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Research Article

Preparation of biodegradable microcapsules containing zidovudine (AZT) using solvent evaporation technique

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Pages 257-267 | Received 22 Nov 1994, Accepted 27 Jul 1995, Published online: 27 Sep 2008

References

  • Alex R., Bodmeier R. Encapsulation of water-soluble drugs by a modified solvent evaporation method. I. Effect of process and formulation variables on drug entrapment. Journal of Microencapsulation 1990; 7: 347–355
  • Alonso M. J., Cohen S., Park T. G., Gupta R. K., Siber G. R., Langer R. Determinants of release rate of tetanus vaccine from polyester microspheres. Pharmaceutical Research 1993; 10: 945–953
  • Arshady R. Microspheres and microcapsules, a survey of manufacturing techniques: part III: solvent evaporation. Polymer Engineering and Science 1990; 30: 915–924
  • Brook I. Approval of zidovudine (AZT) for acquired immunodeficiency syndrome. J. Amer. Med. Ass. 1987; 258: 1517
  • Calverley D., Haley L., Ballem P. Red blood cell alloimmunization in transfused patients on AZT. British Journal of Haematology 1991; 78: 248–250
  • Child S., Montaner J., Tsoukas C., Fanning M., Le T., Wall R. A., Ruedy J. Canadian multicenter azidothymidine trial: AZT pharmacokinetics. Journal of Acquired Immunity Deficiency Syndromes 1991; 4: 865–870
  • Chow F-P. R., Hamburger A. W. In vivo evaluation of the anemia induced by azidothymidine (AZT) in a murine model of AIDS. European Journal of Haematology 1991; 47: 91–97
  • Cleland J. L., Langer R. Formulation and delivery of proteins and peptides: design and development strategies. Formulation and Delivery of Proteins and Peptides, J. L. Cleland, R. Langer. American Chemical Society, Washington, DC 1994; 1–19
  • Colson E. R., Horwitz R. I., Bia F. J., Viscoli C. M. Zidovudine (AZT) for the treatment of patients infected with human immunodeficiency virus type 1. An evaluation of effectiveness in clinical practice. Archives of Internal Medicine 1991; 151: 709–713
  • Devita V. T., Broder S., Fauci A. S., Kovacs J. A., Chabner B. A. Developmental therapeutics and the acquired immunodeficiency syndrome. Annals of Internal Medicine 1987; 106: 568–581
  • Douglas R. D. Antimicrobial agents. The Pharmacological Basis of Therapeutics, A. G. Gilman, T. W. Rall, A. S. Nies, P. Taylor. Pergamon Press, New York 1990; 1182–1184
  • Drew R. H., Weller S., Gallis H. A., Walmer K. A. R., Bartlett J. A., Blum M. R. Bioequivalence assessment of zidovudine (Retrovir) syrup, solution, and capsule formulations in patients infected with human immunodeficiency virus. Antimicrobial Agents and Chemotherapy 1989; 33: 1801–1803
  • Fischl M. A., Richman D. D., Grieco M. H., Gottlieb M. S., Volverding P. A., Laskin O. L., Leedom J. M., Groopman J. E., Mildvan D., Schooley R. T., Jackson G. G., Durack D. T., King D. and the AZT Collaborative Working Group, The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. New England Journal of Medicine 1987; 317: 185–191
  • Fischl M. A., Richman D. D., Hansen N., Collier A. C., Carey J. T., Para M. F., Hardy W. D., Powderly W. G., Allan J. D., Wong B., Merigan T. C., Dolin R., McAuliffe V. J., Hyslop N. E., Rhame F. S., Balfour H. H., Spector S. A., Volberding P., Pettinelli C., Anderson J. and the AIDS Clinical Trials Group, The safety and efficacy of zidovudine (AZT) in the treatment of subjects with mildly symptomatic human immunodeficiency virus type 1 (HIV) infection. Annals of Internal Medicine 1990; 112: 727–737
  • Fong J. W. US Patent. 4,384,975, 1983, Process for preparation of microspheres
  • Fong J. W. US Patent. 4,479,911, 1984, Process for preparation of microspheres and modification of release rate of core material
  • Fong J. W. Microencapsulation by solvent evaporation and organic phase separation process. Controlled Release Systems: Fabrication Technology, D. S. T. Hsieh. CRC Press, Florida 1988; Vol. I: 88–108
  • Furr B. J., Hutchinson F. G. A biodegradable delivery system for peptides: preclinical experience with the gonadotorphin-releasing hormone agonist Zoladex®. Journal of Controlled Release 1992; 21: 117–128
  • Gallo J. M., Sanzgiri Y., Howerth E. W., Finco T. S., Wilson J., Johnston J., Tackett R., Budsberg S. C. Serum, cerebrospinal fluid, and brain concentrations of a new zidovudine formulation following chronic administration via an implantable pump in dogs. Journal of Pharmaceutical Science 1992; 81: 11–15
  • Gallo J. M., Clark L. N., Rubino J. T. Pump delivery of azidothymidine: potential for constant concentrations and improved brain delivery. Journal of Controlled Release 1989; 9: 249–253
  • Hirsch M. S. AIDS Commentary. Azidothymidine. Journal of Infectious Disease 1988; 157: 427–431
  • Kanke M., Simmons G. H., Weiss D. L., Bivins B. A., DeLuca P. P. Clearance of 114Ce-labeled microspheres from blood and distribution in specific organs following intravenous and intraarterial administration in beagle dogs. Journal of Pharmaceutical Science 1980; 69: 755
  • Klecker R., Collins J., Yarchoan R., Thomas R., Jenkins J. F., Broder S., Myers C. E. Plasma and cerebrospinal fluid pharmacokinetics of 3-azido-3-deonythymidine: a novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases. Clinical Pharmacology and Therapeutics 1987; 41: 407–412
  • Lewis D. H. Biodegradable polymers as drug delivery systems. Drugs and Pharmaceutical Sciences, M. Chasin, R. Langer. Marcel Dekker, New York 1990; Vol. 45: 1–42
  • Lutton J. D., Mathew A., Levere R. D., Abraham N. G. Role of heme metabolism in AZT-induced bone marrow tonicity. American Journal of Haematology 1990; 35: 1–5
  • Nihant N., Stassen S., Grandfils C., Jerome R., Teyssie Ph. Micro-encapsulation by coacervation of poly(lactide-co-glycolide). II Encapsulation of a dispersed aqueous phase. Polymer International 1993; 32: 171–176
  • Okada H., Inoue Y., Heya T., Ueno H., Ogawa Y., Toguchi H. Pharmacokinetics of once-a-month injectable microspheres of leuprolide acetate. Pharmaceutical Research 1991; 8: 787–791
  • Okada H. One-month release injectable microspheres of leuprolide acetate, a superactive aginist of LH-RH. Proceedings of the International Symposium on Controlled Release of Bioactive Materials 1989; 16: 12–13
  • Okada H., Ogawa Y., Yashiki T. US Patent. 4,652,441, 1987, Prolonged release microcapsules and its production
  • Pizzo P. A., Eddy J., Fallon J., Balis F. M., Murphy R. F., Moss H., Wolters P., Brouwers P., Jarosinski P., Rubin M., Broder S., Yarchoan R., Brunetti A., Maha M., Nusinoff-Lehrman S., Poplack D. G. Effect of continuous intravenous infusion of zidovudine (AZT) in children with symptomatic HIV infection. New England Journal of Medicine 1988; 319: 889–896
  • Posner M. R., Darnowski W., Calabresi P., Brunetti I., Corvese D., Curt G., Cummings F. J., Clark J., Browne M. J., Beitz J., Weitberg A. B. Oral zidovudine, continuous-infusion fluorouracil, and oral leucovorin calcium: a phase 1 study. Journal of the National Cancer Institute 1990; 82: 1710–1714
  • Richman D. D., Andrews J. Results of continued monitoring of participants in the placebo-controlled trial of zidovudine for serious human immunodeficiency virus infection. American Journal of Medicine 1988; 85: 208–213, (suppl 2A)
  • Richman D. D., Fischl M. A., Grieco M. H., Gottliab M. S., Volberding P. A., Laskin O. L., Leedom J. M., Groopman J. E., Mildvan D., Hirsch M. S., Jackson G. G., Durack D. T., Nusinoff-Lehrman S. and the AZT Collaborative Working Group, The tonicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complen. New England Journal of Medicine 1987; 317: 192–197
  • Shargel L., Yu A. B. C. Applied Biopharmaceutics and Pharmacokinetics. Appleton & Lange, Connecticut 1993; 435–463
  • Schugens Ch., Laruelle N., Nihant N., Grandfils Ch., Jerome R., Teyssie Ph. Effect of emulsion stability on the morphology and porosity of semicrystalline poly 1-lactide microparticles prepared by w/o/w double emulsion-evaporation. Journal of Controlled Release 1994; 32: 161–176
  • Van Besauw J. F., Claeys D. A. US Patent. 3,645,911, 1972, Method of encapsulating aqueous or hydrophilic material
  • Wakiyama N., Juni K., Nakano M. Preparation and evaluation in vitro of polylactic acid microspheres containing local anesthetics. Chemical and Pharmaceutical Bulletin 1981; 29: 3363

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