1,970
Views
45
CrossRef citations to date
0
Altmetric
Research Article

Long-term follow-up of late morbidity, cosmetic outcome and body image after breast conserving therapy. A study from the Danish Breast Cancer Cooperative Group (DBCG)

, , &
Pages 259-269 | Received 28 Aug 2012, Accepted 23 Oct 2012, Published online: 07 Dec 2012

References

  • Blichert-Toft M, Rose C, Andersen JA, Overgaard M, Axelsson CK, Andersen KW, . Danish randomized trial comparing breast conservation therapy with mastectomy: Six years of life-table analysis. Danish Breast Cancer Cooperative Group. J Natl Cancer Inst Monogr 1992;19–25.
  • Jacobson JA, Danforth DN, Cowan KH, d’Angelo T, Steinberg SM, Pierce L, . Ten-year results of a comparison of conservation with mastectomy in the treatment of stage I and II breast cancer. N Engl J Med 1995;332: 907–11.
  • van TG, Voogd AC, Peterse JL, Nielsen M, Andersen KW, Mignolet F, . Prognosis after treatment for loco-regional recurrence after mastectomy or breast conserving therapy in two randomised trials (EORTC 10801 and DBCG-82TM). EORTC Breast Cancer Cooperative Group and the Danish Breast Cancer Cooperative Group. Eur J Cancer 1999; 35:32–8.
  • Fisher B, Jeong JH, Anderson S, Bryant J, Fisher ER, Wolmark N. Twenty-five-year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation. N Engl J Med 2002;347:567–75.
  • Blichert-Toft M, Nielsen M, During M, Moller S, Rank F, Overgaard M, . Long-term results of breast conserving surgery vs. mastectomy for early stage invasive breast cancer: 20-year follow-up of the Danish randomized DBCG-82TM protocol. Acta Oncol 2008;47:672–81.
  • Clarke M, Collins R, Darby S, Davies C, Elphinstone P, Evans E, . Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: An overview of the randomised trials. Lancet 2005;366:2087–106.
  • Ewertz M, Kempel MM, During M, Jensen MB, Andersson M, Christiansen P, . Breast conserving treatment in Denmark, 1989–1998. A nationwide population-based study of the Danish Breast Cancer Co-operative Group. Acta Oncol 2008;47:682–90.
  • Moller S, Jensen MB, Ejlertsen B, Bjerre KD, Larsen M, Hansen HB, . The clinical database and the treatment guidelines of the Danish Breast Cancer Cooperative Group (DBCG); its 30-years experience and future promise. Acta Oncol 2008;47:506–24.
  • DBCG - 89 protocol [Danish Breast Cancer Cooperative Group], 2012. [cited 2012 June 25]. Available from: http://dbcg.dk/PDF%20Filer/DBCG%2089%20protokol.pdf
  • Overgaard M, Christensen JJ. Postoperative radiotherapy in DBCG during 30 years. Techniques, indications and clinical radiobiological experience. Acta Oncol 2008;47:639–53.
  • Ejlertsen B, Mouridsen HT, Jensen MB. Adjuvant cyclophosphamide, methotrexate, and fluorouracil in premonopausal patients with node-positive breast cancer: Indirect comparison of dose and schedule in DBCG trials 77, 82, and 89. Acta Oncol 2008;47:662–71.
  • Pezner RD, Patterson MP, Hill LR, Vora N, Desai KR, Archambeau JO, . Breast retraction assessment: An objective evaluation of cosmetic results of patients treated conservatively for breast cancer. Int J Radiat Oncol Biol Phys 1985;11:575–8.
  • Cardoso JS, Cardoso MJ. Towards an intelligent medical system for the aesthetic evaluation of breast cancer conservative treatment. Artif Intell Med 2007;40:115–26.
  • Johansen J, Overgaard J, Rose C, Engelholm SA, Gadeberg CC, Kjaer M, . Cosmetic outcome and breast morbidity in breast-conserving treatment – results from the Danish DBCG-82TM national randomized trial in breast cancer. Acta Oncol 2002;41:369–80.
  • Whitley E, Ball J. Statistics review 4: Sample size calculations. Crit Care 2002;6:335–41.
  • Collette S, Collette L, Budiharto T, Horiot JC, Poortmans PM, Struikmans H, . Predictors of the risk of fibrosis at 10 years after breast conserving therapy for early breast cancer: A study based on the EORTC Trial 22881-10882 ‘boost versus no boost’. Eur J Cancer 2008;44:2587–99.
  • Poortmans PM, Collette L, Bartelink H, Struikmans H, Van den Bogaert WF, Fourquet A, . The addition of a boost dose on the primary tumour bed after lumpectomy in breast conserving treatment for breast cancer. A summary of the results of EORTC 22881-10882 “boost versus no boost” trial. Cancer Radiother 2008;12:565–70.
  • Johansen J, Overgaard J, Overgaard M. Effect of adjuvant systemic treatment on cosmetic outcome and late normal-tissue reactions after breast conservation. Acta Oncol 2007;46:525–33.
  • Curran D, van Dongen JP, Aaronson NK, Kiebert G, Fentiman IS, Mignolet F, . Quality of life of early-stage breast cancer patients treated with radical mastectomy or breast-conserving procedures: Results of EORTC Trial 10801. The European Organization for Research and Treatment of Cancer (EORTC), Breast Cancer Co-operative Group (BCCG). Eur J Cancer 1998;34:307–14.
  • Whelan TJ, Pignol JP, Levine MN, Julian JA, MacKenzie R, Parpia S, . Long-term results of hypofractionated radiation therapy for breast cancer. N Engl J Med 2010;362: 513–20.
  • Wazer DE, Kaufman S, Cuttino L, DiPetrillo T, Arthur DW. Accelerated partial breast irradiation: An analysis of variables associated with late toxicity and long-term cosmetic outcome after high-dose-rate interstitial brachytherapy. Int J Radiat Oncol Biol Phys 2006;64:489–95.
  • Wazer DE, Morr J, Erban JK, Schmid CH, Ruthazer R, Schmidt-Ullrich RK. The effects of postradiation treatment with tamoxifen on local control and cosmetic outcome in the conservatively treated breast. Cancer 1997;80:732–40.
  • Clarke D, Martinez A, Cox RS. Analysis of cosmetic results and complications in patients with stage I and II breast cancer treated by biopsy and irradiation. Int J Radiat Oncol Biol Phys 1983;9:1807–13.
  • Ewertz M, Jensen AB. Late effects of breast cancer treatment and potentials for rehabilitation. Acta Oncol 2011;50:187–93.
  • Hvilsom GB, Holmich LR, Frederiksen K, Steding-Jessen M, Friis S, Dalton SO. Socioeconomic position and breast reconstruction in Danish women. Acta Oncol 2011;50: 265–73.
  • Dundas KL, Atyeo J, Cox J. What is a large breast? Measuring and categorizing breast size for tangential breast radiation therapy. Australas Radiol 2007;51:589–93.
  • Strombeck JO, Malm M. Priority grouping in a waiting list of patients for reduction mammaplasty. Ann Plast Surg 1986;17:498–502.
  • Ringberg A, Bageman E, Rose C, Ingvar C, Jernstrom H. Of cup and bra size: Reply to a prospective study of breast size and premenopausal breast cancer incidence. Int J Cancer 2006;119:2242–3.
  • Andreassen CN, Alsner J, Overgaard M, Overgaard J. Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes. Radiother Oncol 2003;69:127–35.
  • Andreassen CN. Can risk of radiotherapy-induced normal tissue complications be predicted from genetic profiles?Acta Oncol 2005;44:801–15.
  • Andreassen CN, Alsner J, Overgaard M, Sorensen FB, Overgaard J. Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATM – a study based on DNA from formalin fixed paraffin embedded tissue samples. Int J Radiat Biol 2006;82:577–86.
  • Alsner J, Rodningen OK, Overgaard J. Differential gene expression before and after ionizing radiation of subcutaneous fibroblasts identifies breast cancer patients resistant to radiation-induced fibrosis. Radiother Oncol 2007;83: 261–6.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.