163
Views
12
CrossRef citations to date
0
Altmetric
Original Article

Plasma Homocysteine and Asymmetrical Dimethyl-l-Arginine (ADMA) and Whole Blood DNA Methylation in Early and Neovascular Age-Related Macular Degeneration: A Pilot Study

, , , , &
Pages 88-96 | Received 28 May 2014, Accepted 17 Dec 2014, Published online: 22 Jan 2015

REFERENCES

  • Friedman DS, O'Colmain BJ, Muñoz B, Tomany SC, McCarty C, de Jong PT, et al. Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol 2004;122:564–572
  • Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report number 8. Arch Ophthalmol 2001;119:1417–1436
  • Beatty S, Koh H, Phil M, Henson D, Boulton M. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol 2000;45:115–134
  • Despriet DD, Klaver CC, Witteman JC, Bergen AA, Kardys I, de Maat MP, et al. Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration. JAMA 2006;296:301–309
  • Khan JC, Thurlby DA, Shahid H, Clayton DG, Yates JR, Bradley M, et al. Smoking and age related macular degeneration: the number of pack years of cigarette smoking is a major determinant of risk for both geographic atrophy and choroidal neovascularisation. Br J Ophthalmol 2006;90:75–80
  • Yang Z, Camp NJ, Sun H, Tong Z, Gibbs D, Cameron DJ, et al. A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science 2006;314:992–993
  • Yates JR, Sepp T, Matharu BK, Khan JC, Thurlby DA, Shahid H, et al. Complement C3 variant and the risk of age-related macular degeneration. N Engl J Med 2007;357:553–561
  • Finkelstein JD. Methionine metabolism in mammals. J Nutr Biochem 1990;1:228–237
  • Axer-Siegel R, Bourla D, Ehrlich R, Dotan G, Benjamini Y, Gavendo S. Association of neovascular age-related macular degeneration and hyperhomocysteinemia. Am J Ophthalmol 2004;137:84–89
  • Vine AK, Stader J, Branham K, Musch DC, Swaroop A. Biomarkers of cardiovascular disease as risk factors for age-related macular degeneration. Ophthalmology 2005;112:2076–2080
  • Coral K, Raman R, Rathi S, Rajesh M, Sulochana KN, Angayarkanni N, et al. Plasma homocysteine and total thiol content in patients with exudative age-related macular degeneration. Eye 2006;20:203–207
  • Kamburoglu G, Gumus K, Kadayifcilar S, Eldem B. Plasma homocysteine, vitamin B12 and folate levels in age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 2006;244:565–569
  • Seddon JM, Gensler G, Klein ML, Milton RC. Evaluation of plasma homocysteine and risk of age-related macular degeneration. Am J Ophthalmol 2006;141:201–203
  • Rochtchina E, Wang JJ, Flood VM, Mitchell P. Elevated serum homocysteine, low serum vitamin B12, folate, and age-related macular degeneration: the Blue Mountains Eye Study. Am J Ophthalmol 2007;143:344–346
  • Javadzadeh A, Ghorbanihaghjo A, Bahreini E, Rashtchizadeh N, Argani H, Alizadeh S. Plasma oxidized LDL and thiol-containing molecules in patients with exudative age-related macular degeneration. Mol Vis 2010;16:2578–2584
  • Szuba A, Podgórski M. Asymmetric dimethylarginine (ADMA) a novel cardiovascular risk factor – evidence from epidemiological and prospective clinical trials. Pharmacol Rep 2006;58:16–20
  • Chen S, Li N, Deb-Chatterji M, Dong Q, Kielstein JT, Weissenborn K, et al. Asymmetric dimethyarginine as marker and mediator in ischemic stroke. Int J Mol Sci 2012;13:15983–16004
  • Hsu CP, Lin SJ, Chung MY, Lu TM. Asymmetric dimethylarginine predicts clinical outcomes in ischemic chronic heart failure. Atherosclerosis. 2012;225:504–510
  • Zinellu A, Pinna A, Sotgia S, Zinellu E, Usai MF, Carta F, et al. Increased plasma asymmetric dimethylarginine (ADMA) levels in retinal venous occlusive disease. Clin Chem Lab Med 2008;46:387–392
  • Böger RH, Bode-Böger SM, Sydow K, Heistad DD, Lentz SR. Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia. Arterioscler Thromb Vasc Biol 2000;20:1557–1564
  • Böger RH. Association of asymmetric dimethylarginine and endothelial dysfunction. Clin Chem Lab Med 2003;41:1467–1472
  • Hunter A, Spechler PA, Cwanger A, Song Y, Zhang Z, Ying GS, et al. DNA methylation is associated with altered gene expression in AMD. Invest Ophthalmol Vis Sci 2012;53:2089–2105
  • Wei L, Liu B, Tuo J, Shen D, Chen P, Li Z, et al. Hypomethylation of the IL17RC promoter associates with age-related macular degeneration. Cell Rep 2012;2:1151–1158
  • Beatty S, Chakravarthy U, Nolan JM, Muldrew KA, Woodside JV, Denny F, et al. Secondary outcomes in a clinical trial of carotenoids with coantioxidants versus placebo in early age-related macular degeneration. Ophthalmology 2013;120:600–606
  • Klein R, Davis MD, Magli YL, Segal P, Klein BE, Hubbard L. The Wisconsin age-related maculopathy grading system. Ophthalmology 1991;98:1128–1134
  • Pinna A, Carru C, Zinellu A, Dore S, Deiana L, Carta F. Plasma homocysteine and cysteine levels in retinal vein occlusion. Invest Ophthalmol Vis Sci 2006;47:4067–4071
  • Zinellu A, Sotgia S, Zinellu E, Pinna A, Carta F, Gaspa L, et al. High-throughput CZE-UV determination of arginine and dimethylated arginines in human plasma. Electrophoresis 2007;28:1942–1948
  • Sotgia S, Carru C, Franconi F, Fiori PB, Manca S, Pettinato S, et al. Rapid quantification of total genomic DNA methylation degree by short-end injection capillary zone electrophoresis. J Chromatogr A 2008;1185:145–150
  • Chambers JC, McGregor A, Jean-Marie J, Kooner JS. Acute hyperhomocysteinaemia and endothelial dysfunction. Lancet 1998;351:36–37
  • Mujumdar VS, Hayden MR, Tyagi SC. Homocyst(e)ine induces calcium second messenger in vascular smooth muscle cells. J Cell Physiol 2000;183:28–36
  • Jakubowski H. Pathophysiological consequences of homocysteine excess. J Nutr 2006;136:1741S–1749S
  • Weiss N. Mechanisms of increased vascular oxidant stress in hyperhomocys, teinemia and its impact on endothelial function. Curr Drug Metab 2005;6:27–36
  • Cooke JP, Tsao PS. Is NO an endogenous antiatherogenic molecule? Arterioscler Thromb 1994;14:653–655
  • Böger RH, Sydow K, Borlak J, Thum T, Lenzen H, Schubert B, et al. LDL cholesterol upregulates synthesis of asymmetric dimethylarginine (ADMA) in human endothelial cells. Involvement of S-adenosylmethionine dependent methyltransferases. Circ Res 2000;87:99–105
  • Vallance P, Leone A, Calver A, Collier J, Moncada S. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 1992;339:572–575
  • Achan V, Broadhead M, Malaki M, Whitley G, Leiper J, MacAllister R, et al. Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase. Arterioscler Thromb Vasc Biol 2003;23:1455–1459
  • Heuberger RA, Fisher AI, Jacques PF, Klein R, Klein BE, Palta M, et al. Relation of blood homocysteine and its nutritional determinants to age-related maculopathy in the third National Health and Nutrition Examination Survey. Am J Clin Nutr 2002;76:897–902
  • Wang JJ, Ross RJ, Tuo J, Burlutsky G, Tan AG, Chan CC, et al. The LOC387715 polymorphism, inflammatory markers, smoking, and age-related macular degeneration. A population-based case-control study. Ophthalmology 2008;115:693–699
  • van Lookeren Campagne M, LeCouter J, Yaspan BL, Ye W. Mechanisms of age-related macular degeneration and therapeutic opportunities. J Pathol 2014;232:151–164
  • Nygard O, Refsum H, Ueland PM, Vollset SE. Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study. Am J Clin Nutr 1998;67:263–270
  • Refsum H, Fiskerstrand T, Guttormsen AB, Ueland PM. Assessment of homocysteine status. J Inherit Metab Dis 1997;20:286–294
  • Nurk E, Tell GS, Nygård O, Refsum H, Ueland PM, Vollset SE. Plasma total homocysteine is influenced by prandial status in humans: the Hordaland Homocysteine Study. J Nutr 2001;131:1214–1216
  • Lip PL, Blann AD, Hop-Ross M, Gibson JM, Lip GY. Age-related macular degeneration is associated with increased vascular endothelial growth factor, hemorrheology and endothelial dysfunction. Ophthalmology 2001;108:705–710
  • The Eye Disease Case-Control Study Group. Risk factors for neovascular age-related macular degeneration. Arch Ophthalmol 1992;110:1701–1708
  • McCarty CA, Mukesh BN, Fu CL, Mitchell P, Wang JJ, Taylor HR. Risk factors for age-related maculopathy: the Visual Impairment Project. Arch Ophthalmol 2001;119:1455–1462
  • Bernstein BE, Meissner A, Lander ES. The mammalian epigenome. Cell 2007;128:669–681
  • Feinberg AP. Phenotypic plasticity and the epigenetics of human disease. Nature 2007;447:433–440
  • Laird PW, Jaenisch R. DNA methylation and cancer. Hum Mol Genet 1994;3:1487–1495
  • Liu L, Wylie RC, Andrews LG, Tollefsbol TO. Aging, cancer and nutrition: the DNA methylation connection. Mech Ageing Dev 2003;124:989–998
  • Oliver VF, Franchina M, Jaffe AE, Branham KE, Othman M, Heckenlively JR, et al. Hypomethylation of the IL17RC promoter in peripheral blood leukocytes is not a hallmark of age-related macular degeneration. Cell Rep 2013;5:1527–1535

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.