17
Views
14
CrossRef citations to date
0
Altmetric
Miscellaneous Article

Mapping the Clock Rhythm Mutation to the Period Locus of Drosophila Melanogaster by Germline Transformation

, &
Pages 173-179 | Received 11 Dec 1991, Published online: 11 Jul 2009

References

  • Baylies M. K., Bargiello T. A., Jackson F. R., Young M. W. Changes in abundance and structure of the per gene product can alter periodicity of the Drosophila clock. Nature 1987; 326: 390–392
  • Baylies M. K., Sehgal A., Young M. W. New short period mutations define a possible regulatory domain in the Drosophila clock protein per. 1992, Submitted
  • Blackman R. K., Sanicola M., Raftery L. A., Gillevet T., Gelbart W. M. An extensive 3′ cis-regulatory region directs the imaginal disk expression of the decapentaplegic, a member of the TGF family in. Drosophila. Development 1991; 111: 657–666
  • Brunner A., Wolf R., Pflugfelder G. O., Poeck B., Heisenberg M. Mutations in the proximal region of the omb locus reveal a gradient of neuroanatomical and behavioral phenotypes. J. Neurogenet. 1992; 8: 53–55
  • Citri Y., Colot H. V., Jacquier A. C., Yu Q., Hall J. C., Baltimore D., Rosbash M. A family of unusually spliced and biologically active transcripts encoded by a Drosophila clock gene. Nature 1987; 326: 42–47
  • Coté G. G., Brody S. Cireadian rhythms in Drosophila melanogaster: analysis of period as a function of gene dosage at the per (period) locus. J. Theoret. Biol. 1986; 121: 487–503
  • Dunlap J. C. Closely watched clocks: molecular analysis of circadian rhythms in Neurospora and. Drosophila. Trends Genet. 1990; 6: 159–165
  • Dushay M. S., Konopka R. J., Orr D., Greenacre M. L., Kyriacou C. P., Rosbash M., Hall J. C. Phenotypic and genetic analysis of Clock, a new circadian rhythm mutant in. Drosophila melanogaster Genetics 1990; 125: 557–578
  • Ewer J., Frisch B., Hamblen-Coyle M. J., Rosbash M., Hall J. C. Expression of the period clock gene within different cell types in the brain of Drosophila adults and mosaic analysis of these cells' influence on circadian behavioral rhythms. J. Neurosci. 1992, in press
  • Gailey D. A., Villella A., Tully T. Reassessment of the effect of biological rhythm mutants on learning in. Drosophila melanogaster J. Comp. Physiol. 1991; 169: 685–697
  • Hall J. C. Complex brain and behavioral functions disrupted by mutations in. Drosophila. Devel. Genet. 1984; 4: 355–378
  • Hall J. C. Genetics of circadian rhythms. Ann. Rev. Genet. 1990; 24: 569–697
  • Hall J. C., Kyriacou C. P. Genetics of biological rhythms in. Drosophila. Adv. Insect Physiol. 1990; 22: 221–298
  • Hamblen M., Zehring W. A., Kyriacou C. P., Reddy P., Yu Q., Wheeler D. A., Zwiebel L. J., Konopka R. J., Rosbash M., Hall J. C. Germ-line transformation involving DNA from the period locus in Drosophila melanogaster: overlapping genomic fragments that restore circadian and ultradian rhythmicity to per0 and per- mutants. J. Neurogenet. 1986; 3: 249–291
  • Hamblen-Coyle M., Konopka R. J., Zwiebel L. J., Colot H. V., Dowse H. B., Rosbash M., Hall J. C. A new mutation at the period locus with some novel effects on circadian rhythms. J. Neurogenet. 1989; 5: 229–256
  • Jackson F. R., Bargiello T. A., Yun S-H., Young M. W. Product of per locus of Drosophila shares homology with proteoglycans. Nature 1986; 320: 185–188
  • Kellum R., Schedl P. A position-effect assay for boundaries of higher order chromosomal domains. Cell 1991; 64: 941–950
  • Konopka R. J., Wells S., Lee T. Mosaic analysis of a Drosophila clock mutant. Molec. Gen. Genet. 1983; 190: 284–288
  • Liu X., Yu Q., Huang Z., Zweibel L. J., Hall J. C., Rosbash M. The strength and periodicity of D. melanogaster circadian rhythms are differentially affected by alterations in period gene expression. Neuron 1991; 6: 753–766
  • Orr D. P-Y. Behavioral neurogenetic studies of a circadian clock. Drosophila melanogaster. California Institute of Technology, Pasadena, CAUSA. 1982, Ph.D. thesis
  • Pirrotta V., Hadfield C., Pretorius G. H.J. Microdissection and cloning of the white locus and the 3B1–3C2 region of the. Drosophila X chromosome. EMBO J. 1983; 2: 927–934
  • Robertson H. M., Preston D. R., Phillis R. W., Johnson-Schlitz D., Benz W. K., Engels W. R. A stable genomic source of P element transposase in. Drosophila melanogaster. Genetics 1988; 119: 75–83
  • Rutila J. E., Edery I., Hall J. C., Rosbash M. The analysis of new short-period circadian rhythm mutants suggests features of D. melanogaster period gene function. J. Neurogenet. 1992, in press
  • Smith R. F., Konopka R. J. Effects of dosage alterations at the per locus on the period of the circadian clock of. Drosophila. Molec. Gen. Genet. 1982; 185: 30–36
  • Wheeler D. A., Kyriacou C. P., Greenacre M. L., Yu Q., Rutila J. E., Rosbash M., Hall J. C. Molecular transfer of a species-specific behavior from Drosophila simulans to. Drosophila melanogaster. Science 1991; 251: 1082–1085
  • Yu Q., Colot H. V., Kyriacou C. P., Hall J. C., Rosbash M. Behaviour modification by in vitro mutagenesis of a variable region within the period gene of. Drosophila. Nature 1987a; 326: 765–769
  • Yu Q., Jacquier A. C., Citri Y., Hamblen M., Hall J. C., Rosbash M. Molecular mapping of point mutations in the perod gene that stop or speed up biological clocks in. Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 1987b; 84: 784–788

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.