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Research Article

Acute Toxicity of Stevioside, A Natural Sweetener, and its Metabolite, Steviol, in Several Animal Species

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Pages 31-44 | Published online: 27 Sep 2008

References

  • Kinghorn A. D., Soejarto D. D. Stevioside. In Alternative Sweeteners, Vol. 2, L. O. Nabors, R. C. Gelardi. Dekker, New York (1991); 157–171
  • Isima N., Kakayama H. Sensory evaluation of stevioside as a sweetener. Natl. Food Res. Inst. (1976); 31: 80–85
  • Xili L., Chengjiany B., Eryi X., Reiming S., Yuengming W., Haodany, Zhiyian H. Chronic oral toxicity and carcinogenicity study of stevioside in rats. Fd. Chem. Toxic. (1992); 30: 957–965
  • Sasaki K. Use of stevioside sweeteners in drinks. New Food Ind. (1983); 25: 38–43
  • Fugita H., Edahiro T. Safety and utilization of Stevia sweetener. Shokuhin Kogyo (1979); 22: 65–72
  • Akashi H., Yokoyama Y. Dried-leaf extracts of Stevia. Toxicological test. Shokuhin Kogyo (1975); 18: 34–43
  • Wood H. B, Allerton R., Dichi H. W., Fletcher H. G. Stevioside. I: The structure of glucose moieties. J. Org. Chem. (1955); 20: 875–879
  • Mosseting E., Wes W. R. Stevioside. II: The structure of aglycone. J. Org. Chem. (1955); 20: 884–888
  • Wingard R. E, Brown J. P, Enderlin F. E, Dale J. A, Hale R. E., Seitz C. T. Intestinal degradation and absorption of the glycoside sweeteners stevioside and rebaudioside A. Experientia (1980); 36: 519–520
  • Yamamoto N. S, Bracht A. M.K., Ishii E. L, Kemmelmeier F. S, Alvarez, Bracht A. Effect of steviol and its structural analogues on glucose production and oxygen uptake in rat renal tubules. Experientia (1985); 41: 55–57
  • Toskulkao C, Sutheerawatananon M., Piyachaturawat P. Inhibitory effect of steviol, a metabolite of stevioside, on glucose absorption in everted hamster intestine in vitro. Toxicology Lett. (1995); 80: 153–159
  • Pezzuto J. M, Compadre C. M, Swanson S. M, Nanayakkara N. P.D., Kinghorn A. D. Metabolically activated steviol, the aglycone of stevioside, is mutagenic. Proc. Natl. Acad. Sci. (1985); 82: 2478–2482
  • Adduci J., Buddhasukh D., Ternai B. Improved isolation and purification of stevioside. J. Sci. Soc. Thailand (1987); 12: 179–183
  • Ogawa T., Nozaki M., Matsui M. Total synthesis of stevioside. Tetrahedron (1980); 36: 2641–2648
  • Litchfield J. T., Wilcoxon F. A simplified method of evaluating dose-effect experiments. J. Pharmac. Exp. Ther. (1949); 69: 99–113
  • Lowry O. H, Rosebrough N. J, Farr A. L., Randall R. J. Protein measurement with the folin-phenol reagent. J. Biol. Chem. (1951); 193: 265–275
  • Klaassen C., Doull J. Evaluation of safety: Toxicological evaluation In Cassarett and Doull's Toxicology, 2nd Edition, J. Doull, C. D. Klaassen, M. O. Amdur. Macmillan Publishing Co., New York (1986); 12
  • Glinsukon T., Pimbua J., Panichkul T. Stevioside, a natural sweetener from Stevia rebaudiana Bertoni: Toxicological evaluation. Thai J. Toxicol. (1988); 4: 1–22
  • Toskulkao C, Deechakawan W., Leardkamolkarn V., Glinsukon T., Buddhasukh D. The low calorie natural sweetener stevioside: Nephrotoxicity and its relation to urinary enzyme excretion in the rat. Phytother. Res. (1994); 8: 281–286
  • Bracht A. K, Alvarez M., Bracht A. Effects of Stevia rebaudiana natural products on rat liver mitochondria. Biochem. Pharmacol. (1985); 34: 873–882
  • Yamamoto N. S, Bracht A. K, Ishii E. L, Kemmelmeier F. S, Alvarez M., Bracht A. Effect of steviol and its structural analogues on glucose production and oxygen uptake in rat renal tubules. Experientia (1985); 41: 55–57
  • Toskulkao C, Deechakawan W., Temcharoen P., Buddhasukh D., Glinsukon T. Nephrotoxic effects of stevioside and steviol in rat renal cortical slices. J. Clin. Biochem. Nutr. (1994); 16: 123–131
  • Comprade C. M, Hussain R. A, Nanayakkara N. P.D., Pezzuto J. M., Kinghorn A. D. Mass spectral analysis of some derivatives and in vitro metabolites of steviol, the aglycone of the natural sweeteners, stevioside, rebaudioside and rubusoside. Biomed. Environm. Mass Spectro. (1988); 15: 211–222

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