170
Views
7
CrossRef citations to date
0
Altmetric
Research Article

A comprehensive study to evaluate the effect of constant low voltage iontophoresis on transungual delivery

, , , &
Pages 807-815 | Received 28 Apr 2012, Accepted 13 Aug 2012, Published online: 12 Oct 2012

References

  • Effendy I, Lecha M, Feuilhade de Chauvin M, Di Chiacchio N, Baran R; European Onychomycosis Observatory. (2005). Epidemiology and clinical classification of onychomycosis. J Eur Acad Dermatol Venereol, 19 Suppl 1:8–12.
  • Finch JJ, Warshaw EM. (2007). Toenail onychomycosis: Current and future treatment options. Dermatol Ther, 20:31–46.
  • Kumar S, Kimball AB. (2009). New antifungal therapies for the treatment of onychomycosis. Expert Opin Investig Drugs, 18:727–734.
  • Katz HI. (1997). Possible drug interactions in oral treatment of onychomycosis. J Am Podiatr Med Assoc, 87:571–574.
  • Gupta AK. (2001). The use of the new oral antifungal agents, itraconazole, terbinafine, and fluconazole, to treat onychomycosis and other dermatomycoses. Curr Probl Dermatol, 13: 220–238.
  • Weitzman I, Summerbell RC. (1995). The dermatophytes. Clin Microbiol Rev, 8:240–259.
  • Baran R, Kaoukhov A. (2005). Topical antifungal drugs for the treatment of onychomycosis: An overview of current strategies for monotherapy and combination therapy. J Eur Acad Dermatol Venereol, 19:21–29.
  • Van Hoogdalem EJ, Van den Hoven WE, Terpstra IJ, Van Zijtveld J, Verschoor JSC, Visser JN. (1997). Nail penetration of the antifungal agent oxiconazole after repeated topical application in healthy volunteers, and the effect of acetylcysteine. Eur J Pharm Sci, 5: 119–127.
  • Kobayashi Y, Miyamoto M, Sugibayashi K, Morimoto Y. (1999). Drug permeation through the three layers of the human nail plate. J Pharm Pharmacol, 51:271–278.
  • Malhotra GG, Zatz JL. (2002). Investigation of nail permeation enhancement by chemical modification using water as a probe. J Pharm Sci, 91:312–323.
  • Hui X, Chan TC, Barbadillo S, Lee C, Maibach HI, Wester RC. (2003). Enhanced econazole penetration into human nail by 2-n-nonyl-1,3-dioxolane. J Pharm Sci, 92:142–148.
  • Hao J, Li SK. (2008). Transungual iontophoretic transport of polar neutral and positively charged model permeants: Effects of electrophoresis and electroosmosis. J Pharm Sci, 97:893–905.
  • Baran R, Hay RJ, Garduno JI. (2008). Review of antifungal therapy and the severity index for assessing onychomycosis: Part I. J Dermatolog Treat, 19:72–81.
  • Elkeeb R, AliKhan A, Elkeeb L, Hui X, Maibach HI. (2010). Transungual drug delivery: Current status. Int J Pharm, 384:1–8.
  • Nair AB, Kim HD, Davis SP, Etheredge R, Barsness M, Friden PM et al. (2009). An ex vivo toe model used to assess applicators for the iontophoretic ungual delivery of terbinafine. Pharm Res, 26:2194–2201.
  • Nair AB, Chakraborty B, Murthy SN. (2010). Effect of polyethylene glycols on the trans-ungual delivery of terbinafine. Curr Drug Deliv, 7:407–414.
  • Traynor MJ, Turner RB, Evans CR, Khengar RH, Jones SA, Brown MB. (2010). Effect of a novel penetration enhancer on the ungual permeation of two antifungal agents. J Pharm Pharmacol, 62:730–737.
  • Amichai B, Nitzan B, Mosckovitz R, Shemer A. (2010). Iontophoretic delivery of terbinafine in onychomycosis: A preliminary study. Br J Dermatol, 162:46–50.
  • Dutet J, Delgado-Charro MB. (2009). In vivo transungual iontophoresis: Effect of DC current application on ionic transport and on transonychial water loss. J Control Release, 140:117–125.
  • Nair AB, Vaka SR, Sammeta SM, Kim HD, Friden PM, Chakraborty B et al. (2009). Trans-ungual iontophoretic delivery of terbinafine. J Pharm Sci, 98:1788–1796.
  • Smith KA, Hao J, Li SK. (2009). Effects of ionic strength on passive and iontophoretic transport of cationic permeant across human nail. Pharm Res, 26:1446–1455.
  • Narasimha Murthy S, Wiskirchen DE, Bowers CP. (2007). Iontophoretic drug delivery across human nail. J Pharm Sci, 96:305–311.
  • Hao J, Li SK. (2008). Mechanistic study of electroosmotic transport across hydrated nail plates: Effects of pH and ionic strength. J Pharm Sci, 97:5186–5197.
  • Nair AB, Kim HD, Chakraborty B, Singh J, Zaman M, Gupta A et al. (2009). Ungual and trans-ungual iontophoretic delivery of terbinafine for the treatment of onychomycosis. J Pharm Sci, 98:4130–4140.
  • Hao J, Smith KA, Li SK. (2009). Iontophoretically enhanced ciclopirox delivery into and across human nail plate. J Pharm Sci, 98:3608–3616.
  • Kim JH, Lee CH, Choi HK. (2001). A method to measure the amount of drug penetrated across the nail plate. Pharm Res, 18:1468–1471.
  • Dutet J, Delgado-Charro MB. (2010). Electroosmotic transport of mannitol across human nail during constant current iontophoresis. J Pharm Pharmacol, 62:721–729.
  • Kokjohn K, Bradley M, Griffiths B, Ghannoum M. (2003). Evaluation of in vitro activity of ciclopirox olamine, butenafine HCl and econazole nitrate against dermatophytes, yeasts and bacteria. Int J Dermatol, 42 Suppl 1:11–17.
  • Leyden J. (1998). Pharmacokinetics and pharmacology of terbinafine and itraconazole. J Am Acad Dermatol, 38:S42–S47.
  • Hui X, Shainhouse Z, Tanojo H, Anigbogu A, Markus GE, Maibach HI et al. (2002). Enhanced human nail drug delivery: Nail inner drug content assayed by new unique method. J Pharm Sci, 91:189–195.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.