Drug distribution in wet granulation: foam versus spray

References

• Keary CM, Sheskey PJ. (2004). Preliminary report of the discovery of a new pharmaceutical granulation process using foamed aqueous binders. Drug Dev Ind Pharm, 30:831–845.
   PubMed Web of Science ®Google Scholar
• Hapgood KP, lveson SM, Litster JD, Liu LX. (2007). Granulation rate processes. In: Salman AD, Hounslow MJ, Seville JPK, eds. Handbook of Powder Technology. Amsterdam, The Netherlands: Elsevier Science BV, 897–977.
   Google Scholar
• Sheskey P, Keary C, Clark D, Balwinski K. (2007). Scale-up trials of foam-granulation technology--high shear. Pharmac Tech, 31:94–108.
   Google Scholar
• Tan MXL, Wong LS, Lum KH, Hapgood KP. (2009). Foam and drop penetration kinetics into loosely packed powder beds. Chem Eng Sci, 64:2826–2836.
   Web of Science ®Google Scholar
• Tan MXL, Hapgood KP. (2011). Foam granulation: binder dispersion and nucleation in mixer-granulators. Chem Eng Res Des, 89:526–536.
   Web of Science ®Google Scholar
• Tan MXL, Hapgood KP. (2011). Foam granulation: liquid penetration or mechanical dispersion? Chem Eng Sci, 66:5204–5211.
   Web of Science ®Google Scholar
• Cantor SL, Kothari S, Koo OMY. (2009). Evaluation of the physical and mechanical properties of high drug load formulations: wet granulation vs. novel foam granulation. Powder Technol, 195:15–24.
   Web of Science ®Google Scholar
• Tan MXL, Hapgood KP. (2012). Foam granulation: Effects of formulation and process conditions on granule size distribution. Powder Technol, 218:149–156.
   Web of Science ®Google Scholar
• Zhang D, Flory JH, Panmai S, Batra U, Kaufman MJ. (2002). Wettability of pharmaceutical solids: Its measurement and influence on wet granulation. Colloids Surf A, 206:547–554.
   Web of Science ®Google Scholar
• Vemavarapu C, Surapaneni M, Hussain M, Badawy S. (2009). Role of drug substance material properties in the processibility and performance of a wet granulated product. Int J Pharm, 374:96–105.
   PubMed Web of Science ®Google Scholar
• Hapgood KP, Khanmohammadi B. (2009). Granulation of hydrophobic powders. Powder Technol, 189:253–262.
   Web of Science ®Google Scholar
• Ojile JE, Macfarlane CB, Selkirk AB. (1982). Drug distribution during massing and its effect on dose uniformity in granules. Int J Pharmac, 10:99–107.
   Web of Science ®Google Scholar
• Scott AC, Hounslow MJ, Instone T. (2000). Direct evidence of heterogeneity during high-shear granulation. Powder Technol, 113:205–213.
   Web of Science ®Google Scholar
• Johansen A, Schaefer T. (2001). Effects of interactions between powder particle size and binder viscosity on agglomerate growth mechanisms in a high shear mixer. Eur J Pharm Sci, 12:297–309.
   PubMed Web of Science ®Google Scholar
• Ennis BJ, Tardos G, Pfeffer R. (1991). A microlevel-based characterization of granulation phenomena. Powder Technol, 65:257–272.
   Web of Science ®Google Scholar
• Iveson SM, Litster JD, Hapgood KP, Ennis BJ. (2001). Nucleation, growth and breakage phenomena in agitated wet granulation processes: a review. Powder Technol, 117:3–39.
   Web of Science ®Google Scholar
• van den Dries K, Vromans H. (2002). Relationship between inhomogeneity phenomena and granule growth mechanisms in a high-shear mixer. Int J Pharm, 247:167–177.
   PubMedGoogle Scholar
• van den Dries K, Vromans H. (2003). Experimental and modelistic approach to explain granulate inhomogeneity through preferential growth. Eur J Pharm Sci, 20:409–417.
   PubMed Web of Science ®Google Scholar
• Vromans H, Poels-Janssen HG, Egermann H. (1999). Effects of high-shear granulation on granulate homogeneity. Pharm Dev Technol, 4:297–303.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Johnson KC. (1997). Effect of drug particle size on content uniformity of low-dose solid dosage forms. Int J Pharm, 154:179–183.
   Web of Science ®Google Scholar
• Bouwman AM, Visser MR, Meesters GM, Frijlink HW. (2006). The use of stokes deformation number as a predictive tool for material exchange behaviour of granules in the ‘equilibrium phase’ in high shear granulation. Int J Pharm, 318:78–85.
   PubMedGoogle Scholar
• van den Dries K, de Vegt OM, Girard V, Vromans H. (2003). Granule breakage phenomena in a high shear mixer; influence of process and formulation variables and consequences on granule homogeneity. Powder Technol, 133:228–236.
   Web of Science ®Google Scholar
• Kobubo H, Sunada H. (1996). Effect of process variables on the properties and binder distribution of granules prepared by a high shear mixer. Chem Pharm Bull, 44:1546–1549.
   Web of Science ®Google Scholar
• Betz G, Bürgin PJ, Leuenberger H. (2003). Power consumption profile analysis and tensile strength measurements during moist agglomeration. Int J Pharm, 252:11–25.
   PubMed Web of Science ®Google Scholar
• Betz G, Bürgin PJ, Leuenberger H. (2004). Power consumption measurement and temperature recording during granulation. Int J Pharm, 272:137–149.
   PubMedGoogle Scholar
• Laicher A, Profitlich T, Schwitzer K, Ahlert D. (1997). A modified signal analysis system for end-point control during granulation. Eur J Pharm Sci, 5:7–14.
   Web of Science ®Google Scholar
• Leuenberger H, Puchkov M, Krausbauer E, Betz G. (2009). Manufacturing pharmaceutical granules: is the granulation end-point a myth? Powder Technol, 189:141–148.
   Web of Science ®Google Scholar
• Nguyen TH, Shen W, Hapgood K. (2010). Effect of formulation hydrophobicity on drug distribution in wet granulation. Chem Eng J, 164:330–339.
   Web of Science ®Google Scholar
• Nguyen T, Shen W, Hapgood K. (2009). Drop penetration time in heterogeneous powder beds. Chem Eng Sci, 64:5210–5221.
   Web of Science ®Google Scholar
• Aussillous P, Quéré D. (2001). Liquid marbles. Nature, 411:924–927.
   PubMed Web of Science ®Google Scholar
• Bier HP, Leuenberger H, Sucker H. (1979). Determination of the uncritical quantity of granulating liquid by power measurements on planetary mixers. Pharm Ind, 41:375–380.
   Google Scholar
• Holm P, Schaefer T, Larsen C. (2001). End-point detection in a wet granulation process. Pharm Dev Technol, 6:181–192.
   PubMed Web of Science ®Google Scholar
• Aulton ME, Banks M. (1979). Influence of the hydrophobicity of the powder mix on fluidised bed granulation. International conference on powder technology in pharmacy. Basel, Switzerland: Powder Advisory Centre.
   Google Scholar
• Jaiyeoba KT, Spring MS. (1980). The granulation of ternary mixtures: the effect of the solubility of the excipients. J Pharm Pharmacol, 32:1–5.
   PubMed Web of Science ®Google Scholar
• Belohlav Z, Brenkov L, Hanika J, Durdil P, Rapek P, Tomasek V. (2007). Effect of drug active substance particles on wet granulation process. Chem Eng Res Des, 85:974–980.
   Web of Science ®Google Scholar
• Lerk CF, Schoonen AJ, Fell JT. (1976). Contact angles and wetting of pharmaceutical powders. J Pharm Sci, 65:843–847.
   PubMed Web of Science ®Google Scholar
• Leuenberger H. (1982). Granulation, new techniques. Pharm Acta Helv, 57:72–82.
   PubMedGoogle Scholar
• van den Dries K, Vromans H. (2009). Quantitative proof of liquid penetration-involved granule formation in a high shear mixer. Powder Technol, 189:165–171.
   Web of Science ®Google Scholar
• van den Dries K, Vromans H. (2004). Qualitative proof of liquid dispersion and penetration-involved granule formation in a high shear mixer. Eur J Pharm Biopharm, 58:551–559.
   PubMed Web of Science ®Google Scholar
• Hapgood KP, Litster JD, White ET, Mort PR, Jones DG. (2004). Dimensionless spray flux in wet granulation: Monte-carlo simulations and experimental validation. Powder Technol, 141:20–30.
   Web of Science ®Google Scholar
• Holm P, Schaefer T, Kristensen HG. (1985). Granulation in high-speed mixers part v. power consumption and temperature changes during granulation. Powder Technol, 43:213–223.
   Web of Science ®Google Scholar
• Holm P, Schaefer T, Kristensen HG. (1985). Granulation in high-speed mixers part vi. Effects of process conditions on power consumption and granule growth. Powder Technol, 43:225–233.
   Web of Science ®Google Scholar
• Schaefer T, Johnsen D, Johansen A. (2004). Effects of powder particle size and binder viscosity on intergranular and intragranular particle size heterogeneity during high shear granulation. Eur J Pharm Sci, 21:525–531.
   PubMed Web of Science ®Google Scholar
• Crooks MJ, Schade HW. (1978). Fluidized bed granulation of a microdose pharmaceutical powder. Powder Technol, 19:103–108.
   Web of Science ®Google Scholar
• Rossetti D, Simons SJR, Pagliai P, Ward R, Fitzpatrick S. (2004). Predicting the performance of granulation binders through micro-mechanistic observations. Part Part Syst Character, 21:284–292.
   Web of Science ®Google Scholar
• Miyamoto Y, Ryu A, Sugawara S, Miyajima M, Ogawa S, Matsui M et al. (1998). Simultaneous optimization of wet granulation process involving factor of drug content dependency on granule size. Drug Dev Ind Pharm, 24:1055–1065.
   PubMed Web of Science ®Google Scholar
• Wan LSC, Heng PWS, Muhuri G. (1992). Incorporation and distribution of a low dose drug in granules. Int J Pharm, 88:159–163.
   Web of Science ®Google Scholar
• Horisawa E, Komura A, Danjo K, Otsuka A. (1995). Effect of binder characteristics on the strength of agglomerates prepared by the wet method ii. Chem Pharm Bull, 43:488–492.
   Web of Science ®Google Scholar