434
Views
20
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE

A novel segmental challenge model for bleomycin-induced pulmonary fibrosis in sheep

, , , , , , & show all
Pages 115-134 | Received 13 Apr 2014, Accepted 05 Nov 2014, Published online: 22 Dec 2014

REFERENCES

  • Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, Colby TV, Cordier JF, Flaherty KR, Lasky JA, Lynch DA, Ryu JH, Swigris JJ, Wells AU, Ancochea J, Bouros D, Carvalho C, Costabel U, Ebina M, Hansell DM, Johkoh T, Kim DS, King TE, Jr., Kondoh Y, Myers J, Muller NL, Nicholson AG, Richeldi L, Selman M, Dudden RF, Griss BS, Protzko SL, Schunemann HJ, Fibrosis AEJACoIP: An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med. 2011;183(6):788–824.
  • Günther A, Korfei M, Mahavadi P, von der Beck D, Ruppert C, Markart P: Unravelling the progressive pathophysiology of idiopathic pulmonary fibrosis. Eur Respir Rev. 2012;21(124):152–160.
  • King T, Schwarz M, Brown K, Tooze J, Colby T, Waldron J, Flint A, Thurlbeck W, Cherniack R: Idiopathic pulmonary fibrosis: relationship between histopathologic features and mortality. Am J Respir Crit Care Med. 2001;164(6): 1025–1032.
  • Sandbo N: Mechanisms of fibrosis in IPF. In: Keith C, Meyer SDN, eds. Idiopathic Pulmonary Fibrosis: A Comprehensive Clinical Guide Series Respiratory Medicine. Vol. 9. New York: Humana Press; 2014:164–205.
  • Talmadge TE, Jr, Bradford WZ, Castro-Bernardini S, Fagan EA, Glaspole I, Glassberg MK, Gorina E, Hopkins PM, Kardatzke D, Lancaster L: A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis. N Engl J Med. 2014;370(22):2083–2092.
  • Richeldi L, du Bois RM, Raghu G, Azuma A, Brown KK, Costabel U, Cottin V, Flaherty KR, Hansell DM, Inoue Y, Kim DS, Kolb M, Nicholson AG, Noble PW, Selman M, Taniguchi H, Brun M, Le Maulf F, Girard M, Stowasser S, Schlenker-Herceg R, Disse B, Collard HR, Investigators IT: Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. N Engl J Med. 2014;370(22):2071–2082.
  • Moore B, Hogaboam C: Murine models of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2008;294(2):152–160.
  • Moore B, Lawson W, Oury T, Sisson T, Raghavendran K, Hogaboam C: Animal models of fibrotic lung disease. Am J Respir Cell Mol Biol. 2013;49(2):167–179.
  • Moeller A, Ask K, Warburton D, Gauldie J, Kolb M: The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis? Intl J Biochem Cell Biol. 2008;40(3):362–382.
  • Fabrizio L, Paolo S, Stefania C, Luca R: The big clinical trials in idiopathic pulmonary fibrosis. Curr Opin Pulmon Med. 2012;18:428–432
  • Bischof R, Snibson K, Shaw R, Meeusen E: Induction of allergic inflammation in the lungs of sensitized sheep after local challenge with house dust mite. Clin Exp Allergy. 2003;33(3):367–375.
  • Snibson KJ, Bischof RJ, Slocombe RF, Meeusen EN: Airway remodelling and inflammation in sheep lungs after chronic airway challenge with house dust mite. Clin Exp Allergy. 2005;35(2):146–152.
  • Van der Velden J, Barker D, Barcham G, Koumoundouros E, Snibson K: Assessment of peripheral airway function following chronic allergen challenge in a sheep model of asthma. PloS one. 2011;6(12):e28740, 1–6
  • Collie DD, Baker A, Mauchline S, Porteous D, Mc LG: Ovine bronchoalveolar lavage cellularity: reproducibility and the effect of multiple repeated lavage. Res Vet Sci. 1999;67(2): 137–140.
  • Collie DD, McLean N, Sallenave JM, Baker A, Blundell R, Milne E, Rhind S, Woodall C: Local lung responses following endobronchial elastase and lipopolysaccharide instillation in sheep. Int J Chron Obstruct Pulmon Dis. 2006;1(2):189–199.
  • Balazs G, Noma S, Khan A, Eacobacci T, Herman PG: Bleomycin-induced fibrosis in pigs: evaluation with CT. Radiology. 1994;191(1):269–272.
  • Bray B, Osman M, Ashtyani H, Mandl I, Turino G: The fibronectin content of canine lungs is increased in bleomycin-induced fibrosis. Exp Mol Pathol. 1986;44(3):353–363.
  • Berzon D, Menkes H, Dannenberg A, Gertner A, Terry P, Plump D, Bromberger-Barnea B: Interstitial fibrosis and collateral ventilation. J Appl Physiol. 1986;61(1):300–303.
  • Michel RP, Hakim TS, Freeman CR: Distribution of pulmonary vascular resistance in experimental fibrosis. J Appl Physiol. 1988;65(3):1180–1190.
  • Degryse A, Tanjore H, Xu X, Polosukhin V, Jones B, McMahon F, Gleaves L, Blackwell T, Lawson W: Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2010;299(4): 442–452.
  • Tsai LW, Hoffman AM, Mazan MR, Ingenito EP: Bronchoscopic measurement of collateral ventilation in a sheep model of emphysema. Respiration. 2007;74(5):565–571.
  • Cetti E, Moore A, Geddes D: Collateral ventilation. Thorax. 2006;61(5):371–373.
  • Cherniack RM, Colby TV, Flint A, Thurlbeck WM, Waldron J, Ackerson L, King TEJr: Quantitative assessment of lung pathology in idiopathic pulmonary fibrosis. The BAL Cooperative Group Steering Committee. Am Rev Respir Dis. 1991;144(4):892–900.
  • Izbicki G, Segel M, Christensen T, Conner M, Breuer R: Time course of bleomycin-induced lung fibrosis. Intl J Exp Pathol. 2002;83(3):111–119.
  • Atik A, Sozo F, Orgeig S, Suri L, Hanita T, Harding R, De Matteo R: Long-term pulmonary effects of intrauterine exposure to endotoxin following preterm birth in sheep. Reprod Sci. 2012;19(12):1352–1364.
  • Maritz G, Probyn M, De Matteo R, Snibson K, Harding R: Lung parenchyma at maturity is influenced by postnatal growth but not by moderate preterm birth in sheep. Neonatology. 2008;93(1):28–35.
  • Van der Velden J, Barker D, Barcham G, Koumoundouros E, Snibson K: Increased vascular density is a persistent feature of airway remodeling in a sheep model of chronic asthma. Exp Lung Res. 2012;38(6):307–315.
  • Van Der Velden J, Sum G, Barker D, Koumoundouros E, Barcham G, Wulff H, Castle N, Bradding P, Snibson K: KCa3.1 channel-blockade attenuates airway pathophysiology in a sheep model of chronic asthma. PloS one. 2013;8(6):e66886, 1–7.
  • Samuel CS: Determination of collagen content, concentration, and sub-types in kidney tissue. Methods Mol Biol. 2009;466:223–235.
  • Moodley Y, Vaghjiani V, Chan J, Baltic S, Ryan M, Tchongue J, Samuel CS, Murthi P, Parolini O, Manuelpillai U: Anti-inflammatory effects of adult stem cells in sustained lung injury: a comparative study. PloS One. 2013;8(8):e69299, 1–9
  • Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, Preibisch S, Rueden C, Saalfeld S, Schmid B, Tinevez J-Y, White D, Hartenstein V, Eliceiri K, Tomancak P, Cardona A: Fiji: an open-source platform for biological-image analysis. Nat Methods. 2012;9(7):676–682.
  • Abraham T, Hogg J: Extracellular matrix remodeling of lung alveolar walls in three dimensional space identified using second harmonic generation and multiphoton excitation fluorescence. J Struct Biol. 2010;171(2):189–196.
  • Pena A-M, Fabre A, Débarre D, Marchal-Somme J, Crestani B, Martin J-L, Beaurepaire E, Schanne-Klein M-C: Three-dimensional investigation and scoring of extracellular matrix remodeling during lung fibrosis using multiphoton microscopy. Microsc Res Tech. 2007;70(2):162–170.
  • Bouljihad M, Leipold HW: An ultrastructural study of pulmonary bronchiolar and alveolar epithelium in sheep. J Vet Med. 1994;41(8):573–586.
  • Mercer R, Russell M, Crapo J: Alveolar septal structure in different species. J Appl Physiol. 1994;77(3):1060–1066.
  • Maritz G, Cock M, Louey S, Suzuki K, Harding R: Fetal growth restriction has long-term effects on postnatal lung structure in sheep. Pediatr Res. 2004;55(2):287–295.
  • Haber PS, Colebatch HJ, Ng CK, Greaves IA: Alveolar size as a determinant of pulmonary distensibility in mammalian lungs. J Appl Physiol Respir Environ Exerc Physiol. 1983;54(3):837–845.
  • Mercer R, Crapo J: Spatial distribution of collagen and elastin fibers in the lungs. J Appl Physiol. 1990;69(2):756–765.
  • Suki B, Ito S, Stamenovic D, Lutchen KR, Ingenito EP: Biomechanics of the lung parenchyma: critical roles of collagen and mechanical forces. J Appl Physiol. 2005;98(5):1892–1899.
  • Suki B, Bates J: Extracellular matrix mechanics in lung parenchymal diseases. Respir Physiol Neurobiol. 2008;163 (1–3):33–43.
  • Enomoto N, Suda T, Kono M, Kaida Y, Hashimoto D, Fujisawa T, Inui N, Nakamura Y, Imokawa S, Funai K, Chida K: Amount of elastic fibers predicts prognosis of idiopathic pulmonary fibrosis. Respir Med. 2013;107(10):1608–1616.
  • Faffe D, Zin W. Lung parenchymal mechanics in health and disease. Physiol Rev. 2009;89(3):759–775.
  • Leslie KO: Idiopathic pulmonary fibrosis may be a disease of recurrent, tractional injury to the periphery of the aging lung: a unifying hypothesis regarding etiology and pathogenesis. Arch Pathol Lab Med. 2012;136(6):591–600.
  • Meyer KC, Nathan SD: Idiopathic pulmonary fibrosis: A Comprehensive Clinical Guide. Idiopathic Pulmonary Fibrosis: A Comprehensive Clinical Guide. New York: Humana Press; 2014.
  • Lazo J, Hoyt D, Sebti S, Pitt B: Bleomycin: a pharmacologic tool in the study of the pathogenesis of interstitial pulmonary fibrosis. Pharmacol Therapeut. 1990;47(3):347–358.
  • Cherniack RM, Colby TV, Flint A, Thurlbeck WM, Waldron JA, Jr., Ackerson L, Schwarz MI, King TE, Jr: Correlation of structure and function in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 1995;151(4):1180–1188.
  • Chung MP, Monick MM, Hamzeh NY, Butler NS, Powers LS, Hunninghake GW: Role of repeated lung injury and genetic background in bleomycin-induced fibrosis. Am J Respir Cell Mol Biol. 2003;29(3 Pt 1):375–380.
  • Polosukhin V, Degryse A, Newcomb D, Jones B, Ware L, Lee J, Loyd J, Blackwell T, Lawson W: Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice. Exp Lung Res. 2012;38(3):135–146.
  • Shen A, Haslett C, Feldsien D, Henson P, Cherniack R: The intensity of chronic lung inflammation and fibrosis after bleomycin is directly related to the severity of acute injury. Am Rev Respir Dis. 1988;137(3):564–571.
  • Chaudhary N, Schnapp A, Park J: Pharmacologic differentiation of inflammation and fibrosis in the rat bleomycin model. Am J Respir Crit Care Med. 2006;173(7):769–776.
  • Walters D, Kleeberger S: Mouse models of bleomycin-induced pulmonary fibrosis. Curr Protoc Pharmacol. 2008; Chap 5, Sect 46:1–17.
  • Tatler A, Jenkins G: TGF-β activation and lung fibrosis. Proc Am Thoracic Soc. 2012;9(3):130–136.
  • Lomas NJ, Watts KL, Akram KM, Forsyth NR, Spiteri MA: Idiopathic pulmonary fibrosis: immunohistochemical analysis provides fresh insights into lung tissue remodelling with implications for novel prognostic markers. Intl J Clin Exp Pathol. 2012;5(1):58–71.
  • Khalil N, O'Connor R, Flanders K, Unruh H: TGF-beta 1, but not TGF-beta 2 or TGF-beta 3, is differentially present in epithelial cells of advanced pulmonary fibrosis: an immunohistochemical study. Am J Respir Cell Mol Biol. 1996;14(2):131–138.
  • Coker R, Laurent G, Shahzeidi S, Lympany P, du Bois R, Jeffery P, McAnulty R: Transforming growth factors-beta 1, -beta 2, and -beta 3 stimulate fibroblast procollagen production in vitro but are differentially expressed during bleomycin-induced lung fibrosis. Am J Pathol. 1997;150(3):981–991.
  • Broekelmann T, Limper A, Colby T, McDonald J: Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. Proc Natl Acad Sci USA. 1991;88(15):6642–6646.
  • Cosgrove G, Brown K, Schiemann W, Serls A, Parr J, Geraci M, Schwarz M, Cool C, Worthen G: Pigment epithelium-derived factor in idiopathic pulmonary fibrosis: a role in aberrant angiogenesis. Am J Respir Crit Care Med. 2004;170(3):242–251.
  • Vij R, Noth I: Peripheral blood biomarkers in idiopathic pulmonary fibrosis. Transl Res. 2012;159(4):218–227.
  • Parra E, Teodoro W, Velosa AP, de Oliveira C, Yoshinari N, Capelozzi V: Interstitial and vascular type V collagen morphologic disorganization in usual interstitial pneumonia. J Histochem Cytochem. 2006;54(12):1315–1325.
  • Hay E: Cell Biology of Extracellular Matrix. 1991. Berlin: Springer Science and Business Media.
  • Chen W-L, Hu P-S, Ghazaryan A, Chen S-J, Tsai T-H, Dong C-Y: Quantitative analysis of multiphoton excitation autofluorescence and second harmonic generation imaging for medical diagnosis. Comput Med Imag Graphics. 2012;36(7):519–526.
  • Ley B, Collard H, King T: Clinical course and prediction of survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2011;183(4):431–440.
  • Collard H, King T, Bartelson B: Changes in clinical and physiologic variables predict survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2003;168(5):538–542.
  • Ley B, Ryerson C, Vittinghoff E, Ryu J, Tomassetti S, Lee J, Poletti V, Buccioli M, Elicker B, Jones K, King T, Collard H: A multidimensional index and staging system for idiopathic pulmonary fibrosis. Annls Intern Med. 2012;156(10):684–691.
  • du Bois R, Nathan S, Richeldi L, Schwarz M, Noble P: Idiopathic pulmonary fibrosis: lung function is a clinically meaningful endpoint for phase III trials. Am J Respir Crit Care Med. 2012;186(8):712–715.
  • Bachofen H, Scherrer M: Lung tissue resistance in diffuse interstitial pulmonary fibrosis. J Clin Invest. 1967;46(1):133–140.
  • Fulmer J, Roberts W, von Gal E, Crystal R: Morphologic–physiologic correlates of the severity of fibrosis and degree of cellularity in idiopathic pulmonary fibrosis. J Clin Invest. 1979;63(4):665–676.
  • Fulmer J, Roberts W: Small airways and interstitial pulmonary disease. Chest. 1980;77(4):470–472.
  • Figueira de Mello GC, Ribeiro Carvalho CR, Adib Kairalla R, Nascimento Saldiva PH, Fernezlian S, Ferraz Silva LF, Dolhnikoff M, Mauad T. Small airway remodeling in idiopathic interstitial pneumonias: a pathological study. Respiration. 2010;79(4):322–332.
  • Fulmer J, Roberts W, von Gal E, Grystal R: Small airways in idiopathic pulmonary fibrosis. Comparison of morphologic and physiologic observations. J Clin Invest. 1977;60(3):595–610.
  • Verbeken E, Cauberghs M, Lauweryns J, Van de Woestijne K: Structure and function in fibrosing alveolitis. J Appl Physiol. 1994;76(2):731–742.
  • Ostrow D, Cherniack RM: Resistance to airflow in patients with diffuse interstitial lung disease. Am Rev Respir Dis. 1973;108(2):205–210.
  • Schofield NC, Davies RJ, Cameron IR, Green M: Small airways in fibrosing alveolitis. Am Rev Respir Dis. 1976;113(6):729–735.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.