REFERENCES
- Adayev, T., Chen-Hwang, M. C., Murakami, N., Wang, R., Hwang, Y.W. (2006). MNB/DYRK1A phosphorylation regulates the interactions of synaptojanin 1 with endocytic accessory proteins. Biochem Biophys Res Commun, 351, 1060–1065.
- Ahn, Y. M., Seo, M. S., Kim, S. H., Kim, Y., Juhnn, Y. S., Kim, Y. S. (2006). The effects of MK-801 on the phosphorylation of Ser338-c-Raf-MEK-ERK pathway in the rat frontal cortex. Int J Neuropsychopharmacol 4, 1–6
- Ahn, Y. M., Seo, M. S, Kim, S. H, Kim, Y., Yoon, S. C, Juhnn, Y. S, Kim, Y. S. (2005). Increased phosphorylation of Ser473-Akt, Ser9-GSK-3beta and Ser133-CREB in the rat frontal cortex after MK-801 intraperitoneal injection. Int J Neuropsychopharmacol 8, 607–613.
- Benavides-Piccione, R., Ballesteros-Yáñez, I., de Lagrán, M. M., Elston, G., Estivill, X., Fillat, C., Defelipe, J., Dierssen, M. (2004). On dendrites in Down syndrome and DS murine models: A spiny way to learn. Prog Neurobiol 74, 111–126.
- Canfield, M. A., Honein, M. A., Yuskiv, N., Xing, J., Mai, C. T., Collins, J. S., . (2006). National estimates and race/ethnic-specific variation of selected birth defects in the United States, 1999–2001. Birth Defects Res A Clin Mol Teratol 76, 747–756.
- Chapman, R. S, Hesketh, L. J. (2001). Language, cognition, and short-term memory in individuals with Down syndrome. Downs Syndr Res Pract 7, 1–7.
- Chen, S., Cowan, C. N. F., Grant, P. M. (1991). Orthogonal least squares learning algorithm for radial basis function networks. IEEE Trans Neural Networks 2, 302–309.
- Cortes, C., Vapnik. V. (1995). Support-vector networks. Machine Learn 20, 273–297.
- Costa, A. C., Scott-McKean, J. J., Stasko, M. R. (2008). Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test. Neuropsycopharmacology 33, 1624–1632.
- Costa, A. C, Stasko, M. R, Schmidt, C., Davisson, M. T. (2010). Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pde6b(rd1). Behav Brain Res. 206, 52–62.
- Efron, B. (1979). Bootstrap methods: Another look at the jackknife. Ann Stat, 7, 1–26.
- Espina, V., Wulfkuhle, J., Liotta, L. A. (2009). Application of laser microdissection and reverse-phase protein microarrays to the molecular profiling of cancer signal pathway networks in the tissue microenvironment. Clin Lab Med 29, 1–13.
- Fernandez-Martinez, J., Vela, E. M, Tora-Ponsioen, M., Ocaña, O. H., Nieto, M. A, Galceran, J. (2009). Attenuation of Notch signalling by the Down-syndrome-associated kinase DYRK1A. J Cell Sci 122, 1574–1583.
- Fleming, I. N, Batty, I. H, Prescott, A. R, Gray, A., Kular, G. S, Stewart, H., Downes, C. P. (2004). Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1. Biochem J 382, 857–865.
- Friedman, J., Hastie, T., Tibshirani, R. (2000). Additive logistic regression: A statistical view of boosting. Ann Stat, 38, 337–374.
- Galceran, J., de Graaf, K., Tejedor, F. J, Becker, W. (2003). The MNB/DYRK1A protein kinase: Genetic and biochemical properties. J Neural Transm Suppl 67, 139–148.
- Gardiner, K., Costa, A. C. (2006). The genes of human chr21: Choosing candidates for relevance to intellectual disability. Am J Med Genet 142, 196–205.
- Gardiner, K., Fortna, A., Bechtel, L., Davisson, M. T. (2003). Mouse models of Down syndrome: How useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions. Gene 318, 137–147.
- Gardiner, K. J. (2010). Molecular basis of pharmacotherapies for cognition in Down syndrome. Trends in Pharmacol Sci 32, 66–73.
- Guyon, I., Weston, J., Barnhill, S., Vapnik, V. (2002). Gene selection for cancer classification using support vector machines. Machine Learn, 46, 389–422.
- John, G., Kohavi, R., Pfleger, K. (1994). Irrelevant features and the subset selection problem. Proceedings 11th International Conference on Machine Learning (121–129). New Brunswick, NJ: Morgan Kaufmann, Los Altos.
- Koller, D., Sahami, M. (1996). Toward optimal feature selection. Proceedings 13th International Conference on Machine Learning (284–292). Bari, Italy, Morgan Kaufmann, San Mateo, CA.
- Langley, P., Iba, W., Thompson, K (1992). An analysis of Bayesian classifiers. Proceedings of the Tenth National Conference on Artificial Intelligence (1992) San Jose: AAAI Press. 223–228.
- Lieberman, D. N, Mody, I. (1994). Regulation of NMDA channel function by endogenous Ca(2+)-dependent phosphatase. Nature 369, 235–239.
- Lockrow, J., Boger, H., Bimonte-Nelson, H., Granholm, A. C. (2010). Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome. Behav Brain Res., Apr 2. [Epub ahead of print]
- Maier, T., Güell, M., Serrano L. (2009). Correlation of mRNA and protein in complex biological samples. FEBS Lett 583, 3966–3973.
- McCallum, A., Nigam, K. (1998). A comparison of event models for naive Bayes text classification. AAAI-98 Workshop on Learning for Text Categorization (41–48).
- Miyakawa, T., Leiter, L. M., Gerber, D. J., Gainetdinov, R. R., Sotnikova, T. D., Zeng, H., Caron, M. G., Tonegawa, S. (2003). Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia. Proc Natl Acad Sci USA 100, 8987–8992.
- Nadel, L. (2003). Down's syndrome: A genetic disorder in biobehavioral perspective. Genes Brain Behav, 2, 156–166.
- Nishimura, T., Yamaguchi, T., Tokunaga, A., Hara, A., Hamaguchi, T., Kato, K., Iwamatsu, A., Okano, H., Kaibuchi, K. (2006). Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2. Mol Biol Cell 17, 1273–1285.
- Park, J., Sandberg, I. W. (1991). Universal approximation using radial-basis-function networks. Neural Comput, 3, 246–257.
- Pritchard, M., Reeves, R. H., Dierssen, M., Patterson, D., Gardiner, K. (2008). Down syndrome and the genes of human chromosome 21: Current knowledge and future potentials. Cyto Genet Genome Res 121, 67–77.
- Rueda, N., Llorens-Martín, M., Flórez J, Valdizán, E., Banerjee, P., Trejo, J. L, Martínez-Cué, C. (2010). Memantine normalizes several phenotypic features in the Ts65Dn mouse model of Down syndrome. J Alzheimers Dis. 21, 277–290.
- Salehi, A., Faizi, M., Colas, D., Valletta, J., Laguna, J., Takimoto-Kimura, R., Kleschevnikov, A., Wagner, S. L, Aisen, P., Shamloo, M., Mobley, W. C. (2009). Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome. Sci Transl Med, 1, 7ra17.
- Sananbenesi, F., Fischer, A., Schrick, C., Spiess, J., Radulovic, J. (2002). Phosphorylation of hippocampal Erk-1/2, Elk-1, and p90-Rsk-1 during contextual fear conditioning: Interactions between Erk-1/2 and Elk-1. Mol Cell Neurosci 21, 463–476.
- Siddiqui, A., Lacroix, T., Scott-McKean, J., Stasko, M., Costa, A. C., Gardiner, K. (2008). Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801. Genes Brain Behav 7, 810–820.
- Tolias, K. F, Bikoff, J. B, Kane, C. G, Tolias, C. S, Hu, L., Greenberg, M. E. (2007). The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development. Proc Natl Acad Sci U S A 104, 7265–7270.
- Wiseman, F. K., Alford, K. A., Tybulewicz, V. L., Fisher, E. M. (2009). Down syndrome–recent progress and future prospects. Hum Mol Genet 18(R1), R75–R83.
- Witten, I. H, Frank, E. (2005). Data mining: Practical machine learning tools and techniques (2nd). San Francisco: Morgan Kaufmann.