149
Views
6
CrossRef citations to date
0
Altmetric
Research Article

Ameliorative Effect of Pimpinella anisum Oil on Immunohistochemical and Ultrastuctural Changes of Cerebellum of Albino Rats Induced by Aspartame

, PhD & , PhD
Pages 224-236 | Received 23 Dec 2013, Accepted 27 Jan 2014, Published online: 31 Mar 2014

References

  • Trocho C, Pardo R, Rafecas I, et al. Formaldehyde derived from dietary aspartame binds to tissue components in vivo. Life Sci 1998;63: 337–49
  • Soffritti M, Belpoggi F, Degli Esposti D, et al. First experimental demonstration of the multipotential carcinogenic effects of aspartame administered in the feed to Sprague-Dawley rats. Environ Health Perspect 2006;114: 379–85
  • Aspartame Information Center. Aspartame Information Center Homepage. Available from: http://www.aspartame.org/ [last accessed 27 Oct 2005]
  • Rowe RC, Sheskey PJ, Quinn ME. Hand book of pharmaceutical excipients, 6th ed. London: Pharmaceutical Press and American Pharmacists Association; 2009
  • Olney JW, Farber NB, Spitznagel E, et al. Increasing brain tumor rates: Is there a link to aspartame? J Neuropathol Exp Neurol 1996;55: 1115–23
  • Camfield PR, Camfield CS, Dooley JM, et al. Aspartame exacerbates EEG spike wave discharge in children with generalized absence epilepsy: A double-blind controlled study. Neurology 1992;42: 1000–3
  • Mackey SA, Berlin CM Jr. Effect of dietary aspartame on plasma concentrations of phenylalanine and tyrosine in normal and homozygous phenylketonuric patients. Clin Pediatr (Phila) 1992;31: 394–9
  • El-Haliem NGA, Mohamed DS. The effect of aspartame on the histological structure of the liver and renal cortex of adult male albino rat and the possible protective effect of Pimpinella anisum oil. Egypt J Histol 2011;34: 715–26
  • Beal MF, Hyman BT, Koroshetz W. Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? Trends Neurosci 1993;16: 125–31
  • Christian B, McConnaughey K, Bethea E, et al. Chronic aspartame affects T-maze performance, brain cholinergic receptors and Na+, K+-ATPase in rats. Pharmacol Biochem Behav 2004;78: 121–7
  • Moser RH. Aspartame and memory loss. JAMA 1994;272: 1543
  • Van den Eeden SK, Koepsell TD, et al. Aspartame ingestion and headaches: A randomized crossover trial. Neurology 1994;44: 1787–93
  • Brock TO, O’Callaghan JP. Quantitative changes in the synaptic vesicle proteins synapsin I and p38 and the astrocyte specific protein glial fibrillary acidic protein are associated with chemical-induced injury to the rat central nervous system. J Neurosci 1987;7: 931–42
  • Marnett LJ. Cyclooxygenase mechanisms. Curr Opin Chem Biol 2000;4: 545–52
  • Smith WL, DeWitt DL, Garavito RM. Cyclooxygenases: Structural, cellular and molecular biology. Annu Rev Biochem 2000;69: 145–82
  • Smith WL, Garavito RM, DeWitt DL. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J Biol Chem 1996;271: 33157–60
  • Singer II, Kawka DW, Schloemann S, et al. Cyclooxygenase 2 is induced in colonic epithelial cells in inflammatory bowel disease. Gastroenterology 1998;115: 297–306
  • Minghetti L. Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. J Neuropathol Exp Neurol 2004;63: 901–10
  • Benchaar C, Calsamiglia S, Chaves AV, et al. A review of plant-derived essential oils in ruminant nutrition and production. Anim Feed Sci Technol 2008;145: 209–28
  • Kucukkurt G, Avci A, Eryavuz I, et al. Uyarlar effects of supplementation of aniseed (Pimpinella anisum L.) at various amounts to diets on lipid peroxidation, antioxidant activity and some biochemical parameters in laying quails (Coturnix coturnix japonica) Kocatepe. Vet J 2009;2: 1–5
  • Gulcin U, Oktay M, Kirecci E, Kufrevioglu U. Screening of antioxidant and antimicrobial activities of anise (Pimpinella anisum) seed extracts. Food Chem 2003;83: 371–82
  • El-Haliem NGA. The effect of aspartame on the pituitary thyroid axis of adult male albino rat and the possible protective effect of Pimpinella anisum oil: Histological and immunohistochemical study. Egypt J Histol 2013;36: 195–205
  • Aboabrahim Z. Zakhirah kharazmshahi, vol. 2. Tehran: National Works Publications, 1970
  • Lershin BI. Experimental drug therapy of toxic hepatitis. Patol Fiziol Eksp Ter 1972;16: 66–7
  • Fernstrom JD. Oral aspartame and plasma phenylalanine: Pharmacokinetic difference between rodents and man and relevance to CNS effects of phenylalanine. Short note. J Neural Transm 1989;75: 159–64
  • Hjelle JJ, Dudley RE, Marietta, MP, et al. Plasma concentrations and pharmacokinetics of phenylalanine in rats and mice administered aspartame. Pharmacology 1992;44: 48–60
  • Bancroft JD, Stevens A. Theory and practice of histological techniques, 4th ed. Edinburgh: Churchill Livingstone; 1996
  • Kiernan JA. Histological and histochemical methods: Theory and practice. 3rd ed. Oxford: Butterworth–Heinemann; 1999
  • Therland KL, Stubbe J, Thiesson HC, et al. Cycloxygenase-2 is expressed in vasculature of normal and ischemic adult human kidney and is colocalized with vascular prostaglandin E2 EP4 receptors. J Am Soc Nephrol 2004;15: 1189–98
  • Giorno R. A comparison of two immunoperoxidase staining methods based on the avidin–biotin interaction. Diagn Immunol 1984;2: 161–6
  • Hayat MA. Principles and techniques of electron microscopy. Biological applications, 3rd ed. Hampshire and London: CRC Press; 1989: 24–74
  • Abd El-Samad AA. Light and electron microscopic study on the effect of aspartame on the cerebellar cortex of male albino rat. Egypt J Histol 2010;33: 419–30
  • Magnuson BA, Burdock GA, Doull J, et al. Aspartame: A safety evaluation based on current use levels, regulations and toxicological and epidemiological studies. Crit Rev Toxicol 2007;37: 629–727
  • Gartner LP, Hiatt JL. Color textbook of histology, 2nd ed. Baltimore: Lippincott Williams & Wilkins; 2001
  • Alleva R, Borghi B, Santarelli L, et al. In vitro effect of aspartame in angiogenesis induction. Toxicol In Vitro 2011;25: 286–93
  • Rezin GT, Cardoso MR, Gonçalves CL, et al. Inhibition of mitochondrial respiratory chain in brain of rats subjected to an experimental model of depression. Neurochem Int 2008;53: 395–400
  • Felts PA, Baker TA, Smith, KJ. Conduction in segmentally demyelinated mammalian central axons. J Neurosci 1997;17: 7267–77
  • Elsn KS. Radical scavenging and iron-chelating activities of some greens used as traditional dishes in Mediterranean diet. Int J Food Sci Nutr 2004;55: 67–74
  • Barbour B, Keller BU, Llano I, Marty A. Prolonged presence of glutamate during excitatory synaptic transmission to cerebellar Purkinje cells. Neuron 1994;12: 1331–43
  • Bruce Keller AJ. Microglial-neuronal interactions in synaptic damage and recovery. J Neurosci Res 1999;58: 191–201
  • Eng LF, Ghirnikar RS. GFAP and astrogliosis. Brain Pathol 1994;4: 229–37
  • Hwang DY, ChaEe KR, Kang TS, et al. Alterations in behavior, amyloid-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer’s disease. FASEB J 2002;16: 805--13
  • Koki A, Khan NK, Woerner BM, et al. Cyclooxygenase-2 in human pathological disease. Adv Exp Med Biol 2002;507: 177–84
  • Boje KM, Jaworowicz D Jr, Raybon JJ. Neuroinflammatory role of prostaglandins during experimental meningitis: Evidence suggestive of an in vivo relationship between nitric oxide and prostaglandins. J Pharmacol Exp Ther 2003;304: 319–25
  • Strauss KI, Barbe MF, Marshall R, et al. Prolonged cyclooxygenase-2 induction in neurons and glia following traumatic brain injury in the rat. J Neurotrauma 2000;17: 695–711
  • Pasinetti GM, Aisen PS. Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain. Neuroscience 1998;87: 319–24
  • Aisen PS. The potential of anti-inflammatory drugs for the treatment of Alzheimer’s disease. Lancet Neurol 2002;1: 279–84

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.