Expression of ghrelin is correlated to a favorable outcome in invasive breast cancer

References

• Hortobagyi GN, de la Garza Salazar J, Pritchard K, Amadori D, Haidinger R, Hudis CA, . The global breast cancer burden: Variations in epidemiology and survival. Clin Breast Cancer 2005;6:391–401.
   PubMedGoogle Scholar
• Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thurlimann B, Senn HJ. Strategies for subtypes – dealing with the diversity of breast cancer: Highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann Oncol 2011;22:1736–47.
   PubMed Web of Science ®Google Scholar
• Cheang MC, Chia SK, Voduc D, Gao D, Leung S, Snider J, . Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer. J Natl Cancer Inst 2009;101:736–50.
   PubMed Web of Science ®Google Scholar
• Gnant M, Harbeck N, Thomssen C. St. Gallen 2011: Summary of the Consensus Discussion. Breast Care (Basel) 2011;6:136–41.
   PubMed Web of Science ®Google Scholar
• Arvat E, Di Vito L, Broglio F, Papotti M, Muccioli G, Dieguez C, . Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans. J Endocrinol Invest 2000;23:493–5.
   PubMed Web of Science ®Google Scholar
• Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N, . Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 2001;120:337–45.
   PubMed Web of Science ®Google Scholar
• Inui A. Ghrelin: An orexigenic and somatotrophic signal from the stomach. Nat Rev Neurosci 2001;2:551–60.
   PubMed Web of Science ®Google Scholar
• Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999;402:656–60.
   PubMed Web of Science ®Google Scholar
• Tack J, Depoortere I, Bisschops R, Delporte C, Coulie B, Meulemans A, . Influence of ghrelin on interdigestive gastrointestinal motility in humans. Gut 2006;55:327–33.
   PubMed Web of Science ®Google Scholar
• Tang SQ, Jiang QY, Zhang YL, Zhu XT, Shu G, Gao P, . Obestatin: Its physicochemical characteristics and physiological functions. Peptides 2008;29:639–45.
   PubMed Web of Science ®Google Scholar
• Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, . Obestatin, a peptide encded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 2005;310:996–9.
   PubMed Web of Science ®Google Scholar
• Gronberg M, Amini RM, Stridsberg M, Janson ET, Saras J. Neuroendocrine markers are expressed in human mammary glands. Regul Pept 2010;160:68–74.
   PubMedGoogle Scholar
• Cassoni P, Papotti M, Ghe C, Catapano F, Sapino A, Graziani A, . Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines. J Clin Endocrinol Metab 2001;86:1738–45.
   PubMed Web of Science ®Google Scholar
• Laban C, Bustin SA, Jenkins PJ. The GH-IGF-I axis and breast cancer. Trends Endocrinol Metab 2003;14:28–34.
   PubMed Web of Science ®Google Scholar
• Chen A, Laskar-Levy O, Koch Y. Selective expression of neuropeptides in the rat mammary gland: Somatostatin gene is expressed during lactation. Endocrinology 1999;140:5915–21.
   PubMedGoogle Scholar
• Kahan Z, Arencibia JM, Csernus VJ, Groot K, Kineman RD, Robinson WR, . Expression of growth hormone-releasing hormone (GHRH) messenger ribonucleic acid and the presence of biologically active GHRH in human breast, endometrial, and ovarian cancers. J Clin Endocrinol Metab 1999;84:582–9.
   PubMed Web of Science ®Google Scholar
• Schally AV, Varga JL. Antagonistic analogs of growth hormone-releasing hormone: New potential antitumor agents. Trends Endocrinol Metab 1999;10:383–91.
   PubMed Web of Science ®Google Scholar
• Jeffery PL, Murray RE, Yeh AH, McNamara JF, Duncan RP, Francis GD, . Expression and function of the ghrelin axis, including a novel preproghrelin isoform, in human breast cancer tissues and cell lines. Endocr Relat Cancer 2005;12:839–50.
   PubMedGoogle Scholar
• Elkabets M, Gifford AM, Scheel C, Nilsson B, Reinhardt F, Bray MA, . Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. J Clin Invest 2011;121:784–99.
   PubMed Web of Science ®Google Scholar
• Borgquist S, Holm C, Stendahl M, Anagnostaki L, Landberg G, Jirstrom K. Oestrogen receptors alpha and beta show different associations to clinicopathological parameters and their co-expression might predict a better response to endocrine treatment in breast cancer. J Clin Pathol 2008;61: 197–203.
   PubMedGoogle Scholar
• Gronberg M, Tsolakis AV, Magnusson L, Janson ET, Saras J. Distribution of obestatin and ghrelin in human tissues: Immunoreactive cells in the gastrointestinal tract, pancreas, and mammary glands. J Histochem Cytochem 2008; 56:793–801.
   PubMed Web of Science ®Google Scholar
• Altman D. Practical statistics for medical research. London, UK: Chapman & Hall; 1991.
   Google Scholar
• McShane LM, Altman DG, Sauerbrei W, Taube SE, Gion M, Clark GM. REporting recommendations for tumor MARKer prognostic studies (REMARK). Breast Cancer Res Treat 2006;100:229–35.
   PubMed Web of Science ®Google Scholar
• Aydin S, Aydin S, Ozkan Y, Kumru S. Ghrelin is present in human colostrum, transitional and mature milk. Peptides 2006;27:878–82.
   PubMed Web of Science ®Google Scholar
• Aydin S, Ozkan Y, Erman F, Gurates B, Kilic N, Colak R, . Presence of obestatin in breast milk: Relationship among obestatin, ghrelin, and leptin in lactating women. Nutrition Epub 2008 May 20.
   Google Scholar
• Kierson JA, Dimatteo DM, Locke RG, Mackley AB, Spear ML. Ghrelin and cholecystokinin in term and preterm human breast milk. Acta Paediatr 2006;95:991–5.
   PubMed Web of Science ®Google Scholar
• Gnanapavan S, Kola B, Bustin SA, Morris DG, McGee P, Fairclough P, . The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 2002;87:2988.
   PubMed Web of Science ®Google Scholar
• Seim I, Collet C, Herington AC, Chopin LK. Revised genomic structure of the human ghrelin gene and identification of novel exons, alternative splice variants and natural antisense transcripts. BMC Genomics 2007;8:298.
   PubMedGoogle Scholar
• Sinicrope FA, Dannenberg AJ. Obesity and breast cancer prognosis: Weight of the evidence. J Clin Oncol 2011; 29:4–7.
   PubMed Web of Science ®Google Scholar