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Research Article

Microencapsulation of budesonide with dextran by spray drying technique for colon-targeted delivery: an in vitro/in vivo evaluation in induced colitis in rat

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Pages 62-73 | Received 15 May 2010, Accepted 01 Oct 2010, Published online: 20 Dec 2010

References

  • Aslan A, Temiz M, Atik E, Polat G, Sahinler N, Besirov E, Aban N, Parsak CK. Effectiveness of mesalamine and propolis in experimental colitis. Adv Ther 2007; 24(5)1085–97
  • Bickston SJ, Cominelli F. Inflammatory bowel disease: Short- and long-term treatments. Dis Mon 1998; 44(4)141–72
  • Billon A, Bataille B, Cassanas G, Jacob M. Development of spray-dried acetaminophen microparticles using experimental designs. Int J Pharm 2000; 203(1–2)159–68
  • Cooper HS, Murthy SN, Shah RS, Sedergran DJ. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest 1993; 69: 238–49
  • Cui N, Friend DR, Fedorak RN. A budesonide prodrug accelerates treatment of colitis in rats. Gut 1994; 35(10)1439–46
  • Dieleman LA, Palmen MJHJ, Akol H, Bloemena E, Peña AS, Meuwissen SGM, Van Rees EP. Chronic experimental colitis induced by dextransulfate sodium (DSS) is characterized by Th1 and Th2 cytokines. Clin Exp Immunol 1998; 114: 385–91
  • Edsbacker S, Andersson T, McKeage K, Goa KL. Pharmacokinetics of budesonide (Entocort EC) capsules for Crohn's disease. Clin Pharmacokinet 2004; 43(12)803–21
  • Edsbacker S, Larsson P, Wollmer P. Gut delivery of budesonide, a locally active corticosteroid, from plain and controlled-release capsules. Eur J Gastroenterol Hepatol 2002; 14: 1357–62
  • Ei-Arini SK, Leuenberger H. Modelling of drug release from polymer matrices: Effect of drug loading. Int J Pharm 1995; 121(2)141–8
  • El Medany A, Mahgoub A, Mustafa A, Arafa M, Morsi M. The effects of selective cyclooxygenase-2 inhibitors, celecoxib and rofecoxib, on experimental colitis induced by acetic acid in rats. Eur J Pharmacol 2005; 507: 291–9
  • Fedorak RN, Bistritz L. Targeted delivery, safety, and efficacy of oral enteric-coated formulations of budesonide. Adv Drug Delev Rev 2005; 57(2)303–16
  • Friend DR. Issues in oral administration of locally acting glucocorticosteroids for treatment of inflammatory bowel disease. Aliment Pharmacol Ther 1998; 12(7)591–603
  • Gohel MC, Panchal MK. Novel use of similarity factors and Sd for the development of diltiazem HCl modified-release tablets using a 32 factorial design. Drug Dev Ind Pharm 2002; 28(1)77–87
  • Gorgulu S, Yagci G, Kaymakcioglu N, Ozkara M, Kurt B, Ozcan A, Kaya O, Sadir S, Tufan T. Hyperbaric oxygen enhances the efficiency of 5-aminosalicylic acid in acetic acid-induced colitis in rats. Dig Dis Sci 2006; 51(3)480–7
  • He P, Davis SS, Illum L. Chitosan microspheres prepared by spray drying. Int J Pharm 1999; 187: 53–65
  • Knigge KL. Inflammatory bowel disease. Clin Cornerstone 2002; 4(4)49–57
  • Lee JS, Jung YJ, Doh MJ, Kim YM. Synthesis and properties of dextran-nalidixic acid ester as a colon-specific prodrug of nalidixic acid. Drug Dev Ind Pharm 2001; 27(4)331–6
  • McLeod AD, Friend DR, Tozer TN. Synthesis and chemical stability of glucocorticoid-dextran esters: Potential prodrugs for colon-specific delivery. Int J Pharm 1993; 92(1–3)105–14
  • Moretti MDL, Gavini E, Juliano C, Pirisino G, Giunchedi P. Spray-dried microspheres containing ketoprofen formulated into capsules and tablets. J Microencapsul 2001; 18(1)111–21
  • Paiva LAF, Gurgel LA, De Sousa ET, Silveira ER, Silva RM, Santos FA, Rao VSN. Protective effect of Copaifera langsdorffii oleo-resin against acetic acid-induced colitis in rats. J Ethnopharmacol 2004; 93(1)51–6
  • Palmieri GF, Wehrleï P, Stamm A. Evaluation of spray drying as a method to prepare microcapsules for controlled drug release. Drug Dev Ind Pharm 1994; 20: 2859–79
  • Rama Prasad YV, Krishnaiah YSR, Satyanarayana S. In vitro evaluation of guar gum as a carrier for colon-specific drug delivery. J Control Release 1998; 51: 281–7
  • Rodriguez M, Antunez JA, Taboada C, Seijo B, Torres D. Colon-specific delivery of budesonide from microencapsulated cellulosic cores: Evaluation of the efficacy against colonic inflammation in rats. J Pharm Pharmacol 2001; 53(9)1207–15
  • Shyale S, Chowdhary KPR, Krishnaiah YSR. Development of colon-targeted albendazole-b-cyclodextrin-complex drug delivery systems. Drug Dev Res 2005; 65: 76–83
  • Swaminath A, Kornbluth A. Optimizing drug therapy in inflammatory bowel disease. Curr Gastroenterol Rep 2007; 9(6)513–20
  • Tozaki H, Fujita T, Komoike J, Kim SI, Terashima H, Muranishi S, Okabe S, Yamamoto A. Colon-specific delivery of budesonide with azopolymer-coated pellets: Therapeutic effects of budesonide with a novel dosage form against 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats. J Pharm Pharmacol 1999; 51(3)257–61
  • Varshosaz J, Emami J, Ahmadi F, Tavakoli N, Minaiyan M, Fassihi A, Mahzouni P, Dorkoosh F. Preparation of budesonide–dextran conjugates using glutarate spacer as a colon-targeted drug delivery system: In vitro/in vivo evaluation in induced ulcerative colitis. J Drug Target 2010a, Posted online on April 30 (Epub ahead of print)
  • Varshosaz J, Emami J, Fassihi A, Tavakoli N, Minaiyan M, Ahmadi F, Mahzouni P, Dorkoosh F. Effectiveness of budesonide-succinate-dextran conjugate as a novel prodrug of budesonide against acetic acid-induced colitis in rats. Int J Colorectal Dis 2010b; 25(10)1159–65
  • Varshosaz J, Emami J, Tavakoli N, Fassihi A, Minaiyan M, Ahmadi F, Dorkoosh F. Synthesis and evaluation of dextran-budesonide conjugates as colon specific prodrugs for treatment of ulcerative colitis. Int J Pharm 2009; 365: 69–76
  • Wan LS, Heng PWS, Chia CGH. Spray drying as a process for microencapsulation and the effect of different coating polymers. Drug Dev Ind Pharm 1992; 18: 997–1011
  • Williams KL, Randall Fuller C, Dieleman LA, DaCosta CM, Haldeman KM, Sartor RB, Lund PK. Enhanced survival and mucosal repair after dextran sodium sulfate-induced colitis in transgenic mice that overexpress growth hormone. Gastroenterol 2001; 120(4)925–37

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