Advanced search
Publication Cover
Current Eye Research Volume 3, 1984 - Issue 5
Submit an article Journal homepage
3
Views
7
CrossRef citations to date
0
Altmetric
Original Article

The ocular hypotensive action of SK&F 86466 in the conscious rabbit

William D. Matthews Departments of Pharmacology, Smith Kline and French Laboratories, 1500 Spring Garden Street, Philadelphia, PA, 19101
,
Anthony Sulpizio Departments of Pharmacology, Smith Kline and French Laboratories, 1500 Spring Garden Street, Philadelphia, PA, 19101
,
Philip J. Fowler Departments of Pharmacology, Smith Kline and French Laboratories, 1500 Spring Garden Street, Philadelphia, PA, 19101
,
Robert Demarinis Departments of Medicinal Chemistry, Smith Kline and French Laboratories, 1500 Spring Garden Street, Philadelphia, PA, 19101
,
J. Paul Hieble Departments of Pharmacology, Smith Kline and French Laboratories, 1500 Spring Garden Street, Philadelphia, PA, 19101
&
Michael V.W. Bergamini Department of Pharmacology, Allergan Pharmaceuticals
Pages 737-742 | Received 05 Dec 1983, Accepted 06 Mar 1984, Published online: 02 Jul 2009

References

  • Potter D. H. Adrenergic pharmacology of aqueous humor dynamics. Pharmacol Rev 1981; 33: 133–153
  • Langer S. Z. Presynaptic receptors and their role In the regulation of transmitter release. Br. J. Pharmac 1977; 60: 481–497
  • Wilkberg J. E. The pharmacologic classification of adrenergic alpha and alpha receptors and their meahcnlsms of action. Acta Physiol. Scand. Suppl 1979; 468: 1–99
  • Timmermans P. B.H.W.H., van Zwleten P. A. The postsynaptic α2-adrenoceptor. J. Auton. Pharmac 1981; 1: 171–183
  • Starke K. Presynaptic receptors. Ann. Rev. Pharmacol. Toxicol 1981; 21: 7–30
  • Langer S. Z. Presynaptic regulation of catecholamine release. Biochem. Pharmacol 1974; 23: 1793–1800
  • DeHarinis R. H., Hleble J. P., Matthews W. D. 6-Chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazeplne: a potent and selective antagonist of a -adrenoceptors. J. Med. Chem 1983; 26: 1213–1214
  • Hleble J. P., Matthews W. D., DeMarlnis R. M. Selective blockade of the prejunctional alpha -adrenoceptor by SK&F 86466. Fed. Proc 1983; 32: 384
  • Cochran W. G., Cox G. M. Factorial experiments with main effects confounded: split-plot designs. “Experimental Designs”, 2nd ed. Wiley and Sons, Inc., NY 1966; 293–316
  • Green K., Kim K. Interaction of adrenergic antagonists with prostaglandin E2 and tetrahydrocannabinol in the eye. Invest. Ophthalmol 1976; 15: 102–112
  • Sears M. L., Barany E. Outflow resistance and adrenergic mechanisms. Effects of sympathectomy, N-(2-chloroethyl) dibenzylamine hydrochloride (dlbenamine), and dichloroisoproterenol on the outflow resistance of the rabbit eye. Arch. Ophthalmol 1960; 64: 839–848
  • Langham M. E., Slmjee A., Josephs S. The alpha and beta adrenergic responses to epinephrine in the rabbit eye. Exp. Eye Res 1973; 15: 75–84
  • Paterson G. D., Paterson G. Drug therapy of glaucoma. Br. J. Ophthalmol 1972; 56: 288–318
  • Cambridge D., Davey M. J., Mass Ingham R. Prazosin, a selective antagonist of postsynaptic α-adrenoceptors. Br. J. Pharmacol 1977; 59: 514P–515P
  • Smith B. R., Murray D. L., Leopold I. H. Influence of topically applied prazosin on the intraocular pressure of experimental animals. Arch. Ophthalmol 1979; 97: 1933–1936
  • Rowland J. M., Potter D. E. The effect of topical prazosin on normal and elevated intraocular pressure and blood pressure in rabbits. Eur. J. Pharmacol 1980; 64: 361–363
  • Krupin T., Felth M., Becker B. Effect of prazosin on aqueous humor dynamics In rabbits. Arch. Ophthalmol 1980; 98: 1639–1642
  • Chiou G. C.Y. Effects of α1 and α2 activation of adrenergic receptors on aqueous humor dynamics. Life Sci 1983; 32: 1699–1704
  • Murray D. L., Leopold I. H. Evidence for more than one type of alpha-adrenergic receptor in rabbits eyes. Invest. Ophthalmol. Visual Sci 1980; 19: 66
  • Innemee H. C., deJonge A., vanHeel J. C.A., Timmermans P. B.M.W.M., van Zwieten P. A. The effect of selective α1 and α2 adrenoceptor stimulation on Intraocular pressure in the conscious rabbit. Arch. Pharmacol 1981; 316: 294–298
  • Mlttag T. Ocular effects of selective alpha-adrenergic agents: a new drug paradox? Ann. Ophthalmol 1983; 282: 201–202
  • Mizoguchi H., Leach K., Petrella L., Feldmann B., Matthews W. D., Bergamini M. V.W. The preliminary investigations into the mechanism of ocular hypotensive action of SK&F 86466-A in rabbits. Invest. Ophthalmol 1983; 24: 89

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.