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Research Article

Carl Paxson Sherwin, American Pioneer in Drug Metabolism

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Pages 493-530 | Published online: 22 Sep 2008

References

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  • Williams R. T. Detoxication Mechanisms. Wiley, New York 1959; 13–22
  • Sherwin C. P. The fate of foreign organic compounds in the animal body. Physiol. Rev. 1922; 2: 238–276
  • Axelrod J. Microsomal enzymes that metabolize drugs. Current Contents (Life Sciences) 1991; 34: 10
  • Axelrod J. The enzymatic conversion of codeine to morphine. J. Pharmacol. Exp. Ther. 1955; 115: 259–267
  • Axelrod J. The enzymic cleavage of aromatic ethers. Biochem J. 1956; 63: 634–639
  • Axelrod J. The enzymatic N-demethylation of narcotic drugs. J. Pharmacol. Exp. Ther. 1956; 117: 322–330
  • Sherwin C. Phenylacetyl-d-glutamin ein Stoffwechsel Produkt des menschlichen Korpers nach Eingabe von Phenylessigsäure. Inaugural-Dissertation zur Erlangung der Doktorwurde. Eberhard-Karls-Universitat, Tubingen 1915
  • Thierfelder H., Sherwin C. P. Phenylacetyl-glutamin, ein Stoffwechsel-Produkt des menschlichen Korpers nach Eingabe von Phenylessigsäure. Ber. dtsch. chem. Ges. 1914; 47: 2630–2634
  • Thierfelder H., Sherwin C. P. Phenylacetylglutamin und sein Bildung im menschlichen Korper nach Eingabe von Phenylessigsaure. Z. Physiol. Chim. 1915; 94: 1–9
  • Parke D. V. Editorial, Xenobiotica 1971; 1, A
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  • Jenner P., Testa B., DiCarlo F. J. Xenobiotic and endobiotic metabolizing enzymes: An overstretched discrimination. TIPS 1981; 2: 135–137
  • Ahmad S. The functional roles of cytochrome P-450 mediated systems: Present knowledge and future areas of investigations. Drug Metab. Rev. 1979; 10: 1–14
  • Power F. W., Sherwin C. P. The detoxication of putrefactive products by the human body. Arch. Internal Med. 1927; 39: 60–66
  • Vesell H., Sherwin C. P. Testing of liver function. I: Detoxication of the liver. Arch. Internal Med. 1926; 37: 257–263
  • Killian J. A., Sherwin C. P. Chemical studies in normal and abnormal pregnancies. Am. J. Obstet. Gynecol. 1921; 2: 6–16
  • Wolf M., Sherwin C. P. Value of sweetened condensed milk as food for babies. Arch. Pediatrics 1923; 40: 397–402
  • Sherwin C. P. Relation of metabolism to dentition. Dental Cosmos 1932; 74: 45–49
  • Sherwin C. P., Hawk P. B. Fasting studies. VII. The putrefaction in the intestine of a man during fasting and during subsequent periods of low and high protein ingestion. J. Biol. Chem. 1912; 11: 169–177
  • Sherwin C. P., Hawk P. B. Fasting studies. XIV. Elimination of urinary indican during two fasts of over one hundred days each. Biochem. Bull. 1914; 3: 416–419
  • Bullowa J. G. M., Sherwin C. P. Can fasting fowls synthesize glycocoll or ornithine. Proc. Soc. Exptl. Biol. Med. 1922; 20: 125–128
  • Sherwin C. P., Hawk P. B. Studies on water drinking. XIX. Intestinal putrefaction as influenced by the ingestion of softened and distilled waters. J. Am. Chem. Soc. 1914; 36: 1779–1785
  • Sherwin C. P., May C. E. Concerning the sugar content of watermelons. J. Ind. Eng. Chem. 1912; 4: 585–588
  • Sherwin C. P. What constitutes an intoxicating beverage. New York Med. J. May 31, 1919; 1–10
  • Voegtlin C., Sherwin C. P. Adenine and guanine in cow's milk. J. Biol. Chem. 1918; 33: 145–149
  • Ambrose A. M., Sherwin C. P. Detoxication mechanisms. Ann. Rev. Biochem. 1933; 2: 377–396
  • Harrow B., Sherwin C. P. Detoxication mechanisms. Ann. Rev. Biochem. 1935; 4: 263–278
  • Neumeister R. Lehrbuch der Physiologische Chemie, 2:346: Jena
  • New York, in The Encyclopedia Americana. American Corporation, New York, Vol. 20: 214a
  • History of Elkhart County. Charles C. Chapman and Company, Chicago 1881; 1094
  • Ibid. 1169
  • Simons R. S. The Rivers of Indiana. Indiana University Press, Bloomington 1985; 72
  • The Bristol Banner, May 22, 1885 (courtesy of Betty Huster, Bristol Indiana Historical Society)
  • Booth Tarkington. The Encyclopedia Americana. American Corporation, New York, Vol. 26: 271
  • History of Elkhart County, op. cit. 1178
  • Private communication, Isabel Sherwin Harris
  • Janssen W. F. The Story of the Laws Behind the Labels. FDA Consumer June, 1981; 32ff
  • Private communication, Effie Nickless Sherwin
  • Annual Catalog of Hanover College. Hanover, Indiana, 1908. See “Faculty,” p. 8; and “Department of Chemistry,”. 55–58
  • Archives, Stetson University. courtesy Dorothy Minor, University Archivist, DuPont-Ball Library. Letters of Carl Paxson Sherwin dated April 24, 1909; May 3, 1909; May 6, 1909; June 11, 1909; June 21, 1909; and June 23 1909
  • Blatherwick N., Sherwin C. P.P, Hawk B. Intestinal putrefaction and bacterial development accompanying water drinking and fasting. J. Biol. Chem. 1912; 11: 7
  • Blatherwick N., Sherwin C. P.P, Hawk B. The specific role of foods in relation to the composition of the urine. J. Biol. Chem. 1914; 17: 40
  • Sherwin C. P. Comparative metabolism of certain aromatic acids. J. Biol. Chem. 1917; 31: 307–310
  • Sherwin C. P. Comparative metabolism of certain aromatic acids. II. Fate of p-hydroxybenzoic acid and p-hydroxyacetic acid in the organism of the monkey. J. Biol. Chem. 1918; 36: 309–318
  • Power F. W. Detoxication of phenylacetic acid by the chimpanzee. Proc. Soc. Exp. Biol. Med. 1936; 33: 598–600
  • Sherwin C. P., Helfand M. Comparative metabolism of certain aromatic acids. III. Fate of p-nitrophenylacetic acid in the organism of fowl, dog and man. J. Biol. Chem. 1919; 40: 17–27
  • Sherwin C. P., Crowdle J. H. Detoxication in the organism of the fowl. Proc. Soc. Exptl. Biol. Med. 1922; 19: 318–320
  • Crowdle J. H., Sherwin C. P. The chemical defense mechanism of the fowl. J. Biol. Chem. 1923; 55: 15–31
  • Crowdle J. H., Sherwin C. P. Synthesis of amino acids in the animal organism. II. The synthesis of ornithine in the body of the fowl. J. Biol. Chem. 1923; 55: 365–371
  • Bullowa J. G. M., Sherwin C. P. Can fasting fowls synthesize glycocoll or ornithine. Proc. Soc. Exptl. Biol. Med. 1922; 20: 125–128
  • Muldoon J. A., Shiple G. J., Sherwin C. P. Is cystine synthesized in the animal body. Proc. Soc. Exptl. Bio. Med. 1922; 20: 46–47
  • Muldoon J. A., Shiple G. J., Sherwin C. P. Synthesis of amino acids in the animal organism. III. The synthesis of cystine in the body of the dog. J. Biol. Chem. 1924; 59: 675–681
  • Novello N. J., Harrow B., Sherwin C. P. Studies in methylation J. Pharmacol. 27, Proc. 242–243 (1926);. J. Biol. Chem. 1926; 27: 54
  • Muenzen J. B., Cerecedo L. R., Sherwin C. P. The comparative metabolism of certain aromatic acids. X. Fate of m-nitro- m-amino-m-hydroxy-, and m-chloro-phenylacetic acids in man, dog, and rabbit. J. Biol. Chem. 1926; 68: 503–511
  • Sherwin C. P., Kennard K. S. Toxicity of phenylacetic acid. J. Biol. Chem. 1919; 40: 259–264
  • Shiple J., Muldoon A., Sherwin C. P. The formation of ethereal sulfates. J. Biol. Chem. 1924; 60: 59–67
  • Sherwin C. P. Acetylation as a physiologic reaction. Proc. Exptl. Biol. Med. 1924; 22: 182
  • Muenzen J. B., Cerecedo L. R., Sherwin C. P. Acetylation as a detoxication reaction. Proc. Am. Soc. Biol. Chem. 1925; 63: 16–17
  • Muenzen J. B., Cerecedo L. R., Sherwin C. P. Acetylation as a detoxicating reaction. Proc. Am. Soc. Biol. Chem., J. Biol. Chem. 1925; 63: 16–17
  • Muenzen J. B., Cerecedo L. R., Sherwin C. P. Comparative metabolism of certain aromatic acids. VIII. Acetylation of amino compounds. J. Biol. Chem. 1926; 67: 469–476
  • Harrow B., Power F. W., Sherwin C. P. Acetylation. Proc. Soc. Exp. Biol. Med. 1927; 24: 422–424
  • Harrow B., Mazur A., Sherwin C. P. Studies in acetylation. The fate of p-aminobenzoic acid in the rabbit. J. Biol. Chem. 1932; 102: 35–38
  • Adeline S. M., Cerecedo R., Sherwin C. P. Detoxication of aromatic cyanides. J. Biol. Chem. 1926; 70: 461–469
  • Ambrose A. M., Power F. W., Sherwin C. P. Further studies on the detoxication of phenylacetic acid. J. Biol. Chem. 1933; 101: 669–675
  • Sherwin C. P., Daly J. A., Hynes W. A. Metabolism of onitrobenzaldehyde m-nitrobenzaldehyde, and p-nitrophenylacetaldehyde. Proc. Am. Soc. Biol. Chem., J. Biol. Chem. 1920; 41(3)37
  • Sherwin C. P., Hynes W. A. The metabolism of nitrobenzaldehydes and nitrophenylacetaldehyde. J. Biol. Chem. 1921; 41: 297–301
  • Rose A. R., Shiple G. J., Sherwin C. P. The oxidation of cystine and cysteine in the animal organism. Am. J. Physiol. 1924; 69: 518–530
  • Shiple G. J., Sherwin C. P. The fate of some of the phenylacetylated amino-acids in the animal organism. J. Biol. Chem. 1922; 53: 463–478
  • Cerecedo L. R., Sherwin C. P. Comparative metabolism of certain aromatic acids. V. Fate of some ring substitution products of phenylacetic acid in the organisms of the dog, rabbit and man. J. Biol. Chem. 1923; 58: 215–224
  • Cerecedo L. R., Sherwin C. P. Comparative metabolism of certain aromatic acids. VII. Fate of p-chloro p-bromo, and p-amino acids in the dog, the rabbit, and man. J. Biol. Chem. 1924; 62: 217–230
  • Novello N. J., Miriam S. R., Sherwin C. P. Comparative metabolsim of certain aromatic acids. IX. Fate of some halogen derivatives of benzoic acid in the animal body. J. Biol. Chem. 1926; 67: 555–566
  • Miriam S. R., Wolf J. T., Sherwin C. P. Comparative metabolism of certain aromatic acids. XI. Fate of diphenylacetic acid in the animal body. J. Biol. Chem. 1927; 71: 249–253
  • Miriam S. R., Wolf J. T., Sherwin C. P. Comparative metabolism of certain aromatic acids. XII. Fate of triphenylacetic acid, also triphenylmethane and triphenylcarbinol in the animal body. J. Biol. Chem. 1927; 71: 695–698
  • Sherwin C. P., Wolf W., Wolf M. Effect of glutamine production on urinary nitrogen. Proc. Am. Physiol., Am. J. Physiol. 1919; 51: 202
  • Sherwin C. P., Wolf M., Wolf W. The maximum production of glutamine by the human body as measured by the output of phenylacetylglutamine. J. Biol. Chem. 1919; 37: 113–119
  • Shiple G. J., Sherwin C. P. Synthesis of amino acids in animal organisms. I. Synthesis of glycocoll and glutamine in the human organism. J. Am. Chem. Soc. 1922; 44: 618–624
  • Shiple G. J., Sherwin C. P. Some derivatives of cystine and cysteine. J. Biol. Chem. 1923; 55: 671–686
  • Sherwin C. P., Rose A. R. Cystine metabolism. II. Proc. Soc. Exptl. Biol. Med. 1923; 21: 8–11
  • Shiple G. J., Rose A. R., Sherwin C. P. Cystine metabolism. Proc. Soc. Exptl. Bio. Med. 1923; 20: 360–362
  • Harrow B., Sherwin C. P. Synthesis of amino acids in the animal body. IV. Synthesis of histidine. J. Biol. Chem. 1926; 70: 683–695
  • Sherwin C. P., Shiple G. L., Rose A. R. Sulfur metabolism. J. Biol. Chem. 1927; 73: 607–615
  • Berczeller L. Uber die Ausscheidung von Korperfremden Substanzen in Harn. Biochem. Z. 1917; 84: 75–79
  • Rose A. R., Sherwin C. P. Surface tension and the detoxication of foreign organic substances. Proc. Am. Soc. Biol. Chem., J. Biol. Chem. 1924; 59: 50–51
  • Rose A. R., Sherwin C. P. Surface tension as a factor in detoxification. J. Biol. Chem. 1926; 68: 565–573
  • Harrow B., Sherwin C. P. The Chemistry of the Hormones. Williams and Wilkins, Baltimore, MD 1934; 218
  • A Textbook of Biochemistry, B. Harrow, C. P. Sherwin. W. R. Saunders, Philadelphia, PA 1935; 797
  • Harrow B., Mazur A., Borek E., Sherwin C. P. Studien uber Acetylierung. II. Mitteilung: Der Einfluss verschiedener Stoffe auf die Bildung von Paraaminobenzoesaure am Kaninchen. Biochem. Z. 1937; 293: 302–304
  • Paxson Sherwin Carl, Jr. Letter October 29, 1985

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