The effects of Andrographis paniculata (Burm.f.) Nees extract and diterpenoids on the CYP450 isoforms’ activities, a review of possible herb–drug interaction risks

References

• Bachmann KA, Lewis JD (2005). Predicting inhibitory drug–drug interactions and evaluating drug interaction reports using inhibition constants. Ann Pharmacother 39:1064–1072
   PubMed Web of Science ®Google Scholar
• Balachandran P, Govindarajan R (2005). Cancer–an ayurvedic perspective. Pharmacol Res 51:19–30
   PubMed Web of Science ®Google Scholar
• Barret B. (2007). Viral upper respiratory infection. In: Rakel D, ed. Integrative medicine, 2nd ed. Philadelphia: Saunders Elsevier, 1238
   Google Scholar
• Bjornsson TD, Callaghan JT, Einolf HJ, et al. (2003). The conduct of in vitro and in vivo drug–drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective. Drug Metab Dispos 31:815–832
   PubMed Web of Science ®Google Scholar
• Boobis A, Watelet JB, Whomsley R, et al. (2009). Drug interactions. Drug Metab Rev 41:486–527
   PubMed Web of Science ®Google Scholar
• Breidenbach T, Hoffmann MW, Becker T, et al. (2000). Drug interaction of St John's wort with cyclosporin. Lancet 355:1912
   PubMed Web of Science ®Google Scholar
• Cheung HY, Cheung SH, Li J, et al. (2005). Andrographolide isolated from Andrographis paniculata induces cell cycle arrest and mitochondrial-mediated apoptosis in human leukemic HL-60 cells. Planta Med 71:1106–1111
   PubMed Web of Science ®Google Scholar
• Chien CF, Wu YT, Lee WC, et al. (2010). Herb-drug interaction of Andrographis paniculata extract and andrographolide on the pharmacokinetics of theophylline in rats. Chem Biol Interact 184:458–465
   PubMed Web of Science ®Google Scholar
• Choudhury BR, Haque SJ, Poddar MK. (1987). In vivo and in vitro effects of kalmegh (Andrographis paniculata) extract and andrographolide on hepatic microsomal drug metabolizing enzymes. Planta Med 53:135–140
   PubMedGoogle Scholar
• Choudhury BR, Poddar MK. (1984). Andrographolide and kalmegh (Andrographis paniculata) extract: in vivo and in vitro effect on hepatic lipid peroxidation. Methods Find Exp Clin Pharmacol 6:481–485
   PubMed Web of Science ®Google Scholar
• Dai GF, Zhao J, Jiang ZW, et al. (2011). Anti-inflammatory effect of novel andrographolide derivatives through inhibition of NO and PGE2 production. Int Immunopharmacol 11:2144–2149
   PubMed Web of Science ®Google Scholar
• Fahmi OA, Kish M, Boldt S, Obach RS. (2010). Cytochrome P450 3A4 mRNA is a more reliable marker than CYP3A4 activity for detecting pregnane X receptor-activated induction of drug-metabolizing enzymes. Drug Metab Dispos 38:1605–1611
   PubMed Web of Science ®Google Scholar
• FDA. (2006). Guidance for Industry: Drug Interaction Studies – Study Design, Data Analysis, and Implications for Dosing and Labeling. Available from: http://www.fda.gov/OHRMS/DOCKETS/98fr/06d-0344-gdl0001.pdf. Accessed on September 2006
   Google Scholar
• FDA (2012). Guidance for Industry. Drug Interaction Studies – Study Design, Data Analysis, Implications for Dosing and Labeling Recommendations. Available from: http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm292362.pdf. Accessed on February 2012
   Google Scholar
• Frye RF, Fitzgerald SM, Lagattuta TF, et al. (2004). Effect of St John's wort on imatinib mesylate pharmacokinetics. Clin Pharmacol Ther 76:323–329
   PubMed Web of Science ®Google Scholar
• Geethangili M, Rao YK, Fang SH, Tzeng YM. (2008). Cytotoxic constituents from Andrographis paniculata induce cell cycle arrest in jurkat cells. Phytother Res 22:1336–1341
   PubMed Web of Science ®Google Scholar
• Gibson GG, Plant NJ, Swales KE, et al. (2002). Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man. Xenobiotica 32:165–206
   PubMed Web of Science ®Google Scholar
• Hanapi N, Azizi J, Ismail S, Mansor S. (2010). Evaluaition of selected Malaysian medicinal plants on phase I drug metabolzing enzymes, CYP2C9, CYP2D6 and CYP3A4 activities in vitro. Int J Pharmacol 6:494–499
   Google Scholar
• Hebert MF, Roberts JP, Prueksaritanont T, Benet LZ. (1992). Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction. Clin Pharmacol Ther 52:453–457
   PubMed Web of Science ®Google Scholar
• Heinrich M, Modarai M, Kortenkamp A. (2008). Herbal extracts used for upper respiratory tract infections: are there clinically relevant interactions with the cytochrome P450 enzyme system?. Planta Med 74:657–660
   PubMed Web of Science ®Google Scholar
• Ioannides C. (2002). Pharmacokinetic interactions between herbal remedies and medicinal drugs. Xenobiotica 32:451–478
   PubMed Web of Science ®Google Scholar
• Jain DC, Gupta MM, Saxena S, Kumar S. (2000). LC analysis of hepatoprotective diterpenoids from Andrographis paniculata. J Pharm Biomed Anal 22:705–709
   PubMed Web of Science ®Google Scholar
• Jarukamjorn K, Don-in K, Makejaruskul C, et al. (2006). Impact of Andrographis paniculata crude extract on mouse hepatic cytochrome P450 enzymes. J Ethnopharmacol 105:464–467
   PubMed Web of Science ®Google Scholar
• Johne A, Schmider J, Brockmoller J, et al. (2002). Decreased plasma levels of amitriptyline and its metabolites on comedication with an extract from St. John's wort (Hypericum perforatum). J Clin Psychopharmacol 22:46–54
   PubMed Web of Science ®Google Scholar
• Karliova M, Treichel U, Malago M, et al. (2000). Interaction of Hypericum perforatum (St. John's wort) with cyclosporin A metabolism in a patient after liver transplantation. J Hepatol 33:853–855
   PubMed Web of Science ®Google Scholar
• Lazarou J, Pomeranz BH, Corey PN. (1998). Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA 279:1200–1205
   PubMed Web of Science ®Google Scholar
• Lee W-R, Chung C-L, Hsiao C-J, et al. (2012). Suppression of matrix metalloproteinase-9 expression by andrographolide in human monocytic THP-1 cells via inhibition of NF-κB activation. Phytomedicine 19:270–277
   PubMed Web of Science ®Google Scholar
• Leucuta SE, Vlase L. (2006). Pharmacokinetics and metabolic drug interactions. Curr Clin Pharmacol 1:5–20
   PubMedGoogle Scholar
• Li J, Cheung H-Y, Zhang Z, et al. (2007). Andrographolide induces cell cycle arrest at G2/M phase and cell death in HepG2 cells via alteration of reactive oxygen species. Eur J Pharmacol 568:31–44
   PubMed Web of Science ®Google Scholar
• Lin JH. (2006). CYP induction-mediated drug interactions: in vitro assessment and clinical implications. Pharm Res 23:1089–1116
   PubMed Web of Science ®Google Scholar
• Lucey MR, Kolars JC, Merion RM, et al. (1990). Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450 IIIA. Lancet 335:11–15
   PubMed Web of Science ®Google Scholar
• Mannel M. (2004). Drug interactions with St John's wort: mechanisms and clinical implications. Drug Saf 27:773–797
   PubMed Web of Science ®Google Scholar
• Markowitz JS, Donovan JL, DeVane CL, et al. (2003). Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA 290:1500–1504
   PubMed Web of Science ®Google Scholar
• Matsuda T, Kuroyanagi M, Sugiyama S, et al. (1994). Cell differentiation-inducing diterpenes from Andrographis paniculata Nees. Chem Pharm Bull (Tokyo) 42:1216–1225
   PubMed Web of Science ®Google Scholar
• Naritomi Y, Teramura Y, Terashita S, Kagayama A. (2004). Utility of microtiter plate assays for human cytochrome P450 inhibition studies in drug discovery: application of simple method for detecting quasi-irreversible and irreversible inhibitors. Drug Metab Pharmacokinet 19:55–61
   PubMedGoogle Scholar
• Niki Y, Soejima R, Kawane H, et al. (1987). New synthetic quinolone antibacterial agents and serum concentration of theophylline. Chest 92:663–669
   PubMed Web of Science ®Google Scholar
• Ogu CC, Maxa JL. (2000). Drug interactions due to cytochrome P450. Proc (Bayl Univ Med Cent) 13:421–423
   PubMedGoogle Scholar
• Pan Y, Abd-Rashid BA, Ismail Z, et al. (2011a). In vitro determination of the effect of Andrographis paniculata extracts and andrographolide on human hepatic cytochrome P450 activities. J Nat Med 65:440–447
   PubMed Web of Science ®Google Scholar
• Pan Y, Abd-Rashid BA, Ismail Z, et al. (2011b). In vitro modulatory effects of Andrographis paniculata, Centella asiatica and Orthosiphon stamineus on cytochrome P450 2C19 (CYP2C19). J Ethnopharmacol 133:881–887
   PubMed Web of Science ®Google Scholar
• Pascussi JM, Gerbal-Chaloin S, Drocourt L, et al. (2003). The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors. Biochim Biophys Acta 1619:243–253
   PubMed Web of Science ®Google Scholar
• Pekthong D, Blanchard N, Abadie C, et al. (2009). Effects of Andrographis paniculata extract and Andrographolide on hepatic cytochrome P450 mRNA expression and monooxygenase activities after in vivo administration to rats and in vitro in rat and human hepatocyte cultures. Chem Biol Interact 179:247–255
   PubMed Web of Science ®Google Scholar
• Pekthong D, Martin H, Abadie C, et al. (2008). Differential inhibition of rat and human hepatic cytochrome P450 by Andrographis paniculata extract and andrographolide. J Ethnopharmacol 115:432–440
   PubMed Web of Science ®Google Scholar
• Pelkonen O, Turpeinen M, Hakkola J, et al. (2008). Inhibition and induction of human cytochrome P450 enzymes: current status. Arch Toxicol 82:667–715
   PubMed Web of Science ®Google Scholar
• Pelkonen O, Xu Q, Fan TP. (2014). Why is research on herbal medicinal products important and how can we improve its quality? J Tradit Complement Med 4:1–7
   Google Scholar
• Piscitelli SC, Burstein AH, Chaitt D, et al. (2000). Indinavir concentrations and St John's wort. Lancet 355:547–548
   PubMed Web of Science ®Google Scholar
• Pole S. (2006). Ayurvedic medicine; The principles of traditional medicine. Philadelphia: Churchill Livingstone Elsevier
   Google Scholar
• Pratheeshkumar P, Kuttan G. (2011). Andrographolide inhibits human umbilical vein endothelial cell invasion and migration by regulating MMP-2 and MMP-9 during angiogenesis. J Environ Pathol Toxicol Oncol 30:33–41
   PubMed Web of Science ®Google Scholar
• Reyes BA, Bautista ND, Tanquilut NC, et al. (2006). Anti-diabetic potentials of Momordica charantia and Andrographis paniculata and their effects on estrous cyclicity of alloxan-induced diabetic rats. J Ethnopharmacol 105:196–200
   PubMed Web of Science ®Google Scholar
• Ruschitzka F, Meier PJ, Turina M, et al. (2000). Acute heart transplant rejection due to Saint John's wort. Lancet 355:548–549
   PubMed Web of Science ®Google Scholar
• Sheeja K, Kuttan G. (2007). Activation of cytotoxic T lymphocyte responses and attenuation of tumor growth in vivo by Andrographis paniculata extract and andrographolide. Immunopharmacol Immunotoxicol 29:81–93
   PubMed Web of Science ®Google Scholar
• Shen YC, Chen CF, Chiou WF. (2002). Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its anti-inflammatory effect. Br J Pharmacol 135:399–406
   PubMed Web of Science ®Google Scholar
• Sperber AD. (1991). Toxic interaction between fluvoxamine and sustained release theophylline in an 11-year-old boy. Drug Saf 6:460–462
   PubMed Web of Science ®Google Scholar
• Tan ML, Tan HK, Oon CE, et al. (2012). Identification of genes involved in the regulation of 14-deoxy-11,12-didehydroandrographolide-induced toxicity in T-47D mammary cells. Food Chem Toxicol 50:431–444
   PubMed Web of Science ®Google Scholar
• Tang C, Prueksaritanont T. (2010). Use of in vivo animal models to assess pharmacokinetic drug–drug interactions. Pharm Res 27:1772–1787
   PubMed Web of Science ®Google Scholar
• Unger M. (2013). Pharmacokinetic drug interactions involving Ginkgo biloba. Drug Metab Rev 45:353–385
   PubMed Web of Science ®Google Scholar
• Varma A, Padh H, Shrivastava N. (2011). Andrographolide: a new plant-derived antineoplastic entity on horizon. Evid Based Complement Alternat Med 2011:815390
   Google Scholar
• Walsky RL, Obach RS. (2004). Validated assays for human cytochrome P450 activities. Drug Metab Dispos 32:647–660
   PubMed Web of Science ®Google Scholar
• WHO. (2002). WHO traditional medicine strategy 2002–2005. Geneva: World Health Organization
   Google Scholar
• Wiart C, Kumar K, Yusof MY, et al. (2005). Antiviral properties of ent-labdene diterpenes of Andrographis paniculata nees, inhibitors of herpes simplex virus type 1. Phytother Res 19:1069–1070
   PubMed Web of Science ®Google Scholar
• Wijnands WJ, Vree TB, van Herwaarden CL. (1986). The influence of quinolone derivatives on theophylline clearance. Br J Clin Pharmacol 22:677–683
   PubMed Web of Science ®Google Scholar
• Xia YF, Ye BQ, Li YD, et al. (2004). Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50. J Immunol 173:4207–4217
   PubMed Web of Science ®Google Scholar
• Yamada H, Ishii Y, Yamamoto M, Oguri K. (2006). Induction of the hepatic cytochrome P450 2B subfamily by xenobiotics: research history, evolutionary aspect, relation to tumorigenesis, and mechanism. Curr Drug Metab 7:397–409
   PubMed Web of Science ®Google Scholar
• Ye JF, Zhu H, Zhou ZF, et al. (2011). Protective mechanism of andrographolide against carbon tetrachloride-induced acute liver injury in mice. Biol Pharm Bull 34:1666–1670
   PubMed Web of Science ®Google Scholar