A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1 -2 and -3 in the European Prospective Investigation into Cancer and Nutrition (EPIC)

References

• Albanes D, Winick M. 1988. Are cell number and cell proliferation risk factors for cancer?. J Natl Cancer Inst. 80:772–775.
   PubMed Web of Science ®Google Scholar
• Allen NE, Key TJ, Appleby PN, Travis RC, Roddam AW, Rinaldi S, Egevad L, Rohrmann S, Linseisen J, Pischon T, Boeing H, Johnsen NF, Tjønneland A, Grønbæk H, Overvad K, Kiemeney L, Bueno-de-Mesquita HB, Bingham S, Kay TK, Tumino R, Berrino F, Mattiello A, Sacerdote C, Palli D, Quirós JR, Ardanaz E, Navarro C, Larrañaga N, Gonzalez C, Sanchez MJ, Trichopoulou A, Travezea C, Trichopoulos D, Jenab M, Ferrari P, Riboli E, Kaaks R. 2007. Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 concentrations and prostate cancer risk: Results from the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev. 16:1121–1127.
   PubMed Web of Science ®Google Scholar
• Baibas N, Bamia C, Vassilopoulou E, Sdrolias J, Trichopoulou A, Trichopoulos D. 2003. Dietary and lifestyle factors in relation to plasma insulin-like growth factor I in a general population sample. Eur J Cancer Prev. 12:229–234.
   PubMed Web of Science ®Google Scholar
• Ben-Shlomo Y, Holly J, McCarthy A, Savage P, Davies D, Gunnell D, Davey Smith G. 2003. An investigation of fetal, postnatal and childhood growth with insulin-like growth factor I and binding protein 3 in adulthood. Clin Endocrinol (Oxf). 59:366–373.
   PubMed Web of Science ®Google Scholar
• Butler AA, Le Roith D. 2001. Control of growth by the somatropic axis: Growth hormone and the insulin-like growth factors have related and independent roles. Annu Rev Physiol. 63:141–164.
   PubMed Web of Science ®Google Scholar
• Calle EE, Kaaks R. 2004. Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms. Nat Rev Cancer. 4:579–591.
   PubMed Web of Science ®Google Scholar
• Clark JM. 2006. The epidemiology of nonalcoholic fatty liver disease in adults. J Clin Gastroenterol. 40:S5–S10.
   PubMed Web of Science ®Google Scholar
• Conover CA, Lee PDK. 1990. Insulin regulation of insulin-like growth factor-binding protein production in cultured HepG2 cells. J Clin Endocrinol Metab. 70:1062–1067.
   PubMed Web of Science ®Google Scholar
• Cust AE, Allen NE, Rinaldi S, Dossus L, Friedenreich C, Olsen A, Tjønneland A, Overvad K, Clavel-Chapelon F, Boutron-Ruault M, Linseisen J, Chang-Claude J, Boeing H, Schulz M, Benetou V, Trichopoulou A, Trichopoulos D, Palli D, Berrino F, Tumino R, Mattiello A, Vineis P, Quirós JR, Agudo A, Sánchez MJ, Larrañaga N, Navarro C, Ardanaz E, Bueno-de-Mesquita HB, Peeters PHM, VanGils CH, Bingham S, Khaw KT, Key T, Slimani N, Riboli E, Kaaks R. 2007. Serum levels of C-peptide, IGFBP-1 and IGFBP-2 and endometrial cancer risk; results from the European Prospective Investigation into Cancer and Nutrition. Int J Cancer. 120:2656–2664.
   PubMed Web of Science ®Google Scholar
• DeLellis K, Rinaldi S, Kaaks RJ, Kolonel LN, Henderson B, Le Marchand L. 2004. Dietary and lifestyle correlates of plasma insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3): The Multiethnic Cohort. Cancer Epidemiol Biomarkers Prev. 13:1444–1451.
   PubMed Web of Science ®Google Scholar
• DeLellis Henderson K, Le Marchand L. 2007. Obesity and insulin-like growth factor-I in African Americans and whites. Cancer Epidemiol Biomarkers Prev. 16:1526.
   PubMed Web of Science ®Google Scholar
• Fall CHD, Pndit AN, Law CM, Yajnik CS, Clark PM, Breier B, Osmond C, Shiell AW, Gluckman PD. 1995. Size at birth and plasma insulin-like growth factor-1 concentrations. Arch Dis Child. 73:287–293BarkerDJP.
   PubMed Web of Science ®Google Scholar
• Faupel-Badger JM, Berrigan D, Ballard-Barbash R, Potischman N. 2009. Anthropometric correlates of insulin-like growth factor 1 (IGF-1) and IGF binding protein-3 (IGFBP-3) levels by race/ethnicity and gender. Ann Epidemiol. 19:841–849.
   PubMed Web of Science ®Google Scholar
• Frystyk J. 2004. Free insulin-like growth factors – Measurements and relationships to growth hormone secretion and glucose homeostasis. Growth Horm IGF Res. 14:337–375.
   PubMed Web of Science ®Google Scholar
• Gasser T, Sheehy A, Molinari L, Largo RH. 2001. Growth of early and late maturers. Ann Hum Biol. 28:328–336.
   PubMed Web of Science ®Google Scholar
• Goodman-Gruen D, Barrett-Connor E. 1997. Epidemiology of insulin-like growth factor-I in elderly men and women: The Rancho Bernardo Study. Am J Epidemiol. 145:970–976.
   PubMed Web of Science ®Google Scholar
• Gram IT, Norat T, Rinaldi S, Dossus L, Lukanova A, Téhard B, Clavel-Chapelon F, Van Gils CH, Van Noord PAH, Peeters PHM, Bueno-De-Mesquita HB, Nagel G, Linseisen J, Lahmann PH, Boeing H, Palli D, Sacerdote C, Panico S, Tumino R, Sieri S, Dorronsoro M, Quirós JR, Navarro CA, Barricarte A, Tormo M, González CA, Overvad K, Johnsen SP, Olsen A, Tjønneland A, Travis R, Allen N, Bingham S, Khaw K, Stattin P, Trichopoulou A, Kalapothaki V, Psaltopoulou T, Casagrande C, Riboli E, Kaaks R. 2006. Body mass index, waist circumference and waist-hip ratio and serum levels of IGF-I and IGFBP-3 in European women. Int J Obes. 30:1623–1631.
   Web of Science ®Google Scholar
• Gunnell D. 2000. Height, insulin-like growth factors and cancer risk. Growth Horm IGF Res. 10:39–40.
   Web of Science ®Google Scholar
• Haftenberger M, Lahmann PH, Panico S, Gonzalez CA, Seidell JC, Boeing H, Giurdanella MC, Krogh V, Bueno-De-Mesquita HB, Peeters PHM, Skeie G, Hjartåker A, Rodriguez M, Quirós JR, Berglund G, Janlert U, Khaw KT, Spencer EA, Overvad K, Tjønneland A, Clavel-Chapelon F, Tehard B, Miller AB, Klipstein-Grobusch K, Benetou V, Kiriazi G, Riboli E, Slimani N. 2002. Overweight, obesity and fat distribution in 50- to 64-year-old participants in the European Prospective Investigation into Cancer and Nutrition (EPIC). Public Health Nutr. 5:1147–1162.
   PubMed Web of Science ®Google Scholar
• Heald AH, Sharma R, Anderson SG, Vyas A, Siddals K, Patel J, Bhatnagar D, Prabharkaran D, Rudenski A, Hughes E, Durrington P, Gibson JM, Cruickshank JK. 2005. Dietary intake and the insulin-like growth factor system: Effects of migration in two related populations in India and Britain with markedly different dietary intake. Public Health Nutr. 8:620–627.
   PubMed Web of Science ®Google Scholar
• Holmes MD, Pollak MN, Willett WC, Hankinson SE. 2002. Dietary correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations. Cancer Epidemiol Biomarkers Prev. 11:852–861.
   PubMed Web of Science ®Google Scholar
• Irwin ML, McTiernan A, Bernstein L, Gilliland FD, Baumgartner R, Baumgartner K, Ballard-Barbash R. 2005. Relationship of obesity and physical activity with C-peptide, leptin, and insulin-like growth factors in breast cancer survivors. Cancer Epidemiol Biomarkers Prev. 14:2881–2998.
   PubMed Web of Science ®Google Scholar
• Jenab M, Riboli E, Cleveland RJ, Norat T, Rinaldi S, Nieters A, Biessy C, Tjønneland A, Olsen A, Overvad K, Grønbæk H, Clavel-Chapelon F, Boutron-Ruault M, Linseisen J, Boeing H, Pischon T, Trichopoulos D, Oikonomou E, Trichopoulou A, Panico S, Vineis P, Berrino F, Tumino R, Masala G, Peters PH, Van Gils CH, Bueno-de-Mesquita HB, Ocké MC, Lund E, Mendez MA, Tormo MJ, Barricarte A, Martínez-García C, Dorronsoro M, Quirós JR, Hallmans G, Palmqvist R, Berglund G, Manjer J, Key T, Allen NE, Bingham S, Khaw K, Cust A, Kaaks R. 2007. Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer. 121:368–376.
   PubMed Web of Science ®Google Scholar
• Jones JI, Clemmons DR. 1995. Insulin-like growth factors and their binding proteins: Biological actions. Endocr Rev. 16:3–34.
   PubMed Web of Science ®Google Scholar
• Juul A, Bang P, Hertel NT, Main K, Dalgaard P, Jørgensen K, Müller J, Hall K, Skakkebæk NE. 1994. Serum insulin-like growth factor-I in 1030 healthy children, adolescents, and adults: Relation to age, sex, stage of puberty, testicular size, and body mass index. J Clin Endocrinol Metab. 78:744–752.
   PubMed Web of Science ®Google Scholar
• Juul A, Fisker S, Scheike T, Hertel T, Müller J, Ørskov H, Skakkebæk NE. 2000. Serum levels of growth hormone binding protein in children with normal and precocious puberty: Relation to age, gender, body composition and gonadal steroids. Clin Endocrinol (Oxf). 52:165–172.
   PubMed Web of Science ®Google Scholar
• Kaaks R, Lukanova A, Kurzer MS. 2002. Obesity, endogenous hormones, and endometrial cancer risk: A synthetic review. Cancer Epidemiol Biomarkers Prev. 11:1531–1543.
   PubMed Web of Science ®Google Scholar
• Key TJ, Appleby PN, Reeves GK, Roddam A, Dorgan JF, Longcope C, Stanczyk FZ, Stephenson HEJr., Falk RT, Miller R, Schatzkin A, Allen DS, Fentiman IS, Wang DY, Dowsett M, Thomas HV, Hankinson SE, Toniolo P, Akhmedkhanov A, Koenig K, Shore RE, Zeleniuch-Jacquotte A, Berrino F, Muti P, Micheli A, Krogh V, Sieri S, Pala V, Venturelli E, Secreto G, Barrett-Connor E, Laughlin GA, Kabuto M, Akiba S, Stevens RG, Neriishi K, Land CE, Cauley JA, Kuller LH, Cummings SR, Helzlsouer KJ, Alberg AJ, Bush TL, Comstock GW, Gordon GB, Miller SR. 2003. Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. J Natl Cancer Inst. 95:1218–1226.
   PubMed Web of Science ®Google Scholar
• Larnkjaer A, Ingstrup HK, Schack-Nielsen L, Hoppe C, Mølgaard C, Skovgaard IM, Juul A, Michaelsen KF. 2009. Early programming of the IGF-I axis: Negative association between IGF-I in infancy and late adolescence in a 17-year longitudinal follow-up study of healthy subjects. Growth Horm IGF Res. 19:82–86.
   PubMed Web of Science ®Google Scholar
• Lukanova A, Lundin E, Zeleniuch-Jacquotte A, Muti P, Mure A, Rinaldi S, Dossus L, Micheli A, Arslan A, Lenner P, Shore RE, Krogh V, Koenig KL, Riboli E, Berrino F, Hallmans G, Stattin P, Toniolo P, Kaaks R. 2004. Body mass index, circulating levels of sex-steroid hormones, IGF-I and IGF-binding protein-3: A cross-sectional study in healthy women. Eur J Endocrinol. 150:161–171.
   PubMed Web of Science ®Google Scholar
• Lukanova A, Söderberg S, Stattin P, Palmqvist R, Lundin E, Biessy C, Rinaldi S, Riboli E, Hallmans G, Kaaks R. 2002. Nonlinear relationship of insulin-like growth factor (IGF)-I and IGF-I/IGF-binding protein-3 ratio with indices of adiposity and plasma insulin concentrations (Sweden). Cancer Causes Contr. 13:509–516.
   PubMed Web of Science ®Google Scholar
• Ong K, Kratzsch J, Kiess W, Dunger D. 2002. Circulating IGF-I levels in childhood are related to both current body composition and early postnatal growth rate. J Clin Endocrinol Metab. 87:1041–1044.
   PubMed Web of Science ®Google Scholar
• Peeters PH, Lukanova A, Allen N, Berrino F, Key T, Dossus L, Rinaldi S, van Gils CH, Bueno-de-Mesquita HB, Boeing H, Schulz M, Chang-Claude J, Linseisen J, Panico S, Sacerdote C, Palli D, Tumino R, Trichopoulou A, Trichopolos D, Bamia C, Larranaga N, Ardanaz E, Pera G, Quirós JR, Martínez-García C, Navarro C, Bingham SA, Khaw KT, Clavel F, Tjonneland A, Olsen A, Overvad K, Tetsche MS, Lund E, Lundin E, Berglund G, Riboli E, Kaaks R. 2007. Serum IGF-I, its major binding protein (IGFBP-3) and epithelial ovarian cancer risk: The European Prospective Investigation into Cancer and Nutrition (EPIC). Endocr Relat Cancer. 14:81–90.
   PubMed Web of Science ®Google Scholar
• Probst-Hensch NM, Wang H, Goh VHH, Seow A, Lee H, Yu MC. 2003. Determinants of circulating insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations in a cohort of Singapore men and women. Cancer Epidemiol Biomarkers Prev. 12:739–746.
   PubMed Web of Science ®Google Scholar
• Probst-Hensch NM, Yuan J, Stanczyk FZ, Gao Y, Ross RK, Yu MC. 2001. IGF-1, IGF-2 and IGFBP-3 in prediagnostic serum: Association with colorectal cancer in a cohort of Chinese men in Shanghai. Br J Cancer. 85:1695–1699.
   PubMed Web of Science ®Google Scholar
• Renehan AG, Zwahlen M, Minder C, O'Dwyer ST, Shalet SM, Egger M. 2004. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: Systematic review and meta-regression analysis. Lancet. 363:1346–1353.
   PubMed Web of Science ®Google Scholar
• Riboli E, Hunt KJ, Slimani N, Ferrari P, Norat T, Fahey M, Charrondière UR, Hémon B, Casagrande C, Vignat J, Overvad K, Tjønneland A, Clavel-Chapelon F, Thiébaut A, Wahrendorf J, Boeing H, Trichopoulos D, Trichopoulou A, Vineis P, Palli D, Bueno-de-Mesquita HB, Peeters PHM, Lund E, Engeset D, González CA, Barricarte A, Berglund G, Hallmans G, Day NE, Key TJ, Kaaks R, Saracci R. 2002. European Prospective Investigation into Cancer and Nutrition (EPIC): Study populations and data collection. Public Health Nutr. 5:1113–1124.
   PubMed Web of Science ®Google Scholar
• Rinaldi S, Peeters PHM, Berrino F, Dossus L, Biessy C, Olsen A, Tjonneland A, Overvad K, Clavel-Chapelon F, Boutron-Ruault MC, Téhard B, Nagel G, Linseisen J, Boeing H, Lahmann PH, Trichopoulou A, Trichopoulos D, Koliva M, Palli D, Panico S, Tumino R, Sacerdote C, Van Gils CH, Van Noord P, Grobbee DE, Bueno-De-Mesquita HB, Gonzalez CA, Agudo A, Chirlaque MD, Barricarte A, Larrañaga N, Quiros JR, Bingham S, Khaw KT, Key T, Allen NE, Lukanova A, Slimani N, Saracci R, Riboli E, Kaaks R. 2006. IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC). Endocr Relat Cancer. 13:593–605.
   PubMed Web of Science ®Google Scholar
• Rogers I, Metcalfe C, Gunnell D, Emmett P, Dunger D, Holly J. 2006. Insulin-like growth factor-I and growth in height, leg length, and trunk length between ages 5 and 10 years. J Clin Endocrinol Metab. 91:2514–2519.
   PubMedGoogle Scholar
• Sandhu MS, Gibson JM, Heald AH, Dunger DB, Wareham NJ. 2004. Association between insulin-like growth factor-I: Insulin-like growth factor-binding protein-1 ratio and metabolic and anthropometric factors in men and women. Cancer Epidemiol Biomarkers Prev. 13:166–170.
   PubMed Web of Science ®Google Scholar
• Scacchi M, Pincelli AI, Cavagnini F. 1999. Growth hormone in obesity. Int J Obes. 23:260–271.
   PubMed Web of Science ®Google Scholar
• Schernhammer ES, Tworoger SS, Eliassen AH, Missmer SA, Holly JM, Pollak MN, Hankinson SE. 2007. Body shape throughout life and correlations with IGFs and GH. Endocr Relat Cancer. 14:721–732.
   PubMed Web of Science ®Google Scholar
• Schmid C, Schlapfer I, Waldvogel M, Meier PJ, Schwander J, Boni-Schnetzler M, Zapf J, Froesch ER. 1992. Differential regulation of insulin-like growth factor binding protein (IGFBP)-2 mRNA in liver and bone cells by insulin and retinoic acid in vitro. FEBS Lett. 303:205–209.
   PubMed Web of Science ®Google Scholar
• Spencer EA, Appleby PN, Davey GK, Key TJ. 2002. Validity of self-reported height and weight in 4808 EPIC-Oxford participants. Public Health Nutr. 5:561–565.
   PubMed Web of Science ®Google Scholar
• Teramukai S, Rohan T, Eguchi H, Oda T, Shinchi K, Kono S. 2002. Anthropometric and behavioral correlates of insulin-like growth factor I and insulin-like growth factor binding protein 3 in middle-aged Japanese men. Am J Epidemiol. 156:344–348.
   PubMed Web of Science ®Google Scholar
• Key TJ, Appleby PN, Reeves GK, Roddam AW, The Endogenous Hormones and Breast Cancer Collaborative Group. 2010. Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: Pooled individual data analysis of 17 prospective studies. Lancet Oncol. 11:530–542.
   PubMed Web of Science ®Google Scholar
• Trichopoulos D, Lipworth L. 1995. Is cancer causation simpler than we thought, but more intractable?. Epidemiology. 6:347–349.
   PubMed Web of Science ®Google Scholar
• Walenkamp MJE, Wit JM, Kant SG, Pereira AM, Karperien M, Oostdijk W, Van Duyvenvoorde HA, Losekoot M, Breuning MH, Romijn JA. 2006. Genetic disorders in the growth hormone – Insulin-like growth factor-I axis. Horm Res. 66:221–230.
   PubMedGoogle Scholar
• Wheatcroft SB, Kearney MT. 2009. IGF-dependent and IGF-independent actions of IGF-binding protein-1 and -2: Implications for metabolic homeostasis. Trends Endocrinol Metab. 20:153–162.
   PubMed Web of Science ®Google Scholar
• World Cancer Research Fund/American Institute for Cancer Research. 2007. Food, nutrition, physical activity, and the prevention of cancer: A global perspective. Washington DC: AICR.
   Google Scholar