Genoprotective and hepatoprotective effects of Guarana (Paullinia cupana Mart. var. sorbilis) on CCl₄-induced liver damage in rats

References

• Basile A, Ferrara L, Pezzo MD, et al. (2005). Antibacterial and antioxidant activities of ethanol extract from Paullinia cupana. J Ethnopharmacol 102:32–36
   PubMed Web of Science ®Google Scholar
• Belliardo F, Martelli A, Valle MG. (1985). HPLC determination of caffeine and theophylline in Paullinia cupana Kunth (guaraná) and Cola spp. samples. Z Lebensm Unters Forsch 1180:398–401
   Google Scholar
• Bittencourt LS, Machado DC, Machado MM, et al. (2013). The protective effects of guaraná extract (Paullinia cupana) on fibroblast NIH-3T3 cells exposed to sodium nitroprusside. Food Chem Toxicol 53:119–125
   PubMed Web of Science ®Google Scholar
• Bohr V, Anson RM, Mazur S, Dianov G. (1998). Oxidative DNA damage processing and changes with aging. Toxicol Lett 103:47–52
   Web of Science ®Google Scholar
• Boozer CN, Nasser JA, Heymsfield SB, et al. (2001). An herbal supplement containing Ma Huang-Guaraná for weight loss: a randomized, double-blind trial. Int J Obes Relat Metab Disord 25:316–324
   PubMed Web of Science ®Google Scholar
• Brautbar N, Williams J. (2002). Industrial solvents and liver toxicity: risk assessment, risk factors and mechanisms. Int J Hyg Environ Health 205:479–491
   PubMed Web of Science ®Google Scholar
• Calabrese EJ. (2006). The failure of dose-response models to predict low dose effects: a major challenge for biomedical, toxicological and aging research. Biogerontology 7:119–122
   PubMed Web of Science ®Google Scholar
• Calabrese EJ. (2013). Hormetic mechanisms. Crit Rev Toxicol 43:580–606
   PubMed Web of Science ®Google Scholar
• Campos AR, Barros AI, Albuquerque FA, et al. (2005). Acute effects of guarana (Paullinia cupana Mart.) on mouse behaviour in forced swimming and open field tests. Phytother Res 19:441–443
   PubMed Web of Science ®Google Scholar
• Collins AR, Duthie SJ, Dobson VL. (1993). Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA. Carcinogenesis 14:1733–1735
   PubMed Web of Science ®Google Scholar
• Costa Krewer C, Ribeiro EE, et al. (2011). Habitual intake of guaraná and metabolic morbidities: an epidemiological study of an elderly Amazonian population. Phytother Res 25:1367–1374
   PubMed Web of Science ®Google Scholar
• Da Fonseca CA, Leal J, Costa SS, Leitão AC. (1994). Genotoxic and mutagenic effects of guaraná (Paullinia cupana) in prokaryotic organisms. Mutat Res 321:165–173
   PubMed Web of Science ®Google Scholar
• Das RK, Hossain SU, Bhattacharya S. (2007). Protective effect of diphenylmethyl selenocyanate against CCl4-induced hepatic injury. J Appl Toxicol 27:527–537
   PubMed Web of Science ®Google Scholar
• Espinola EB, Dias RF, Mattei R, Carlini EA. (1997). Pharmacological activity of guaraná (Paullinia cupana Mart.) in laboratory animals. J Ethnopharmacol 55:223–229
   PubMed Web of Science ®Google Scholar
• Fukumasu H, Avanzo JL, Heidor R, et al. (2006). Proctetive effects of guarana (Paullinia cupana Mart. var sorbilis) against DEN-induced DNA damage on mouse liver. Food Chem Toxicol 44:862–867
   PubMed Web of Science ®Google Scholar
• Hamilton ML, Van Remmen H, Drake JA, et al. (2001). Does oxidative damage to DNA increase with age. Proc Natl Acad Sci USA 98:10469–10474
   PubMed Web of Science ®Google Scholar
• Hartmann A, Agurell E, Beevers C, et al. (2003). Recommendations for conducting the in vivo alkaline comet assay: 4th International Comet Assay Workshop. Mutagenesis 18:45–51
   PubMed Web of Science ®Google Scholar
• Henman AR. (1982). Guaraná (Paullinia cupana var. sorbilis): ecological and social perspectives on an economic plant of the central Amazon basin. J Ethnopharmacol 6:311–338
   PubMed Web of Science ®Google Scholar
• Janakat S, Al-Merie H. (2002). Optimization of the dose and route of injection, and characterisation of the time course of carbon tetrachloride-induced hepatotoxicity in the rat. J Pharmacol Toxicol Methods 48:41–44
   PubMed Web of Science ®Google Scholar
• Kennedy DO, Haskell CF, Wesnes KA, Scholey AB. (2004). Improved cognitive performance in human volunteers following administration of guaraná (Paullinia cupana) extract: comparison and interaction with Panax ginseng. Pharmacol Biochem Behav 79:401–411
   PubMed Web of Science ®Google Scholar
• Lee SH, Heo SI, Li L, et al. (2008). Antioxidant and hepatoprotective activities of Cirsium setidens NAKAI against CCl4-induced liver damage. Am J Chin Med 36:107–114
   PubMed Web of Science ®Google Scholar
• Leite RP, Wada RS, Monteiro JC, et al. (2010). Protective effect of guaraná (Paullinia cupana var. sorbilis) pretreatment on cadmium-induced damages in adult Wistar testis. Biol Trace Elem Res 141:262–274
   PubMed Web of Science ®Google Scholar
• Lin HM, Tseng HC, Wang CJ, et al. (2008). Hepatoprotective effects of Solanum nigrum Linn. extract against CCl4-induced oxidative damage in rats. Chem Biol Interact 171:283–293
   PubMed Web of Science ®Google Scholar
• Mattei R, Dias RF, Espínola EB, et al. (1998). Guarana (Paullinia cupana): toxic behavioral effects in laboratory animals and antioxidant activity in vitro. J Ethnopharmacol 60:111–116
   PubMed Web of Science ®Google Scholar
• Nadin S, Vargas-Roig L, Ciocca D. (2001). A silver staining method for single-cell gel assay. J Histochem Cytochem 49:1183–1186
   PubMed Web of Science ®Google Scholar
• O’Dea JA. (2003). Consumption of nutritional supplements among adolescents: usage and perceived benefits. Health Educ Res 18:98–107
   PubMed Web of Science ®Google Scholar
• Oliveira CH, Moraes ME, Moraes MO, et al. (2005). Clinical toxicology study of an herbal medicinal extract of Paullinia cupana, Trichilia catigua, Ptychopetalum olacoides and Zingiber officinale (Catuama) in healthy volunteers. Phytother Res 19:54–57
   PubMed Web of Science ®Google Scholar
• Opala T, Rzymski P, Pischel I, et al. (2006). Efficacy of 12 weeks supplementation of a botanical extract-based weight loss formula on body weight, body composition and blood chemistry in healthy, overweight subjects – a randomized double-blind placebo-controlled clinical trial. Eur J Med Res 11:343–350
   PubMed Web of Science ®Google Scholar
• Orhan DD, Aslan M, Aktay G, et al. (2003). Evaluation of hepatoprotective effect of Gentiana olivieri herbs on subacute administration and isolation of active principle. Life Sci 72:2273–2283
   PubMed Web of Science ®Google Scholar
• Otobone FJ, Sanches AC, Nagae R, et al. (2007). Effect of lyophilized extracts from guaraná seeds [Paullinia cupana var. sorbilis (Mart.) Ducke] on behavioral profiles in rats. Phytother Res 21:531–535
   PubMed Web of Science ®Google Scholar
• Pinheiro CE, de Oliveira SS, da Silva SM, et al. (1987). Effect of guaraná and Stévia rebaudiana Bertoni (leaves) extracts, and stevioside, on the fermentation and synthesis of extracellular insoluble polysaccharides of dental plaque. Rev Odontol Univ Sao Paulo 1:9–13
   PubMedGoogle Scholar
• Porchezhian E, Ansari SH. (2005). Hepatoprotective activity of Abutilon indicum on experimental liver damage in rats. Phytomedicine 12:62–64
   PubMed Web of Science ®Google Scholar
• Ray S, Phadke S, Patel C, et al. (2005). Short-term and long-term in vivo exposure to an ephedra and caffeine containing metabolic nutrition system does not induce cardiotoxicity in B6C3F1 mice. Arch Toxicol 79:330–340
   PubMed Web of Science ®Google Scholar
• Recknagel RO, Glende EA Jr, Dolak JA, Waller RL. (1989). Mechanisms of carbon tetrachloride toxicity. Pharmacol Ther 43:139–154
   PubMed Web of Science ®Google Scholar
• Schimpl FC, da Silva JF, Gonçalves JFC, Mazzafera P. (2013). Guarana: revisiting a highly caffeinated plant from the Amazon. J Ethnopharmacol 150:14–31
   PubMed Web of Science ®Google Scholar
• Singh NP, McCoy MT, Tice RR, Schneider EL. (1988). A simple technique for quantification of low levels of DNA damage in individual cells. Exp Cell Res 175:184–191
   PubMed Web of Science ®Google Scholar
• Subramoniam A, Pushpangadan P. (1999). Development of phytomedicines for liver disease. Indian J Pharmacol 31:166–175
   Google Scholar
• Tatsch E, Bochi GV, Pereira RS, et al. (2011). A simple and inexpensive automated technique for measurement of serum nitrite/nitrate. Clin Biochem 44:348–350
   PubMed Web of Science ®Google Scholar
• Tice RR, Agurell E, Anderson D, et al. (2000). Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 35:206–221
   PubMed Web of Science ®Google Scholar
• Vanderauwera S, Suzuki N, Miller G, et al. (2011). Extranuclear protection of chromosomal DNA from oxidative stress. Proc Natl Acad Sci USA 108:1711–1716
   PubMed Web of Science ®Google Scholar
• Wang T, Sun NL, Zhang WD, et al. (2008). Protective effect of dehydrocavidine on carbon tetrachloride-induced acute hepatotoxicity in rats. J Ethnopharmacol 117:300–308
   PubMed Web of Science ®Google Scholar
• Weber LW, Boll M, Stampfl A. (2003). Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit Rev Toxicol 33:105–136
   PubMed Web of Science ®Google Scholar
• Yamaguti-Sasaki E, Ito LA, Canteli VC, et al. (2007). Antioxidant capacity and in vitro prevention of dental plaque formation by extracts and condensed tannins of Paullinia cupana. Molecules 12:1950–1963
   PubMed Web of Science ®Google Scholar
• Zeidán-Chuliá F, Gelain DP, Kolling EA, et al. (2013). Major components of energy drinks (caffeine, taurine, and guarana) exert cytotoxic effects on human neuronal SH-SY5Y cells by decreasing reactive oxygen species production. Oxid Med Cell Longev 2013:791795
   PubMed Web of Science ®Google Scholar
• Zimmerman HJ, Seeff LB. (1970). Enzymes in hepatic disease. In: Goodly EL, ed. Diagnostic enzymology. Philadelphia: Lea & Febiger, 1–38
   Google Scholar