291
Views
38
CrossRef citations to date
0
Altmetric
Environmental Determinants

Endotoxin Exposure and Childhood Wheeze and Asthma: A Meta-Analysis of Observational Studies

, M.D., M.PH., , M.D., PH.D., , PH.D., , M.D., M.PH., , M.B.B.S., , M.PH. & , DR.P.H. show all
Pages 685-693 | Published online: 06 Jul 2011

References

  • World Health Organization. WHO factsheet 307: Asthma. Available at: http://www.who.int/mediacentre/factsheets/fs307/en/index.html. Acce‐ ssed May 9, 2011.
  • Centers for Disease Control and Prevention. National Health Interview Survey data, Table 1–1, lifetime asthma population estimates—in thousands—by age, United States: National Health Interview Survey, 2007. US Department of Health and Human Services, CDC. 2010. Available at: http://www.cdc.gov/asthma/nhis/07/table1-1.htm. Accessed May 9, 2011.
  • Centers for Disease Control and Prevention. National Health Interview Survey data, Table 2–1 lifetime asthma prevalence percent by age, United States: National Health Interview Survey, 2007. US Department of Health and Human Services, CDC. 2010. Available at: http://www.cdc.gov/asthma/nhis/07/table2-1.htm. Accessed May 9, 2011.
  • National Center for Health Statistics. Health, United States, 2006 Chart book on trends in the health of Americans. Available at: http://www.cdc.gov/nchs/data/hus/hus06.pdf. Accessed May 9, 2011.
  • Masoli M, Fabian D, Holt S, Beasley R, Global Initiative for Asthma (GINA) Program. The global burden of asthma: executive summary of the GINA dissemination committee report. Allergy 2004; 59(5):469–478.
  • Baena-Cagnani CE. The global burden of asthma and allergic diseases: the challenge for the new century. Curr Allergy Asthma Rep 2001; 1(4):297–298.
  • Metsala J, Kilkkinen A, Kaila M, Tapanainen H, Klaukka T, Gissler M, Virtanen SM. Perinatal factors and the risk of asthma in childhood—a population-based register study in Finland. Am J Epidemiol 2008; 168(2):170–178.
  • Radon K. The two sides of the “endotoxin coin”. Occup Environ Med 2006; 63(1):73–78.
  • Murakami D, Yamada H, Yajima T, Masuda A, Komune S, Yoshikai Y. Lipopolysaccharide inhalation exacerbates allergic airway inflammation by activating mast cells and promoting Th2 responses. Clin Exp Allergy 2007; 37(3):339–347.
  • Smit LA, Heederik D, Doekes G, Lammers JW, Wouters IM. Occupational endotoxin exposure reduces the risk of atopic sensitization but increases the risk of bronchial hyperresponsiveness. Int Arch Allergy Immunol 2010; 152(2):151–158.
  • Braun-Fahrlander C, Riedler J, Herz U, Eder W, Waser M, Grize L, Maisch S, Carr D, Gerlach F, Bufe A, Lauener RP, Schierl R, Renz H, Nowak D, Von Mutius E, Allergy and Endotoxin Study Team. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002; 347(12):869–877.
  • Douwes J, van Strien R, Doekes G, Smit J, Kerkhof M, Gerritsen J, Postma D, de Jongste J, Travier N, Brunekreef B. Does early indoor microbial exposure reduce the risk of asthma? The prevention and incidence of asthma and mite allergy birth cohort study. J Allergy Clin Immunol 2006; 117(5):1067–1073.
  • Sordillo JE, Hoffman EB, Celedon JC, Litonjua AA, Milton DK, Gold DR. Multiple microbial exposures in the home may protect against asthma or allergy in childhood. Clin Exp Allergy 2010; 40(6):902–910.
  • Bertelsen RJ, Carlsen KC, Carlsen KH, Granum B, Doekes G, Haland G, Mowinckel P, Lovik M. Childhood asthma and early life exposure to indoor allergens, endotoxin and beta(1,3)-glucans. Clin Exp Allergy 2010; 40(2):307–316.
  • Yilmaz M, Altintas DU, Bingol-Karakoc G, Inal A, Kilic M, Sutolukta Z, Guneser-Kendirli S. Exposure to house dust endotoxin and allergic sensitization in allergic and non-allergic children living in Adana, Turkey. Turk J Pediatr 2009; 51(3):225–231.
  • Bolte G, Bischof W, Borte M, Lehmann I, Wichmann HE, Heinrich J, LISA Study Group. Early endotoxin exposure and atopy development in infants: results of a birth cohort study. Clin Exp Allergy 2003; 33(6):770–776.
  • Celedon JC, Milton DK, Ramsey CD, Litonjua AA, Ryan L, Platts-Mills TA, Gold DR. Exposure to dust mite allergen and endotoxin in early life and asthma and atopy in childhood. J Allergy Clin Immunol 2007; 120(1):144–149.
  • Gehring U, Bischof W, Fahlbusch B, Wichmann HE, Heinrich J. House dust endotoxin and allergic sensitization in children. Am J Respir Crit Care Med 2002; 166(7):939–944.
  • Gehring U, Strikwold M, Schram-Bijkerk D, Weinmayr G, Genuneit J, Nagel G, Wickens K, Siebers R, Crane J, Doekes G, Di Domenicantonio R, Nilsson L, Priftanji A, Sandin A, El-Sharif N, Strachan D, van Hage M, von Mutius E, Brunekreef B, ISAAC Phase Two Study Group. Asthma and allergic symptoms in relation to house dust endotoxin: phase two of the international study on asthma and allergies in childhood (ISAAC II). Clin Exp Allergy 2008; 38(12):1911–1920.
  • Rennie DC, Lawson JA, Kirychuk SP, Paterson C, Willson PJ, Senthilselvan A, Cockcroft DW. Assessment of endotoxin levels in the home and current asthma and wheeze in school-age children. Indoor Air 2008; 18(6):447–453.
  • Thorne PS, Kulhankova K, Yin M, Cohn R, Arbes Jr, SJ, Zeldin DC. Endotoxin exposure is a risk factor for asthma: the national survey of endotoxin in United States housing. Am J Respir Crit Care Med 2005; 172(11):1371–1377.
  • Tavernier G, Fletcher G, Gee I, Watson A, Blacklock G, Francis H, Fletcher A, Frank T, Frank P, Pickering CA, Niven R. IPEADAM study: indoor endotoxin exposure, family status, and some housing characteristics in English children. J Allergy Clin Immunol 2006; 117(3):656–662.
  • Carlsten C, Ferguson A, Dimich-Ward H, Chan H, Dybuncio A, Rousseau R, Becker A, Chan-Yeung M. Association between endotoxin and mite allergen exposure with asthma and specific sensitization at age 7 in high-risk children. Pediatr Allergy Immunol 2011; 22(3):320–326.
  • Campo P, Kalra HK, Levin L, Reponen T, Olds R, Lummus ZL, Cho SH, Khurana Hershey GK, Lockey J, Villareal M, Stanforth S, Lemasters G, Bernstein DI. Influence of dog ownership and high endotoxin on wheezing and atopy during infancy. J Allergy Clin Immunol 2006; 118(6):1271–1278.
  • El-Sharif N, Douwes J, Hoet P, Nemery B. Childhood asthma and indoor aeroallergens and endotoxin in Palestine: a case–control study. J Asthma 2006; 43(3):241–247.
  • Gehring U, Bolte G, Borte M, Bischof W, Fahlbusch B, Wichmann HE, Heinrich J, LISA study group. Lifestyle-related factors on the immune system and the development of allergies in childhood. Exposure to endotoxin decreases the risk of atopic eczema in infancy: a cohort study. J Allergy Clin Immunol 2001; 108(5):847–854.
  • Gillespie J, Wickens K, Siebers R, Howden-Chapman P, Town I, Epton M, Fitzharris P, Fishwick D, Crane J, New Zealand Asthma and Allergy Birth Cohort Study Group. Endotoxin exposure, wheezing, and rash in infancy in a New Zealand birth cohort. J Allergy Clin Immunol 2006; 118(6):1265–1270.
  • Lawson JA, Dosman JA, Rennie DC, Beach J, Newman SC, Senthilselvan A. Relationship between indoor environment and asthma and wheeze severity among rural children and adolescents. J Agromed 2009; 14(2):277–285.
  • Perzanowski MS, Miller RL, Thorne PS, Barr RG, Divjan A, Sheares BJ, Garfinkel RS, Perera FP, Goldstein IF, Chew GL. Endotoxin in inner-city homes: associations with wheeze and eczema in early childhood. J Allergy Clin Immunol 2006 May; 117(5):1082–1089.
  • Phipatanakul W, Celedon JC, Sredl DL, Weiss ST, Gold DR. Mouse exposure and wheeze in the first year of life. Ann Allergy Asthma Immunol 2005; 94(5):593–599.
  • Ferris BG. Epidemiology standardization project (American Thoracic Society). Am Rev Respir Dis 1978; 118(6 Pt 2):1–120.
  • Ryan PH, Bernstein DI, Lockey J, Reponen T, Levin L, Grinshpun S, Villareal M, Hershey GK, Burkle J, LeMasters G. Exposure to traffic-related particles and endotoxin during infancy is associated with wheezing at age 3 years. Am J Respir Crit Care Med 2009; 180(11):1068–1075.
  • Tischer C, Gehring U, Chen CM, Kerkhof M, Koppelman G, Sausenthaler S, Herbarth O, Schaaf B, Lehmann I, Kramer U, Berdel D, Von Berg A, Bauer CP, Koletzko S, Wichmann HE, Brunekreef B, Heinrich J. Respiratory health in children and indoor exposure to (1,3)-{beta}-D-glucan, EPS mould components, and endotoxin. Eur Respir J 2010.
  • Wickens K, Lane JM, Fitzharris P, Siebers R, Riley G, Douwes J, Smith T, Crane J. Farm residence and exposures and the risk of allergic diseases in New Zealand children. Allergy 2002; 57(12):1171–1179.
  • Von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP, STROBE Initiative. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol 2008; 61(4):344–349.
  • Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003; 327(7414):557–560.
  • Gumedze FN, Jackson D. A random effects variance shift model for detecting and accommodating outliers in meta-analysis. BMC Med Res Methodol 2011; 11:19.
  • Rullo VE, Arruda LK, Cardoso MR, Valente V, Zampolo AS, Nobrega F, Naspitz CK, Sole D. Respiratory infection, exposure to mouse allergen and breastfeeding: role in recurrent wheezing in early life. Int Arch Allergy Immunol 2009; 150(2):172–178.
  • Asher MI, Keil U, Anderson HR, Beasley R, Crane J, Martinez F, Mitchell EA, Pearce N, Sibbald B, Stewart AW. International study of asthma and allergies in childhood (ISAAC): rationale and methods. Eur Respir J 1995; 8(3):483–491.
  • Jagielo PJ, Thorne PS, Watt JL, Frees KL, Quinn TJ, Schwartz DA. Grain dust and endotoxin inhalation challenges produce similar inflammatory responses in normal subjects. Chest 1996; 110(1):263–270.
  • Keman S, Jetten M, Douwes J, Borm PJ. Longitudinal changes in inflammatory markers in nasal lavage of cotton workers. Relation to endotoxin exposure and lung function changes. Int Arch Occup Environ Health 1998; 71(2):131–137.
  • Park JH, Gold DR, Spiegelman DL, Burge HA, Milton DK. House dust endotoxin and wheeze in the first year of life. Am J Respir Crit Care Med 2001; 163(2):322–328.
  • Hu D, Zhang RB, Wu J. Study on the relations between concentration of endotoxin in dwelling and atopic asthma in school-age children. Zhonghua Liu Xing Bing Xue Za Zhi 2007; 28(4):354–357.
  • Ober C, Vercelli D. Gene-environment interactions in human disease: nuisance or opportunity? Trends Genet 2011; 27(3):107–115.
  • Gereda JE, Leung DY, Thatayatikom A, Streib JE, Price MR, Klinnert MD, Liu AH. Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma. Lancet 2000; 355(9216):1680–1683.
  • Custovic A. Hygiene hypothesis for asthma: pros and cons. Program and abstracts of the American academy of allergy. Asthma and Immunology 60th Anniversary Meeting; March 7–12, 2003, Denver, CO, USA.
  • Von Mutius E. Hygiene hypothesis for asthma: pros and cons. Program and abstracts of the American Academy of Allergy, Asthma and Immunology 60th Anniversary Meeting; March 7–12, 2003; Denver, CO, USA.
  • Park JH, Cox-Ganser J, Rao C, Kreiss K. Fungal and endotoxin measurements in dust associated with respiratory symptoms in a water-damaged office building. Indoor Air 2006; 16(3):192–203.
  • Doreswamy V, Peden DB. Modulation of asthma by endotoxin. Clin Exp Allergy 2011; 41(1):9–19.
  • Smit LA, Heederik D, Doekes G, Koppelman GH, Bottema RW, Postma DS, Wouters IM. Endotoxin exposure, CD14 and wheeze among farmers: a gene-environment interaction. Occup Environ Med 2011.
  • Kobayashi M, Saitoh S, Tanimura N, Takahashi K, Kawasaki K, Nishijima M, Fujimoto Y, Fukase K, Akashi-Takamura S, Miyake K. Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering. J Immunol 2006; 176(10):6211–6218.
  • Simpson A, John SL, Jury F, Niven R, Woodcock A, Ollier WE, Custovic A. Endotoxin exposure, CD14, and allergic disease: an interaction between genes and the environment. Am J Respir Crit Care Med 2006; 174(4):386–392.
  • Zambelli-Weiner A, Ehrlich E, Stockton ML, Grant AV, Zhang S, Levett PN, Beaty TH, Barnes KC. Evaluation of the CD14/-260 polymorphism and house dust endotoxin exposure in the Barbados asthma genetics study. J Allergy Clin Immunol 2005; 115(6):1203–1209.
  • Sackesen C, Karaaslan C, Keskin O, Tokol N, Tahan F, Civelek E, Soyer OU, Adalioglu G, Tuncer A, Birben E, Oner C, Kalayci O. The effect of polymorphisms at the CD14 promoter and the TLR4 gene on asthma phenotypes in Turkish children with asthma. Allergy 2005; 60(12):1485–1492.
  • Abraham JH, Gold DR, Dockery DW, Ryan L, Park JH, Milton DK. Within-home versus between-home variability of house dust endotoxin in a birth cohort. Environ Health Perspect 2005; 113(11):1516–1521.
  • Racila DM, Kline JN. Perspectives in asthma: molecular use of microbial products in asthma prevention and treatment. J Allergy Clin Immunol 2005; 116(6):1202–1205.
  • Eder W, von Mutius E. Hygiene hypothesis and endotoxin: What is the evidence? Curr Opin Allergy Clin Immunol 2004; 4(2):113–117.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.