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Research Article

Identifying hypoxia in human tumors: A correlation study between 18F-FMISO PET and the Eppendorf oxygen-sensitive electrode

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Pages 934-940 | Received 11 Jun 2010, Accepted 13 Aug 2010, Published online: 13 Sep 2010

References

  • Overgaard J. Sensitization of hypoxic tumour cells – clinical experience. Int J Radiat Biol 1989;56:801–11.
  • Overgaard J, Horsman MR. Modification of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitizers. Semin Radiat Oncol 1996;6:10–21.
  • Overgaard J. Hypoxic radiosensitization: Adored and ignored. J Clin Oncol 2007;25:4066–74.
  • Kolstad P. Intercapillary distance, oxygen tension and local recurrence in cervix cancer. Scand J Clin Lab Invest Suppl 1968;106:145–57.
  • Hockel M, Vorndran B, Schlenger K, Baussmann E, Knapstein PG. Tumor oxygenation: A new predictive parameter in locally advanced cancer of the uterine cervix. Gynecol Oncol 1993;51:141–9.
  • Nordsmark M, Overgaard M, Overgaard J. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol 1996;41:31–9.
  • Fyles AW, Milosevic M, Wong R, Kavanagh MC, Pintilie M, Sun A, . Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother Oncol 1998;48:149–56.
  • Nordsmark M, Bentzen SM, Rudat V, Brizel D, Lartigau E, Stadler P, . Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. Radiother Oncol 2005;77: 18–24.
  • Lapi SE, Voller TF, Welch MJ. Positron emission tomography imaging of hypoxia. PET Clin 2009;4:39–47.
  • Rajendran JG, Krohn KA. Imaging hypoxia and angiogenesis in tumors. Radiol Clin North Am 2005;43:169–87.
  • Franko AJ, Koch CJ, Garrecht BM, Sharplin J, Hughes D. Oxygen dependence of binding of misonidazole to rodent and human tumors in vitro. Cancer Res 1987;47: 5367–76.
  • Koh WJ, Rasey JS, Evans ML, Grierson JR, Lewellen TK, Graham MM, . Imaging of hypoxia in human tumors with [F-18]fluoromisonidazole. Int J Radiat Oncol Biol Phys 1992;22:199–212.
  • Rajendran JG, Schwartz DL, O'Sullivan J, Peterson LM, Ng P, Scharnhorst J, . Tumor hypoxia imaging with [F-18]fluoromisonidazole positron emission tomography in head and neck cancer. Clin Cancer Res 2006;12: 5435–41.
  • Rasey JS, Koh WJ, Evans ML, Peterson LM, Lewellen TK, Graham MM, . Quantifying regional hypoxia in human tumors with positron emission tomography of [18F]fluoromisonidazole: A pretherapy study of 37 patients. Int J Radiat Oncol Biol Phys 1996;36:417–28.
  • Sorensen BS, Toustrup K, Horsman MR, Overgaard J, Alsner J. Identifying pH independent hypoxia induced genes in human squamous cell carcinomas in vitro. Acta Oncol 2010; 49:895–905.
  • Bentzen L, Keiding S, Nordsmark M, Falborg L, Hansen SB, Keller J, . Tumour oxygenation assessed by 18F-fluoromisonidazole PET and polarographic needle electrodes in human soft tissue tumours. Radiother Oncol 2003;67:339–44.
  • Nordsmark M, Bentzen SM, Overgaard J. Measurement of human tumour oxygenation status by a polarographic needle electrode. An analysis of inter- and intratumour heterogeneity. Acta Oncol 1994;33:383–9.
  • Bentzen L, Keiding S, Horsman MR, Falborg L, Hansen SB, Overgaard J. Feasibility of detecting hypoxia in experimental mouse tumours with 18F-fluorinated tracers and positron emission tomography—a study evaluating [18F]Fluoro-2-deoxy-D-glucose. Acta Oncol 2000;39:629–37.
  • Gagel B, Reinartz P, DiMartino E, Zimny M, Pinkawa M, Maneschi P, . pO(2) Polarography versus positron emission tomography ([(18)F] fluoromisonidazole, [(18)F]-2-fluoro-2′-deoxyglucose). An appraisal of radiotherapeutically relevant hypoxia. Strahlenther Onkol 2004;180:616–22.
  • Gagel B, Piroth M, Pinkawa M, Reinartz P, Zimny M, Kaiser HJ, . pO polarography, contrast enhanced color duplex sonography (CDS), [18F] fluoromisonidazole and [18F] fluorodeoxyglucose positron emission tomography: Validated methods for the evaluation of therapy-relevant tumor oxygenation or only bricks in the puzzle of tumor hypoxia? BMC Cancer 2007;7:113.
  • Nordsmark M, Loncaster J, Aquino-Parsons C, Chou SC, Gebski V, West C, . The prognostic value of pimonidazole and tumour pO2 in human cervix carcinomas after radiation therapy: A prospective international multi-center study. Radiother Oncol 2006;80:123–31.
  • Busk M, Horsman MR, Overgaard J. Resolution in PET hypoxia imaging: Voxel size matters. Acta Oncol 2008;47: 1201–10.
  • Busk M, Horsman MR, Jakobsen S, Hansen KV, Bussink J, van der Kogel A, . Can hypoxia-PET map hypoxic cell density heterogeneity accurately in an animal tumor model at a clinically obtainable image contrast? Radiother Oncol 2009; 92:429–36.
  • Chang J, Wen B, Kazanzides P, Zanzonico P, Finn RD, Fichtinger G, . A robotic system for 18F-FMISO PET-guided intratumoral pO2 measurements. Med Phys 2009;36: 5301–9.
  • Horsman MR, Khalil AA, Nordsmark M, Grau C, Overgaard J. Relationship between radiobiological hypoxia and direct estimates of tumour oxygenation in a mouse tumour model. Radiother Oncol 1993;28:69–71.
  • Horsman MR, Khalil AA, Siemann DW, Grau C, Hill SA, Lynch EM, . Relationship between radiobiological hypoxia in tumors and electrode measurements of tumor oxygenation. Int J Radiat Oncol Biol Phys 1994;29:439–42.
  • Rajendran JG, Wilson DC, Conrad EU, Peterson LM, Bruckner JD, Rasey JS, . [(18)F]FMISO and [(18)F]FDG PET imaging in soft tissue sarcomas: Correlation of hypoxia, metabolism and VEGF expression. Eur J Nucl Med Mol Imaging 2003;30:695–704.

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