ACTN3 genotypes of Rugby Union players: Distribution, power output and body composition

References

• Ahmetov II, Druzhevskaya AM, Astratenkova IV, Popov DV, Vinogradova OL, Rogozkin VA. 2010. The ACTN3 R577polymorphism in Russian endurance athletes. Brit J Sports Med. 44:649–652.
   PubMed Web of Science ®Google Scholar
• Bell W, Evans WD, Cobner DM, Eston RG. 2005. The regional placement of bone mineral mass, fat mass, and lean soft tissue mass in young adult Rugby Union players. Ergonomics. 48:1462–1472.
   PubMed Web of Science ®Google Scholar
• Blanchard A, Ohanian V, Critchley D. 1989. The structure and function of α-actinin. J Mus Res Cell Motility. 10:280–289.
   PubMed Web of Science ®Google Scholar
• Booth FW, Lees SJ. 2006. Physically active subjects should be the control group. Med Sci Sports Exerc. 38:405–406.
   PubMed Web of Science ®Google Scholar
• Clarkson PM, Devaney JM, Gordish-Dressman H, Thompson PD, Hubal MJ, Urso M, Price TB, Angelopoulos TJ, Gordon PM, Moyna NM, Pescatello LS, Visich PS, Zoeller RF, Seip RL, Hoffman EP. 2005. ACTN3 genotype is associated with increases in muscle strength in response to resistance training in women. J App Physiol. 99:154–163.
   PubMed Web of Science ®Google Scholar
• Djinovic-Carugo K, Gautel M, Yianne J, Young P. 2002. The spectrin repreat; a structural platform for cytoskeleton protein assemblies. FEBS Lett. 513:119–123.
   PubMedGoogle Scholar
• Doring FE, Onur S, Geisen U, Boulay MR, Perusse L, Rankinen T, Rauramaa R, Wolfahrt B, Bouchard C. 2010. ACTN3 R577X and other polymorphisms are not associated with elite endurance athlete status in the Genathlete study. J Sport Sci. 28:1355–1359.
   PubMed Web of Science ®Google Scholar
• Druzhevskaya AM, Ahmetov II, Astratenkova IV, Rogozkin VA. 2008. Association of the ACTN3 R577X polymorphism with power athlete status in Russians. Eur J App Physiol. 103:631–634.
   PubMed Web of Science ®Google Scholar
• Duthie G, Pyne D, Hooper S. 2003. Applied physiology and game analysis of Rugby Union. Sports Med. 33:973–991.
   PubMed Web of Science ®Google Scholar
• Eynon N, Duarte JA, Oliveira J, Sagiv M, Yamin C, Meckel Y, Sagiv M, Goldhammer E. 2009. ACTN3 R557X polymorphism and Israeli top-level athletes. Int J Sports Med. 11:839–842.
   Google Scholar
• Gomez-Gallego F, Santiago C, Gonzalez-Freire M, Muniesa CA, Fernandez del Valle M, Perez M, Foster C, Lucia A. 2009. Endurance performance: genes or gene combinations?. Int J Sports Med. 30:66–72.
   PubMedGoogle Scholar
• Gore SM, Altman DG. 1982. How large a sample?. In Gore SM, Altman DG (editor), Statistics and ethics in medical practiceLondon: British Medical Association6–8.
   Google Scholar
• Hanson ED, Ludlow AT, Sheaff AK, Park J, Roth SM. 2010. ACTN3 genotype does not influence muscle power. Int J Sports Med. 31:834–838.
   PubMedGoogle Scholar
• Jardine MA, Wiggins TM, Myburgh KH, Noakes TD. 1988. Physiological characteristics of rugby players including muscle glycogen content and muscle fibre composition. South Afr Med J. 73:529–532.
   PubMed Web of Science ®Google Scholar
• Linthorne NP. 2001. Analysis of standing vertical jumps using a force platform. Am J Phys. 69:1198–1204.
   Web of Science ®Google Scholar
• Lucia A, Gomez-Gallego F, Santiago C, Bandres F, Earnest C, Rabadan M, Alonso JM, Hoyos J, Cordova A, Villa G, Foster C. 2006. ACTN3 genotype in professional endurance cyclists. Int J Sports Med. 27:1–5.
   PubMedGoogle Scholar
• MacArthur DG, North KN. 2004. A gene for speed? The evolution and function of α-actinin-3. BioEssays. 26:786–795.
   PubMed Web of Science ®Google Scholar
• MacArthur DG, North KN. 2007. ACTN3: a genetic influence on muscle function and athletic performance. Exerc Sport Sci Rev. 35:30–34.
   PubMed Web of Science ®Google Scholar
• MacArthur DG, Seto JT, Chan S, Quinlan KGR, Raftery JM, Turner N, Nicholson MD, Kee AJ, Hardeman EC, Gunning PW, Cooney GJ, Head SI, Yang N, North KN. 2008. An ACTN3 knockout mouse provides mechanistic insights into the association between α-actinin-3 deficiency and human athletic performance. Hum Mol Genet. 17:1076–1086.
   PubMed Web of Science ®Google Scholar
• MacArthur DG, Seto JT, Rafterty JM, Quinlan KG, Huttley GA, Hook JW, Lemckert FA, Kee AJ, Edwards MR, Bermam Y, Hardeman EC, Gunning PW, Easteal S, Yang N, North KN. 2007. Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans. Nat Genet. 39:1261–1265.
   PubMed Web of Science ®Google Scholar
• McCauley T, Mastana SS, Folland JP. 2010. ACE I/D and ACTN3 R/X polymorphism and muscle function and muscularity of older Caucasian men. Eur J Appl Physiol. 109:269–277.
   PubMed Web of Science ®Google Scholar
• Mills M, Yang N, Weinberger R, Douglas L, Woude V, Beggs AH, Easteal S, North K. 2001. Differential expression of the acting binding proteins, α-actinin -2 and -3, in different species: implications for the evolution of functional redundancy. Hum Mol Genet. 10:1335–1346.
   PubMed Web of Science ®Google Scholar
• Moran CN, Yang N, Bailey MES, Tsiokanos A, Jamurtas A, MacArthur DG, North K, Pitsiladis YP, Wilson RH. 2007. Association analysis of the ACTN3 R577X polymorphism and complex quantitative body composition and performance phenotypes in adolescent Greeks. Eur J Hum Genet. 15:88–93.
   PubMed Web of Science ®Google Scholar
• Niemi A-K, Majamaa K. 2005. Mitochondrial DNA and ACTN3 genotypes in Finnish elite endurance and sprint athletes. Eur J Hum Genet. 13:965–969.
   PubMed Web of Science ®Google Scholar
• Norman B, Esbjornsson M, Rundqvist H, Osterlund T, von Walden F, Tesch PA. 2009. Strength, power, fibre types, and mRNA expression in trained men and women with different ACTN3 R577X genotypes. J Appl Physiol. 106:959–965.
   PubMedGoogle Scholar
• North KN, Yang N, Wattanasirichaigoon D, Mills M, Easteal S, Beggs AH. 1999. A common nonsense mutation results in α-actinin-3 deficiency in the general population. Nat Genet. 21:353–354.
   PubMed Web of Science ®Google Scholar
• Papadimitriou ID, Papadopoulos C, Kouvatsi A, Triantaphyllidis C. 2008. The ACTN3 gene in elite Greek track and field athletes. Int J Sports Med. 29:352–355.
   PubMed Web of Science ®Google Scholar
• Roberts SP, Trewartha G, Higgitt RJ, El-abd J, Stokes KA. 2008. The physical demands of elite English rugby union. J Sport Sci. 26:825–833.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Romo G, Ruiz JR, Santiago C, Fiuza-Luces C, Gonzalez-Freire M, Gomez-Gallego F, Moran M, Lucia A. 2010. Does the ACE I/D polymorphism alone or in combination with the ACTN3 R577X polymorphism, influence muscle power phenotypes in young, non-athletic adults?. Eur J Appl Physiol. 110:1099–1106.
   PubMed Web of Science ®Google Scholar
• Roth SM, Walsh S, Liu D, Metter EJ, Ferrucci L, Hurley BF. 2008. The ACTN3 R577X allele is under represented in elite-level strength athletes. Eur J Hum Genet. 16:391–394.
   PubMed Web of Science ®Google Scholar
• Ruiz JR, Fernandez del Valle M, Verde Z, Diez-Vega I, Santiago C. ACTN3 R577X polymorphism does not influence explosive leg muscle power in elite volleyball players. Scan J Med Sci Sports. (EPub ahead of print). 2010.
   Google Scholar
• Santiago C, Gonzalez-Freire M, Serratosa L, Morate FJ, Meyer T, Gomez-Gallego F, Lucia A. 2008. ACTN3 genotype in professional soccer players. Brit J Sports Med. 42:71–73.
   PubMed Web of Science ®Google Scholar
• Santiago C, Rodriguez-Romo G, Gomez-Gallego F, Gonzalez-Freire M, Yvert T, Verde Z, Naclerio F, Altmae S, Esteve-Lanao J, Ruiz JR, Lucia A. 2010. Is there an association between ACTN3 R577X polymorphism and muscle power phenotypes in young, non-athletic adults?. Scan J Med Sci Sports. 20:771–778.
   PubMed Web of Science ®Google Scholar
• Saunders CJ, September AV, Xenophontos SL, Cariolou MA, Anastassiades LC, Noakes TD, Collins M. 2007. No association of the ACTN3 gene R577X polymorphism with endurance performance in Ironman triathletes. Ann Hum Genet. 71:777–781.
   PubMed Web of Science ®Google Scholar
• Van Damme R, Wilson RS, Vanhooydonk B, Aerts P. 2002. Performance constraints in decathletes. Nature. 415:755–756.
   PubMed Web of Science ®Google Scholar
• Vincent B, De Bock K, Ramaeckers M, Van den Eede E, Van Leemputte M, Hespel P, Thomis MA. 2007. ACTN3 (R577X) genotype is associated with fibre type distribution. Physiol Genomics. 32:58–63.
   PubMed Web of Science ®Google Scholar
• Walsh S, Liu D, Metter EJ, Ferrucci L, Roth SM. 2008. ACTN3 genotype is associated with muscle phenotypes in women across the adult age span. J Appl Physiol. 105:1486–1491.
   PubMed Web of Science ®Google Scholar
• Yang N, Garton F, North K. 2009. α-actinin-3 and performance. In Collins M (editor), Genetics and Sports. London: Karger88–101.
   Google Scholar
• Yang N, MacArthur DG, Gulbin JP, Allan G, Hahn AG, Beggs AH, Easteal S, North K. 2003. ACTN3 genotype is associated with human elite athletic performance. Am J Hum Genet. 73:627–631.
   PubMed Web of Science ®Google Scholar
• Yang N, MacArthur DG, Wolde B, Onywera VO, Boit MK, Lau SYM, Wilson RH, Scott RA, Pitsiladis YP, North K. 2007. The ACTN3 R577X polymorphism in East and West African athletes. Med Sci Sports Exerc. 39:1985–1988.
   PubMed Web of Science ®Google Scholar
• Yang N, Schindeler A, McDonald MM, Seto JT, Houweling PJ, Lek M, Hogarth M, Morse AR, Raftery JM, Balasuriya D, MacArthur DG, Berman Y, Eisman JA, Nguyen TV, Center JR, Prince RL, Wilson SG, Zhu K, Little DG, North KN. 2011. α-actinin-3 deficiency is associated with reduced bone mass in human and mouse. Bone 49: 790–798..
   Google Scholar