542
Views
23
CrossRef citations to date
0
Altmetric
Research Article

The Dopamine Transporter Expression Level Differentially Affects Responses to Cocaine and Amphetamine

, , &
Pages 112-121 | Received 06 Mar 2014, Accepted 21 Mar 2014, Published online: 27 Mar 2014

REFERENCES

  • Achat-Mendes, C., Lynch, L. J., Sullivan, K. A., Vallender, E. J., & Miller, G. M. (2012). Augmentation of methamphetamine-induced behaviors in transgenic mice lacking the trace amine-associated receptor 1. Pharmacol Biochem Behav, 101, 201–207.
  • Budygin, E. A., Brodie, M. S., Sotnikova, T. D., Mateo, Y., John, C. E., Cyr, M., et al. (2004). Dissociation of rewarding and dopamine transporter-mediated properties of amphetamine. Proc Natl Acad Sci U S A, 101, 7781–7786.
  • Cagniard, B., Beeler, J. A., Britt, J. P., McGehee, D. S., Marinelli, M., & Zhuang, X. (2006). Dopamine scales performance in the absence of new learning. Neuron, 51, 541–547.
  • Carboni, E., Imperato, A., Perezzani, L., & Di Chiara, G. (1989). Amphetamine, cocaine, phencyclidine and nomifensine increase extracellular dopamine concentrations preferentially in the nucleus accumbens of freely moving rats. Neuroscience, 28, 653–661.
  • Cerruti, C., Pilotte, N. S., Uhl, G., & Kuhar, M. J. (1994). Reduction in dopamine transporter mRNA after cessation of repeated cocaine administration. Brain Res Mol Brain Res, 22, 132–138.
  • Creese, I., & Iversen, S. D. (1975). The pharmacological and anatomical substrates of the amphetamine response in the rat. Brain Res, 83, 419–436.
  • Fuke, S., Suo, S., Takahashi, N., Koike, H., Sasagawa, N., & Ishiura, S. (2001). The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression. Pharmacogenomics J, 1, 152–156.
  • Gainetdinov, R. R., Wetsel, W. C., Jones, S. R., Levin, E. D., Jaber, M., & Caron, M. G. (1999a). Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. Science, 283, 397–401.
  • Gainetdinov, R. R., Jones, S. R., & Caron, M. G. (1999b). Functional hyperdopaminergia in dopamine transporter knock-out mice. Biol Psychiatry, 46, 303–311.
  • Gelernter, J., Kranzler, H. R., Satel, S. L., & Rao, P. A. (1994). Genetic association between dopamine transporter protein alleles and cocaine-induced paranoia. Neuropsychopharmacology, 11, 195–200.
  • Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., & Caron, M. G. (1996). Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature, 379, 606–612.
  • Guindalini, C., Howard, M., Haddley, K., Laranjeira, R., Collier, D., Ammar, N., et al. (2006). A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample. Proc Natl Acad Sci U S A, 103, 4552–4557.
  • Hall, F. S., Li, X. F., Randall-Thompson, J., Sora, I., Murphy, D. L., Lesch, K. P., Caron, M., & Uhl, G. R. (2009). Cocaine-conditioned locomotion in dopamine transporter, norepinephrine transporter and 5-HT transporter knockout mice. Neuroscience, 162, 870–880.
  • Hall, F. S., Li, X. F., Sora, I., Xu, F., Caron, M., Lesch, K. P., et al. (2002). Cocaine mechanisms: Enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions. Neuroscience, 115, 153–161.
  • Haycock, J. W., Becker, L., Ang, L., Furukawa, Y., Hornykiewicz, O., & Kish, S. J. (2003). Marked disparity between age-related changes in dopamine and other presynaptic dopaminergic markers in human striatum. J Neurochem, 87, 574–585.
  • Heinz, A., Goldman, D., Jones, D. W., Palmour, R., Hommer, D., Gorey, J. G., et al. (2000). Genotype influences in vivo dopamine transporter availability in human striatum. Neuropsychopharmacology, 22, 133–139.
  • Hernandez, L., & Hoebel, B. G. (1988). Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis. Life Sci, 42, 1705–1712.
  • Hnasko, T. S., Sotak, B. N., & Palmiter, R. D. (2007). Cocaine-conditioned place preference by dopamine-deficient mice is mediated by serotonin. J Neurosci, 27, 12484–12488.
  • Jones, S. R., Gainetdinov, R. R., Jaber, M., Giros, B., Wightman, R. M., & Caron, M. G. (1998a). Profound neuronal plasticity in response to inactivation of the dopamine transporter. Proc Natl Acad Sci U S A, 95, 4029–4034.
  • Jones, S. R., Gainetdinov, R. R., Wightman, R. M., & Caron, M. G. (1998b). Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter. J Neurosci, 18, 1979–1986.
  • Kahlig, K. M., Binda, F., Khoshbouei, H., Blakely, R. D., McMahon, D. G., Javitch, J. A., et al. (2005). Amphetamine induces dopamine efflux through a dopamine transporter channel. Proc Natl Acad Sci U S A, 102, 3495–3500.
  • Kahlig, K. M., & Galli, A. (2003). Regulation of dopamine transporter function and plasma membrane expression by dopamine, amphetamine, and cocaine. Eur J Pharmacol, 479, 153–158.
  • Kuczenski, R., Segal, D. S., & Aizenstein, M. L. (1991). Amphetamine, cocaine, and fencamfamine: Relationship between locomotor and stereotypy response profiles and caudate and accumbens dopamine dynamics. J Neurosci, 11, 2703–2712.
  • Letchworth, S. R., Nader, M. A., Smith, H. R., Friedman, D. P., & Porrino, L. J. (2001). Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys. J Neurosci, 21, 2799–2807.
  • Lindblom, J., Johansson, A., Holmgren, A., Grandin, E., Nedergard, C., Fredriksson, R., et al. (2006). Increased mRNA levels of tyrosine hydroxylase and dopamine transporter in the VTA of male rats after chronic food restriction. Eur J Neurosci, 23, 180–186.
  • Lott, D. C., Kim, S. J., Cook, E. H., Jr., & de Wit, H. (2005). Dopamine transporter gene associated with diminished subjective response to amphetamine. Neuropsychopharmacology, 30, 602–609.
  • Mateo, Y., Budygin, E. A., John, C. E., & Jones, S. R. (2004). Role of serotonin in cocaine effects in mice with reduced dopamine transporter function. Proc Natl Acad Sci U S A, 101, 372–377.
  • Medvedev, I. O., Gainetdinov, R. R., Sotnikova, T. D., Bohn, L. M., Caron, M. G., & Dykstra, L. A. (2005). Characterization of conditioned place preference to cocaine in congenic dopamine transporter knockout female mice. Psychopharmacology (Berl), 180, 408–413.
  • Mill, J., Asherson, P., Browes, C., D’Souza, U., & Craig, I. (2002). Expression of the dopamine transporter gene is regulated by the 3’ UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR. Am J Med Genet, 114, 975–979.
  • Moghaddam, B., & Bunney, B. S. (1989). Differential effect of cocaine on extracellular dopamine levels in rat medial prefrontal cortex and nucleus accumbens: Comparison to amphetamine. Synapse, 4, 156–161.
  • Morice, E., Denis, C., Giros, B., & Nosten-Bertrand, M. (2004). Phenotypic expression of the targeted null-mutation in the dopamine transporter gene varies as a function of the genetic background. Eur J Neurosci, 20, 120–126.
  • Mortensen, O. V., & Amara, S. G. (2003). Dynamic regulation of the dopamine transporter. Eur J Pharmacol, 479, 159–170.
  • Nomikos, G. G., Damsma, G., Wenkstern, D., & Fibiger, H. C. (1990). In vivo characterization of locally applied dopamine uptake inhibitors by striatal microdialysis. Synapse, 6, 106–112.
  • Pifl, C., Drobny, H., Reither, H., Hornykiewicz, O., & Singer, E. A. (1995). Mechanism of the dopamine-releasing actions of amphetamine and cocaine: Plasmalemmal dopamine transporter versus vesicular monoamine transporter. Mol Pharmacol, 47, 368–373.
  • Powell, S. B., Lehmann-Masten, V. D., Paulus, M. P., Gainetdinov, R. R., Caron, M. G., & Geyer, M. A. (2004). MDMA “ecstasy” alters hyperactive and perseverative behaviors in dopamine transporter knockout mice. Psychopharmacology (Berl), 173, 310–317.
  • Riddle, E. L., Fleckenstein, A. E., & Hanson, G. R. (2005). Role of monoamine transporters in mediating psychostimulant effects. AAPS J, 7, E847–E851.
  • Robinson, T. E., & Berridge, K. C. (1993). The neural basis of drug craving: An incentive-sensitization theory of addiction. Brain Res Brain Res Rev, 18, 247–291.
  • Rocha, B. A., Fumagalli, F., Gainetdinov, R. R., Jones, S. R., Ator, R., Giros, B., et al. (1998). Cocaine self-administration in dopamine-transporter knockout mice. Nat Neurosci, 1, 132–137.
  • Salahpour, A., Ramsey, A. J., Medvedev, I. O., Kile, B., Sotnikova, T. D., Holmstrand, E., et al. (2008). Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter. Proc Natl Acad Sci U S A, 105, 4405–4410.
  • Schenk, J. O. (2002). The functioning neuronal transporter for dopamine: Kinetic mechanisms and effects of amphetamines, cocaine and methylphenidate. Prog Drug Res, 59, 111–131.
  • Sora, I., Hall, F. S., Andrews, A. M., Itokawa, M., Li, X. F., Wei, H. B., et al. (2001). Molecular mechanisms of cocaine reward: Combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. Proc Natl Acad Sci U S A, 98, 5300–5305.
  • Sora, I., Wichems, C., Takahashi, N., Li, X. F., Zeng, Z., Revay, R., et al. (1998). Cocaine reward models: Conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice. Proc Natl Acad Sci U S A, 95, 7699–7704.
  • Spielewoy, C., Biala, G., Roubert, C., Hamon, M., Betancur, C., & Giros, B. (2001). Hypolocomotor effects of acute and daily d-amphetamine in mice lacking the dopamine transporter. Psychopharmacology (Berl), 159, 2–9.
  • Sulzer, D., Chen, T. K., Lau, Y. Y., Kristensen, H., Rayport, S., & Ewing, A. (1995). Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport. J Neurosci, 15, 4102–4108.
  • Torres, G. E., Gainetdinov, R. R., & Caron, M. G. (2003). Plasma membrane monoamine transporters: Structure, regulation and function. Nat Rev Neurosci, 4, 13–25.
  • Van, R., & Hurkmans, A. T. (1964). Mechanism of action of psychomotor stimulant drugs. significance of dopamine in locomotor stimulant action. Int J Neuropharmacol, 3, 227–239.
  • VanNess, S. H., Owens, M. J., & Kilts, C. D. (2005). The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density. BMC Genet, 6, 55.
  • Venton, B. J., Seipel, A. T., Phillips, P. E., Wetsel, W. C., Gitler, D., Greengard, P., et al. (2006). Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool. J Neurosci, 26, 3206–3209.
  • Wall, S. C., Gu, H., & Rudnick, G. (1995). Biogenic amine flux mediated by cloned transporters stably expressed in cultured cell lines: Amphetamine specificity for inhibition and efflux. Mol Pharmacol, 47, 544–550.
  • Williams, J. M., & Galli, A. (2006). The dopamine transporter: A vigilant border control for psychostimulant action. Handb Exp Pharmacol, xx, 215–232.
  • Wise, R. A. (2006). Role of brain dopamine in food reward and reinforcement. Philos Trans R Soc Lond B Biol Sci, 361, 1149–1158.
  • Zhuang, X., Oosting, R. S., Jones, S. R., Gainetdinov, R. R., Miller, G. W., Caron, M. G., et al. (2001). Hyperactivity and impaired response habituation in hyperdopaminergic mice. Proc Natl Acad Sci U S A, 98, 1982–1987.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.