Ferritin concentrations in synovial fluid are higher in osteoarthritis patients with HFE gene mutations (C282Y or H63D)

References

• Xie F, Lo N-N, Lee H-P, Cieza A, Li S-C. Validation of the International Classification of Functioning, Disability, and Health (ICF) Brief Core Set for osteoarthritis. Scand J Rheumatol 2008;37:450–61.
   PubMed Web of Science ®Google Scholar
• Madsen SH, Sondergaard BC, Bay-Jensen AC, Karsdal MA. Cartilage formation measured by a novel PIINP assay suggests that IGF-I does not stimulate but maintains cartilage formation ex vivo. Scand J Rheumatol 2009;38:222–6.
   PubMed Web of Science ®Google Scholar
• Carroll GJ. Polyarticular osteoarthritis: two major phenotypes hypothesized. Med Hypotheses 2006;66:315–18.
   PubMed Web of Science ®Google Scholar
• Allen KJ, Gurrin LC, Constantine CC, Osborne NJ, Delatycki MB, Nicoll AJ, Iron-overload-related disease in HFE hereditary hemochromatosis. N Engl J Med 2008;358:221–30.
   PubMed Web of Science ®Google Scholar
• Schumacher HR Jr. Arthropathy in hemochromatosis. Hosp Pract (Minneap) 1998;33:81–6, 89–90, 93; discussion 93–84.
   PubMed Web of Science ®Google Scholar
• Vaiopoulos G, Papanikolaou G, Politou M, Jibreel I, Sakellaropoulos N, Loukopoulos D. Arthropathy in juvenile hemochromatosis. Arthritis Rheum 2003;48:227–30.
   PubMed Web of Science ®Google Scholar
• Economides AN, Carpenter LR, Rudge JS, Wong V, Koehler-Stec EM, Hartnett C, Cytokine traps: multi-component, high-affinity blockers of cytokine action. Nature Med 2003;9:47–52.
   PubMed Web of Science ®Google Scholar
• Pelletier JP, DiBattista JA, Roughley P, McCollum R, Martel-Pelletier J. Cytokines and inflammation in cartilage degradation. Rheum Dis Clin North Am 1993;19:545–68.
   PubMed Web of Science ®Google Scholar
• Manicourt DH, Poilvache P, Van Egeren A, Devogelaer JP, Lenz ME, Thonar EJ. Synovial fluid levels of tumor necrosis factor alpha and oncostatin M correlate with levels of markers of the degradation of crosslinked collagen and cartilage aggrecan in rheumatoid arthritis but not in osteoarthritis. Arthritis Rheum 2000;43:281–8.
   PubMed Web of Science ®Google Scholar
• Carroll G, Bell M, Wang H, Chapman H, Mills J. Antagonism of the IL-6 cytokine subfamily – a potential strategy for more effective therapy in rheumatoid arthritis. Inflamm Res 1998;47:1–7.
   PubMed Web of Science ®Google Scholar
• Plater-Zyberk C, Buckton J, Thompson S, Spaull J, Zanders E, Papworth J, Amelioration of arthritis in two murine models using antibodies to oncostatin M. Arthritis Rheum 2001; 44:2697–702.
   PubMed Web of Science ®Google Scholar
• Tetlow LC, Adlam DJ, Woolley DE. Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes. Arthritis Rheum 2001;44:585–94.
   PubMed Web of Science ®Google Scholar
• Cawston T. Matrix metalloproteinases and TIMPs: properties and implications for the rheumatic diseases. Mol Med Today 1998;4:130–7.
   PubMedGoogle Scholar
• Tchetverikov I, Lohmander LS, Verzijl N, Huizinga TW, TeKoppele JM, Hanemaaijer R, MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis. Ann Rheum Dis 2005; 64:694–8.
   PubMed Web of Science ®Google Scholar
• Tchetverikov I, Ronday HK, Van El B, Kiers GH, Verzijl N, TeKoppele JM, MMP profile in paired serum and synovial fluid samples of patients with rheumatoid arthritis. Ann Rheum Dis 2004;63:881–3.
   PubMed Web of Science ®Google Scholar
• Kellgren JH. Atlas of standard radiographs. In: Jeffrey MR, Ball J, Eds. The Epidemiology of Chronic Rheumatism. Oxford: Blackwell Scientific Publications; 1963:1–9.
   Google Scholar
• Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315–24.
   PubMed Web of Science ®Google Scholar
• Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 1996;13:399–408.
   PubMed Web of Science ®Google Scholar
• Swinkels DW, Janssen MCH, Bergmans J, Marx JJM. Hereditary hemochromatosis: genetic complexity and new diagnostic approaches. Clin Chem 2006;52:950–68.
   PubMed Web of Science ®Google Scholar
• Askari AD, Muir WA, Rosner IA, Moskowitz RW, McLaren GD, Braun WE. Arthritis of hemochromatosis. Clinical spectrum, relation to histocompatibility antigens, and effectiveness of early phlebotomy. Am J Med 1983;75:957–65.
   PubMed Web of Science ®Google Scholar
• Milman N, Hansen SE, Strandberg Pedersen N. Synovial fluid ferritin in rheumatic diseases. Scand J Rheumatol 1985;14:33–6.
   PubMed Web of Science ®Google Scholar
• Reyes PA, Delgado EA, Lopez-Karpovitch X. Ferritin measurement in synovial tissue and fluid in patients with inflammatory joint disease. Rev Invest Clin 1986;38:135–8.
   PubMedGoogle Scholar
• Ahmadzadeh N, Shingu M, Nobunaga M. Iron-binding proteins and free iron in synovial fluids of rheumatoid arthritis patients. Clin Rheumatol 1989;8:345–51.
   PubMed Web of Science ®Google Scholar
• Kumon Y, Suehiro T, Nishiya K, Hashimoto K, Nakatani K, Sipe JD. Ferritin correlates with C-reactive protein and acute phase serum amyloid A in synovial fluid, but not in serum. Amyloid 1999 1999;6:130–5.
   Google Scholar
• Abe E, Arai M. Synovial fluid ferritin in traumatic hemarthrosis, rheumatoid arthritis and osteoarthritis. Tohoku J Exp Med 1992;168:499–505.
   PubMed Web of Science ®Google Scholar
• Klockars M, Pettersson T, Vilja P, von Essen R. Synovial fluid ferritin, lactoferrin and adenosine deaminase in rheumatic diseases. Br J Rheumatol 1990;29:318–19.
   PubMedGoogle Scholar
• Carroll GJ. HFE gene mutations are associated with osteoarthritis in the index or middle finger metacarpophalangeal joints. J Rheumatol 2006;33:741–3.
   PubMed Web of Science ®Google Scholar
• Olynyk JK, Cullen DJ, Aquilia S, Rossi E, Summerville L, Powell LW. A population-based study of the clinical expression of the hemochromatosis gene. N Engl J Med 1999;341:718–24.
   PubMed Web of Science ®Google Scholar
• Carroll G, Breidahl W, Jazayeri J. Confirmation of two major polyarticular osteoarthritis (POA) phenotypes – differentiation on the basis of joint topography. Osteoarthritis Cartilage 2009;17:891–5.
   PubMed Web of Science ®Google Scholar
• Alizadeh BZ, Njajou OT, Hazes JM, Hofman A, Slagboom PE, Pols HA, The H63D variant in the HFE gene predisposes to arthralgia, chondrocalcinosis and osteoarthritis. Ann Rheum Dis 2007;66:1436–42.
   PubMed Web of Science ®Google Scholar
• Houssiau FA, Devogelaer J-P, Damme JV, Deuxchaisnes CND, Snick JV. Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides. Arthritis Rheum 1988;31:784–8.
   PubMed Web of Science ®Google Scholar
• Swaak AJ, van Rooyen A, Nieuwenhuis E, Aarden LA. Interleukin-6 (IL-6) in synovial fluid and serum of patients with rheumatic diseases. Scand J Rheumatol 1988;17:469–74.
   PubMed Web of Science ®Google Scholar
• Cunnane G, Fitzgerald O, Beeton C, Cawston TE, Bresnihan B. Early joint erosions and serum levels of matrix metalloproteinase 1, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 in rheumatoid arthritis. Arthritis Rheum 2001;44:2263–74.
   PubMed Web of Science ®Google Scholar
• Green MJ, Gough AK, Devlin J, Smith J, Astin P, Taylor D, Serum MMP-3 and MMP-1 and progression of joint damage in early rheumatoid arthritis. Rheumatology (Oxford) 2003;42:83–8.
   PubMed Web of Science ®Google Scholar
• Ruddell RG, Hoang-Le D, Barwood JM, Rutherford PS, Piva TJ, Watters DJ, Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells. Hepatology 2009;49:887–900.
   PubMed Web of Science ®Google Scholar