Biology-guided adaptive radiotherapy (BiGART) is progressing towards clinical reality

References

• Grau C, Hoyer M, Lindegaard J, Overgaard J. The emerging evidence for stereotactic body radiotherapy. Acta Oncol 2006;45:771–4.
   PubMed Web of Science ®Google Scholar
• Grau C, Muren LP, Hoyer M, Lindegaard J, Overgaard J. Image-guided adaptive radiotherapy – integration of biology and technology to improve clinical outcome. Acta Oncol 2008;47:1182–5.
   PubMed Web of Science ®Google Scholar
• Muren LP, Rossi C, Hug E, Lee A, Glimelius B. Establishing and expanding the indications for proton and particle therapy. Acta Oncol 2013;52:459–62.
   PubMed Web of Science ®Google Scholar
• Grau C, Olsen DR, Overgaard J, Hoyer M, Lindegaard JC, Muren LP. Biology-guided adaptive radiation therapy – presence or future? Acta Oncol 2010;49:884–7.
   PubMed Web of Science ®Google Scholar
• Grau C, Hoyer M, Alber M, Overgaard J, Lindegaard JC, Muren LP. Biology-guided adaptive radiotherapy (BiGART) – more than a vision? Acta Oncol 2013;52:1243–7.
   PubMed Web of Science ®Google Scholar
• Krishna MC, Matsumoto S, Saito K, Matsuo M, Mitchell JB, Ardenkjaer-Larsen JH. Magnetic resonance imaging of tumor oxygenation and metabolic profile. Acta Oncol 2013;52:1248–56.
   PubMed Web of Science ®Google Scholar
• Hoeben BA, Bussink J, Troost EG, Oyen WJ, Kaanders JH. Molecular PET imaging for biology-guided adaptive radiotherapy of head and neck cancer. Acta Oncol 2013;52: 1257–71.
   PubMed Web of Science ®Google Scholar
• Combs SE, Debus J. Treatment with heavy charged particles: Systematic review of clinical data and current clinical (comparative) trials. Acta Oncol 2013;52:1272–86.
   PubMed Web of Science ®Google Scholar
• Nielsen T, Nielsen NC, Holm TH, Ostergaard L, Horsman MR, Busk M. Ultra-high field 1H magnetic resonance imaging approaches for acute hypoxia. Acta Oncol 2013;52:1287–92.
   PubMed Web of Science ®Google Scholar
• Rodal J, Rusten E, Sovik A, Skogmo HK, Malinen E. Functional imaging to monitor vascular and metabolic response in canine head and neck tumors during fractionated radiotherapy. Acta Oncol 2013;52:1293–9.
   PubMed Web of Science ®Google Scholar
• Busk M, Jakobsen S, Horsman MR, Mortensen LS, Iversen AB, Overgaard J, et al. PET imaging of tumor hypoxia using 18F-labeled pimonidazole. Acta Oncol 2013;52:1300–7.
   PubMed Web of Science ®Google Scholar
• Monnich D, Troost EG, Kaanders JH, Oyen WJ, Alber M, Zips D, et al. Correlation between tumor oxygenation and 18F-fluoromisonidazole PET data simulated based on microvessel images. Acta Oncol 2013;52:1308–13.
   PubMed Web of Science ®Google Scholar
• Ravn S, Holmberg M, Sorensen P, Frokjaer JB, Carl J. Differences in supratentorial white matter diffusion after radiotherapy – new biomarker of normal brain tissue damage? Acta Oncol 2013;52:1314–9.
   PubMed Web of Science ®Google Scholar
• Iversen AB, Busk M, Horsman MR. Induction of hypoxia by vascular disrupting agents and the significance for their combination with radiation therapy. Acta Oncol 2013;52:1320–6.
   PubMed Web of Science ®Google Scholar
• Winther M, Alsner J, Tramm T, Nordsmark M. Hypoxia-regulated gene expression and prognosis in loco-regional gastroesophageal cancer. Acta Oncol 2013;52:1327–35.
   PubMed Web of Science ®Google Scholar
• Isebaert S, Haustermans K, Van den Bergh L, Joniau S, Dirix P, Oyen R, et al. Identification and characterization of nodal metastases in prostate cancer patients at high risk for lymph node involvement. Acta Oncol 2013;52:1336–44.
   PubMed Web of Science ®Google Scholar
• Hegazy N, Potter R, Kirisits C, Berger D, Federico M, Sturdza A, et al. High-risk clinical target volume delineation in CT-guided cervical cancer brachytherapy: Impact of information from FIGO stage with or without systematic inclusion of 3D documentation of clinical gynecological examination. Acta Oncol 2013;52:1345–52.
   PubMed Web of Science ®Google Scholar
• Leibfarth S, Monnich D, Welz S, Siegel C, Schwenzer N, Schmidt H, et al. A strategy for multimodal deformable image registration to integrate PET/MR into radiotherapy treatment planning. Acta Oncol 2013;52:1353–9.
   PubMed Web of Science ®Google Scholar
• Kallehauge J, Nielsen T, Haack S, Peters DA, Mohamed S, Fokdal L, et al. Voxelwise comparison of perfusion parameters estimated using dynamic contrast enhanced (DCE) computed tomography and DCE-magnetic resonance imaging in locally advanced cervical cancer. Acta Oncol 2013;52:1360–8.
   PubMed Web of Science ®Google Scholar
• Johansson A, Garpebring A, Karlsson M, Asklund T, Nyholm T. Improved quality of computed tomography substitute derived from magnetic resonance (MR) data by incorporation of spatial information – potential application for MR-only radiotherapy and attenuation correction in positron emission tomography. Acta Oncol 2013;52:1369–73.
   PubMed Web of Science ®Google Scholar
• Korsager AS, Stephansen UL, Carl J, Ostergaard LR. The use of an active appearance model for automated prostate segmentation in magnetic resonance. Acta Oncol 2013;52:1374–7.
   PubMed Web of Science ®Google Scholar
• Rusten E, Rodal J, Bruland O, Malinen E. Biologic targets identified from dynamic 18FDG-PET and implications for image-guided therapy. Acta Oncol 2013;52:1378–83.
   PubMed Web of Science ®Google Scholar
• Schmid MP, Fidarova E, Potter R, Petric P, Bauer V, Woehs V, et al. Magnetic resonance imaging for assessment of parametrial tumour spread and regression patterns in adaptive cervix cancer radiotherapy. Acta Oncol 2013; 52:1384–90.
   PubMed Web of Science ®Google Scholar
• Carvalho S, Leijenaar RT, Velazquez ER, Oberije C, Parmar C, van Elmpt W, et al. Prognostic value of metabolic metrics extracted from baseline positron emission tomography images in non-small cell lung cancer. Acta Oncol 2013;52:1398–404.
   PubMed Web of Science ®Google Scholar
• Leijenaar RT, Carvalho S, Velazquez ER, van Elmpt WJ, Parmar C, Hoekstra OS, et al. Stability of FDG-PET radiomics features: An integrated analysis of test-retest and inter-observer variability. Acta Oncol 2013;52:1391–7.
   PubMed Web of Science ®Google Scholar
• De Ruysscher D, Sharifi H, Defraene G, Kerns SL, Christiaens M, De Ruyck K, et al. Quantification of radiation-induced lung damage with CT scans: The possible benefit for radiogenomics. Acta Oncol 2013;52:1405–10.
   PubMed Web of Science ®Google Scholar
• Thor M, Bentzen L, Elstrøm UV, Petersen JB, Muren LP. Dose/volume-based evaluation of the accuracy of deformable image registration for the rectum and bladder. Acta Oncol 2013;52:1411–6.
   PubMed Web of Science ®Google Scholar
• Mattiucci GC, Boldrini L, Chiloiro G, D’Agostino GR, Chiesa S, De Rose F, et al. Automatic delineation for replanning in nasopharynx radiotherapy: What is the agreement among experts to be considered as benchmark? Acta Oncol 2013;52:1417–22.
   PubMed Web of Science ®Google Scholar
• Thornqvist S, Hysing LB, Zolnay AG, Sohn M, Hoogeman MS, Muren LP, et al. Adaptive radiotherapy in locally advanced prostate cancer using a statistical deformable motion model. Acta Oncol 2013;52:1423–9.
   PubMed Web of Science ®Google Scholar
• Ahmad R, Bondar L, Voet P, Mens JW, Quint S, Dhawtal G, et al. A margin-of-the-day online adaptive intensity- modulated radiotherapy strategy for cervical cancer provides superior treatment accuracy compared to clinically recommended margins: A dosimetric evaluation. Acta Oncol 2013;52:1430–6.
   PubMed Web of Science ®Google Scholar
• Worm ES, Hoyer M, Fledelius W, Hansen AT, Poulsen PR. Variations in magnitude and directionality of respiratory target motion throughout full treatment courses of stereotactic body radiotherapy for tumors in the liver. Acta Oncol 2013;52:1437–44.
   PubMed Web of Science ®Google Scholar
• Skyt PS, Petersen JB, Yates ES, Poulsen PR, Ravkilde TL, Balling P, et al. Dosimetric verification of complex radiotherapy with a 3D optically based dosimetry system: Dose painting and target tracking. Acta Oncol 2013;52:1445–50.
   PubMed Web of Science ®Google Scholar
• Tuomikoski L, Korhonen J, Collan J, Keyrilainen J, Visapaa H, Sairanen J, et al. Implementation of adaptive radiation therapy for urinary bladder carcinoma: Imaging, planning and image guidance. Acta Oncol 2013;52:1451–7.
   PubMed Web of Science ®Google Scholar
• Damkjaer SM, Aznar MC, Pedersen AN, Vogelius IR, Bangsgaard JP, Josipovic M. Reduced lung dose and improved inspiration level reproducibility in visually guided DIBH compared to audio coached EIG radiotherapy for breast cancer patients. Acta Oncol 2013;52:1458–63.
   PubMed Web of Science ®Google Scholar
• Furtado H, Steiner E, Stock M, Georg D, Birkfellner W. Real-time 2D/3D registration using kV-MV image pairs for tumor motion tracking in image guided radiotherapy. Acta Oncol 2013;52:1464–71.
   PubMed Web of Science ®Google Scholar
• Nielsen MS, Nystrom MW, Carl J. Potential position errors using fiducial markers for gated image guided radiotherapy. Acta Oncol 2013;52:1472–6.
   PubMed Web of Science ®Google Scholar
• Thing RS, Bernchou U, Mainegra-Hing E, Brink C. Patient-specific scatter correction in clinical cone beam computed tomography imaging made possible by the combination of Monte Carlo simulations and a ray tracing algorithm. Acta Oncol 2013;52:1477–83.
   PubMed Web of Science ®Google Scholar
• Persoon LC, Egelmeer AG, Ollers MC, Nijsten SM, Troost EG, Verhaegen F. First clinical results of adaptive radiotherapy based on 3D portal dosimetry for lung cancer patients with atelectasis treated with volumetric-modulated arc therapy (VMAT). Acta Oncol 2013;52:1484–9.
   PubMed Web of Science ®Google Scholar
• Schmidt ML, Hoffmann L, Kandi M, Moller DS, Poulsen PR. Dosimetric impact of respiratory motion, interfraction baseline shifts, and anatomical changes in radiotherapy of non-small cell lung cancer. Acta Oncol 2013;52:1490–6.
   PubMed Web of Science ®Google Scholar
• Ravkilde T, Keall PJ, Grau C, Hoyer M, Poulsen PR. Time-resolved dose reconstruction by motion encoding of volumetric modulated arc therapy fields delivered with and without dynamic multi-leaf collimator tracking. Acta Oncol 2013;52:1497–503.
   PubMed Web of Science ®Google Scholar
• Combs SE, Kessel K, Habermehl D, Haberer T, Jakel O, Debus J. Proton and carbon ion radiotherapy for primary brain tumors and tumors of the skull base. Acta Oncol 2013;52:1504–9.
   PubMed Web of Science ®Google Scholar
• Lindegaard JC, Fokdal LU, Nielsen SK, Juul-Christensen J, Tanderup K. MRI-guided adaptive radiotherapy in locally advanced cervical cancer from a Nordic perspective. Acta Oncol 2013;52:1510–9.
   PubMed Web of Science ®Google Scholar
• Ellegaard MB, Knap MM, Hoffmann L. Inter-tester reproducibility of tumour change in small cell lung cancer patients undergoing chemoradiotherapy. Acta Oncol 2013;52:1520–5.
   PubMed Web of Science ®Google Scholar
• Thorsen LB, Thomsen MS, Overgaard M, Overgaard J, Offersen BV, Danish Breast Cancer Cooperative Group Radiotherapy C. Quality assurance of conventional non-CT-based internal mammary lymph node irradiation in a prospective Danish Breast Cancer Cooperative Group trial: The DBCG-IMN study. Acta Oncol 2013;52:1526–34.
   PubMed Web of Science ®Google Scholar
• Mortensen HR, Overgaard J, Jensen K, Specht L, Overgaard M, Johansen J, et al. Factors associated with acute and late dysphagia in the DAHANCA 6 & 7 randomized trial with accelerated radiotherapy for head and neck cancer. Acta Oncol 2013;52:1535–42.
   PubMed Web of Science ®Google Scholar
• Lonbro S, Dalgas U, Primdahl H, Johansen J, Nielsen JL, Overgaard J, et al. Lean body mass and muscle function in head and neck cancer patients and healthy individuals – results from the DAHANCA 25 study. Acta Oncol 2013;52:1543–51.
   PubMed Web of Science ®Google Scholar
• Jeppesen SS, Schytte T, Jensen HR, Brink C, Hansen O. Stereotactic body radiation therapy versus conventional radiation therapy in patients with early stage non-small cell lung cancer: An updated retrospective study on local failure and survival rates. Acta Oncol 2013;52:1552–8.
   PubMed Web of Science ®Google Scholar
• Jorgensen AY, Maraldo MV, Brodin NP, Aznar MC, Vogelius IR, Rosenschold PM, et al. The effect on esophagus after different radiotherapy techniques for early stage Hodgkin's lymphoma. Acta Oncol 2013;52:1559–65.
   PubMed Web of Science ®Google Scholar
• Kristian A, Revheim ME, Qu H, Maelandsmo GM, Engebraten O, Seierstad T, et al. Dynamic (18)F-FDG-PET for monitoring treatment effect following anti-angiogenic therapy in triple-negative breast cancer xenografts. Acta Oncol 2013;52:1566–72.
   PubMed Web of Science ®Google Scholar
• Warren S, Partridge M, Fokas E, Eccles CL, Brunner TB. Comparing dose-volume histogram and radiobiological endpoints for ranking intensity-modulated arc therapy and 3D-radiotherapy treatment plans for locally-advanced pancreatic cancer. Acta Oncol 2013;52:1573–8.
   PubMed Web of Science ®Google Scholar
• Behrens CF, Andreasen TB, Lindberg H, Buhl SK, Vestergaard A, Elstrom UV, et al. Quantitative image quality evaluation of pelvic computed tomography-based imaging systems: A novel concept in radiotherapy. Acta Oncol 2013;52:1579–82.
   PubMed Web of Science ®Google Scholar
• Josipovic M, Persson GF, Hakansson K, Damkjaer SM, Bangsgaard JP, Westman G, et al. Deep inspiration breath hold radiotherapy for locally advanced lung cancer: Comparison of different treatment techniques on target coverage, lung dose and treatment delivery time. Acta Oncol 2013;52:1582–6.
   PubMed Web of Science ®Google Scholar
• Metwally MA, Frederiksen KD, Overgaard J. Compliance and toxicity of the hypoxic radiosensitizer nimorazole in the treatment of patients with head and neck squamous cell carcinoma (HNSCC). Acta Oncol 2014;53:654–61.
   PubMed Web of Science ®Google Scholar
• Tramm T, Kyndi M, Myhre S, Nord S, Alsner J, Sorensen FB, et al. Relationship between the prognostic and predictive value of the intrinsic subtypes and a validated gene profile predictive of loco-regional control and benefit from post-mastectomy radiotherapy in patients with high-risk breast cancer. Acta Oncol 2014;53:1337–46.
   PubMed Web of Science ®Google Scholar
• Bentzen J, Toustrup K, Eriksen JG, Primdahl H, Andersen LJ, Overgaard J. Locally advanced head and neck cancer treated with accelerated radiotherapy, the hypoxic modifier nimorazole and weekly cisplatin. Results from the DAHANCA18 phase II study. Acta Oncol 2015;54:1001–7.
   Web of Science ®Google Scholar
• Stokkevåg CH, Engeseth GM, Hysing LB, Ytre-Hauge KS, Ekanger C, Muren LP. Risk of radiation-induced secondary rectal and bladder cancer following radiotherapy of prostate cancer. Acta Oncol 2015;54:1316–24.
   Google Scholar
• Grantzau T, Mellemkjaer L, Overgaard J. Second primary cancers after adjuvant radiotherapy in early breast cancer patients: A national population based study under the Danish Breast Cancer Cooperative Group (DBCG). Radiother Oncol 2013;106:42–9.
   PubMed Web of Science ®Google Scholar
• Grantzau T, Thomsen MS, Vaeth M, Overgaard J. Risk of second primary lung cancer in women after radiotherapy for breast cancer. Radiother Oncol 2014;111:366–73.
   PubMed Web of Science ®Google Scholar
• Lyngholm CD, Overgaard J, Christiansen PM, Alsner J. Validation of a gene expression profile predictive of the risk of radiation-induced fibrosis in women treated with breast conserving therapy. Acta Oncol 2015;54:1658–61.
   PubMedGoogle Scholar
• Farr KP, Møller DS, Khalil AA, Kramer S, Morsing A, Grau C. Loss of lung function after chemo-radiotherapy for NSCLC measured by perfusion SPECT/CT: Correlation with radiation dose and clinical morbidity. Acta Oncol 2015;54:1349–53.
   Google Scholar
• Thor M, Olsson CE, Oh JH, Petersen SE, Alsadius D, Bentzen L, et al. Relationships between dose to the gastro-intestinal tract and patient-reported symptom domains after radiotherapy for localized prostate cancer. Acta Oncol 2015;54:1325–33.
   Google Scholar
• Jakobi A, Stützer K, Bandurska-Luque A., Löck S, Haase R, Wack L-J, et al. NTCP reduction for advanced head and neck cancer patients using proton therapy for complete or sequential boost treatment versus photon therapy. Acta Oncol 2015;54:1699–1705.
   Google Scholar
• Langendijk JA, Lambin P, De Ruysscher D, Widder J, Bos M, Verheij M. Selection of patients for radiotherapy with protons aiming at reduction of side effects: The model-based approach. Radiother Oncol 2013;107:267–73.
   PubMed Web of Science ®Google Scholar
• Grau C. The model-based approach to clinical studies in particle radiotherapy – a new concept in evidence based radiation oncology? Radiother Oncol 2013;107:265–6.
   PubMed Web of Science ®Google Scholar
• Sørensen BS, Horsman MR, Alsner J, Overgaard J, Durante M, Scholz M, et al. Relative biological effectiveness of carbon ions for tumor control, acute skin damage and late radiation- induced fibrosis in a mouse model. Acta Oncol 2015;54: 1623–30.
   PubMed Web of Science ®Google Scholar
• Borren A, Groenendaal G, Moman MR, Boeken Kruger AE, van Diest PJ, van Vulpen M, et al. Accurate prostate tumour detection with multiparametric magnetic resonance imaging: Dependence on histological properties. Acta Oncol 2014;53:88–95.
   PubMed Web of Science ®Google Scholar
• Hoskin P. Hypoxia dose painting in prostate and cervix cancer. Acta Oncol 2015;54:1259–62.
   PubMed Web of Science ®Google Scholar
• Sand HMB, Brunø AH, Andersen LJ, Carl J. Correlation between pretreatment FDG-PET biological target volume and location of T-site failure after definitive radiation therapy for head and neck cancers. Acta Oncol 2015;54:1676–80.
   Google Scholar
• Rasmussen GR, Vogelius IR, Rasmussen JH, Schumaker L, Ioffe O, Cullen K, et al. Immunohistochemical biomarkers and FDG uptake on PET/CT in head and neck squamous cell carcinoma. Acta Oncol 2015;54:1415–21.
   Google Scholar
• Mönnich D, Welz S, Thorwarth D, Pfannenberg C, Mauz P-S, la Fougère C. et al. Robustness of quantitative hypoxia PET image analysis for predicting local tumor control. Acta Oncol 2015;54:1363–8.
   Google Scholar
• Zegers CML, van Elmpt W, Hoebers FJP, Troost EGC, Öllers MC, Mottaghy FM, et al. Imaging of tumour hypoxia and metabolism in patients with head and neck squamous cell carcinoma. Acta Oncol 2015;54:1377–83.
   Google Scholar
• Clark HD, Moiseenko VV, Rackley TP, Thomas SD, Wu JS, Reinsberg SA. Development of a method for functional aspect identification in parotid using dynamic contrast- enhanced magnetic resonance imaging and concurrent stimulation. Acta Oncol 2015;54:1681–5.
   Google Scholar
• Casares-Magaz O, Thor M, Liao D, Frokjar JB, Kramer P, Krogh K, et al. An image-based method to quantify biomechanical properties of the rectum in radiotherapy of prostate cancer. Acta Oncol 2015;54:1334–41.
   Google Scholar
• Tvilum M, Khalil AA, Møller DS, Hoffmann L, Knap MM. Clinical outcome of image-guided adaptive radiotherapy in the treatment of lung cancer patients. Acta Oncol 2015;54:1429–36.
   Google Scholar
• Grønborg C, Vestergaard A, Høyer M, Söhn M, Pedersen EM, Petersen JB, et al. Intra-fractional bladder motion and margins in adaptive radiotherapy for urinary bladder cancer. Acta Oncol 2015;54:1461–6.
   PubMed Web of Science ®Google Scholar
• Kurz C, Dedes G, Resch A, Reiner M, Ganswindt U, Nijhuis R, et al. Comparing cone-beam CT intensity correction methods for dose recalculation in adaptive intensity modulated photon and proton therapy for head and neck cancer. Acta Oncol 2015;54:1651–7.
   PubMed Web of Science ®Google Scholar
• Vestergaard A, Muren LP, Lindberg H, Jakobsen KL, Petersen JB, Elstrom UV, et al. Normal tissue sparing in a phase II trial on daily adaptive plan selection in radiotherapy for urinary bladder cancer. Acta Oncol 2014;53: 997–1004.
   PubMed Web of Science ®Google Scholar
• Noel CE, Parikh PJ, Spencer CR, Green OL, Hu Y, Mutic S. et al. Comparison of onboard low-field magnetic resonance imaging versus onboard computed tomography for anatomy visualization in radiotherapy.Acta Oncol 2015;54: 1651–7.
   PubMedGoogle Scholar
• Lagendijk JJW, Raaymakers BW, Raaijmakers AJE, Overweg J, Brown KJ, Kerkhof EM, et al. MRI/linac integration. Radiother Oncol 2008;86:25–9.
   PubMed Web of Science ®Google Scholar
• Fledelius W, Keall PJ, Cho BC, Yang XH, Morf D, Scheib S, et al. Tracking latency in image-based dynamic MLC tracking with direct image access. Acta Oncol 2011;50:952–9.
   PubMed Web of Science ®Google Scholar
• Ravkilde T, Keall PJ, Hojbjerre K, Fledelius W, Worm E, Poulsen PR. Geometric accuracy of dynamic MLC tracking with an implantable wired electromagnetic transponder. Acta Oncol 2011;50:944–51.
   PubMed Web of Science ®Google Scholar
• Poulsen PR, Worm ES, Hansen R, Larsen LP, Grau C, Høyer M. Respiratory gating based on internal electromagnetic motion monitoring during stereotactic liver radiation therapy: First results. Acta Oncol 2015;54:1444–52.
   Web of Science ®Google Scholar
• Casares-Magaz O, Toftegaard J, Muren LP, Kallehauge JF, Bassler N, Poulsen PR, et al. A method for selection of beam angles robust to intra-fractional motion in proton therapy of lung cancer. Acta Oncol 2014;53:1058–63.
   PubMed Web of Science ®Google Scholar
• Andersen AG, Casares-Magaz O, Muren LP, Toftegaard J, Bentzen L, Thörnqvist S, et al. A method for evaluation of proton plan robustness towards inter-fractional motion applied to pelvic lymph node irradiation. Acta Oncol 2015;54:1643–50.
   PubMed Web of Science ®Google Scholar
• Seco J, Spadea MF. Imaging in particle therapy: State of the art and future perspective. Acta Oncol 2015;54:1254–8.
   PubMed Web of Science ®Google Scholar
• Zschaeck S, Haase R, Abolmaali N, Perrin R, Stützer K, Appold S, et al. Spatial distribution of FMISO in head and neck squamous cell carcinomas during radio-chemotherapy and its correlation to pattern of failure. Acta Oncol 2015;54:1354–62.
   Google Scholar
• Rasmussen JH, Vogelius IR, Aznar MC, Fischer BM, Christensen CB, Friborg J, et al. Spatio-temporal stability of pre-treatment 18F-Fludeoxyglucose uptake in head and neck squamous cell carcinomas sufficient for dose painting. Acta Oncol 2015;54:1415–21.
   Google Scholar
• Berkovic P, Paelinck L, Lievens Y, Goddeeris B, Derie C, Gulyban A, et al. Adaptive radiotherapy for locally-advanced non-small cell lung cancer, can we predict when and for whom? Acta Oncol 2015;54:1437–43.
   Google Scholar
• Lakosi F, de Cuypere M, Viet PN, Jansen N, Warlimont B, Gulyban A, et al. Clinical efficacy and toxicity of radio- chemotherapy and MRI-guided brachytherapy for locally advanced cervical cancer patients: A mono-institutional experience. Acta Oncol 2015;54:1558–66.
   PubMed Web of Science ®Google Scholar
• Majercakova K, Pötter R, Banerjee S, Kirisits C, Sturdza AE, Georg P, et al. Evaluation of planning aims and dose prescription in image-guided adaptive brachytherapy and radiochemotherapy for cervical cancer: Vienna clinical experience in 225 patients. Acta Oncol 2015;54:1551–7.
   PubMed Web of Science ®Google Scholar
• Malinen E, Søvik Å. Dose or ‘LET’ painting – what is the optimal particle therapy of hypoxic tumors? Acta Oncol 2015;54:1614–22.
   PubMed Web of Science ®Google Scholar
• Lievens Y, Pijls-Johannesma M. Health economic controversy and cost-effectiveness of proton therapy. Semin Radiat Oncol 2013;23:1275–81.
   Web of Science ®Google Scholar
• Johansen C, Dalton SO. Survivorship – searching for new directions. Acta Oncol 2015;54:569–73.
   PubMed Web of Science ®Google Scholar
• Thor M, Bentzen L, Hysing LB, Ekanger C, Helle SI, Karlsdottir A, et al. Prediction of rectum and bladder morbidity following radiotherapy of prostate cancer based on motion-inclusive dose distributions. Radiother Oncol 2013;107:147–52.
   PubMed Web of Science ®Google Scholar
• Lievens Y, Borras JM, Grau C. Cost calculation: A necessary step towards widespread adoption of advanced radiotherapy technology. Acta Oncol 2015;54:1275–81.
   PubMed Web of Science ®Google Scholar
• Borras JM, Lievens Y, Grau C. The need for radiotherapy in Europe in2020: Not only data but also a cancer plan.Acta Oncol 2015;54:1268–74.
   Google Scholar
• Grau C, Defourny N, Malicki J, Dunscombe P, Borras JM, Coffey M, et al. Radiotherapy equipment and departments in the European countries: Final results from the ESTRO-HERO survey. Radiother Oncol 2014;112:155–64.
   PubMed Web of Science ®Google Scholar
• Lievens Y, Defourny N, Coffey M, Borras JM, Dunscombe P, Slotman B, et al. Radiotherapy staffing in the European countries: Final results from the ESTRO-HERO survey. Radiother Oncol 2014;112:178–86.
   PubMed Web of Science ®Google Scholar
• Massaccesi M, Corti M, Azario L, Balducci M, Ferro M, Mantini G, et al. Can automation in radiotherapy reduce costs? Acta Oncol 2015;54:1282–8
   PubMed Web of Science ®Google Scholar