261
Views
25
CrossRef citations to date
0
Altmetric
Research Article

Formulation and characterization of ethylcellulose microparticles containing .l-alanyl- l-glutamine peptide

, , , , , & show all
Pages 1308-1317 | Received 14 Feb 2013, Accepted 10 Jun 2013, Published online: 17 Jul 2013

References

  • Cryer PE, Davis SN, Shamoon H. Hypoglycemia in diabetes. Diabetes Care 2003;26:1902–12
  • Gazola VAFG, Garcia RF, Hartmann EM, et al. Glycemia recovery with oral amino acid administration during experimental short-term insulin-induced hypoglycemia. J Diabetes Complications 2007;21:320–5
  • Garcia RF, Gazola VAFG, Barrena HC, et al. Blood amino acids concentration during insulin induced hypoglycemia in rats: the role of alanine and glutamine in glucose recovery. Amino Acids 2007;33:151–5
  • Nascimento KF, Garcia RF, Gazola VAFG, et al. Contribution of hepatic glycogenolysis and gluconeogenesis in the defense against short-term insulin induced hypoglycemia in rats. Life Sci 2008;82:1018–22
  • Jauch-Chara K, Hallschmid M, Gais S, Oltmanns KM, Peters A, Born J, Schultes B. Awakening and counterregulatory response to hypoglycemia during early and late sleep. Diabetes 2007;56:1938–42
  • Jauch-Chara K, Hallschmid M, Gais S, et al. Hypoglycemia during sleep impairs consolidation of declarative memory in type 1 diabetic and healthy humans. Diabetes Care 2007;30:2040–5
  • Gabriely I, Shamoon H. Awakening from sleep and hypoglycemia in type 1 diabetes mellitus. PLoS Med 2007;4:239–40
  • Felisberto-Junior AM, Manso FC, Gazola VAFG, et al. Oral glutamine dipeptide prevents against prolonged hypoglycemia induced by detemir insulin in rats. Biol Pharm Bull 2009;32:232–6
  • Garcia RF, Gazola VAFG, Hartmann EM, et al. Oral glutamine dipeptide promotes acute glycemia recovery in rats submitted to long-term insulin induced hypoglycemia. Lat Am J Pharm 2008;27:229–34
  • Oda S, Mullaney T, Bowles AJ, et al. Safety studies of l-alanyl-l-glutamine (l-AG). Regul Toxicol Pharmacol 2008;50:226–38
  • Radan I, Rajer E, Bratina NU, et al. Motor activity during asymptomatic nocturnal hypoglycemia in adolescents with type 1 diabetes mellitus. Acta Diabetol 2004;41:33–7
  • Matsumoto A, Matsukawa Y, Suzuki T, et al. The polymer-alloys method as a new preparation method of biodegradable microspheres: principle and application to cisplatin loaded microspheres. J Control Release 1997;48:19–27
  • Venkatesan P, Manavalan R, Valliappan K. Microencapsulation: a vital technique in novel drug delivery system. J Pharm Sci Res 2009;1:26–35
  • Ng S, Choi J, Han H, et al. Novel microencapsulation of potential drugs with low molecular weight and high hydrophilicity: hydrogen peroxide as a candidate compound. Int J Pharm 2010;384:120–7
  • Bruschi ML, Cardoso MLC, Lucchesi MB, Gremião MP. Gelatin microparticles containing propolis obtained by spray-drying technique: preparation and characterization. Int J Pharm 2003;264:45–55
  • Freitas S, Merkle HP, Gander B. Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology. J Control Release 2005;102:313–32
  • Kilpeläinen M, Mönkäre J, Vlasova MA, et al. Nanostructured porous silicon microparticles enable sustained peptide (Melanotan II) deliver. Eur J Pharm Biopharm 2011;77:20–5
  • Kilpeläinen M, Riikonen J, Vlasova MA, et al. In vivo delivery of a peptide, ghrelin antagonist, with mesoporous silicon microparticles. J Control Release 2009;137:166–70
  • Bahri ZE, Taverdet J-L. Elaboration and characterization of microparticles loaded by pesticide model. Powder Technol 2007;172:30–40
  • Li M, Rouaud O, Poncelet D. Microencapsulation by solvent evaporation: state of the art for process engineering approaches. Int J Pharm 2008;363:26–39
  • Muschert S, Siepmann F, Leclercq B, et al. Prediction of drug release from ethylcellulose coated pellets. J Control Release 2009;135:71–9
  • Murtaza G. Ethylcellulose microparticles: a review. Acta Pol Pharm 2012;69:11–22
  • Rogers TL, Wallick D. Reviewing the use of ethylcellulose, methylcellulose and hypromellose in microencapsulation. Part 1: materials used to formulate microcapsules. Drug Dev Ind Pharm 2012;38:129–57
  • Rogers TL, Wallick D. Reviewing the use of ethylcellulose, methylcellulose and hypromellose in microencapsulation. Part 2: techniques used to make microcapsules. Drug Dev Ind Pharm 2012;37:1259–71
  • Rogers TL, Wallick D. Reviewing the use of ethylcellulose, methylcellulose and hypromellose in microencapsulation. Part 3: applications for microcapsules. Drug Dev Ind Pharm 2012;38:521–39
  • Barber TA. Pharmaceutical particulate matter: analysis and control. Buffalo Grove: Interpharm Press; 1993
  • Villa Nova M, Gonçalves MCP, Rodrigues R, et al. Comparison of three methods for quantification of l-alanyl-l-glutamine. Lat Am J Pharm 2013;32:184–90
  • Higuchi T. Mechanism of sustained-action medication: theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci 1963;52:1145–9
  • Ritger PL, Peppas NA. A simple equation for description of solute release. II. Fickian and anomalous release from swellable devices. J Control Release 1987;5:37–42
  • Jones DS, Woolfson AD, Brown AF, et al. Design, characterization and preliminary clinical evaluation of a novel mucoadhesive topical formulation containing tetracycline for the treatment of periodontal disease. J Control Release 2000;67:357–68
  • Suthar V, Pratap A, Raval H. Studies on poly (hydroxy alkanoates)/(ethylcellulose) blends. Bull Mater Sci 2000;23:215–9
  • Kecel S, Ozel AE, Akyuz S, Celik S. Conformational analysis and vibrational spectroscopic investigation of l-alanyl-l-glutamine dipeptide. Spectroscopy 2010;24:219–32
  • Langkilde FW, Svantesson A. Identification of celluloses with Fourier-Transform (FT) mid-infrared, FT-Raman and near-infrared spectrometry. J Pharm Biomed Anal 1995;13:409–14
  • Buttini F, Colombo P, Rossi A, et al. Particles and powders: tools of innovation for non-invasive drug administration. J Control Release 2012;161:693–702
  • Baccarin MA, Evangelista RC, Lucinda-Silva RM. Ethylcelullose microspheres containing sodium diclofenac: development and characterization. Acta Farm Bonaerense 2006;25:401–4
  • Des Rieux A, Fievez V, Garinot M, et al. Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach. J Control Release 2006;116:1–27
  • Farago PV, Raffin RP, Pohlman AR, et al. Physicochemical characterization of a hydrophilic model drug-loaded PHBV microparticles obtained by the double emulsion/solvent evaporation technique. J Braz Chem Soc 2008;19:1298–305
  • Bazzo GC, Lemos-Senna E, Gonçalves MC, Pires ATN. Effect of preparation conditions on morphology, drug content and release profiles of poly(hydroxybutyrate) microparticles containing piroxicam. J Braz Chem Soc 2008;19:914–21
  • Avachat AM, Bornare PN, Dash RR. Sustained release microspheres of ropinirole hydrochloride: effect of process parameters. Acta Pharm 2011;61:363–76
  • Elkharraz K, Ahmed AR, Dashevsky A, Bodmeier R. Encapsulation of water-soluble drugs by an o/o/o-solvent extraction microencapsulation method. Int J Pharm 2011;409:89–95
  • Herrmann J, Bodmeier, R. Biodegradable, somatostatin acetate containing microspheres prepared by various aqueous and non-aqueous solvent evaporation methods. Eur J Pharm Biopharm 1998;45:75–82
  • O’Donnel PB, McGinity JW. Preparation of microspheres by the solvent evaporation technique. Adv Drug Deliver Rev 1997;28:25–42
  • Meng FT, Ma GH, Qiu W, Su ZG. W/O/W double emulsion technique using ethyl acetate as organic solvent: effects of its diffusion rate on the characteristics of microparticles. J Control Release 2003;91:407–16
  • Ubrich N, Bouillot P, Pellerin C, et al. Preparation and characterization of propranolol hydrochloride nanoparticles: a comparative study. J Control Release 2004;97:291–300
  • Pérez MH, Zinutti C, Lamprecht A, et al. The preparation and evaluation of poly(ε-caprolactone) microparticles containing both a lipophilic and a hydrophilic drug. J Control Release 2000;65:429–38
  • Hasan AS, Socha M, Lamprecht A, et al. Effect of the microencapsulation of nanoparticles on the reduction of burst release. Int J Pharm 2007;344:53–61
  • Santana DP, Fonseca SGC, Bedor DCG, et al. Aplicação termoanalítica no desenvolvimento e caracterização de micropartículas de PLGA contendo lapachol. Rev Ciênc Farm Básica Apl 2008;29:261–6
  • Tran V, Benoît J, Venier-Julienne M. Why and how to prepare biodegradable, monodispersed, polymeric microparticles in the field of pharmacy? Int J Pharm 2011;407:1–11
  • Bertram U, Bodmeier R. In situ gelling, bioadhesive nasal inserts for extended drug delivery: in vitro characterization of a new nasal dosage form. Eur J Pharm Sci 2006;27:62–71
  • Moebus K, Siepmann J, Bodmeier R. Novel preparation techniques for alginate-poloxamer microparticles controlling protein release on mucosal surfaces. Eur J Pharm Sci 2012;45:358–66
  • Francisco LMB, Cerquetani JA, Bruschi ML. Development and characterization of gelatin and ethylcellulose microparticles designed as platforms to delivery fluoride. Drug Dev Ind Pharm 2012. doi:10.3109/03639045.2012.728610
  • Ferreira SBS, Dias BRA, Obrégon CS, et al. Microparticles containing propolis and metronidazole: in vitro characterization, release study and antimicrobial activity against periodontal pathogens. Pharm Dev Technol 2013. doi:10.3109/10837450.2013.763262
  • Tirkkonen S, Urtti A, Paronen P. Buffer controlled release of indomethacin from ethylcellulose microcapsules. Int J Pharm 1995;124:219–29

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.