Hypofractionated passively scattered proton radiotherapy for low- and intermediate-risk prostate cancer is not associated with post-treatment testosterone suppression

References

• Brenner DJ, Hall EJ. Fractionation and protraction for radiotherapy of prostate carcinoma. Int J Radiat Oncol Biol Phys 1999;43:1095–101.
   PubMed Web of Science ®Google Scholar
• Duchesne GM, Peters LJ. What is the alpha/beta ratio for prostate cancer? Rationale for hypofractionated high-dose-rate brachytherapy. Int J Radiat Oncol Biol Phys 1999;44:747–8.
   PubMed Web of Science ®Google Scholar
• Brenner DJ. Toward optimal external-beam fractionation for prostate cancer. Int J Radiat Oncol Biol Phys 2000;48:315–6.
   PubMed Web of Science ®Google Scholar
• Kupelian PA, Reddy CA, Klein EA, Willoughby TR. Short-course intensity-modulated radiotherapy (70 GY at 2.5 GY per fraction) for localized prostate cancer: Preliminary results on late toxicity and quality of life. Int J Radiat Oncol Biol Phys 2001;51:988–93.
   PubMed Web of Science ®Google Scholar
• Kupelian PA, Reddy CA, Carlson TP, Altsman KA, Willoughby TR. Preliminary observations on biochemical relapse-free survival rates after short-course intensity-modulated radiotherapy (70 Gy at 2.5 Gy/fraction) for localized prostate cancer. Int J Radiat Oncol Biol Phys 2002;53:904–12.
   PubMed Web of Science ®Google Scholar
• Zagars GK, Pollack A. Serum testosterone levels after external beam radiation for clinically localized prostate cancer. Int J Radiat Oncol Biol Phys 1997;39:85–9.
   PubMed Web of Science ®Google Scholar
• Segal RJ, Reid RD, Courneya KS, Sigal RJ, Kenny GP, Prud’Homme DG, . Randomized controlled trial of resistance or aerobic exercise in men receiving radiation therapy for prostate cancer. J Clin Oncol 2009;27:344–51.
   PubMed Web of Science ®Google Scholar
• Pickles T, Graham P. What happens to testosterone after prostate radiation monotherapy and does it matter? J Urol 2002;167:2448–52.
   PubMed Web of Science ®Google Scholar
• Tomic R, Bergman B, Damber JE, Littbrand B, Lofroth PO. Effects of external radiation therapy for cancer of the prostate on the serum concentrations of testosterone, follicle-stimulating hormone, luteinizing hormone and prolactin. J Urol 1983;130: 287–9.
   PubMed Web of Science ®Google Scholar
• Oermann EK, Suy S, Hanscom HN, Kim JS, Lei S, Yu X, . Low incidence of new biochemical and clinical hypogonadism following hypofractionated stereotactic body radiation therapy (SBRT) monotherapy for low- to intermediate-risk prostate cancer. J Hematol Oncol. 2011;4:12.
   PubMed Web of Science ®Google Scholar
• Mendenhall NP, Li Z, Hoppe BS, Marcus RB, Jr., Mendenhall WM, Nichols RC, . Early outcomes from three prospective trials of image-guided proton therapy for prostate cancer. Int J Radiat Oncol Biol Phys 2012;82:213–21.
   PubMed Web of Science ®Google Scholar
• Coen JJ, Paly JJ, Niemierko A, Weyman E, Rodrigues A, Shipley WU, . Long-term quality of life outcome after proton beam monotherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys 2012;82:e201–9.
   Google Scholar
• Yoon M, Ahn SH, Kim J, Shin DH, Park SY, Lee SB, . Radiation-induced cancers from modern radiotherapy techniques: Intensity-modulated radiotherapy versus proton therapy. Int J Radiat Oncol Biol Phys 2010;77:1477–85.
   PubMed Web of Science ®Google Scholar
• Nichols RC, Jr., Morris CG, Hoppe BS, Henderson RH, Marcus RB, Jr., Mendenhall WM, . Proton radiotherapy for prostate cancer is not associated with post-treatment testosterone suppression. Int J Radiat Oncol Biol Phys 2012; 82:1222–6.
   PubMed Web of Science ®Google Scholar
• Daniell HW, Clark JC, Pereira SE, Niazi ZA, Ferguson DW, Dunn SR, . Hypogonadism following prostate-bed radiation therapy for prostate carcinoma. Cancer 2001; 91:1889–95.
   PubMed Web of Science ®Google Scholar
• Yoon FH, Perera F, Fisher B, Stitt L. Alterations in hormone levels after adjuvant chemoradiation in male rectal cancer patients. Int J Radiat Oncol Biol Phys 2009;74:1186–90.
   PubMed Web of Science ®Google Scholar
• Yau I, Vuong T, Garant A, Ducruet T, Doran P, Faria S, . Risk of hypogonadism from scatter radiation during pelvic radiation in male patients with rectal cancer. Int J Radiat Oncol Biol Phys 2009;74:1481–6.
   PubMed Web of Science ®Google Scholar
• Seal US. FSH and LH elevation after radiation for treatment of cancer of the prostate. Invest Urol 1979;16:278–80.
   PubMedGoogle Scholar
• Grigsby PW, Perez CA. The effects of external beam radiotherapy on endocrine function in patients with carcinoma of the prostate. J Urol 1986;135:726–7.
   PubMed Web of Science ®Google Scholar
• Boehmer D, Badakhshi H, Kuschke W, Bohsung J, Budach V. Testicular dose in prostate cancer radiotherapy: Impact on impairment of fertility and hormonal function. Strahlenther Onkol 2005;181:179–84.
   PubMed Web of Science ®Google Scholar
• King CR, Maxim PG, Hsu A, Kapp DS. Incidental testicular irradiation from prostate IMRT: It all adds up. Int J Radiat Oncol Biol Phys 2010;77:484–9.
   PubMed Web of Science ®Google Scholar
• Mydlo JH, Lebed B. Does brachytherapy of the prostate affect sperm quality and/or fertility in younger men? Scand J Urol Nephrol 2004;38:221–4.
   PubMed Web of Science ®Google Scholar
• Taira AV, Merrick GS, Galbreath RW, Butler WM, Lief JH, Allen ZA, . Serum testosterone kinetics after brachytherapy for clinically localized prostate cancer. Int J Radiat Oncol Biol Phys 2012;82:e33–8.
   Google Scholar
• Izard MA. Leydig cell function and radiation: A review of the literature. Radiother Oncol 1995;34:1–8.
   PubMed Web of Science ®Google Scholar
• Rowley MJ, Leach DR, Warner GA, Heller CG. Effect of graded doses of ionizing radiation on the human testis. Radiat Res 1974;59:665–78.
   PubMed Web of Science ®Google Scholar
• Shapiro E, Kinsella TJ, Makuch RW, Fraass BA, Glatstein E, Rosenberg SA, . Effects of fractionated irradiation of endocrine aspects of testicular function. J Clin Oncol 1985; 3:1232–9.
   PubMed Web of Science ®Google Scholar
• Hall EJ. Intensity-modulated radiation therapy, protons, and the risk of second cancers. Int J Radiat Oncol Biol Phys 2006;65:1–7.
   PubMed Web of Science ®Google Scholar
• Paganetti H, Bortfeld T, Delaney TF. Neutron dose in proton radiation therapy: In regard to Eric J. Hall (Int J Radiat Oncol Biol Phys 2006;65:1–7). Int J Radiat Oncol Biol Phys 2006;66:1594–5; author reply 5.
   PubMed Web of Science ®Google Scholar
• Shin D, Yoon M, Kwak J, Shin J, Lee SB, Park SY, . Secondary neutron doses for several beam configurations for proton therapy. Int J Radiat Oncol Biol Phys 2009;74: 260–5.
   PubMed Web of Science ®Google Scholar
• Mesoloras G, Sandison GA, Stewart RD, Farr JB, Hsi WC. Neutron scattered dose equivalent to a fetus from proton radiotherapy of the mother. Med Phys 2006;33:2479–90.
   PubMed Web of Science ®Google Scholar