823
Views
23
CrossRef citations to date
0
Altmetric
Research Article

Genetic basis of cranial cruciate ligament rupture (CCLR) in dogs

, , , &
Pages 275-281 | Received 10 Oct 2013, Accepted 27 Mar 2014, Published online: 25 Apr 2014

References

  • Whitehair JG, Vasseur PB, Willits NH. Epidemiology of cranial cruciate ligament rupture in dogs. J Am Vet Med Assoc 1993;203:1016–19
  • Gianotti SM, Marshall SW, Hume PA, Bunt L. Incidence of anterior cruciate ligament injury and other knee ligament injuries: a national population-based study. J Sci Med Sport 2009;12:622–7
  • Hill CL, Seo GS, Gale D, Totterman SM, Gale ME, Felson DT. Cruciate ligament integrity in osteoarthritis of the knee. Arthritis Rheum 2005;52:794–9
  • Flynn RK, Pedersen CL, Birmingham TB, Kirkley A, Jackowski D, Fowler PJ. The familial predisposition toward tearing the anterior cruciate ligament: a case control study. Am J Sports Med 2005;33:23–8
  • Posthumus M, Collins M, van der Merwe L, O'Cuinneagain D, van der Merwe W, Ribbans WJ, Schwellnus MP, Raleigh SM. Matrix metalloproteinase genes on chromosome 11q22 and the risk of anterior cruciate ligament (ACL) rupture. Scand J Med Sci Sports 2012;22:523–33
  • Posthumus M, September AV, Keegan M, O'Cuinneagain D, van der Merwe W, Schwellnus M, Collins M. Genetic risk factors for anterior cruciate ligament ruptures: COL1A1 gene variant. Br J Sports Med 2009;43:352–6
  • Posthumus M, September AV, O'Cuinneagain D, van der Merwe W, Schwellnus MP, Collins M. The COL5A1 gene is associated with increased risk of anterior cruciate ligament ruptures in female participants. Am J Sports Med 2009;37:2234–40
  • September AV, Posthumus M, Collins M. Application of genomics in the prevention, treatment and management of Achilles tendinopathy and anterior cruciate ligament ruptures. Recent Patents DNA Gene Sequences 2012;6:216–23
  • Khoschnau S, Melhus H, Jacobson A, Rahme H, Bengtsson H, Ribom E, Grundberg E, Mallmin H, Michaelsson K. Type I collagen alpha1 Sp1 polymorphism and the risk of cruciate ligament ruptures or shoulder dislocations. Am J Sports Med 2008;36:2432–6
  • Megens HJ, Groenen MAM. Domestication: a long-term genetic experiment Domesticated species form a treasure-trove for molecular characterization of Mendelian traits by exploiting the specific genetic structure of these species in across-breed genome wide association studies. Heredity 2012;109:1–3
  • Ostrander EA. Both ends of the leash – the human links to good dogs with bad genes. N Engl J Med 2012;367:636–46
  • Parker HG, Shearin AL, Ostrander EA. Man's best friend becomes biology's best in show: genome analyses in the domestic dog. Annual Rev Genet 2010;44:309–36
  • Lequarre A-S, Andersson L, Andre C, Fredholm M, Hitte C, Leeb T, Lohi H, Lindblad-Toh K, Georges M. LUPA: a European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs. Vet J 2011;189:155–9
  • Sharp NJ, Kornegay JN, Van Camp SD, Herbstreith MH, Secore SL, Kettle S, Hung WY, Constantinou CD, Dykstra MJ, Roses AD. An error in dystrophin mRNA processing in golden retriever muscular dystrophy, an animal homologue of Duchenne muscular dystrophy. Genomics 1992;13:115–21
  • Lin L, Faraco J, Li R, Kadotani H, Rogers W, Lin X, Qiu X, de Jong PJ, Nishino S, Mignot E. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 1999;98:365–76
  • Drogemuller C, Becker D, Brunner A, Haase B, Kircher P, Seeliger F, Fehr M, Baumann U, Lindblad-Toh K, Leeb T. A missense mutation in the SERPINH1 gene in Dachshunds with osteogenesis imperfecta. PLoS Genet 2009;5:e1000579
  • Wilke V, Zhang S, Evans R, Conzemius M, Rothschild M. Identification of chromosomal regions associated with cranial cruciate ligament rupture in a population of Newfoundlands. Am J Vet Res 2009;70:1013–17
  • Wilke VL, Conzemius MG, Kinghorn BP, Macrossan PE, Cai W, Rothschild MF. Inheritance of rupture of the cranial cruciate ligament in Newfoundlands. J Am Vet Med Assoc 2006;228:61–4
  • Comerford EJ, Tarlton JF, Innes JF, Johnson KA, Amis AA, Bailey AJ. Metabolism and composition of the canine anterior cruciate ligament relate to differences in knee joint mechanics and predisposition to ligament rupture. J Orthop Res 2005;23:61–6
  • Clements DN, Carter SD, Innes JF, Ollier WE, Day PJ. Gene expression profiling of normal and ruptured canine anterior cruciate ligaments. Osteoarthritis Cartilage 2008;16:195–203
  • Duval JM, Budsberg SC, Flo GL, Sammarco JL. Breed, sex, and body weight as risk factors for rupture of the cranial cruciate ligament in young dogs. J Am Vet Med Assoc 1999;215:811–14
  • Bennett D, Tennant B, Lewis DG, Baughan J, May C, Carter S. A reappraisal of anterior cruciate ligament disease in the dog. J Small Anim Pract 1988;29:275–97
  • Morris E, Lipowitz AJ. Comparison of tibial plateau angles in dogs with and without cranial cruciate ligament injuries. J Am Vet Med Assoc 2001;218:363–6
  • Wingfield C, Amis A, Stead A, Law H. Comparison of the biomechanical properties of rottweiler and racing greyhound cranial cruciate ligaments. J Small Anim Pract 2000;41:303–7
  • Wingfield C, Amis A, Stead A, Law H. Cranial cruciate stability in the rottweiler and racing greyhound: an in vitro study. J Small Anim Pract 2000;41:193–7
  • Romani WA, Langenberg P, Belkoff SM. Sex, collagen expression, and anterior cruciate ligament strength in rats. J Athl Train 2010;45:22–8
  • Adachi N, Nawata K, Maeta M, Kurozawa Y. Relationship of the menstrual cycle phase to anterior cruciate ligament injuries in teenaged female athletes. Basic Res Cardiol 2008;128:473–8
  • Doom M, de Bruin T, de Rooster H, van Bree H, Cox E. Immunopathological mechanisms in dogs with rupture of the cranial cruciate ligament. Vet Immunol Immunopathol 2008;125:143–61
  • Erne JB, Goring RL, Kennedy FA, Schoenborn WC. Prevalence of lymphoplasmacytic synovitis in dogs with naturally occurring cranial cruciate ligament rupture. J Am Vet Med Assoc 2009;235:386–90
  • El-Hadi M, Charavaryamath C, Aebischer A, Smith CW, Shmon C, Singh B. Expression of interleukin-8 and intercellular cell adhesion molecule-1 in the synovial membrane and cranial cruciate ligament of dogs after rupture of the ligament. Can J Vet Res 2012;76:8–15
  • Clements DN, Kennedy LJ, Short AD, Barnes A, Ferguson J, Ollier WE. Risk of canine cranial cruciate ligament rupture is not associated with the major histocompatibility complex. Vet Comp Orthop Traumatol 2011;24:262–5
  • Temwichitr J, Hazewinkel HA, van Hagen MA, Leegwater PA. Polymorphic microsatellite markers for genetic analysis of collagen genes in suspected collagenopathies in dogs. J Vet Med A Physiol Pathol Clin Med 2007;54:522–6
  • Lester KJ, Hudson JL, Tropeano M, Creswell C, Collier DA, Farmer A, Lyneham HJ, Rapee RM, Eley TC. Neurotrophic gene polymorphisms and response to psychological therapy. Transl Psychiatry 2012;2:e108
  • Tabor HK, Risch NJ, Myers RM. Candidate-gene approaches for studying complex genetic traits: practical considerations. Nat Rev Genet 2002;3:391–7
  • Muir P. Advances in the canine cranial cruciate ligament. USA: Wiley-Blackwell; 2011:43–93
  • Purcell S. PLINK Software V1.07. Available at: http://pngu.mgh.harvard.edu/purcell/plink/
  • Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira M, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC. PLINK: a tool set for whole-genome association and population-based linkage analysis. Am J Hum Genet 2007;81:559–73
  • Baird AEG, Carter SD, Short AD, Innes JF. Genome wide association study (GWAS) identifies genomic regions of association for cruciate ligament rupture in Newfoundland dogs. Anim Genet 2014; in press
  • Kim S, Wong P, Coulombe PA. A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth. Nature 2006;441:362–5
  • Moll R, Divo M, Langbein L. The human keratins: biology and pathology. Histochem Cell Biol 2008;129:705–33
  • Huang Z, Zhang G. Identification and secondary structure analysis of a keratin-like fibrous protein discovered in ligament of the bivalve Siliqua radiate. Biochemistry (Mosc) 2011;76:1227–32
  • September AV, Schwellnus MP, Collins M. Tendon and ligament injuries: the genetic component. Br J Sports Med 2007;41:241–6 (discussion 6)
  • Chou PY, Fasman GD. Prediction of protein conformation. Biochemistry 1974;13:222–45
  • Chou PY, Fasman GD. Conformational parameters for amino acids in helical, β-sheet, and random coil regions calculated from proteins. Biochemistry 1974;13:211–22
  • Moren A, Olofsson A, Stenman G, Sahlin P, Kanzaki T, Claesson-Welsh L, ten Dijke P, Miyazono K, Heldin CH. Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein. J Biol Chem 1994;269:32469–78
  • Gibson MA, Hatzinikolas G, Davis EC, Baker E, Sutherland GR, Mecham RP. Bovine latent transforming growth factor beta 1-binding protein 2: molecular cloning, identification of tissue isoforms, and immunolocalization to elastin-associated microfibrils. Mol Cell Biol 1995;15:6932–42
  • Kielty CM, Baldock C, Lee D, Rock MJ, Ashworth JL, Shuttleworth CA. Fibrillin: from microfibril assembly to biomechanical function. Philos Trans R Soc Lond B Biol Sci 2002;357:207–17
  • Maki JM, Sormunen R, Lippo S, Kaarteenaho-Wiik R, Soininen R, Myllyharju J. Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissue. Am J Pathol 2005;167:927–36
  • Kuivaniemi H, Peltonen L, Kivirikko KI. Type IX Ehlers-Danlos syndrome and Menkes syndrome: the decrease in lysyl oxidase activity is associated with a corresponding deficiency in the enzyme protein. Am J Hum Genet 1985;37:798–808
  • Wilke V, Conzemius M, Rothschild M. SNP detection and association analyses of candidate genes for rupture of the cranial cruciate ligament in the dog. Anim Genet 2005;36:519–21
  • van Hagen MAE, Leegwater PAJ. Genetic evaluation of collagen COL2a1 in canine cranial cruciate ligament rupture (PhD thesis), Utrecht University; 2004; The Netherlands
  • Clements DN, Short AD, Barnes A, Kennedy LJ, Ferguson JF, Butterworth SJ, Fitzpatrick N, Pead M, Bennett D, Innes JF, Carter SD, Ollier WER. A candidate gene study of canine joint diseases. J Hered 2010;101:54–60

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.