Physiologica 186:5–16.
   PubMed Web of Science ®Google Scholar
• Eppig JJ, O’Brien MJ, Pendola FL, Watanabe S. 1998. Factors affecting the developmental competence of mouse oocytes grown in vitro: follicle stimulating hormone and insulin. Biology of Reproduction 59: 1445–1453.
   PubMed Web of Science ®Google Scholar
• Esinler I, Bozdag G, Yarali H. 2008. Impact of isolated obesity on ICSI outcome. Reproductive Biomedicine Online 17:583–587.
   PubMed Web of Science ®Google Scholar
• Fedorcsak P, Storeng R, Dale PO, Tanbo T, Abyholm T. 2000. Obesity is a risk factor for early pregnancy loss after IVF or ICSI. Acta Obstetricia et Gynecologica Scandinavica 79:43–48.
   PubMed Web of Science ®Google Scholar
• Fowke JH, Matthews CE, Yu H, Cai Q, Cohen S, Buchowski MS . 2010. Racial differences in the association between body mass index and serum IGF1, IGF2 and IGFBP3. Endocrine-related Cancer 17:51–60.
   PubMed Web of Science ®Google Scholar
• Fried G, Remaeus K, Harlin J, Krog E, Csemiczky G, Aanesen A . 2003. Inhibin B predicts oocyte number and the ratio IGF-I/IGFBP-1 may indicate oocyte quality during ovarian hyperstimulation for in vitro fertilization. Journal of Assisted Reproduction and Genetics 20:167–176.
   PubMed Web of Science ®Google Scholar
• Gonzalez RR, Caballero-Campo P, Jasper M, Mercader A, Devoto L, Pellicer A and Simon C. 2000. Leptin and leptin receptor are expressed in the human endometrium and endometrial leptin secretion is regulated by the human blastocyst. Journal of Clinical Endocrinology and Metabolism 85:4883–4888.
   PubMed Web of Science ®Google Scholar
• Gosman GG, Katcher HI and Legro RS. 2006. Obesity and the role of gut and adipose hormones in female reproduction. Human Reproduction Update 12:585–601.
   PubMed Web of Science ®Google Scholar
• Georgios A, Eleni K, Ioannis S, Vassilios L, Constantinos L, Themis M . 2005. Serum and follicular fluid leptin levels are correlated with human embryo quality. Reproduction 130:917–921.
   PubMed Web of Science ®Google Scholar
• Glueck CJ, Sieve L, Zhu B, Wang P. 2006. Plasminogen activator inhibitor activity, 4G5G polymorphism of the plasminogen activator inhibitor 1 gene, and first-trimester miscarriage in women with polycystic ovary syndrome. Metabolism 55:345–352.
   PubMed Web of Science ®Google Scholar
• Guidice LC. 2006. Endometrium in PCOS: Implantation and predisposition to endocrine CA. Best Practice and Research: Clinical Endocrinology and Metabolism 20:235–244.
   PubMed Web of Science ®Google Scholar
• Howards PP and Cooney MA. 2008. Disentangling causal paths between obesity and in vitro fertilization outcomes: an intractable problem? Fertility and Sterility 89:1604–1605.
   PubMed Web of Science ®Google Scholar
• Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. 1995. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. Journal of Clinical Investigation 95:2409–2415.
   PubMed Web of Science ®Google Scholar
• IOTF and EASO. 2002. Obesity in Europe. The case for action. London: International Obesity Task Force and European Association for the Study of Obesity. Available at: www.iotf.org/media/euobesity.pdf
   Google Scholar
• Kawamura K, Sato N, Fukuda J, Kodama H, Kumagai J, Tanikawa H . 2003. The role of leptin during the development of mouse preimplantation embryos. Molecular and Cellular Endocrinology 202:185–189.
   PubMed Web of Science ®Google Scholar
• Koning AM, Kuchenbecker WK, Groen H, Hoek A, Land JA, Khan KS . 2010. Economic consequences of overweight and obesity in infertility: a framework for evaluating the costs and outcomes of fertility care. Human Reproduction Update 16:246.
   PubMed Web of Science ®Google Scholar
• Landres IV, Milki AA, Lathi RB. 2010. Karyotype of miscarriages in relation to maternal weight. Human Reproduction 25:1123–1126.
   PubMed Web of Science ®Google Scholar
• Lage M, Garcia-Mayor RV, Tome MA, Cordido F, Valle-Inclan F, Considine RV . 1999. Serum leptin levels in women throughout pregnancy and the postpartum period and in women suffering spontaneous abortion. Clinical Endocrinology 50:211–216.
   PubMed Web of Science ®Google Scholar
• Lee KS, Joo BS, Na YJ, Yoon MS, Choi OH, Kim WW. 2000. Relationships between concentrations of tumour necrosis factor-a and nitric oxide in follicular fluid and oocyte quality. Journal of Assisted Reproduction and Genetics 17:222–228.
   PubMed Web of Science ®Google Scholar
• Luke B, Brown M, Stern J, Missmer S, Fujimoto V, Leach R. 2010. Female obesity adversely affects assisted reproductive technology (ART) pregnancy and live birth rates. Human Reproduction 0:1–8.
   Google Scholar
• Ma CH, Yan LY, Qiao J, Sha W, Li L, Chen Y . 2010. Effects of tumour necrosis factor-alpha on porcine oocyte meiosis progression, spindle organization, and chromosome alignment. Fertility and Sterility 93:920–926.
   PubMed Web of Science ®Google Scholar
• Maheshwari A, Stofberg L, Bhattacharya S. 2007. Effect of overweight and obesity on assisted reproductive technology – a systematic review. Human Reproduction Update 13:433–444.
   PubMed Web of Science ®Google Scholar
• McClamrock H. 2008. The great weight debate: do elevations in body mass index (BMI) exert a negative extraovarian effect on in vitro fertilization outcome? Fertility and Sterility 89:1609–1610.
   PubMed Web of Science ®Google Scholar
• Metwally M, Cutting R, Tipton A, Skull J, Ledger WL, Li TC. 2007a. Effect of increased body mass index on oocyte and embryo quality in IVF patients. Reproductive Biomedicine Online 15:532–538.
   PubMed Web of Science ®Google Scholar
• Metwally M, Tuckerman EM, Laird SM, Ledger WL, Li TC. 2007b. Impact of high body mass index on endometrial morphology and function in the peri-implantation period in women with recurrent miscarriage. Reproductive Biomedicine Online 14:328–334.
   PubMed Web of Science ®Google Scholar
• Minge CE, Bennett BD, Norman RJ, Robker RL. 2008. Peroxisome proliferator-activated receptor gamma agonist rosiglitazone reverses the adverse effects of diet-induced obesity on oocyte quality. Endocrinology 149:2646–2656.
   PubMed Web of Science ®Google Scholar
• Okon MA, Laird SM, Tuckerman EM and Li TC. 1998. Serum androgen levels in women who have recurrent miscarriages and their correlation with markers of endometrial function. Fertility and Sterility 69: 682–690.
   PubMed Web of Science ®Google Scholar
• Orvieto R, Meltcer S, Nahum R, Rabinson J, Anteby EY, Ashkenazi J. (2009) The influence of body mass index on in vitro fertilization outcome. International Journal of Gynecology and Obstetrics 104:53–55.
   PubMed Web of Science ®Google Scholar
• Prentice AM. 2006. The emerging epidemic of obesity in developing countries. International Journal of Epidemiology 35:93–99.
   PubMed Web of Science ®Google Scholar
• Qiao J, Feng H. 2010. Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence. Human Reproduction Update 17:17–33.
   PubMed Web of Science ®Google Scholar
• Rittenberg V, Sobaleva S, Al-Hadi A, Khalaf Y, Braude P, El-Toukhy T. 2010. Influence of BMI on miscarriage rate after elective single blastocyst transfer. Hum Reprod 2011 August 3. PMID:21813669 [Epub ahead of print].
   Google Scholar
• Rittenberg V, Sunkara SK, Khalaf Y, Braude P, El-Toukhy T. 2011. Effect of body mass index on pregnancy outcome following IVF treatment: a systematic review and meta-analysis. Reprod Biomed Online 2011. DOI: 10.1016/j.rbmo.2011.06.018 (in press).
   Google Scholar
• Revelli A, DellePiane L, Casano S, Molinari E, Massobrio M, Rinaudo P. 2009. Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics. Reproductive Biology and Endocrinology 7:40.
   PubMed Web of Science ®Google Scholar
• Salim R, Miel J, Savvas M, Lee C, Jurkovic D. 2007. A comparative study of glycodelin concentrations in uterine flushings in women with subseptate uteri, history of unexplained recurrent miscarriage and healthy controls. European Journal of Obstetrics, Gynecology, and Reproductive Biology 133:76–80.
   PubMed Web of Science ®Google Scholar
• Samy N, Hashim M, Sayed M, Said M. 2009. Clinical significance of inflammatory markers in polycystic ovary syndrome: Their relationship to insulin resistance and body mass index. Disease Markers 26: 163–170.
   PubMed Web of Science ®Google Scholar
• Styne-Gross A, Elkind-Hirsch K, Scott R. 2005. Obesity does not impact implantation rates or pregnancy outcome in women attempting conception through oocyte donation. Fertility and Sterility 83:1629–1634.
   PubMed Web of Science ®Google Scholar
• Tamer Erel C, Senturk LM. 2009. The impact of body mass index on assisted reproduction. Current Opinions in Obstetrics and Gynaecology 21: 228–235.
   PubMed Web of Science ®Google Scholar
• Tao Z, Yan L. 2005. Luteinizing hormone and insulin inducing earlier and excess expression of luteinizing hormone receptor messenger ribonucleic acids in granulosa cells of polycystic ovary syndrome. Fertility and Sterility 84(Suppl.): S426–S427.
   PubMedGoogle Scholar
• Tesarik J, Mendoza C. 1997. Direct non-genomic effects of follicular steroids on maturing human oocytes: oestrogen versus androgen antagonism. Human Reproduction Update 3:95–100.
   PubMed Web of Science ®Google Scholar
• Tian L, Shen H, Lu Q, Norman RJ, Wang J. 2007. Insulin resistance increases the risk of spontaneous abortion after assisted reproduction technology treatment. Journal of Clinical Endocrinology and Metabolism 92: 1430–1433.
   PubMed Web of Science ®Google Scholar
• Tuckerman EM, Okon MA, Li TC, Laird SM. 2000. Do androgens have a direct effect on endometrial function? An in vitro study. Fertility and Sterility 74:771–779.
   PubMed Web of Science ®Google Scholar
• van der Steeg JW, Steures P, Eijkemans MJ, Habbema JD, Hompes PG, Michgelsen HW . 2008. Predictive value of pregnancy history in subfertile couples: results from a nationwide cohort study in the Netherlands. Fertility and Sterility 90:521–527.
   PubMed Web of Science ®Google Scholar
• Wabitsch M, Hauner H, Heinze E, Bockmann A, Benz R, Mayer H . 1995. Body fat distribution and steroid hormone concentrations in obese adolescent girls before and after weight reduction. Journal of Clinical Endocrinology and Metabolism 80:3469–3475.
   PubMed Web of Science ®Google Scholar
• Wang TH, Chang CL, Wu HM, Chiu YM, Chen CK, Wang HS. 2006. Insulin-like growth factor-II (IGF-II), IGF-binding protein-3 (IGFBP-3), and IGFBP-4 in follicular fluid are associated with oocyte maturation and embryo development. Fertility and Sterility 86:1392–1401.
   PubMed Web of Science ®Google Scholar
• Wittemer C, Ohl J, Bailly M, Bettahar-Lebugle K, Nisand I. 2000. Does body mass index of infertile women have an impact on IVF procedure and outcome? Journal of Assisted Reproduction and Genetics 17: 547–552.
   PubMed Web of Science ®Google Scholar
• Wood JR, Dumesic DA, Abbott DH, Strauss JF. 2007. Molecular abnormalities in oocytes from women with polycystic ovary syndrome revealed by microarray analysis. Journal of Clinical Endocrinology and Metabolism 92:705–713.
   PubMed Web of Science ®Google Scholar
• WHO. 2006. World Health Organization Fact Sheet 311. Obesity and overweight. Available at: www.who.int/mediacentre/factsheets/fs311/en/index.html (Accessed 26 November 2010).
   Google Scholar
• Veleva Z, Tiitinen A, Vilska S, Hyde´n-Granskog C, Toma´s C, Martikainen H . 2008. High and low BMI increase the risk of miscarriage after IVF/ICSI and FET. Human Reproduction 23:878–884.
   PubMed Web of Science ®Google Scholar
• Yilmaz N, Kilic S, Dogan M, Ozgu E, Kalyoncu A, Mollamahmutoglu L. 2010. The effect of serum and intrafollicular insulin resistance parameters and homocysteine levels of nonobese, nonhyperandrogenemic polycystic ovary syndrome patients on in vitro fertilization outcome. Fertility and Sterility 93:1864–1869.
   PubMed Web of Science ®Google Scholar
• Zhang D, Zhu Y, Gao H, Zhou B, Zhang R, Wang T . 2010. Overweight and obesity negatively affect the outcomes of ovarian stimulation and in vitro fertilisation: A cohort study of 2628 Chinese women. Gynaecological Endocrinology 26:325–332.
   PubMed Web of Science ®Google Scholar