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Research Article

Effect of ionization and vehicle on skin absorption and penetration of azelaic acid

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Pages 985-994 | Received 11 Apr 2011, Accepted 22 Oct 2011, Published online: 23 Nov 2011

References

  • Dermar M, Augusto M, Rudolf S, Constantin E. (1989). Effects of azelaic acid on proliferation and ultrastructure of mouse keratinocytes in vitro. J Invest Dermatol, 93:70–74.
  • Szaraz I, Forsling W. (2002). PVP and azelaic acid adsorption on γ-alumina studied by FT-IR spectroscopy. Vib Spectrosc, 29:15–20.
  • Draelos ZD. (2006). The rationale for advancing the formulation of azelaic acid vehicles. Cutis, 77:7–11.
  • Hadgraft J, Valenta C. (2000). pH, pK(a) and dermal delivery. Int J Pharm, 200:243–247.
  • Potts RO, Guy RH. (1992). Predicting skin permeability. Pharm Res, 9:663–669.
  • Singh BN, Singh RB, Singh J. (2005). Effects of ionization and penetration enhancers on the transdermal delivery of 5-fluorouracil through excised human stratum corneum. Int J Pharm, 298:98–107.
  • Merino V, López A, Kalia YN, Guy RH. (1999). Electrorepulsion versus electroosmosis: effect of pH on the iontophoretic flux of 5-fluorouracil. Pharm Res, 16:758–761.
  • Watkinson AC, Brain KR, Walters KA. (1993). The penetration of ibuprofen through human skin in vitro: vehicle, enhancer and pH effects. In: Brain KR, James V, Walters KA, eds. Prediction of Percutaneous Penetration, vol. 3B. Cardiff: STS Publishing, 335–341.
  • Valenta C, Siman U, Kratzel M, Hadgraft J. (2000). The dermal delivery of lignocaine: influence of ion pairing. Int J Pharm, 197:77–85.
  • Hermens WA, Deurloo MJ, Romeyn SG, Verhoef JC, Merkus FW. (1990). Nasal absorption enhancement of 17 beta-estradiol by dimethyl-beta-cyclodextrin in rabbits and rats. Pharm Res, 7:500–503.
  • Tanghetti E. (2008). Clinical evaluation of a 3-step acne system containing a novel solubilized benzoyl peroxide formulation for the treatment of mild to moderate facial acne vulgaris. J Am Acad Dermatol, 2:128.
  • Howes D, Guy R, Hadgraft J, Heylings J, Hoeck U, Kemper F, et al. (1996). Methods for assessing percutaneous absorption: The report and recommendations of ECVAM Workshop 13. Altern Lab Anim, 24:81–106.
  • Mansour AM, Ibrahiern MM. (2002). Simultaneous determination of azelaic and benzoic acids in topical preparations by liquid chromatography. J Chromatogr, 55:435–437.
  • Goodman M, Barry BW. (1988). Action of penetration enhancers on human skin as assessed by the permeation of model drugs 5-fluorouracil and estradiol. I. Infinite dose technique. J Invest Dermatol, 91:323–327.
  • Irwin WJ, Sanderson FD, Li Wan Po A. (1990). Percutaneous absorption of ibuprofen: vehicle effects on transport through rat skin. Int J Pharm, 66:193–200.
  • Catz P, Friend DR. (1990). Transdermal delivery of levonorgestrel. VIII. Effect of enhancers on rat skin, hairless mouse skin, hairless guinea pig skin, and human skin. Int J Pharm, 58:93–102.
  • Rudy BC, Senkowski BZ. (1973). Fluorouracil. In: Florey K, ed. Analytical Profiles of Drug Substances, vol. 2. New York: Academic Press, 221–244.
  • Cross SE, Roberts MS. (2000). The effect of occlusion on epidermal penetration of parabens from a commercial allergy test ointment, acetone and ethanol vehicles. J Invest Dermatol, 115:914–918.
  • Takahashi K, Sakano H, Rytting JH, Numata N, Kuroda S, Mizuno N. (2001). Influence of pH on the Permeability of p-Toluidine and Aminopyrine Through Shed Snake Skin as a Model Membrane. Drug Dev Ind Pharm, 27:159–164.
  • Swarbrlck J, Lee G, Brom J, and Gensmantel NP. (1984). Drug Permeation Through Human Skin II: Permeability of Ionizable Compounds. J Pharm Sci, 73:1352–1355.
  • Hichaels AS, Chandrasekaran SK, and Shaw JE. (1975). Drug Permeation Through Human Skin. Theory and In Vitro Experimental Measurement. AIChE J, 21:985–996.
  • Fleeker C, Wong O, and Rytting JH. (1989). FacilitatedTransport of Basic and Acidic Drugs in Solutions Through Snakeskin by a New Enhancer-Dodecyl N,N-Dimethylamino Acetate. Pharm Res, 6:443–448.
  • Hayashi T, Sugibayashi K, Morimoto Y. (1992). Calculation of Skin Permeability Coefficient for Ionized and Unionized Species of Indomethacin. Chem Pharm Bull, 40:3090–3093.
  • Kushla GP, Zatz JL. (1991). Influence of pH on Lidocaine Penetration Through Human and Hairless Mouse Skin In Vitro. Int J Pharm, 71:167–173.
  • Wallace SM, Barnett G. (1978). Pharmacokinetic Analysis of Percutaneous Absorption: Evidence of Parallel Penetration Pathways for Methotrexate. J Pharmacokinet Biopharm, 6:315–325.
  • Sudhir RG, Lianli L, Kwon HK. (1999). Transdermal Delivery of Antiparkinsonian Agent, Benztropine. I. Effect of Vehicles on Skin Permeation. Int J Pharm, 192:159–172.
  • Kuo PC, Liu JC, Chang SF, Chien YW. (1989). In Vitro Transdermal Permeation of Oxycodone: (I). Effect of pH, Delipidization and Skin Stripping. Drug Dev Ind Pharm, 15:1199–1215.
  • Kitamura T, Todo H, Sugibayashi K. (2009). Effect of Several Electrolyzed Waters on the Skin Permeation of Lidocaine, Benzoic Acid, and Isosorbide Mononitrate. Drug Dev Ind Pharm, 35:145–153.
  • Kipp JE. (2004). The role of solid nanoparticle technology in the parenteral delivery of poorly water-soluble drugs. Int J Pharm, 284:109–122.

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