Metabolomics of Rabbit Aqueous Humor after Administration of Glucocorticosteroid

REFERENCES

• Yeung CK, Chan KP, Chiang SW, et al. The toxic and stress responses of cultured human retinal pigment epithelium (ARPE19) and human glial cells (SVG) in the presence of triamcinolone. Invest Ophthalmol Vis Sci. 2003;44:5293–5300
   PubMed Web of Science ®Google Scholar
• Roesel M, Tappeiner C, Heinz C, et al. Comparison between intravitreal and orbital floor triamcinolone acetonide after phacoemulsification in patients with endogenous uveitis. Am J Ophthalmol. 2009;147:406–412.
   PubMed Web of Science ®Google Scholar
• Dickerson JE, Steely HT, English-Wright SL, et al. The effect of dexamethasone on integrin and laminin expression in cultured human trabecular meshwork cells. Exp Eye Res. 1998;66:731–738.
   PubMed Web of Science ®Google Scholar
• Stokes J, Noble J, Brett L, et al. Distribution of glucocorticoid and mineralocorticoid receptors and 11ß-hydroxysteroid dehydrogenases in human and rat ocular tissues. Invest Ophthalmol Vis Sci. 2000;41:1629–1638.
   PubMed Web of Science ®Google Scholar
• Vasconcelos-Santos DV, Nehemy PG, Schachat AP, et al. Secondary ocular hypertension after intravitreal injection of 4 mg of triamcinolone acetonide: Incidence and risk factors. Retina. 2008;28:573–580.
   PubMed Web of Science ®Google Scholar
• Smithen LM, Ober MD, Maranan L, et al. Intravitreal triamcinolone acetonide and intraocular pressure. Am J Ophthalmol. 2004;138:740–743.
   PubMed Web of Science ®Google Scholar
• Lau LI, Chen KC, Lee FL, et al. Intraocular pressure elevation after intravitreal triamcinolone acetonide injection in a Chinese population. Am J Ophthalmol. 2008;146:573–578.
   PubMed Web of Science ®Google Scholar
• Fan BJ, Wang DY, Tham CC, et al. Gene expression profiles of human trabecular meshwork cells induced by triamcinolone and dexamethasone. Invest Ophthalmol Vis Sci. 2008;49:1886–1897
   PubMed Web of Science ®Google Scholar
• Chung H, Hwang JJ, Koh JY, et al. Triamcinolone acetonide-mediated oxidative injury in retinal cell culture: Comparison with dexamethasone. Invest Ophthalmol Vis Sci. 2007;48:5742–5749.
   PubMed Web of Science ®Google Scholar
• Nicholson JK, Lindon JC, Holmes E. ‘Metabonomics’: Understanding the meta-bolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica. 1999;29:1181–1189.
   PubMed Web of Science ®Google Scholar
• Fiehn O, Kopka J, Dörmann P, et al. Metabolite profiling for plant functional genomics. Nat Biotechnol. 2000;18:1157–1161.
   PubMed Web of Science ®Google Scholar
• Robertson DG, Reily MD, Baker JD. Metabonomics in pharmaceutical discovery and development. J Proteome Res. 2007;6:526–539.
   PubMed Web of Science ®Google Scholar
• Lindon JC, Holmes E, Nicholson JK. Metabonomics and its role in drug development and disease diagnosis. Expert Rev Mol Diagn. 2004;4:189–199.
   PubMed Web of Science ®Google Scholar
• Pan Z, Gu H, Talaty N, et al. Principal component analysis of urine metabolites detected by NMR and DESI–MS in patients with inborn errors of metabolism. Anal Bioanal Chem. 2007;387:539–549.
   PubMed Web of Science ®Google Scholar
• Gu H, Chen H, Pan Z, et al. Monitoring diet effects via biofluids and their implications for metabolomics studies. Anal Chem. 2007;79:89–97.
   PubMed Web of Science ®Google Scholar
• Bitter C, Suter K, Figueiredo V, et al. Preservative-free triamcinolone acetonide suspension developed for intravitreal injection. J Ocul Pharmacol Ther. 2008;24:62–69.
   PubMed Web of Science ®Google Scholar
• Kalina PH, Erie JC, Rosenbaum L. Biochemical quantification of triamcinolone in subconjunctival depots. Arch Ophthalmol. 1995;113:867–869
   PubMedGoogle Scholar
• Tamm ER. The trabecular meshwork outflow pathways: structural and functional aspects. Exp Eye Res. 2009;88:648–655.
   PubMed Web of Science ®Google Scholar
• Zhang S, Nagana Gowda GA, Asiago V, et al. Correlative and quantitative 1H NMR-based metabolomics reveals specific metabolic pathway disturbances in diabetic rats. Anal Biochem. 2008;383:76–84.
   PubMed Web of Science ®Google Scholar
• Schober MS, Chidlow G, Wood JP, et al. Bioenergetic-based neuroprotection and glaucoma. Clin Exp Ophthalmol. 2008;36:377–385.
   PubMedGoogle Scholar
• Miller AM, Nolan MJ, Choi J, et al. Lactate treatment causes NF-kappa B activation and CD44 shedding in cultured trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2007;48:1615–1621
   PubMedGoogle Scholar
• Wolfe AJ. The acetate switch. Microbiol Mol Biol Rev. 2005;69:12–50.
   PubMed Web of Science ®Google Scholar
• Saether O, Krane J, Risa Ø, et al. High-resolution MAS 1H NMR spectroscopic analysis of rabbit cornea after treatment with dexamethasone and exposure to UV-B radiation. Curr Eye Res. 2005;30:1041–1049.
   PubMed Web of Science ®Google Scholar
• He Y, Leung KW, Zhang YH, et al. Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: Protection by antioxidants. Invest Ophthalmol Vis Sci. 2008;49:1447–1458.
   PubMed Web of Science ®Google Scholar
• Laursen AB, Lorentzen SE. Glucose, pyruvate, L-lactate, and citrate concentrations in the aqueous humour of fasting rabbits in relation to age. Acta Ophthalmol (Copenh). 1975;53:553–562.
   PubMedGoogle Scholar
• Chatziioannou A, Palaiologos G, Kolisis FN. An in-silico model of the biosynthesis of neurotransmitter glutamate, elucidates the complex regulatory role of glucocorticoids in neurotransmitter glutamaterelease. Comput Biol Med. 2009;39:501–511.
   PubMedGoogle Scholar
• Rosa LF, Cury Y, Curi R. Effects of insulin, glucocorticoids and thyroid hormones on the activities of key enzymes of glycolysis, glutaminolysis, the pentose-phosphate pathway and the Krebs cycle in rat macrophages. Endocrinol. 1992;135:213–219.
   Google Scholar
• Jones CG, Hothi SK, Titheradge MA. Effect of dexamethasone on gluconeogenesis, pyruvate kinase, pyruvate carboxylase and pyruvate dehydrogenase flux in isolated hepatocytes. Biochem. 1993;289(Pt 3):821–828.
   Google Scholar
• Franko KL, Giussani DA, Forhead AJ, et al. Effects of dexamethasone on the glucogenic capacity of fetal, pregnant, and non-pregnant adult sheep. Endocrinol. 2007;192:67–73.
   Google Scholar
• Koerts-de Lang E, Hesselink MK, Drost MR, et al. Enzyme activity of rat tibialis anterior muscle differs between treatment with triamcinolone and prednisolone and nutritional deprivation. Eur J Appl Physiol Occup Physiol. 1999;79:274–279.
   PubMedGoogle Scholar
• Bustos R, Sobrino F. Stimulation of glycolysis as an activation signal in rat peritoneal macrophages. Effect of glucocorticoids on this process. Biochem. 1992;282(Pt 1):299–303.
   Google Scholar
• Moreno-Aurioles VR, Sobrino F. Glucocorticoids inhibit fructose 2,6-bisphosphate synthesis in rat thymocytes. Opposite effect of cycloheximide. Biochim Biophys Acta. 1991;1091:96–100.
   PubMedGoogle Scholar
• Acott TS, Kelley MJ. Extracellular matrix in the trabecular meshwork. Exp Eye Res. 2008;86:543–561.
   PubMed Web of Science ®Google Scholar
• Ashworth JL, Biswas S, Wraith E, et al. Mucopolysaccharidoses and the eye. Surv Ophthalmol. 2006;51:1–17.
   PubMed Web of Science ®Google Scholar