Detection of Mercury in the 411-year-old Beard Hairs of the Astronomer Tycho Brahe by Elemental Analysis in Electron Microscopy

REFERENCES

• A Norwegian bishop had heard about poisoning and mentioned this rumor in a letter sent to Copenhagen in 1602. Cf. Bang O. Samling af adskillige opbyggelige og nyttige Materie, saa vel gamle som nye, Vol. 2. Copenhagen; 1745: 529. Translated into German by Philander von der Weistritz [pseudonym for Christian Gottlob Mengel]: Lebensbeschreibung des berühmten und gelehrten Dänischen Sternsehers Tycho v. Brahes, 1–2 Theil. Kopenhagen/Leipzig: Friedrich Christian Pelt; 1756: 195.
   Google Scholar
• In his description of the death (Book V) based partly on a letter written about 1620 by a Dane, the French scientist Pierre Gassendi reported a rumor spread in Denmark, Norway, and Germany saying that the astronomer had been poisoned by jealous enemies from the court. Gassendi P, Tychonis Brahei astronomorum coryphæi vita […]. Paris: Dupuis; 1654: 179.
   Google Scholar
• Already the funeral speech alludes to false inventions concerning the death. Cf. Jessenius J. De vita et morte illustris et generosi viri, domini Tychonis Brahei equitis Dani. Pragæ: Nigrinus; 1601. In: Tychonis Brahe Opera Omnia ed. by J.L.E. Dreyer. 1919;14:234–240. This Danish report has been described in English. Cf. Jacobsen AR & Petersen L. How Tycho Brahe Really Died. In: Planetarian 30,4, 2001: 9–10. www.ips-planetarium.org/?a_jacobsen2001
   Google Scholar
• Kæmpe B, Thykier C. Naturens verden. 1993: 425–434.
   Google Scholar
• Kæmpe B, et al. The Cause of Death of Tycho Brahe in 1601. In: Contributions to Forensic Toxicology. Proceedings of the 31st TIAFT Congress, Leipzig: MOLINA press, 1993: 309–315.
   Google Scholar
• Pallon J. Did mercury-poisoning cause the death of Tycho Brahe? nuclearphysicsa.nuclear.lu.se/docs/historic.pdf (online publication since 1996).
   Google Scholar
• Gilder J, Gilder A-L. Heavenly Intrigue. New York: Doubleday; 2004.
   Google Scholar
• Andersen Vinilandicus, P. Kunstværket, Copenhagen; 2009. Andersen Vinilandicus, P. Les vieux cheveux renfermant la clef d’Hamlet. In: Anthropologie, mythologies et histoire de la chevelure et de la pilosité. Le sens du poil. Ed. by B Lançon & M.-H. Delavaud-Rous, Paris: L’Harmattan; 2011, 319–333.
   Google Scholar
• Fitzpatrick TB, et al. Biology of the melanin pigmentary system. In Fitzpatrick TB, Arndt KA, Clark WH, Eisen AZ, Van Scott EJ, Vaughan JH, eds. Dermatology in General Medicine. New York: McGraw-Hill; 1971: 1–17.
   Google Scholar
• Quevedo WC, et al. Biology of me1anocytes. In: Fitzpatrick TB, et al., eds. Dermatology in General Medicine. New York: McGraw-Hill; 1987.
   Google Scholar
• Ghadially FN. Ultrastructural Patholoy of the Cell and Matrix: Melanosomes. Boston: Butterworth-Heinemann; 1997.
   Google Scholar
• Tycho Brahe’s Latin Recipe has been published after his death. Cf. Tychonis Brahe Opera Omnia, ed. by JLE Dreyer, 1927; 9: 165–166. It has been thoroughly described in English. Cf. Gilder J, Gilder A-L. Heavenly Intrigue. New York: Doubleday; 2004: 231–234.
   Google Scholar
• Jonas L, Fulda G, Salameh T et al. Electron microscopic detection of copper in the liver of two patients with morbus Wilson by EELS and EDX. Ultrastruct Pathol. 2001;25:111–118.
   PubMed Web of Science ®Google Scholar
• Jonas L, Fulda G, Radeck C, Henkel KO, Holzhüter G, Mathieu HJ. Biodegradation of titanium implants after long-time insertion used for the treatment of fractured upper and lower jaws through osteosynthesis: element analysis by electron microscopy and EDX or EELS. Ultrastruct Pathol. 2001;25:375–383.
   PubMed Web of Science ®Google Scholar
• Jonas L, Fulda G, Kröning G, Merkord J, Nizze H. Electron microscopic detection of tin accumulation in biliopancreatic concrements after induction of chronic pancreatitis in rats by di-n-butyltin dichloride. Ultrastruct Pathol. 2002;26:89–98.
   PubMed Web of Science ®Google Scholar
• Jonas L, Baguhl F, Wilken HP, Haas HJ, Nizze H. Copper accumulation in actinomyces druses during endometritis after long-term use of an intrauterine contraceptive device. Ultrastruct Pathol. 2002;26:323–329.
   PubMed Web of Science ®Google Scholar
• Jonas L, Fulda G, Kyank U, Steiner M, Sarich W, Nizze H. Hereditary hemochromatosis of a young girl: detection of early iron deposition in liver cell lysosomes using transmission electron microscopy and electron energy loss spectroscopy. Ultrastruct Pathol. 2002;26:23–26.
   PubMed Web of Science ®Google Scholar
• Jonas L, Baguhl F, Wilken H-P, Haas HJ, Nizze H. Copper accumulation in actinomyces druses during endometritis after long-term use of an intrauterine contraceptive device. Ultrastruct Pathol. 2002; 26:323–329.
   PubMed Web of Science ®Google Scholar
• Jonas L, Bloch C, Zimmermann R, Stadie V, Gross GE, Schäd SG. Detection of silver sulfide deposits in the skin of patients with argyria after long-term use of silver-containing drugs. Ultrastruct Pathol. 2007;31:379–384.
   PubMed Web of Science ®Google Scholar
• Schäd S, Heitland P, Kühn-Velten WN, Gross GE, Jonas L. Time-dependent decrement of dermal gadolinium deposits and significant improvement of skin symptoms in a patient with nephrogenic systemic fibrosis after temporary renal failure. J Cutan Pathol., submitted.
   Google Scholar