Development and in vitro–in vivo evaluation of a water-in-oil microemulsion formulation for the oral delivery of troxerutin

References

• Fan SH, Zhang ZF, Zheng YL, et al. Troxerutin protects the mouse kidney from d-galactose-caused injury through anti-inflammation and anti-oxidation. Int Immunopharmacol 2009;9:91–6
   PubMed Web of Science ®Google Scholar
• Boisseau MR, Taccoen A, Garreau C, et al. Fibrinolysis and hemorheology in chronic venous insufficiency: a double-blind study of troxerutin efficiency. J Cardiovasc Surg 1995;36:369–74
   PubMed Web of Science ®Google Scholar
• Liu CM, Ma JQ, Lou Y. Chronic administration of troxerutin protects mouse kidney against d-galactose-induced oxidative DNA damage. Food Chem Toxicol 2010;48:2809–17
   PubMed Web of Science ®Google Scholar
• Liu F, Xu Y, Rui L, et al. Liquid chromatography/tandem mass spectrometry assay for the quantification of troxerutin in human plasma. Rapid Commun Mass Spectrom 2006;20:3522–6
   PubMed Web of Science ®Google Scholar
• Cui XY, Zhang ML, Guan X, et al. LC-MS-MS Determination of troxerutin in plasma and its application to a pharmacokinetic study. Chromatographia 2011;73:165–9
   Web of Science ®Google Scholar
• Cheng MB, Wang JC, Li YH, et al. Characterization of water-in-oil microemulsion for oral delivery of earthworm fibrinolytic enzyme. J Control Release 2008;129:41–8
   PubMed Web of Science ®Google Scholar
• Yin YM, Cui FD, Mu CF, et al. Docetaxel microemulsion for enhanced oral bioavailability: preparation and in vitro and in vivo evaluation. J Control Release 2009;140:86–94
   PubMed Web of Science ®Google Scholar
• Shishu, Kamalpreet, Maheshwari M. Development and evaluation of novel microemulsion based oral formulations of 5-fluorouracil using non-everted rat intestine sac model. Drug Dev Ind Pharm 2012;38:294–300
   PubMed Web of Science ®Google Scholar
• Caliph SM, Charman WN, Porter CJ. Effect of short-, medium-, and long-chain fatty acid-based vehicles on the absolute oral bioavailability and intestinal lymphatic transport of halofantrine and assessment of mass balance in lymph-cannulated and non-cannulated rats. J Pharm Sci 2000;89:1073–84
   PubMed Web of Science ®Google Scholar
• Sanjula B, Shah FM, Javed A, Alka A. Effect of poloxamer 188 on lymphatic uptake of carvedilol-loaded solid lipid nanoparticles for bioavailability enhancement. J Drug Target 2009;17:249–56
   PubMed Web of Science ®Google Scholar
• Meng J, Hu L. Positively-charged microemulsion for improving the oral bioavailability of alendronate: in-vitro and in-vivo assessment. J Pharm Pharmacol 2011;63:400–8
   PubMed Web of Science ®Google Scholar
• Ritschel WA. Microemulsion technology in the reformulation of cyclosporine: the reason behind the pharmacokinetic properties of Neoral. Clin Transplant 1996;10:364–73
   PubMed Web of Science ®Google Scholar
• Gundogdu E, Alvarez IG, Karasulu E. Improvement of effect of water-in-oil microemulsion as an oral delivery system for fexofenadine: in vitro and in vivo studies. Int J Nanomedicine 2011;6:1631–40
   PubMed Web of Science ®Google Scholar
• Qi J, Zhuang J, Wu W, et al. Enhanced effect and mechanism of water-in-oil microemulsion as an oral delivery system of hydroxysafflor yellow A. Int J Nanomedicine 2011;6:985–91
   PubMed Web of Science ®Google Scholar
• Chen Z, Ma T, Huang C, et al. Efficiency of transcellular transport and efflux of flavonoids with different glycosidic units from flavonoids of Litsea coreana L. in a MDCK epithelial cell monolayer model. Eur J Pharm Sci 2014;53:69–76
   PubMed Web of Science ®Google Scholar
• Kirjavainen M, Urtti A, Mönkkönen J, Hirvonen J. Influence of lipids on the mannitol flux during transdermal iontophoresis in vitro. Eur J Pharm Sci 2000;10:97–102
   PubMed Web of Science ®Google Scholar
• Wu H, Lu C, Zhou A, et al. Enhanced oral bioavailability of puerarin using microemulsion vehicle. Drug Dev Ind Pharm 2009;35:138–44
   PubMed Web of Science ®Google Scholar
• Lin CC, Lin HY, Chi MH, et al. Preparation of curcumin microemulsions with food-grade soybean oil/lecithin and their cytotoxicity on the HepG2 cell line. Food Chem 2014;154:282–90
   PubMed Web of Science ®Google Scholar
• Volpe DA, Asafu-Adjaye EB, Ellison CD, et al. Effect of ethanol on opioid drug permeability through Caco-2 cell monolayers. AAPS J 2008;10:360–2
   PubMed Web of Science ®Google Scholar
• Avramiotis S, Bekiari VV, Lianos P, Xenakis A. Structural and dynamic properties of lecithin-alcohol based w/o microemulsions: a luminescence quenching study. J Colloid Interface Sci 1997;194:326–31
   PubMed Web of Science ®Google Scholar
• Mouri A, Diat O, Lerner DA, et al. Water solubilization capacity of pharmaceutical microemulsions based on Peceol®, lecithin and ethanol. Int J Pharm 2014;475:324–34
   PubMed Web of Science ®Google Scholar
• Bshara H, Osman R, Mansour S, El-Shamy Ael-H. Chitosan and cyclodextrin in intranasal microemulsion for improved brain buspirone hydrochloride pharmacokinetics in rats. Carbohydr Polym 2014;99:297–305
   PubMed Web of Science ®Google Scholar
• Cho YH, Kim S, Bae EK, et al. Formulation of a cosurfactant-free O/W microemulsion using nonionic surfactant mixtures. J Food Sci 2008;73:E115–21
   PubMed Web of Science ®Google Scholar
• Biruss B, Dietl R, Valenta C. The influence of selected steroid hormones on the physicochemical behavior of DPPC liposomes. Chem Phys Lipid 2007;148:84–90
   PubMed Web of Science ®Google Scholar
• Porter CJ, Trevaskis NL, Charman WN. Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nat Rev Drug Discov 2007;6:231–48
   PubMed Web of Science ®Google Scholar
• Li Y, Song J, Tian N, et al. Improving oral bioavailability of metformin hydrochloride using water-in-oil microemulsions and analysis of phase behavior after dilution. Int J Pharm 2014;473:316–25
   PubMed Web of Science ®Google Scholar
• Tang TT, Hu XB, Liao DH, et al. Mechanisms of microemulsion enhancing the oral bioavailability of puerarin: comparison between oil-in-water and water-in-oil microemulsions using the single-pass intestinal perfusion method and a chylomicron flow blocking approach. Int J Nanomedicine 2013;8:4415–26
   PubMed Web of Science ®Google Scholar
• Constantinides PP. Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm Res 1995;12:1561–72
   PubMed Web of Science ®Google Scholar
• Sha X, Yan G, Wu Y, et al. Effect of self-microemulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cells. Eur J Pharm Sci 2005;24:477–86
   PubMed Web of Science ®Google Scholar
• Press B, Di Grandi D. Permeability for intestinal absorption: caco-2 assay and related issues. Curr Drug Metab 2008;9:893–900
   PubMed Web of Science ®Google Scholar
• Guarino VR, Nti-Addae K, Stella VJ. MDCK cell permeability characteristics of a sulfenamide prodrug: strategic implications in considering sulfenamide prodrugs for oral delivery of NH-acids. Bioorg Med Chem Lett 2011;21:172–5
   PubMed Web of Science ®Google Scholar
• Irvine JD, Takahashi L, Lockhart K, et al. MDCK (Madin–Darby canine kidney) cells: a tool for membrane permeability screening. J Pharm Sci 1999;88:28–33
   PubMed Web of Science ®Google Scholar
• Volpe DA. Drug-permeability and transporter assays in Caco-2 and MDCK cell lines. Future Med Chem 2011;3:2063–77
   PubMed Web of Science ®Google Scholar
• Du W, Fan Y, Zheng N, et al. Transferrin receptor specific nanocarriers conjugated with functional 7peptide for oral drug delivery. Biomaterials 2013;34:794–806
   PubMed Web of Science ®Google Scholar
• Napolitano M, Rainaldi G, Bravo E, Rivabene R. Influence of thiol balance on micellar cholesterol handling by polarized Caco-2 intestinal cells. FEBS Lett 2003;551:165–70
   PubMed Web of Science ®Google Scholar