Characterization of Asthma Exacerbations in Primary Care Using Cluster Analysis

References

• Serra-Batlles J, Plaza V, Morejón E, Comella A, Brugués J. Costs of asthma according to the degree of severity. Eur Respir J 1998; 12:1322–1326.
   PubMed Web of Science ®Google Scholar
• Miller MK, Lee JH, Blanc PD, Pasta DJ, Gujrathi S, Barron H, Wenzel SE, Weiss ST for the TENOR Study Group. TENOR risk score predicts healthcare in adults with severe or difficult-to-treat asthma. Eur Respir J 2006; 28:1145–1155.
   PubMed Web of Science ®Google Scholar
• Reddel HK, Taylor DR, Bateman ED, Boulet LP, Boushey HA, Busse WW, Casale TB, Chanez P, Enright PL, Gibson PG, de Jongste JC, Kerstjens HAM, Lazarus SC, Levy ML, Q’Byrne PM, Partridge MR, Pavord ID, Sears MR, Sterk PJ, Stoloff SW, Sullivan SD, Szefler SJ, Thomas MD, Wenzel SE on behalf of the American Thoracic Society/European Respiratory Society Task Force on Asthma Control and Exacerbations. An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med 2009; 180:59–99.
   PubMed Web of Science ®Google Scholar
• Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention. Bethesda: GINA, 2010. Available at: www.ginasthma.org. Accessed September 15, 2011.
   Google Scholar
• National Asthma Education and Prevention Program. Guidelines for the diagnosis and management of asthma. Expert Panel Report 3. NIH Publication No. 08-4051. Bethesda: US Department of Health and Human Services, Public Health Service, National Institutes of Health, National Heart, Lung, and Blood Institute, 2007.
   Google Scholar
• Kiley J, Smith R, Noel P. Asthma phenotypes. Curr Opin Pulm Med 2007; 13:19–23.
   PubMed Web of Science ®Google Scholar
• Humbert M, Menz G, Ying S, Corrigan CJ, Robinson DS, Durham SR, Kay AB. The immunopathology of extrinsic (atopic) and intrinsic (non-atopic) asthma: more similarities than differences. Immunol Today 1999; 20:528–533.
   PubMedGoogle Scholar
• Frades I, Matthiesen R. Overview of techniques in cluster analysis. In: Matthiesen R, ed. Bioinformatic Methods in Clinical Research. New York: Humana Press, 2009:81–105.
   Google Scholar
• Haldar P, Pavord ID, Shaw DE, Berry MA, Thomas M, Brightling CE, Wardlaw AJ, Green RH. Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med 2008; 178:218–224.
   PubMed Web of Science ®Google Scholar
• Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, D’Agostino Jr. R, Castro M, Curran-Everett D, Fitzpatrick AM, Gaston B, Jarjour NN, Sorkness R, Calhoun WJ, Chung KF, Comhair SAA, Dweik RA, Israel E, Peters SP, Busse WW, Erzurum SC, Bleecker ER for the National Heart, Lung, and Blood Institute’s Severe Asthma Research Program. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 2010; 181: 315–323.
   PubMed Web of Science ®Google Scholar
• Fitzpatrick AM, Teague WG, Meyers DA, Peters AP, Li X, Li H, Wenzel SE, Aujla S, Castro M, Bacharier LB, Gaston BM, Bleecker ER, Moore WC; National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. J Allerg Clin Immunol 2011; 127:382–389.
   PubMed Web of Science ®Google Scholar
• Weatherall M, Travers J, Shirtcliffe PM, Marsh SE, Williams MV, Nowitz MR, Aldington S, Beasley R. Distinct clinical phenotypes of airways disease defined by cluster analysis. Eur Respir J 2009; 34:812–818.
   PubMed Web of Science ®Google Scholar
• Mintz M, Gilsenan AW, Bui CL, Ziemiecki R, Stanford RH, Lincourt W, Ortega H. Assessment of asthma control in primary care. Curr Med Res Opin 2009; 25:2523–2531.
   PubMed Web of Science ®Google Scholar
• Liu AH, Gilsenan AW, Stanford RH, Lincourt W, Ziemiecki R, Ortega H. Status of asthma control in pediatric primary care: results from the pediatric Asthma Control Characteristics and Prevalence Survey Study (ACCESS). J Pediatr 2010; 157:276–281, e3.
   PubMed Web of Science ®Google Scholar
• Maindonald J, Braun J. Data Analysis and Graphics Using R: An Example-Based Approach. 2nd ed. Cambridge: Cambridge University Press, 2007.
   Google Scholar
• Breiman L. Random forests. Mach Learn 2001; 45:5–32.
   Web of Science ®Google Scholar
• Pinnock H, Johnson A, Young P, Martin N. Are doctors still failing to assess and treat asthma attacks? An audit of the management of acute attacks in a health district. Respir Med 1999; 93:397–401.
   PubMed Web of Science ®Google Scholar
• Janson S, Weiss K. A national survey of asthma knowledge and practices among specialists and primary care physicians. J Asthma 2004; 41:343–348.
   PubMed Web of Science ®Google Scholar
• Covar RA, Szefler SJ, Zeiger RS, Sorkness CA, Moss M, Mauger DT, Boehmer SJ, Strunk RC, Martinez FD, Taussig LM. Factors associated with asthma exacerbations during a long-term clinical trial of controller medications in children. J Allergy Clin Immunol 2008; 122:741–747, e4.
   PubMed Web of Science ®Google Scholar
• Akinbami L. Asthma prevalence, health care use and mortality: United States, 2003–05. Atlanta, GA: Centers for Disease Control and Prevention, 2006.
   Google Scholar
• Schatz M, Mosen DM, Kosinski M, Vollmer WM, Magid DJ, O’Connor E, Zeiger RS. Predictors of asthma control in a random sample of asthmatic patients. J Asthma 2007; 44:341–345.
   PubMed Web of Science ®Google Scholar
• Schatz M, Rachelefsky G, Krishnan JA. Follow-up after acute asthma episodes: what improves future outcomes? Proc Am Thorac Soc 2009; 6:386–393.
   PubMedGoogle Scholar
• Peters SP, Jones CA, Haselkorn T, Mink DR, Valacer DJ, Weiss ST. Real-world Evaluation of Asthma Control and Treatment (REACT): findings from a national web-based survey. J Allergy Clin Immunol 2007; 119:1454–1461.
   PubMed Web of Science ®Google Scholar