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Research Article

Systemic toxicity and toxicokinetics of a high dose of polyethylene glycol 400 in dogs following intravenous injection

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Pages 208-212 | Received 30 Mar 2010, Accepted 02 Jun 2010, Published online: 12 Feb 2011

References

  • Anonymous. (1993). Final report on the safety assessment of polyethylene glycol (PEGs)-6, -8, -32, -75, -150, -14 m, -20 m. Int J Toxicol 12:429–457.
  • Ashiru, D. A., Patel, R., Basit, A. W. (2008). Polyethylene glycol 400 enhances the bioavailability of a BCS class III drug (ranitidine) in male subjects but not females. Pharm Res 25:2327–2333.
  • Ballantyne, B., Leung, H.-W., Hermansky, S. J., Frantz S. W. (1998). Subchronic, chronic, pharmacokinetic, and genotoxicity studies with Polyox(R) water soluble resin. Toxicol Lett 95:46–47.
  • Basit, A. W., Newton, J. M., Short, M. D., et al. (2001). The effect of polyethylene glycol 400 on gastrointestinal transit: implications for the formulation of poorly water soluble drugs. Pharm Res 18:1146–1150.
  • Cheng, T-L., Chen, B-M., Chan, L-Y., et al. (1997). Poly (ethylene glycol) modification of beta-glucuronidase-antibody conjugates for solid-tumor therapy by targeted activation of glucuronide prodrugs. Cancer Immunol Immunother 44:305–315.
  • David, E. P., a Saleh K. M. (1978). Oral toxicity of polyethylene glycol (PEG-200) in monkeys and rats. Toxicol Lett 2:119–122.
  • DeSantis, G., Jones, J. B. (1999). Chemical modification of enzymes for enhanced functionality. Curr Opin Biotechnol 10:324–330.
  • Hermansky, S. J., Neptun, D. A., Loughran, K. A., Leung, H. W. (1995). Effects of polyethylene glycol 400 (PEG-400) following 13 weeks of gavage treatment in Fischer-344 rats. Food Chem Toxicol 33:139–149.
  • Johnson, B. M., Charman, W. N., Porter, C. J. (2002). An in vitro examination of the impact of polyethylene glycol 400, Pluronic P85, and vitamin E d-a-tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein efflux and enterocyte-based metabolism in excised rat intestine. AAPS PharmSci 4:193–205.
  • Lin, C-F., Hayton, W. L. (1983). Absorption of polyethylene glycol 400 administered orally to mature and senescent rats. Age 6:52–56.
  • Mitchell, A. D., Auletta, A. E., Clive, D., et al. (1997). The L5178Y/tk±mouse lymphoma specific gene and chromosomal mutation assay, a phase III report of the U.S. Environmental Protection Agency Gene-Tox Program.Mutat Res 394:177–303.
  • Olga, B., Salvatore, M., Pasquale, M. (2002). Low molecular weight polyethylene glycol induces chromosome aberrations in Chinese hamster cells cultured in vitro. Mutagenesis 17:261–264.
  • Smyth, H. F., Jr., Carpenter, C. P., Shaffer, C. B. (1947). The toxicity of high molecular weight polyethylene glycols: chronic oral and parenteral administration. J Am Pharmaceut Assoc 36:157–160.
  • Smyth, H. F., Jr., Weil, C. S., Woodside, M. D., Knaak, J. B., et al. (1970). Experimental toxicity of a high molecular weight poly(ethylene oxide). Toxicol Appl Pharmacol 16:442–445.

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