Surface-modified gemcitabine with mucoadhesive polymer for oral delivery†

References

• Abbruzzese JL, Grunewald R, Weeks EA, Gravel D, Adams T, Nowak B, Mineishi S, Tarassoff P, Satterlee W, Raber MN, et al. A phase I clinical, plasma, and cellular pharmacology study of gemcitabine. J Clin Oncol 1991; 9: 491–8
   PubMed Web of Science ®Google Scholar
• Bao W, Zhou J, Luo J. PLGA microspheres with high drug loading and high encapsulation efficiency prepared by a novel solvent evaporation technique. J Microencapsul 2006; 23: 471–9
   PubMed Web of Science ®Google Scholar
• Bergman AM, Kuiper CM, Noordhuis P, Smid K, Voorn DA, Comijn EM, Myhren F, Sandvold ML, Hendriks HR, Fodstad O, et al. Antiproliferative activity and mechanism of action of fatty acid derivatives of gemcitabine in leukemia and solid tumor cell lines and human xenografts. Nucl Nucl Acid 2004; 23: 1329–33
   PubMed Web of Science ®Google Scholar
• Birnbaum D, Brannon-Peppas L. Microparticle drug delivery systems. Humana Press, Totowa, NJ 2003
   Google Scholar
• Brusa P, Immordino ML, Rocco F, Cattel L. Antitumor activity and pharmacokinetics of liposomes containing lipophilic gemcitabine prodrugs. Anticancer Res 2007; 27: 195–200
   PubMed Web of Science ®Google Scholar
• Chen P, Chien PY, Khan AR, Sheikh S, Ali SM, Ahmaad MU, Ahmad I. In vitro and in vivo anti-cancer activity of a novel gemcitabine-cardiolipin conjugate. Anticancer Drug 2006; 17: 53–61
   Google Scholar
• Couvreur P, Barratt G, Fattal E, Legrand PH, Vauthier C. Nanocapsule technology: A review. Crit Rev Ther Drug Carrier Syst 2002; 19: 99–134
   PubMed Web of Science ®Google Scholar
• Esmaeili F, Hosseini-Nasr M, Rad-Malekshahi M, Samadi N, Atyabi F, Dinarvand R. Preparation and antibacterial activity evaluation of rifampicin-loaded poly lactide-co-glycolide nanoparticles. Nanomed Nanotechnol Biol Med 2007; 3: 161–7
   PubMed Web of Science ®Google Scholar
• Heinemann V, Xu YZ, Chubb S, Sen A, Hertel LW, Grindey GB, Plunkett W. Cellular elimination of 2′,2′-difluorodeoxycytidine 5′-triphosphate: A mechanism of self-potentiation. Cancer Res 1992; 52: 533–9
   PubMed Web of Science ®Google Scholar
• Hertel LW, Boder GB, Kroin JS, Rinzel SM, Poore GA, Todd GC, Grindey GB. Evaluation of the antitumor activity of gemcitabine (2′,2′-difluoro-2′-deoxycytidine). Cancer Res 1990; 50: 4417–22
   PubMed Web of Science ®Google Scholar
• Immordino ML, Brusa P, Rocco F, Arpicco S, Ceruti M, Catterl L. Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing lipophilic gemcitabine prodrugs. J Control Rel 2004; 100: 331–46
   PubMed Web of Science ®Google Scholar
• Jain R. The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide)(PLGA) devices. Biomaterials 2000; 21: 2475–90
   PubMed Web of Science ®Google Scholar
• Moghimi SM, Hunter AC, Murray JC. Long-circulating and target-specific nanoparticles: Theory to practice. Pharmacology 2001; 53: 283–318
   Google Scholar
• Noble S, Goa KL. Gemcitabine. A review of its pharmacology and clinical potential in non-small cell lung cancer and pancreatic cancer. Drugs 1997; 54: 447–72
   PubMed Web of Science ®Google Scholar
• Perugini P, Genta I, Conti B, Modena T, Pavanetto F. Long-term release of clodronate from biodegradable microspheres. AAPS PharmSciTech 2001; 2: E10
   PubMedGoogle Scholar
• Plunkett W, Huang P, Xu YZ, Heinemann V, Grunewald R, Gandhi V. Gemcitabine: Metabolism, mechanism of action, and self-potentiation. Semin Oncol 1995; 22: 3–10
   PubMed Web of Science ®Google Scholar
• Samdancioglu S, Calis S, Summu M, Hincal A. Formulation and in vitro evaluation of bisphosphonate loaded microspheres for implantation in osteolysis. Drug Dev Ind Pharm 2006; 32: 473–81
   PubMed Web of Science ®Google Scholar
• Shipley LA, Brown TJ, Cornpropst JD, Hamilton M, Daniels WD, Culp HW. Metabolism and disposition of gemcitabine, and oncolytic deoxycytidine analog, in mice, rats, and dogs. Drug Metab Dispos 1992; 20: 849–55
   PubMed Web of Science ®Google Scholar
• Takeuchi H, Thongborisute J, Matsui Y, Sugihara H, Yamamoto H, Kawashima Y. Novel mucoadhesion tests for polymers and polymer-coated particles to design optimal mucoadhesive drug delivery systems. Adv Drug Del Rev 2005; 57: 1583–94
   PubMed Web of Science ®Google Scholar
• Trickler WJ, Khurana J, Nagvekar AA, Dash AK. Chitosan and glyceryl monooleate nanostructures containing gemcitabine: Potential delivery system for pancreatic cancer treatment. AAPS PharmSciTech 2010; 11: 392–401
   PubMed Web of Science ®Google Scholar
• Trickler WJ, Nagvekar AA, Dash AK. A novel nanoparticle formulation for sustained paclitaxel delivery. AAPS PharmSciTech 2008; 9: 486–93
   PubMed Web of Science ®Google Scholar
• Vauthier C, Dubernet C, Fattal E, Pinto-Alphandary H, Couvreur P. Poly(alkylcyanoacrylates) as biodegradable materials for biomedical applications. Adv Drug Deliv Rev 2003; 55: 519–48
   PubMed Web of Science ®Google Scholar
• Veltkamp SA, Jansen RS, Callies S, Pluim D, Visseren-Grul CM, Rosing H, Susanne KR, Andre VAM, Beijnen JH, Slapak CA, et al. Oral administration of gemcitabine in patients with refractory tumors: A clinical and pharmacologic study. Clin Cancer Res 2008; 14: 3477–86
   PubMed Web of Science ®Google Scholar
• Viswanathan N, Thomas P, Pandit J, Kulkarni M, Mashelkar R. Preparation of non-porous microspheres with high entrapment efficiency of proteins by a (water-in-oil)-in-oil emulsion technique. J Control Rel 1999; 58: 9–20
   PubMed Web of Science ®Google Scholar
• Weidenauer U, Bodmer D, Kissel T. Microencapsulation of hydrophilic drug substance using biodegradable polyesters. Part I: Evaluation of different techniques for the encapsulation of pamidronate di-sodium salt. J Microencapsul 2003; 20: 509–24
   PubMed Web of Science ®Google Scholar
• You S, Kwon H, Lee J, Shin S, Cho C. Studies on the formation of hydrophobic ion-pairing complex of alendronate. Arch Pharm Res 2009; 32: 1055–60
   PubMed Web of Science ®Google Scholar