Biomarkers in pre-eclampsia: A novel approach to early detection of the disease

References

• Abdalla SA, Letarte M. 2006. Hereditary haemorrhagic telangiectasia: current views on genetics and mechanisms of disease. Journal of Medical Genetics 43:97–110.
   PubMed Web of Science ®Google Scholar
• Acilmis YG, Dikensoy E, Kutlar AI, Balat O, Cebesoy FB, Ozturk E . 2011. Homocysteine, folic acid and vitamin B12 levels in maternal and umbilical cord plasma and homocysteine levels in placenta in pregnant women with preeclampsia. Journal of Obstetrics and Gynaecology Research 37:45–50.
   PubMed Web of Science ®Google Scholar
• Alexander GR, Himes JH, Kaufman RB, Mor J, Kogan M. 1996. A United States National Reference for Fetal Growth. Obstetrics and Gynecology 87:163–168.
   PubMed Web of Science ®Google Scholar
• Anim-Nyame N, Sooranna SR, Steer PJ, Johnson MR. 2000. Longitudinal analysis of maternal plasma leptin concentrations during normal pregnancy and preeclampsia. Human Reproduction 15:2033–2036.
   PubMed Web of Science ®Google Scholar
• Autiero M, Waltenberger J, Communi D, Kranz A, Moons M, Lambrechts D . 2003. Role of PLGF in the intra- and intermolecular cross talk between the VEGF receptors Flt-1 and Flk-1. Nature Medicine 9: 936–943.
   PubMed Web of Science ®Google Scholar
• Barbara NP, Wrana LJ, Letarte M. 1999. Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily. Journal of Biological Chemistry 271:584–594.
   Google Scholar
• Bersinger NA, Smarason AK, Muttukrishna S, Groome NP, Redman CW. 2003. Women with preeclampsia have increased serum levels of pregnancy-associated plasma protein A (PAPP-A), inhibin A, activin A and soluble E-selectin. Hypertension in Pregnancy 22:45–55.
   PubMed Web of Science ®Google Scholar
• Burrows FJ, Derbyshire RJ, Tazzari PL, Amlot P, Gazdar AF, King SW . 1995. Up-regulation of endoglin on vascular endothelial cells in human solid tumors: Implications for diagnosis and therapy. Clinical Cancer Research 1:1623–1634.
   PubMed Web of Science ®Google Scholar
• Burger O, Pick E, Zwickel J, Klayman M, Meiri H, Slotky R . 2004. Placental Protein 13 (PP-13): effects on cultured trophoblasts, and its detection in human body fluids in normal and pathological pregnancies. Placenta 25:608–622.
   PubMed Web of Science ®Google Scholar
• CEMACH. 2004. Why mothers die 2000–2002. London: RCOG Press.
   Google Scholar
• Chafetz I, Kuhnreich I, Sammar M, Tal J, Gibor Y, Meiri H . 2007. First trimester placental protein 13 screening for preeclampsia and intrauterine growth restriction. American Journal of Obstetrics and Gynecology 197:35.e1-e7.
   Web of Science ®Google Scholar
• Chaiworapongsa T, Romero R, Espinoza J, Bujold E, Mee Kim Y, Goncalves LF . 2004. Evidence supporting the role for blockade of the vascular endothelial growth factor system in the pathophysiology of preeclampsia. American Journal of Obstetrics and Gynecology 190:1541–1547.
   PubMed Web of Science ®Google Scholar
• Chan TF, Su JH, Chung YF, Hsu YH. 2003. Amniotic fluid and maternal serum leptin levels in pregnant women who subsequently develop preeclampsia. European Journal of Obstetrics, Gynecology, and Reproductive Biology 108:50–53.
   PubMed Web of Science ®Google Scholar
• Cheifetz S, Bellon T, Cales C, Vera S, Bernabeu C, Massagué J . 1992. Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. Journal of Biological Chemistry 267:19027–19030.
   PubMed Web of Science ®Google Scholar
• Collins S, Kuhn CM, Petro AE, Swick AG, Chrunyk BA, Surwit RS. 1996. Role of leptin in fat regulation. Nature 380:677.
   PubMed Web of Science ®Google Scholar
• Conley BS, Smith JD, Guerrero-Esteo M, Bernabeu C, Vary CPH. 2000. Endoglin, a TGF-beta receptor associated protein, is expressed by smooth muscle cells in human atherosclerotic plaques. Atherosclerosis 153: 323–335.
   PubMed Web of Science ®Google Scholar
• Damsky CH, Librach C, Lim KH. 1994. Integrin switching regulates normal trophoblast invasion. Development 120:3657–3666.
   PubMed Web of Science ®Google Scholar
• Decker AG, DeVries JIP, Doelitzsch PM, Huijgens PC, von Blomberg BM, Jakobs C . 1995. Underlying disorders associated with severe early onset preeclampsia. American Journal of Obstetrics and Gynecology 173:1042–1048.
   PubMed Web of Science ®Google Scholar
• Duckitt K, Harrington D. 2005. Risk factors for preeclampsia at antenatal booking: a systematic review of controlled studies. British Medical Journal 330:549–550.
   PubMed Web of Science ®Google Scholar
• Ellis J, Wennerholm UB, Bengtsson A, Lilja H, Pettersson A, Sultan B . 2001. Levels of dimethylarginines and cytokines in mild and severe preeclampsia. Acta Obstetricia et Gynecologica Scandinavica 80:602–608.
   PubMed Web of Science ®Google Scholar
• Eskenazi B, Fenster L Sidney S. 1991. A multivariate analysis of risk factors for preeclampsia. Journal of the American Medical Association 266: 237–241.
   PubMed Web of Science ®Google Scholar
• Ferrara N, Henzel WJ. 1989. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochemical and Biophysical Research Communications 161:851–858.
   PubMed Web of Science ®Google Scholar
• Goldijin-Wessel TA, Wouters MG, van de Molen EF, Spuijbroek MD, Steegers-Theunissen RP, Blom HJ . 1996. Hyperhomocysteinemia: a risk factor for placental abruption or infarction. European Journal of Obstetrics, Gynecology, and Reproductive Biology 66:23–29.
   PubMed Web of Science ®Google Scholar
• Holden D, Fickling S, Whitley G, Nussey S. 1998. Plasma concentrations of asymmetric dimethylarginine, a natural inhibitor of nitric oxide synthase, in normal pregnancy and preeclampsia. American Journal of Obstetrics and Gynecology 178:551–556.
   PubMed Web of Science ®Google Scholar
• Irwin JC, Suen LF, Martina NA, Mark SP, Giudice LC. 1999. Role of the IGF system in trophoblast invasion and pre-eclampsia. Human Reproduction 14:s90–s96.
   PubMed Web of Science ®Google Scholar
• Jerkic M, Rivas-Elena JV, Prieto M, Carron R, Sanz-Rodriguez F, Perez- Barriocanal F . 2004. Endoglin regulates nitric oxide-dependent vasodilatation. FASEB Journal 18:609–611.
   PubMed Web of Science ®Google Scholar
• Kniss DA, Shubert PJ, Zimmerman PD, Landon MB, Gabbe SG. 1994. Insulin like growth factors: their regulation of glucose and amino acid transport in placental trophoblasts isolated from first-trimester chorionic villi. Journal of Reproductive Medicine 39:249–256.
   PubMed Web of Science ®Google Scholar
• Lastres P, Letamendia A, Zhang H, Rius C, Almendro N, Raab U . 1996. Endoglin modulates cellular responses to TGF-beta 1. Journal of Cell Biology 133:1109–1121.
   PubMed Web of Science ®Google Scholar
• Lawrence JB, Oxvig C, Overgaard MT, Sottrup-Jensen L, Gleich GJ, Hays LG . 1999. The insulin-like growth factor (IGF)-dependent binding protein-4 protease secreted by human fibroblasts is pregnancy- associated plasma protein-A. Proceedings of the National Academy of Sciences of the United States of America 96:3149–3153.
   PubMed Web of Science ®Google Scholar
• Lebrin F, Goumans MJ, Jonker L, Carvalho RL, Valdimarsdottir G, Thorikay M . 2004. Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction. EMBO Journal 23:4018–4028.
   PubMed Web of Science ®Google Scholar
• Lepercq J, Catalano P, Hayguel de Mouzon S. 2007. Leptin in pregnancy: facts, questions and future. Gynecologie, Obstetrique et Fertilite 35:89–95.
   PubMedGoogle Scholar
• Leper J, Vallance P. 1999. Biological significance of endogenous methylarginines that inhibit nitric oxide synthases. Cardiovascular Research 43:542–548.
   PubMed Web of Science ®Google Scholar
• Levine RJ, Lam C, Qian C, Yu KF, Maynard SE. 2006. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. New England Journal of Medicine 355:992–1005.
   PubMed Web of Science ®Google Scholar
• Li RH, Poon SC, Yu MY. Wong YF. 2004. Expression of placental leptin in preeclampsia. American Journal of Obstetrics and Gynecology 23:378–385.
   Google Scholar
• Linnemann K, Malek A, Schneider H, Fusch C. 2001. Physiological and pathological regulation of feto/placento/maternal leptin expression. Biochemical Society Transactions 29:86–90.
   PubMed Web of Science ®Google Scholar
• Lin TM, Halbert SP. 1976. Placental localization of human pregnancy- associated plasma proteins.Science (New York, N.Y.) 193:1249–1252.
   PubMed Web of Science ®Google Scholar
• Livingston JC, Maxwell BD. 2003. Preeclampsia: theories and speculations. Wiener Klinische Wochenschrift 115:145–148.
   PubMed Web of Science ®Google Scholar
• Makedos G, Papanikolaou A, Hitoglou A, Kalogiannidis I, Makedos A . 2007. Homocysteine, folic acid and B12 levels in pregnancy complicated with preeclampsia. Archives of Gynecology and Obstetrics 75:121–124.
   Google Scholar
• Mao D, Che J, Li K, Han S, Yue Q, Zhu L. 2003. Association of homocysteine, asymmetric dimethylarginine, and nitric oxide with preeclampsia. Archives of Gynecology and Obstetrics 282:371–375.
   Google Scholar
• Martinez-Abundis E, Gonzalez-Ortiz M, Pascoe-Gonzalez S. 2000. Serum leptin levels and the severity of preeclampsia. Archives of Gynecology and Obstetrics 264:71–73.
   PubMed Web of Science ®Google Scholar
• Mauruotti G, Del Bianco A, Amato AN, Lomardi L, Fulgeri AM, Pietropaolo F. 2005. Preeclampsia and high serum levels of homocysteine. Minerva Ginecologica 57:165–170.
   PubMedGoogle Scholar
• Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S . 2003. Excess placental soluble Fms-like tyrosine kinase-1 (sFlt-1) may contribute to endothelial dysfunction, hypertension and proteinuria in preeclampsia. Journal of Clinical Investigation 111:649–658.
   PubMed Web of Science ®Google Scholar
• Maynard S, Venkatesha S, Thadhani R, Karumanhi SA. 2005. Soluble Fms-like tyrosine kinase-1 and endothelial dysfunction in the pathogenesis of preeclampsia. Pediatric Research 57:1R–7R.
   PubMed Web of Science ®Google Scholar
• McAllister KA, Grogg KM, Johnson DW, Gallione CJ, Baldwin MA, Jackson CE . 1994. Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nature Genetics 8:345–351.
   PubMed Web of Science ®Google Scholar
• McCarthy JF, Misra DN, Roberts JM. 1999. Maternal plasma leptin is increased in preeclampsia and positively correlates with fetal cord concentration. American Journal of Obstetrics and Gynecology 180:731–736.
   PubMed Web of Science ®Google Scholar
• Meekins JW, Pijnenborg R, Hanssens M, Mc Fadyen IR, van Asshe A. 1994. A study of placental bed spiral arteries and trophoblast invasion in normal and severe pre-eclamptic pregnancies. British Journal of Obstetrics and Gynaecology 101:669–674.
   PubMedGoogle Scholar
• Meis PJ, Goldberg RL, Mercer BM. 1998. The preterm prediction study: risk factors for indicated preterm births: Maternal-Fetal Medicine units Network of the national Institute of Child Health and Human Development. American Journal of Obstetrics and Gynecology 178:562–567.
   PubMed Web of Science ®Google Scholar
• Mise H, Sagawa N, Matsumoto T, Yura S, Nanno H, Itoh H . 1998. Augmented placental production of leptin in preeclampsia: a possible involvement of placental hypoxia. Journal of Clinical Endocrinology and Metabolism 83:3225–3229.
   PubMed Web of Science ®Google Scholar
• Moat SJ, McDowell IF. 2005. Homocysteine and endothelial function in human studies. Seminars in Vascular Medicine 5:172–182.
   PubMedGoogle Scholar
• National High Blood Pressure Education Program Working Group. 2000. Report of the National High Blood Pressure Education Program Working Group on high blood pressure in pregnancy. American Journal of Obstetrics and Gynecology 183:s1–s22.
   PubMed Web of Science ®Google Scholar
• Nestler JE. 1990. Insulin-like growth factor II is a potent inhibitor of the aromatase activity of human placental cytotrophoblasts. Endocrinology 127:2064–2070.
   PubMed Web of Science ®Google Scholar
• Nicolaides KH, Bindra R, Turan OM, Chefetz I, Sammar M, Meiri H . 2006. A novel approach to first trimester screening for early pre-eclampsia combining serum PP-13 and Doppler ultrasound. Ultrasound in Obstetrics and Gynecology 27:13–17.
   PubMed Web of Science ®Google Scholar
• Ong CY, Liao AW, Spencer K, Munim S, Nicolaides KH. 2000. First trimester maternal serum free human chorionic gonadotrophin and pregnancy associated plasma protein A as predictors of pregnancy complications. British Journal of Obstetrics and Gynaecology 107:1265–1270.
   Google Scholar
• Pettersson A, Hedner T, Milsom I. 1998. Increased circulating concentrations of asymmetric dimethyl arginine (ADMA), an endogenous inhibitor of nitric oxide synthesis, in preeclampsia. Acta Obstetricia et Gynecologica Scandinavica 77:808–813.
   PubMed Web of Science ®Google Scholar
• Piccano MF. 2000. Is homocysteine a biomarker for identifying women at risk of complications and adverse pregnancy outcomes?American Journal of Clinical Nutrition 71:857–858.
   PubMed Web of Science ®Google Scholar
• Redman CW, Sargent IL. 2005. Latest advances in understanding preeclampsia. Science (New York, N.Y.) 308:1592–1594.
   PubMed Web of Science ®Google Scholar
• Rizos D, Eleftheriades M, Batakis E, Rizou M, Haliasos A, Hassiakos D . 2011. Levels of asymmetric dimethylamine throughout normal pregnancy and in pregnancies complicated with preeclampsia and small for gestational age baby. Journal of Maternal-Fetal and Neonatal Medicine[Epub ahead of print].
   PubMed Web of Science ®Google Scholar
• Romero R, Kusanovic JP, Than NG, Erez O, Gotsch F, Espinoza J . 2008. First trimester maternal serum PP13 in the risk assessment for preeclampsia. American Journal of Obstetrics and Gynecology 199:122.e1–e11.
   PubMed Web of Science ®Google Scholar
• Rubanyi GM. 1993. The role of endothelium in cardiovascular homeostasis and disease. Cardiovascular Pharmacology 22:s1–s4.
   PubMed Web of Science ®Google Scholar
• Sagawa N, Yura S, Itoh H, Mise H, Kakaui K, Korita D . 2002. Role of leptin in pregnancy – a review. Placenta 23:580–586.
   Web of Science ®Google Scholar
• Salahuddin S, Lee Y, Vadnais M, Sachs BP, Karumanchi SA, Lim KH. 2007. Diagnostic utility of soluble Fms-like tyrosine kinase 1 and soluble endoglin in hypertensive diseases of pregnancy. American Journal of Obstetrics and Gynecology 197:28.e1-e6.
   Web of Science ®Google Scholar
• Salomon LJ, Benattar C, Audibert F, Fernandez H, Duyme M, Taieb J . 2003. Severe preeclampsia is associated with high inhibin A and normal leptin levels at 7 to 13 weeks into pregnancy. American Journal of Obstetrics and Gynecology 189:1517–1522.
   PubMed Web of Science ®Google Scholar
• Sandrim VC, Palei AC, Metzger F, Cavalli RC, Duarte G, Tanus-santos JE. 2010. Interethnic differences in ADMA concentrations and negative association with nitric oxide formation in preeclampsia. Clinica Chimica Acta 411:1457–1469.
   PubMed Web of Science ®Google Scholar
• Savvidou MD, Hingorani AD, Tsikas D, Frölich JC, Vallance P, Nicolaides KH. 2003. Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia. Lancet 361:1511–1517.
   PubMed Web of Science ®Google Scholar
• Sawano A, Takahashi T, Yamaguchi S, Aonuma M, Shibuya M. 1996. Flt-1 but not KDR/flk-1 tyrosine kinase is a receptor for placental growth factor which is related to vascular endothelial growth factor. Cell Growth and Differentiation 7:213–221.
   PubMedGoogle Scholar
• Schnabel R, Blankenberg S, Lubos E, Lackner KJ, Rupprecht HJ, Espinola-Klein C . 2005. Asymmetric dimethylarginine and the risk of cardiovascular events and death in patients with coronary artery disease: results from the Athero Gene Study. Circulation Research 97:e53–e9.
   PubMed Web of Science ®Google Scholar
• Schobel HP, Fischer T, Heuszer K, Geiger H, Schmieder RE. 1996. Preeclampsia – a state of sympathetic over activity. New England Journal of Medicine 335:1480–1485.
   PubMed Web of Science ®Google Scholar
• Sibai BM. 1991. Immunologic aspects of preeclampsia. Clinical Obstetrics and Gynecology 34:27–34.
   PubMed Web of Science ®Google Scholar
• Sibai BM. 2003. Diagnosis and management of gestational hypertension and preeclampsia. Obstetrics and Gynecology 102:181–192.
   PubMed Web of Science ®Google Scholar
• Smith GC, Stenhouse EJ, Crossley JA, Aitken DA, Cameron AD, Connor JM. 2002. Early pregnancy levels of pregnancy-associated plasma protein and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirth. Journal of Clinical Endocrinology and Metabolism 87:1762–1767.
   PubMed Web of Science ®Google Scholar
• Spencer K, Cowans NJ, Chefetz I, Tal J, Kuhnreich I, Meiri H. 2007a. Second trimester uterine artery Doppler pulsatility index and maternal serum PP13 as markers of Preeclampsia. Prenatal Diagnosis 27:258–263.
   PubMed Web of Science ®Google Scholar
• Spencer K, Cowans NJ, Chefetz I, Tal J, Meiri H. 2007b. First trimester maternal serum PP-13, PAPP-A and second-trimester uterine Doppler pulsatility index as markers of preeclampsia. Ultrasound in Obstetrics and Gynecology 29:128–134.
   PubMed Web of Science ®Google Scholar
• Sladek SM, Magness RR, Conrad KP. 1997. Nitric Oxide and pregnancy. American Journal of Physiology 272:441–463.
   PubMed Web of Science ®Google Scholar
• Teppa RJ, Ness RB, Crombleholme WR. 2000. Free leptin is increased in normal pregnancy and further increased in preeclampsia. Metabolism: Clinical and Experimental 49:1043–1048.
   PubMed Web of Science ®Google Scholar
• ten Dijke P, Arthur HM. 2007. Extracellular control of TGF-beta signaling in vascular development and disease. Nature Reviews Molecular Cell Biology 8:857–869.
   PubMed Web of Science ®Google Scholar
• Than NG, Sumegi B, Than GN, Berente Z, Bohn H. 1999. Isolation and sequence analysis of a cDNA encoding human placental tissue protein 13 (PP13), a new lysophospholipase, homologue of human eosinophil Charcot-Leyden crystal protein. Placenta 10:703–710.
   Google Scholar
• Trupin LS, Simon LP, Eskenazi B. 1996. Change in paternity: a risk factor for preeclampsia in multiparas. Epidemiology 7:240–244.
   PubMed Web of Science ®Google Scholar
• Yaron Y, Heifetz S, Ochshorn Y, Lehavi O, Orr-Urtreger A. 2002. Decreased first trimester PAPP-A is a predictor of adverse pregnancy outcome. Prenatal Diagnosis 22:778–782.
   PubMed Web of Science ®Google Scholar
• Vallance P, Leone A, Calver A, Collier J, Moncada S. 1992. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 7:572–575.
   Google Scholar
• Venkatesha S, Toposian M, Lam C. 2006. Soluble-endoglin contributes to the pathogenesis of preeclampsia. Nature Medicine 12:642–649.
   PubMed Web of Science ®Google Scholar
• Walker MC, Smith GN, Perkins SL, Keely EJ, Garner PR. 1999. Changes in homocysteine levels during normal pregnancy. American Journal of Obstetrics and Gynecology 180:660–664.
   PubMed Web of Science ®Google Scholar
• Welch GN, Loscalzo J. 1998. Homocysteine and atherothrombosis. New England Journal of Medicine 338:1042–1050.
   PubMed Web of Science ®Google Scholar
• Yoo JH, Lee SC. 2001. Elevated levels of plasma homocyst(e)ine and asymmetric dimethylarginine in elderly patients with stroke. Atherosclerosis 158:425–430.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Damsky CH, Fisher SJ. 1997. Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome?Journal of Clinical Investigation 99:2152–2164.
   PubMed Web of Science ®Google Scholar