Development of thiolated poly(acrylic acid) microparticles for the nasal administration of exenatide

References

• Butler AE, Janson J, Bonner-Weir J, et al. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes miellitus. Diabetes 2003;52:102–10
   PubMed Web of Science ®Google Scholar
• Robles GI, Singh-Franco D. A review of exenatide as adjunctive theraphy in patients with type 2 diabetes. Drug Des Dev Ther 2009;3:219–40
   PubMed Web of Science ®Google Scholar
• Mustata G, Dihn SM. Approaches to oral drug delivery for challenging molecules. CRC Crit Rev Ther Drug Carr Sys 2006;23:1111–35
   Google Scholar
• Khafagy ES, Morishita M, Onuki Y, Takayama K. Current challenges in non-invasive insulin delivery systems: a comparative review. Adv Drug Delivery Rev 2007;59:1521–46
   PubMed Web of Science ®Google Scholar
• Ozsoy Y, Gunor S, Cevher E. Nasal delivery of high moleular weight drugs. Molecules 2009;14:3754–90
   PubMed Web of Science ®Google Scholar
• Leitner VM, Guggi D, Bernkop-Schnurch A. Thiomers in noninvasive polypeptide delivery: in vitro and in vivo characterization of a polycarbophil-cysteine/glutathione gel formulation for human growth hormone. J Pharm Sci 2004;93:1682–91
   PubMed Web of Science ®Google Scholar
• Illum L. Nasal drug delivery: possibilities, problems and solutions. J Control Rel 2003;87:187–98
   PubMed Web of Science ®Google Scholar
• Bernkop-Schnürch A, Steininger S. Synthesis ans characterization of mucoadhesive thiolated polymers. Int J Pharm 2000;194:239–47
   PubMed Web of Science ®Google Scholar
• Clausen A, Bernkop-Schnürch A. In vitro evaluation of the permeation-enhancing effect of thiolated polycarbophil. J Pharm Sci 2000;89:1253–61
   PubMed Web of Science ®Google Scholar
• Marschütz MK, Bernkop-Schnürch A. Thiolated polymers: self-crosslinking properties of thiolated 450 kDa poly(acrylic acid) and their influence on mucoadhesion. Eur J Pharm Biopharm 2002;15:387–94
   Web of Science ®Google Scholar
• Bernkop-Schnürch A, Schwarz V, Steininger S. Polymers with thiol groups: a new generation of mucoadhesive polymers? Pharm Res 1999;16:876–81
   PubMed Web of Science ®Google Scholar
• Leitner VM, Walker GF, Bernkop-Schnurch A. Thiolated polymers: evidence for the formation of disulphide bonds with mucus glycoproteins. Eur J Pharm Biopharm 2003;56:207–14
   PubMed Web of Science ®Google Scholar
• Behl CR, Pimplaskar HK, Sileno AP, Romeo VD. Effects of physicochemical properties and other factors on systemic nasal drug delivery. Adv Drug Delivery Rev 1998;29:89–116
   PubMed Web of Science ®Google Scholar
• Glorieux S, Van der Broeck W, van der Meulenm SM, et al. In vitro culture of porcine respiratory mucosa explants for studying the interaction of porcine viruses with the respiratotory tract. J Virol Methods 2007;142:105–12
   PubMed Web of Science ®Google Scholar
• Schmidt MC, Simmen D, Hilbe M, et al. Validation of excised bovine nasal mucosa as in vitro model to study drug transport andmetabolic pathways in nasal epithelium. J Pharm Sci 2000;89:396–407
   PubMed Web of Science ®Google Scholar
• Toskala E, Haataja J, Shirasaki H, Rautiainen M. Culture of cells harvested with nasal brushing: a method for evaluating ciliary function. Rhinology 2005;29:17–26
   Google Scholar
• Dimova S. High speed digital imaging method for ciliary beat frequency measurement. J Pharm Pharmacol 2005;57:1–6
   PubMedGoogle Scholar
• Ugwoke MI, Agu RU, Jorissen M. Nasal toxicological investigations of Carbopol® 971P formulation of apomorphine: effects on ciliary beat frequency of human nasal primary cell culture and in vivo on rabbit nasal mucosa. Eur J Pharm Biopharm 2000;9:387–96
   Web of Science ®Google Scholar
• Merkus P, Romeijn SG, Verhoef JC, et al. Classification of cilio-inhibitinf effects of nasal drugs. Laryngoscope 2001;111:595–602
   PubMed Web of Science ®Google Scholar
• Sanders P, Washington N, Frier M, et al. The deposition of solution-based and suspension-based aerosols from metered dose inhalers in healthy subjects and asmathic patients. STP Pharm Sci 1997;7:300–6
   Google Scholar
• Jones N. The nose and paranasal sinuses physiology and anatomy. Adv Drug Delivery Rev 2001;51:5–19
   PubMed Web of Science ®Google Scholar
• Marttin E, Nicolaas GM, Schipper NGM, Coos Verhoef J. Nasal mucociliary clearance as a factor in nasal drug delivery. Adv Drug Delivery Rev 1998;29:13–38
   PubMed Web of Science ®Google Scholar
• Arora P, Sharma S, Garg S. Permeability issues in nasal drug delivery. Drug Discov Today 2002;7:967–75
   PubMed Web of Science ®Google Scholar
• Deutel B, Greindl M, Thaurer M, Bernkop-Schnürch A. Novel insulin thiomer nanoparticles: in vivo evaluation of an oral drug delievry system. Biomacromolecules 2008;9:278–85
   PubMed Web of Science ®Google Scholar
• Wadell C, Björk E, Camber O. Nasal drug delivery – evaluation of an in vitro model using porcine nasal mucosa. Eur J Pharm Biopharm 1998;7:197–206
   Web of Science ®Google Scholar
• Di Colo G, Zambito Y, Zaino E. Polymeric enhancers of mucosal epithelia permeability: synthesis, transepithelial penetration-enhancing properties, mechanism of action, safety issues. J Pharm Sci 2008;97:1652–80
   PubMed Web of Science ®Google Scholar
• Ugwoke MI, Verbeke N, Kinget R. The biopharmaceutical aspects of nasal mucoadhesive drug delivery. J Pharm Pharmacol 2001;53:3–22
   PubMed Web of Science ®Google Scholar
• Sommer JU, Gross S, Hörmann K, Stuck BA. Time-dependent changes in nasal ciliary beat frequency. Eur Arch Otorhinolaryngol 2010;267:1383--7
   Google Scholar
• Jorissen M, Willems T, De Boeck K. Duagnostic evaluation of mucociliary transport: from symptoms to coordinated ciliary activity after ciliogenesis in culture. Am J Rhinol 2000;14:345–52
   PubMedGoogle Scholar
• Hoyer H, Schlocker W, Kafedjiiski K. Preparation and evaluation of microparticles from thiolated polymers via jet milling. Eur J Pharm Biopharm 2008;69:476–85
   PubMed Web of Science ®Google Scholar
• Dimova S, Mugabowindekwe R, Willems T, et al. Safety-assestment of 3-methoxyquercetin as an antirhinovial compound for nasal application: effect on ciliary beat frequency. Int J Pharm 2003;263:95–103
   PubMed Web of Science ®Google Scholar