Influence of Mediterranean Diet on Asthma Symptoms, Lung Function, and Systemic Inflammation: A Randomized Controlled Trial

References

• Eder W, Ege MJ, von Mutius E. The asthma epidemic. N Engl J Med 2006; 355:2226–2235.
   PubMed Web of Science ®Google Scholar
• Lai CK, Beasley R, Crane J, Foliaki S, Shah J, Weiland S. Global variation in the prevalence and severity of asthma symptoms: phase three of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 2009; 64:476–483.
   PubMed Web of Science ®Google Scholar
• von Mutius E. Pro: the increase in asthma can be ascribed to cleanliness. Am J Respir Crit Care Med 2001; 164:1106–1107, discussion 1108–1109.
   PubMed Web of Science ®Google Scholar
• Seaton A, Godden DJ, Brown K. Increase in asthma: a more toxic environment or a more susceptible population? Thorax 1994; 49:171–174.
   PubMed Web of Science ®Google Scholar
• Shaheen SO, Sterne JA, Thompson RL, Songhurst CE, Margetts BM, Burney PG. Dietary antioxidants and asthma in adults: population-based case-control study. Am J Respir Crit Care Med 2001; 164:1823–1828.
   PubMed Web of Science ®Google Scholar
• Butland BK, Strachan DP, Anderson HR. Fresh fruit intake and asthma symptoms in young British adults: confounding or effect modification by smoking? Eur Respir J 1999; 13:744–750.
   PubMed Web of Science ®Google Scholar
• Nagel G, Weinmayr G, Kleiner A, Garcia-Marcos L, Strachan DP. Effect of diet on asthma and allergic sensitisation in the International Study on Allergies and Asthma in Childhood (ISAAC) phase two. Thorax 2010; 65:516–522.
   PubMed Web of Science ®Google Scholar
• Romieu I, Varraso R, Avenel V, Leynaert B, Kauffmann F, Clavel-Chapelon F. Fruit and vegetable intakes and asthma in the E3N study. Thorax 2006; 61:209–215.
   PubMed Web of Science ®Google Scholar
• Patel BD, Welch AA, Bingham SA, Luben RN, Day NE, Khaw KT, Lomas DA, Wareham NJ. Dietary antioxidants and asthma in adults. Thorax 2006; 61:388–393.
   PubMed Web of Science ®Google Scholar
• Woods RK, Walters EH, Raven JM, Wolfe R, Ireland PD, Thien FC, Abramson MJ. Food and nutrient intakes and asthma risk in young adults. Am J Clin Nutr 2003; 78:414–421.
   PubMed Web of Science ®Google Scholar
• Hijazi N, Abalkhail B, Seaton A. Diet and childhood asthma in a society in transition: a study in urban and rural Saudi Arabia. Thorax 2000; 55:775–779.
   PubMed Web of Science ®Google Scholar
• Forastiere F, Pistelli R, Sestini P, Fortes C, Renzoni E, Rusconi F, Dell’Orco V, Ciccone G, Bisanti L. Consumption of fresh fruit rich in vitamin C and wheezing symptoms in children. SIDRIA collaborative group, Italy (Italian studies on respiratory disorders in children and the environment). Thorax 2000; 55:283–288.
   PubMed Web of Science ®Google Scholar
• Tabak C, Wijga AH, de Meer G, Janssen NA, Brunekreef B, Smit HA. Diet and asthma in Dutch school children (ISAAC-2). Thorax 2006; 61:1048–1053.
   PubMed Web of Science ®Google Scholar
• Hodge L, Salome CM, Peat JK, Haby MM, Xuan W, Woolcock AJ. Consumption of oily fish and childhood asthma risk. Med J Aust 1996; 164:137–140.
   PubMed Web of Science ®Google Scholar
• Wijga AH, Smit HA, Kerkhof M, de Jongste JC, Gerritsen J, Neijens HJ, Boshuizen HC, Brunekreef B. Association of consumption of products containing milk fat with reduced asthma risk in pre-school children: the PIAMA birth cohort study. Thorax 2003; 58:567–572.
   PubMedGoogle Scholar
• Uddenfeldt M, Janson C, Lampa E, Leander M, Norback D, Larsson L, Rask-Andersen A. High BMI is related to higher incidence of asthma, while a fish and fruit diet is related to a lower—results from a long-term follow-up study of three age groups in Sweden. Respir Med 2010; 104:972–980.
   PubMed Web of Science ®Google Scholar
• Romieu I, Barraza-Villarreal A, Escamilla-Nunez C, Texcalac-Sangrador JL, Hernandez-Cadena L, Diaz-Sanchez D, De Batlle J, Del Rio-Navarro BE. Dietary intake, lung function and airway inflammation in Mexico City school children exposed to air pollutants. Respir Res 2009; 10:122.
   PubMed Web of Science ®Google Scholar
• Chatzi L, Torrent M, Romieu I, Garcia-Esteban R, Ferrer C, Vioque J, Kogevinas M, Sunyer J. Diet, wheeze, and atopy in school children in Menorca, Spain. Pediatr Allergy Immunol 2007; 18:480–485.
   PubMed Web of Science ®Google Scholar
• Chatzi L, Apostolaki G, Bibakis I, Skypala I, Bibaki-Liakou V, Tzanakis N, Kogevinas M, Cullinan P. Protective effect of fruits, vegetables and the Mediterranean diet on asthma and allergies among children in Crete. Thorax 2007; 62:677–683.
   PubMed Web of Science ®Google Scholar
• Garcia-Marcos L, Canflanca IM, Garrido JB, Varela AL, Garcia-Hernandez G, Guillen Grima F, Gonzalez-Diaz C, Carvajal-Uruena I, Arnedo-Pena A, Busquets-Monge RM, Morales Suarez-Varela M, Blanco-Quiros A. Relationship of asthma and rhinoconjunctivitis with obesity, exercise and Mediterranean diet in Spanish schoolchildren. Thorax 2007; 62:503–508.
   PubMed Web of Science ®Google Scholar
• Waser M, Michels KB, Bieli C, Floistrup H, Pershagen G, von Mutius E, Ege M, Riedler J, Schram-Bijkerk D, Brunekreef B, van Hage M, Lauener R, Braun-Fahrlander C. Inverse association of farm milk consumption with asthma and allergy in rural and suburban populations across Europe. Clin Exp Allergy 2007; 37:661–670.
   PubMed Web of Science ®Google Scholar
• Dunder T, Kuikka L, Turtinen J, Rasanen L, Uhari M. Diet, serum fatty acids, and atopic diseases in childhood. Allergy 2001; 56:425–428.
   PubMed Web of Science ®Google Scholar
• Bolte G, Winkler G, Holscher B, Thefeld W, Weiland SK, Heinrich J. Margarine consumption, asthma, and allergy in young adults: results of the German National Health Survey 1998. Ann Epidemiol 2005; 15:207–213.
   PubMedGoogle Scholar
• Haby MM, Peat JK, Marks GB, Woolcock AJ, Leeder SR. Asthma in preschool children: prevalence and risk factors. Thorax 2001; 56:589–595.
   PubMed Web of Science ®Google Scholar
• Murray CS, Simpson B, Kerry G, Woodcock A, Custovic A. Dietary intake in sensitized children with recurrent wheeze and healthy controls: a nested case–control study. Allergy 2006; 61:438–442.
   PubMed Web of Science ®Google Scholar
• Takaoka M, Norback D. Diet among Japanese female university students and asthmatic symptoms, infections, pollen and furry pet allergy. Respir Med 2008; 102:1045–1054.
   PubMed Web of Science ®Google Scholar
• Biltagi MA, Baset AA, Bassiouny M, Kasrawi MA, Attia M. Omega-3 fatty acids, vitamin C and Zn supplementation in asthmatic children: a randomized self-controlled study. Acta Paediatr 2009; 98:737–742.
   PubMed Web of Science ®Google Scholar
• Pearson PJ, Lewis SA, Britton J, Fogarty A. Vitamin E supplements in asthma: a parallel group randomised placebo controlled trial. Thorax 2004; 59:652–656.
   PubMed Web of Science ®Google Scholar
• Shaheen SO, Newson RB, Rayman MP, Wong AP, Tumilty MK, Phillips JM, Potts JF, Kelly FJ, White PT, Burney PG. Randomised, double blind, placebo-controlled trial of selenium supplementation in adult asthma. Thorax 2007; 62:483–490.
   PubMed Web of Science ®Google Scholar
• Wood LG, Garg ML, Powell H, Gibson PG. Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: proof of concept. Free Radic Res 2008; 42:94–102.
   PubMed Web of Science ®Google Scholar
• Fogarty A, Lewis SA, Scrivener SL, Antoniak M, Pacey S, Pringle M, Britton J. Oral magnesium and vitamin C supplements in asthma: a parallel group randomized placebo-controlled trial. Clin Exp Allergy 2003; 33:1355–1359.
   PubMed Web of Science ®Google Scholar
• Moreira A, Moreira P, Delgado L, Fonseca J, Teixeira V, Padrao P, Castel-Branco G. Pilot study of the effects of n-3 polyunsaturated fatty acids on exhaled nitric oxide in patients with stable asthma. J Investig Allergol Clin Immunol 2007; 17:309–313.
   PubMed Web of Science ®Google Scholar
• Thien FCK, De Luca S, Woods RK, Abramson MJ. Dietary marine fatty acids (fish oil) for asthma in adults and children. Cochrane Database of Systematic Reviews 2000, Issue 4. Art. No.: CD001283. DOI: 10.1002/14651858.CD001283
   Google Scholar
• Hodge L, Salome CM, Hughes JM, Liu-Brennan D, Rimmer J, Allman M, Pang D, Armour C, Woolcock AJ. Effect of dietary intake of omega-3 and omega-6 fatty acids on severity of asthma in children. Eur Respir J 1998; 11:361–365.
   PubMed Web of Science ®Google Scholar
• Trichopoulou A, Costacou T, Bamia C, Trichopoulos D. Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med 2003; 348:2599–2608.
   PubMed Web of Science ®Google Scholar
• de Lorgeril M, Renaud S, Mamelle N, Salen P, Martin JL, Monjaud I, Guidollet J, Touboul P, Delaye J. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet 1994; 343:1454–1459.
   PubMed Web of Science ®Google Scholar
• de Lorgeril M, Salen P, Martin JL, Monjaud I, Boucher P, Mamelle N. Mediterranean dietary pattern in a randomized trial: prolonged survival and possible reduced cancer rate. Arch Intern Med 1998; 158:1181–1187.
   PubMed Web of Science ®Google Scholar
• Sofi F, Cesari F, Abbate R, Gensini GF, Casini A. Adherence to Mediterranean diet and health status: meta-analysis. BMJ 2008; 337:a1344.
   PubMed Web of Science ®Google Scholar
• Esposito K, Maiorino MI, Ciotola M, Di Palo C, Scognamiglio P, Gicchino M, Petrizzo M, Saccomanno F, Beneduce F, Ceriello A, Giugliano D. Effects of a Mediterranean-style diet on the need for antihyperglycemic drug therapy in patients with newly diagnosed type 2 diabetes: a randomized trial. Ann Intern Med 2009; 151:306–314.
   PubMed Web of Science ®Google Scholar
• Panagiotakos DB, Dimakopoulou K, Katsouyanni K, Bellander T, Grau M, Koenig W, Lanki T, Pistelli R, Schneider A, Peters A. Mediterranean diet and inflammatory response in myocardial infarction survivors. Int J Epidemiol 2009; 38:856–866.
   PubMed Web of Science ®Google Scholar
• Esposito K, Marfella R, Ciotola M, Di Palo C, Giugliano F, Giugliano G, D’Armiento M, D’Andrea F, Giugliano D. Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. J Am Med Assoc 2004; 292:1440–1446.
   PubMed Web of Science ®Google Scholar
• Salas-Salvado J, Garcia-Arellano A, Estruch R, Marquez-Sandoval F, Corella D, Fiol M, Gomez-Gracia E, Vinoles E, Aros F, Herrera C, Lahoz C, Lapetra J, Perona JS, Munoz-Aguado D, Martinez-Gonzalez MA, Ros E. Components of the Mediterranean-type food pattern and serum inflammatory markers among patients at high risk for cardiovascular disease. Eur J Clin Nutr 2008; 62:651–659.
   PubMed Web of Science ®Google Scholar
• Pitsavos C, Panagiotakos DB, Tzima N, Lentzas Y, Chrysohoou C, Das UN, Stefanadis C. Diet, exercise, and C-reactive protein levels in people with abdominal obesity: the ATTICA epidemiological study. Angiology 2007; 58:225–233.
   PubMed Web of Science ®Google Scholar
• Estruch R, Martinez-Gonzalez MA, Corella D, Salas-Salvado J, Ruiz-Gutierrez V, Covas MI, Fiol M, Gomez-Gracia E, Lopez-Sabater MC, Vinyoles E, Aros F, Conde M, Lahoz C, Lapetra J, Saez G, Ros E. Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial. Ann Intern Med 2006; 145:1–11.
   PubMed Web of Science ®Google Scholar
• Barros R, Moreira A, Fonseca J, de Oliveira JF, Delgado L, Castel-Branco MG, Haahtela T, Lopes C, Moreira P. Adherence to the Mediterranean diet and fresh fruit intake are associated with improved asthma control. Allergy 2008; 63:917–923.
   PubMed Web of Science ®Google Scholar
• von Hertzen L, Haahtela T. Disconnection of man and the soil: reason for the asthma and atopy epidemic? J Allergy Clin Immunol 2006; 117:334–344.
   PubMedGoogle Scholar
• Metcalf PA, Swinburn B, Scragg R, Dryson E. Reproducibility and validity of a food frequency questionnaire in European and Polynesian New Zealanders. Ethn Health 1997; 2:297–308.
   PubMedGoogle Scholar
• Panagiotakos DB, Pitsavos C, Arvaniti F, Stefanadis C. Adherence to the Mediterranean food pattern predicts the prevalence of hypertension, hypercholesterolemia, diabetes and obesity, among healthy adults; the accuracy of the MedDietScore. Prev Med 2007; 44:335–340.
   PubMed Web of Science ®Google Scholar
• Juniper EF, Guyatt GH, Willan A, Griffith LE. Determining a minimal important change in a disease-specific Quality of Life Questionnaire. J Clin Epidemiol 1994; 47:81–87.
   PubMed Web of Science ®Google Scholar
• Juniper EF, O’Byrne PM, Guyatt GH, Ferrie PJ, King DR. Development and validation of a questionnaire to measure asthma control. Eur Respir J 1999; 14:902–907.
   PubMed Web of Science ®Google Scholar
• SAS Institute Inc. SAS/STAT User’s Guide. Version 9.2. Cary, NC: SAS Institute Inc., 2004.
   Google Scholar
• Arvaniti F, Priftis KN, Papadimitriou A, Yiallouros P, Kapsokefalou M, Anthracopoulos MB, Panagiotakos DB. Salty-snack eating, television or video-game viewing, and asthma symptoms among 10- to 12-year-old children: the PANACEA study. J Am Diet Assoc 2011; 111:251–257.
   PubMed Web of Science ®Google Scholar
• Chatzi L, Kogevinas M. Prenatal and childhood Mediterranean diet and the development of asthma and allergies in children. Public Health Nutr 2009; 12:1629–1634.
   PubMedGoogle Scholar
• de Batlle J, Garcia-Aymerich J, Barraza-Villarreal A, Anto JM, Romieu I. Mediterranean diet is associated with reduced asthma and rhinitis in Mexican children. Allergy 2008; 63:1310–1316.
   PubMed Web of Science ®Google Scholar
• Castro-Rodriguez JA, Garcia-Marcos L, Alfonseda Rojas JD, Valverde-Molina J, Sanchez-Solis M. Mediterranean diet as a protective factor for wheezing in preschool children. J Pediatr 2008; 152:823–828, 828.e1–2.
   PubMed Web of Science ®Google Scholar
• Nurmatov U, Devereux G, Sheikh A. Nutrients and foods for the primary prevention of asthma and allergy: systematic review and meta-analysis. J Allergy Clin Immunol 2011; 127(724–733):e730.
   Google Scholar
• Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, Gibson P, Ohta K, O’Byrne P, Pedersen SE, Pizzichini E, Sullivan SD, Wenzel SE, Zar HJ. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008; 31:143–178.
   PubMed Web of Science ®Google Scholar
• Santanello NC, Zhang J, Seidenberg B, Reiss TF, Barber BL. What are minimal important changes for asthma measures in a clinical trial? Eur Respir J 1999; 14:23–27.
   PubMed Web of Science ®Google Scholar
• Chrysohoou C, Panagiotakos DB, Pitsavos C, Das UN, Stefanadis C. Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: the ATTICA study. J Am Coll Cardiol 2004; 44:152–158.
   PubMed Web of Science ®Google Scholar
• Singh RB, Rastogi SS, Verma R, Bolaki L, Singh R. An Indian experiment with nutritional modulation in acute myocardial infarction. Am J Cardiol 1992; 69:879–885.
   PubMed Web of Science ®Google Scholar
• Lindemann J, David Pampe E, Peterkin JJ, Orozco-Cronin P, Belofsky G, Stull D. Clinical study of the effects on asthma-related QOL and asthma management of a medical food in adult asthma patients. Curr Med Res Opin 2009; 25:2865–2875.
   PubMed Web of Science ®Google Scholar
• Tecklenburg SL, Mickleborough TD, Fly AD, Bai Y, Stager JM. Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma. Respir Med 2007; 101:1770–1778.
   PubMed Web of Science ®Google Scholar
• Mickleborough TD, Lindley MR, Ionescu AA, Fly AD. Protective effect of fish oil supplementation on exercise-induced bronchoconstriction in asthma. Chest 2006; 129:39–49.
   PubMed Web of Science ®Google Scholar