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Review Article

Mushroom lectins: Current status and future perspectives

, &
Pages 99-126 | Accepted 25 Aug 2009, Published online: 27 Jan 2010

References

  • Ahmad N, Bansal R, Ahmad A, Rastogi AK, Kidwai JR. 1984. Purification of hemagglutinins from Agaricus bisporus by affinity chromatography. Indian J Biochem Biophys 21: 237–240.
  • Amano K, Takase M, Ando A, Nagata Y. 2003. Production of functional lectin in Pichia pastoris directed by cloned cDNA from Aleuria aurantia. Biosci Biotechnol Biochem 67: 2277–2279.
  • Athamna A. 1989a. Annual Meeting of the Israel Society of Microbiology, January 1989 (Abstr.), Haifa, Israel.
  • Athamna A. 1989b. 89th Annual Meeting of the American Society of Microbiology, May 1989 (Abstr. B-104), New Orleans, LA, USA.
  • Banerjee PC, Ghosh AK, Sengupta S. 1982. Hemagglutinating activity in extracts of mycelia from submerged mushroom cultures. Appl Environ Microbiol 44: 1009–1011.
  • Batra RK, Wang-Johanning F, Wagner E, Garver RI Jr, Curiel DT. 1994. Receptor-mediated gene delivery employing lectin-binding specificity. Gene Ther 1: 255–260.
  • Batterbury M, Tebbs CA, Rhodes JM, Grierson I. 2002. Agaricus bisporus (edible mushroom lectin) inhibits ocular fibroblast proliferation and collagen lattice contraction. Exp Eye Res 74: 361–370.
  • Bhowal J, Guha AK, Chatterjee BP. 2005. Purification and molecular characterization of a sialic acid specific lectin from the phytopathogenic fungus Macrophomina phaseolina. Carbohydr Res 340: 1973–1982.
  • Birck C, Damian L, Marty-Detraves C, Lougarre A, Schulze-Briese C, Koehl P, Fournier D, Paquereau L, Samama JP. 2004. A new lectin family with structure similarity to actinoporins revealed by the crystal structure of Xerocomus chrysenteron lectin XCL. J Mol Biol 344: 1409–1420.
  • Blackwell JM, Ezekowitz RA, Roberts MB, Channon JY, Sim RB, Gordon S. 1985. Macrophage complement and lectin-like receptors bind Leishmania in the absence of serum. J Exp Med 162: 324–331.
  • Brechtel R, Wätzig H, Rüdiger H. 2001. The lectin from the mushroom Pleurotus ostreatus: A phosphatase-activating protein that is closely associated with an α-galactosidase activity. Plant Sci 160: 1025–1033.
  • Brock TD, Madigan MT. 1991. Biology of Microorganisms, 6th edition. Prentice-Hall International, Inc., London, UK.
  • Candy L, Peumans WJ, Menu-Bouaouiche L, Astoul CH, Van Damme J, Van Damme EJ, Erard M, Rougé P. 2001. The Gal/GalNAc-specific lectin from the plant pathogenic basidiomycete Rhizoctonia solani is a member of the ricin-B family. Biochem Biophys Res Commun 282: 655–661.
  • Candy L, Van Damme EJ, Peumans WJ, Menu-Bouaouiche L, Erard M, Rougé P. 2003. Structural and functional characterization of the GalNAc/Gal-specific lectin from the phytopathogenic Ascomycete Sclerotinia sclerotiorum (Lib.) de Bary. Biochem Biophys Res Commun 308: 396–402.
  • Carrizo ME, Capaldi S, Perduca M, Irazoqui FJ, Nores GA, Monaco HL. 2005. The antineoplastic lectin of the common edible mushroom (Agaricus bisporus) has two binding sites, each specific for a different configuration at a single epimeric hydroxyl. J Biol Chem 280: 10614–10623.
  • Chang H-H, Chien P-J, Tong M-H, Sheu F. 2007. Mushroom immunomodulatory proteins possess potential thermal/freezing resistance, acid/alkali tolerance and dehydration stability. Food Chem 105: 597–605.
  • Chattopadhyay TK, Lisgarten JN, Brechtel R, Rüdiger H, Palmer RA. 1999. Crystallization of Pleurotus ostreatus (oyster mushroom) lectin. Acta Crystallogr D Biol Crystallogr 55: 1589–1590.
  • Chumkhunthod P, Rodtong S, Lambert SJ, Fordham-Skelton AP, Rizkallah PJ, Wilkinson MC, Reynolds CD. 2006. Purification and characterization of an N-acetyl-D-galactosamine-specific lectin from the edible mushroom Schizophyllum commune. Biochim Biophys Acta 1760: 326–332.
  • Cioci G, Mitchell EP, Chazalet V, Debray H, Oscarson S, Lahmann M, Gautier C, Breton C, Perez S, Imberty A. 2006. β-propeller crystal structure of Psathyrella velutina lectin: An integrin-like fungal protein interacting with monosaccharides and calcium. J Mol Biol 357: 1575–1591.
  • Colceag J, Mogos S, Hulea S. 1984. Studies on occurrence and characterization of phytolectins in some species of mushrooms. Rev Roum Biochim 21: 263–266.
  • Conrad F, Rudiger H. 1994. The lectin from Pleurotus ostreatus: Purification, characterization and interaction with a phosphatase. Phytochemistry 36: 277–283.
  • Cooper DN, Boulianne RP, Charlton S, Farrell EM, Sucher A, Lu BC. 1997. Fungal galectins, sequence and specificity of two isolectins from Coprinus cinereus. J Biol Chem 272: 1514–1521.
  • Coulet M, Guillot J, Bétail G. 1972. Effect of some mono-and polysaccharides on hemagglutinins of higher mycetes. Acta Pol Pharm 29: 309–318.
  • Coulet M, Mustier J, Guillot J. 1970. Les hémagglutininines des champignons. Rev Mycol 35: 71–89.
  • Damian L, Fournier D, Winterhalter M, Paquereau L. 2005. Determination of thermodynamic parameters of Xerocomus chrysenteron lectin interactions with N-acetylgalactosamine and Thomsen-Friedenreich antigen by isothermal titration calorimetry. BMC Biochem 6: 11–17.
  • Devitashvili E, Kopanadze E, Kachlishvili E, Khardziani T, Elisashvili V. 2008. Evaluation of higher Basidiomycetes mushroom lectin activity in submerged solid-state fermentation of agro-industrial residues. Int J Med Mushrooms 10: 171–179.
  • Driessche EV, Cupere FDe, Beeckmans S. 2000. Protein–carbohydrate interactions in the attachment of enterotoxigenic Escherichia coli to the intestinal mucosa. In: Caron M, Sève A-P, eds., Lectins and Pathology (pp. 135–156 ). Amsterdam, Netherlands: Harwood Academic Publishers.
  • Eckhardt AE, Goldstein IJ. 1983. Occurrence of alpha-D-galactosyl-containing glycoproteins on Ehrlich tumor cell membranes. Biochemistry 22: 5280–5289.
  • Eifler R, Ziska P. 1980. The lectins from Agaricus edulis. Isolation and characterization. Experientia 36: 1285–1286.
  • Elifio SL, Da Silva MDCC, Iacomini M, Gorin PAJ. 2000. A lectin from the lichenized Basidiomycete Dictyonema glabratum. New Phytol 148: 327–334.
  • Elo J, Estola, E, Malmstrom N. 1951. On phytoagglutinins present in mushrooms. Ann Med Exp Biol Fenn 29: 297–308.
  • Endo T, Ohbayashi H, Kanazawa K, Kochibe N, Kobata A. 1992. Carbohydrate binding specificity of immobilized Psathyrella velutina lectin. J Biol Chem 267: 707–713.
  • Ennamany R, Kretz O, Badoc A, Deffieux G, Creppy EE. 1994. Effect of bolesatine, a glycoprotein from Boletus satanas, on rat thymus in vivo. Toxicology 89: 113–118.
  • Entlicher, G, Jesenska, K, Jarsova-Dejlova, L, Jarnik, M, Kocourek, J. 1985. Studies on lectins LXIII. Isolation and characterization of a lectin from stinkhorn mushroom Phallus impudicus L.ex. Pers. In: Bog-Hansen TC, Breborowicz, J, eds., Lectins, Biology, Biochemistry, Clinical Biochemstry (Vol. 4. pp. 491–503 ). Walter de Gruyter, Berlin, Germany.
  • Ewart RB, Kornfeld S, Kipnis DM. 1975. Effect of lectins on hormone release from isolated rat islets of langerhans. Diabetes 24: 705–714.
  • Feng K, Liu QH, Ng TB, Liu HZ, Li JQ, Chen G, Sheng HY, Xie ZL, Wang HX. 2006. Isolation and characterization of a novel lectin from the mushroom Armillaria luteo-virens. Biochem Biophys Res Commun 345: 1573–1578.
  • Finne J. 1982. Occurrence of unique polysialosyl carbohydrate units in glycoproteins of developing brain. J Biol Chem 257: 11966–11970.
  • Ford WW. 1910. The distribution of haemolysins, agglutinins and poisons in fungi, especially the Amanitas, the Entolomas, the Lactarius and the Inocybes. J Pharmacol Exp Ther 2: 285–318.
  • Friedberger E, Brossa GA. 1912. Ueber bie wirkungen von pilzextracten. Wir kung der extrakte von champignon Agaricus campestris, Steinpilz (Boletus edulis) und pfefferling (Cantharellus cibarius) auf rote blutkörperchen. Z Immunitätsforsch Exp Ther 15: 506–517.
  • Fujihashi M, Peapus DH, Nakajima E, Yamada T, Saito JI, Kita A, Higuchi Y, Sugawara Y, Ando A, Kamiya N, Nagata Y, Miki K. 2003. X-ray crystallographic characterization and phasing of a fucose-specific lectin from Aleuria aurantia. Acta Crystallogr D Biol Crystallogr 59: 378–380.
  • Fukumori F, Takeuchi N, Hagiwara T, Ito K, Kochibe N, Kobata A, Nagata Y. 1989. Cloning and expression of a functional fucose-specific lectin from an orange peel mushroom, Aleuria aurantia. FEBS Lett 250: 153–156.
  • Fukumori F, Takeuchi N, Hagiwara T, Ohbayashi H, Endo T, Kochibe N, Nagata Y, Kobata A. 1990. Primary structure of a fucose-specific lectin obtained from a mushroom, Aleuria aurantia. J Biochem 107: 190–196.
  • Furukawa K, Ying R, Nakajima T, Matsuki T. 1995. Hemagglutinins in fungus extracts and their blood group specificity. Exp Clin Immunogenet 12: 223–231.
  • Gachet C, Ennamany R, Kretz O, Ohlmann P, Krause C, Creppy EE, Dirheimer G, Cazenave JP. 1996. Bolesatine induces agglutination of rat platelets and human erythrocytes and platelets in vitro. Hum Exp Toxicol 15: 26–29.
  • Gallagher JT. 1984. Carbohydrate-binding properties of lectins: A possible approach to lectin nomenclature and classification. Biosci Rep 4: 621–632.
  • Gatehouse AMR, Powell KS, Pneumans WJ, Van Damme EJM, Gatehouse JA. 1995. Insecticidal properties of plant lectins: Their potential in plant protection. In: Pustzai, A, Bardocz, S, Eds., Lectins: Biochemical Perspectives (pp. 35–57 ). London, UK: Taylor & Francis.
  • Giollant M. 1991. Les lectines des lactaires du groupe Dapestes: (L. deiciosus, L. deterrimus, L. salmonicolor). Purification, étude biochimique et spécificité. Invervention des lectines dans les phénoménes de reconnaissance moléculaire au cours des événements précoces de la mycorrhization avec les conifers associés. Thése de Doctorat en Pharmacie, Clemont-Ferrend.
  • Giollant M, Guillot J, Damez M, Dussser M, Didier P, Didier E. 1993. Characterization of a lectin from Lactarius deterrimus. Plant Physiol 101: 513–522.
  • Gold ER, Balding, P. 1975. Receptor-specific proteins. Plant and Animal Lectins. Amsterdam, Netherlands: Excerpta Medica.
  • Goldstein IJ, Winter HC, Aurandt J, Confer L, Adamson JT, Hakansson K, Remmer H. 2007. A new alpha-galactosyl-binding protein from the mushroom Lyophyllum decastes. Arch Biochem Biophys 467: 268–274.
  • Goldstein IJ, Hughes RC, Monsigny M, Osawa T, Sharon N. 1980. What should be called a lectin? Nature 285: 66.
  • Goldstein IJ, Winter HC. 2007. Mushroom lectins. In: Kamerling J, Boons G-J, Lee Y, Suzuki A, Taniguchi N, Voragen AGJ, eds., Comprehensive Glycoscience (Vol. 3). UK: Elsevier.
  • Goldstein IJ, Winter HC, Poretz RD. 1997. Plant lectins: Tools for the study of complex carbohydrates. In: Montreuil J, Vliegenthart JFG, Schachter H, eds., Glycoproteins II (pp. 403–407 ). Amsterdam, Netherlands: Elsevier.
  • Grahn EM, Winter HC, Tateno H, Goldstein IJ, Krengel U. 2009. Structural characterization of a lectin from the mushroom Marasmius oreades in complex with the blood group B trisaccharide and calcium. J Mol Biol 390: 457–466.
  • Grant KA, Dickinson JH, Payne MJ, Campbell S, Collins MD, Kroll RG. 1993. Use of the polymerase chain reaction and 16S rRNA sequences for the rapid detection of Brochothrix spp. in foods. J Appl Bacteriol 74: 260–267.
  • Greene WC, Fleisher TA, Waldmann TA. 1981. Suppression of human T and B lymphocyte activation by Agaricus bisporus lectin. I. Suggestive evidence for a surface “suppressor” receptor in human lymphocytes. J Immunol 126: 580–586.
  • Griffaut B, Guiltat C, Guillot J. 1990. In vitro breaking of dormancy in Jerusalem artichoke tuber buds promoted by two N-acetyl hexosamines. Effect on lectin content. Plant Physiol Biochem 28: 683–689.
  • Guillot J, Coulet M. 1974. Properties of the anti (A plus B) lectin of Hygrophorus hypothejus Fr. Fixation, elution, inhibition. Rev Fr Transfus 17: 49–57
  • Guillot, J., Gernaud, L, Gueugnot, I, Damez, M. 1983. Purification and properties of two hemagglutinins of the mushroom Laccaria amethystina. Biochemistry 22: 5365–5369.
  • Guillot J, Giollant M, Damez M, Dusser M. 1991. Isolation and characterization of a lectin from the mushroom, Lactarius deliciosus. J Biochem 109: 840–845.
  • Guillot J, Giollant M, Damez M, Dussser M. 1994. Involvement of fungal lectins in recognition between mushroom and tree during the early stages of mycorrhiza formation. Acta Bot Gallica 141: 443–447.
  • Hajto T, Hostanska K, Frei K, Rordorf C, Gabius HJ. 1990. Increased secretion of tumor necrosis factors alpha, interleukin 1, and interleukin 6 by human mononuclear cells exposed to beta-galactoside-specific lectin from clinically applied mistletoe extract. Cancer Res 50: 3322–3326.
  • Hakomori S. 1992. Functional role of glycosphingolipids in tumor progression. Tohoku J Exp Med 168: 211–222.
  • Hamilton AJ, Jeavons L, Youngchim S, Vanittanakom N, Hay RJ. 1998. Sialic acid-dependent recognition of laminin by Penicillium marneffei conidia. Infect Immun 66: 6024–6026.
  • Han CH, Liu QH, Ng TB, Wang HX. 2005. A novel homodimeric lactose-binding lectin from the edible split gill medicinal mushroom Schizophyllum commune. Biochem Biophys Res Commun 336: 252–257.
  • Haselhorst T, Weimar T, Peters T. 2001. Molecular recognition of sialyl Lewis(x) and related saccharides by two lectins. J Am Chem Soc 123: 10705–10714.
  • Hernandez E, Ortiz R, Lopez F, Masso F, Montano LF, Martinage A, Zenteno E. 1993. Purification and characterization of a galactose-specific lectin from Psilocybe barrerae. Phytochemistry 32: 1209–1211.
  • Hirano S, Matsuura Y, Kusunoki M, Kitagawa Y, Katsube Y. 1987. Two crystalline forms of a lectin from Flammulina veltipes. J Biochem 102: 445–446.
  • Ho JCK, Sze SCW, Shen WZ, Liu WK. 2004. Mitogenic activity of edible mushroom lectins. Biochim Biophys Acta 1671: 9–17.
  • Hohl HR, Balsiger S. 1986. A model system for the study of fungus host surface interactions: Adhesion of Phytophtora megasperma to protoplasts and mesophyll cells of soybean. In: Lugtenberg B, ed., Recognition in Microbe-Plant Symbiotic and Pathogenic Interaction (Vol. 4. pp. 259–272 ), Berlin, Heidelberg, Germany: Springer-Verlag.
  • Horejsí V, Kocourek J. 1978. Studies on lectins. XXXVI. Properties of some lectins prepared by affinity chromatography on O-glycosyl polyacrylamide gels. Biochim Biophys Acta 538: 299–215.
  • Hsu HC, Hsu CI, Lin RH, Kao CL, Lin JY. 1997. Fip-vvo, a new fungal immunomodulatory protein isolated from Volvariella volvacea. Biochem J 323: 557–565.
  • Iijima N, Amano K, Ando A, Nagata Y. 2003. Production of fruiting body lectins of Pleurotus cornucopiae in methylotrophic yeast Pichia pastoris. J Biosci Bioengg 95: 416–418.
  • Ishikawa F, Oishi K, Aida K. 1983. Chitin-binding hemagglutinin associated with cell wall of Conidiobolus lamprauges. Agric Biol Chem 47: 587–592.
  • Janzen DH, Juster HB, Liener IE. 1976. Insecticidal action of the phytohemagglutinin in black beans on a bruchid beetle. Science 192: 795–796.
  • Jung EC, Kim KD, Bae CH, Kim JC, Kim DK, Kim HH. 2007. A mushroom lectin from ascomycete Cordyceps militaris. Biochim Biophys Acta 1770: 833–838.
  • Kan VL, Bennett JE. 1988. Lectin-like attachment sites on murine pulmonary alveolar macrophages bind Aspergillus fumigatus conidia. J Infect Dis 158: 407–414.
  • Kaneko T, Oguri S, Kato SI, Nagata Y. 1993. Developmental appearance of lectin during fruit body formation in Pleurotus cornucopiae. J Gen Appl Microbiol 39: 83–90.
  • Kawagishi H, Abe Y, Nagata T, Kimura A, Chiba S. 1991. A lectin from the mushroom Pholiota aurivella. Agric Biol Chem 55: 2485–2489.
  • Kawagishi H, Mizuno T. 1988. Purification and properties of a β-galactosyl-specific lectin from the fruiting bodies of Ischnoderma resinosum. FEBS Lett 227: 99–102.
  • Kawagishi H, Mori H. 1991. Chemical modification and NMR studies on a mushroom lectin Ischnoderma resinosum agglutinin (IRA). Biochim Biophys Acta 1076: 179–186.
  • Kawagishi H, Mitsunaga S, Yamawaki M, Ido M, Shimada A, Kinoshita T, Murata T, Usui T, Kimura A, Chiba S. 1997. A lectin from mycelia of the fungus Ganoderma lucidum. Phytochemistry 44: 7–10.
  • Kawagishi H, Mori H, Uno A, Kimura A, Chiba S. 1994. A sialic acid-binding lectin from the mushroom Hericium erinaceum. FEBS Lett 340: 56–58.
  • Kawagishi H, Nomura A, Mizuno T, Kimura A, Chiba S. 1990. Isolation and characterization of a lectin from Grifola frondosa fruiting bodies. Biochim Biophys Acta 1034: 247–252.
  • Kawagishi H, Nomura A, Yumen T, Mizuno T, Hagiwara T, Nakamura T. 1988. Isolation and properties of a lectin from the fruiting bodies of Agaricus blazei. Carbohydr Res 183: 150–154.
  • Kawagishi H, Suzuki H, Watanabe H, Nakamura H, Sekiguchi T, Murata T, Usui T, Sugiyama K, Suganuma H, Inakuma T, Ito K, Hashimoto Y, Ohnishi-Kameyama M, Nagata T. 2000. A lectin from an edible mushroom Pleurotus ostreatus as a food intake-suppressing substance. Biochim Biophys Acta 1474: 299–308.
  • Kawagishi H, Takagi J-i, Taira T, Murata T, Usui T. 2001. Purification and characterization of a lectin from the mushroom Mycoleptodonoides aitchisonii. Phytochemistry 56: 53–58.
  • Kawagishi H, Wasa T, Murata T, Usui T, Kimura A, Chiba S. 1996. Two N-acetyl-D-galactosamine-specific lectins from Phaeolepiota aurea. Phytochemistry 41: 1013–1016.
  • Kent D, Sheridan C, Tomkinson HA, White S, Hiscott P, Grierson I. 2003. Edible mushroom (Agaricus bisporus) lectin modulates human retinal pigment epithelial cell behaviour in vitro. Exp Eye Res 76: 213–219.
  • Khan F, Ahmad A, Khan MI. 2007. Purification and characterization of a lectin from endophytic fungus Fusarium solani having complex sugar specificity. Arch Biochem Biophys 457: 243–251.
  • Kim H, Cho K-M, Gerelchuluun T, Lee J-S, Chung K-S, Lee CK. 2007. Lectins isolated from mushroom Fomitella fraxinea enhance MHC-restricted exogenous antigen presentation. Immune Net 7: 197–202.
  • Ko JL, Hsu CI, Lin RH, Kao CL, Lin JY. 1995. A new fungal immunomodulatory protein, FIP-fve isolated from the edible mushroom, Flammulina velutipes and its complete amino acid sequence. Eur J Biochem 228: 244–249.
  • Kobayashi Y, Kobayashi K, Umehara K, Dohra H, Murata T, Usui T, Kawagishi H. 2004. Purification, characterization, and sugar binding specificity of an N-glycolylneuraminic acid-specific lectin from the mushroom Chlorophyllum molybdites. J Biol Chem 279: 53048–53055.
  • Kobayashi Y, Nakamura H, Sekiguchi T, Takanami R, Murata T, Usui T, Kawagishi H. 2005. Analysis of the carbohydrate binding specificity of the mushroom Pleurotus ostreatus lectin by surface plasmon resonance. Anal Biochem 336: 87–93.
  • Kochibe N, Furukawa K. 1980. Purification and properties of a novel fucose-specific hemagglutinin of Aleuria aurantia. Biochemistry 19: 2841–2846.
  • Kochibe N, Matta KL. 1989. Purification and properties of an N-acetylglucosamine-specific lectin from Psathyrella velutina mushroom. J Biol Chem 264: 173–177.
  • Kogure T. 1975. On the specificity of mushroom Pleurotus ostreatus and Pleurotus spodoleucus extracts. Vox Sang 29: 221–227.
  • Konska G. 1988. A survey of domestic species of Basidiomycetes fungi for the presence of lectins in their carpophores. Acta Societatis Botanicorum Poloniae 57: 247–260.
  • Konska G, Guillot J, Dusser M, Damez M, Botton B. 1994. Isolation and characterization of an N-acetyllactosamine-binding lectin from the mushroom Laetiporus sulfureus. J Biochem 116: 519–523.
  • Koyama Y, Katsuno Y, Miyoshi N, Hayakawa S, Mita T, Muto H, Isemura S, Aoyagi Y, Isemura M. 2002. Apoptosis induction by lectin isolated from the mushroom Boletopsis leucomelas in U937 cells. Biosci Biotechnol Biochem 66: 784–789.
  • Koyama Y, Suzuki T, Odani S, Nakamura S, Kominami J, Hirabayashi J, Isemura M. 2006. Carbohydrate specificity of lectins from Boletopsis leucomelas and Aralia cordate. Biosci Biotechnol Biochem 70: 542–545.
  • Kretz O, Creppy EE, Dirheimer G. 1991. Characterization of bolesatine, a toxic protein from the mushroom Boletus satanas Lenz and it’s effects on kidney cells. Toxicology 66: 213–224.
  • Kruger RP, Winter HC, Simonson-Leff N, Stuckey JA, Goldstein IJ, Dixon JE. 2002. Cloning, expression, and characterization of the Galalpha 1,3Gal high affinity lectin from the mushroom Marasmius oreades. J Biol Chem 277: 15002–15005.
  • Lambkin I, Pinilla C, Hamashin C, Spindler L, Russell S, Schink A, Moya-Castro R, Allicotti G, Higgins L, Smith M, Dee J, Wilson C, Houghten R, O’Mahony D. 2003. Toward targeted oral vaccine delivery systems: Selection of lectin mimetics from combinatorial libraries. Pharm Res 20: 1258–1266.
  • Li YR, Liu QH, Wang HX, Ng TB. 2008. A novel lectin with potent antitumor, mitogenic and HIV-1 reverse transcriptase inhibitory activities from the edible mushroom Pleurotus citrinopileatus. Biochim Biophys Acta 1780: 51–57.
  • Licastro F, Morini MC, Kretz O, Dirheimer G, Creppy EE, Stirpe F. 1993. Mitogenic activity and immunological properties of bolesatine, a lectin isolated from the mushroom Boletus satanas Lenz. Int J Biochem 25: 789–792.
  • Liljeblad M, Lundblad A, Påhlsson P. 2000. Analysis of agalacto-IgG in rheumatoid arthritis using surface plasmon resonance. Glycoconj J 17: 323–329.
  • Lin JY, Chou TB. 1984. Isolation and characterization of a lectin from edible mushroom, Volvariella volvacea. J Biochem 96: 35–40.
  • Liu C, Zhao X, Xu XC, Li LR, Liu YH, Zhong SD, Bao JK. 2008. Hemagglutinating activity and conformation of a lactose-binding lectin from mushroom Agrocybe cylindracea. Int J Biol Macromol 42: 138–144.
  • Liu Q, Wang H, Ng TB. 2004. Isolation and characterization of a novel lectin from the wild mushroom Xerocomus spadiceus. Peptides 25: 7–10.
  • Liu Q, Wang H, Ng TB. 2006. First report of a xylose-specific lectin with potent hemagglutinating, antiproliferative and anti-mitogenic activities from a wild ascomycete mushroom. Biochim Biophys Acta 1760: 1914–1919.
  • Liua W, Ho JC, Ng T. 2001. Suppression of cell cycle progression by a fungal lectin: Activation of cyclin-dependent kinase inhibitors. Biochem Pharmacol 61: 33–37.
  • Lockhart CM, Rowell P, Stewart WDP. 1978. Phytohaemagglutinins from the nitrogen-fixing lichens Peltigera canina and Peltigera polydactyla. FEMS Microbiol Lett 3: 127–130.
  • Loganathan D, Winter HC, Judd WJ, Petryniak J, Goldstein IJ. 2003. Immobilized Marasmius oreades agglutinin: Use for binding and isolation of glycoproteins containing the xenotransplantation or human type B epitopes. Glycobiology 13: 955–960.
  • Lutsik-Kordovsky MD, Stasyk TV, Stoika RS. 2001. Analysis of cytotoxicity of lectin and non-lectin proteins from Amanita mushrooms. Exp Oncol 23: 43–45.
  • Mahajan RG, Patil SI, Mohan DR, Shastry P. 2002. Pleurotus eous mushroom lectin (PEL) with mixed carbohydrate inhibition and antiproliferative activity on tumor cell lines. J Biochem Mol Biol Biophys 6: 341–345.
  • Marty-Detraves C, Francis F, Baricault L, Fournier D, Paquereau L. 2004. Inhibitory action of a new lectin from Xerocomus chrysenteron on cell-substrate adhesion. Mol Cell Biochem 258: 49–55.
  • Matsumoto H, Natsume A, Ueda H, Saitoh T, Ogawa H. 2001. Screening of a unique lectin from 16 cultivable mushrooms with hybrid glycoprotein and neoproteoglycan probes and purification of a novel N-acetylglucosamine-specific lectin from Oudemansiella platyphylla fruiting body. Biochim Biophys Acta 1526: 37–43.
  • Matsumura K, Higashida K, Ishida H, Hata Y, Yamamoto K, Shigeta M, Mizuno-Horikawa Y, Wang X, Miyoshi E, Gu J, Taniguchi N. 2007. Carbohydrate binding specificity of a fucose-specific lectin from Aspergillus oryzae: A novel probe for core fucose. J Biol Chem 282: 15700–15708.
  • Mikiashvili NA, Elisashvili VI, Wasser SP, Nevo E. 2006. Comparative study of lectin activity of higher Basidiomycetes. Int J Med Mushrooms 8: 31–38.
  • Mirelman D, Galun E, Sharon N, Lotan R. 1975. Inhibition of fungal growth by wheat germ agglutinin. Nature 256: 414–416.
  • Mo H, Winter HC, Goldstein IJ. 2000. Purification and characterization of a Neu5Acalpha2-6Galbeta1-4Glc/GlcNAc-specific lectin from the fruiting body of the polypore mushroom Polyporus squamosus. J Biol Chem 275: 10623–10629.
  • Mody R, Joshi S, Chaney W. 1995. Use of lectins as diagnostic and therapeutic tools for cancer. J Pharmacol Toxicol Methods 33: 1–10.
  • Moore JS, Wu X, Kulhavy R, Tomana M, Novak J, Moldoveanu Z, Brown R, Goepfert PA, Mestecky J. 2005. Increased levels of galactose-deficient IgG in sera of HIV-1-infected individuals. AIDS 19: 381–389.
  • Musilek, M, Ticha, M, Volc, J, Kocourek, J. 1990. Studies on lectins LXXI. Lectins in mycelial culture of Kuehneromyces mutabilis, Pholiota squarrosa and Flammulina velutipes. In: Kocourek J, Freed DLJ, eds., Lectins-Biology, Biochemistry, Clinical Biochemistry (Vol. 7. pp. 53–56 ). St. Louis, USA: Sigma Chemical Company.
  • Nagata Y, Fukumori F, Sakai H, Hagiwara T, Hiratsuka Y, Kochibe N, Kobata A. 1991. Crystallization and characterization of a lectin obtained from a mushroom, Aleuria aurantia. Biochim Biophys Acta 1076: 187–190.
  • Nagata Y, Yamashita M, Honda H, Akabane J, Uehara K, Saito A, Sumisa F, Nishibori K, Oodaira Y. 2005. Characterization, occurrence, and molecular cloning of a lectin from Grifola frondosa: Jacalin-related lectin of fungal origin. Biosci Biotechnol Biochem 69: 2374–2380.
  • Naisbett B, Woodley J. 1995. The potential use of tomato lectin for oral drug delivery: 4. Immunological consequences. Int J Pharmaceutics 120: 247–254.
  • Nel AE. 2002. T-cell activation through the antigen receptor. Part 1: signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse. J Allergy Clin Immunol 109: 758–770.
  • Ng TB, Lam YW. 2002. Isolation of a novel agglutinin with complex carbohydrate binding specificity from fresh fruiting bodies of the edible mushroom Lyophyllum shimeiji. Biochem Biophys Res Commun 290: 563–568.
  • Ng TB, Ngai PH, Xia L. 2006. An agglutinin with mitogenic and antiproliferative activities from the mushroom Flammulina velutipes. Mycologia 98: 167–171.
  • Ngai PH, Ng TB. 2004. A mushroom (Ganoderma capense) lectin with spectacular thermostability, potent mitogenic activity on splenocytes, and antiproliferative activity toward tumor cells. Biochem Biophys Res Commun 314: 988–993.
  • Ofek I, Kahane I, Sharon N. 1996. Toward anti-adhesion therapy for microbial diseases. Trends Microbiol 4: 297–299.
  • Ogata S, Koganty R, Reddish M, Longenecker BM, Chen A, Perez C, Itzkowitz SH. 1998. Different modes of sialyl-Tn expression during malignant transformation of human colonic mucosa. Glycoconj J 15: 29–35.
  • Ogawa S, Nakajima E, Nagao H, Ohtoshi M, Ando A, Nagata Y. 1998. Synthesis of a lectin in both mycelia and fruit bodies of the Ascomycete mushroom Aleuria aurantia. Biosci Biotechnol Biochem 62: 915–918.
  • Ogawa S, Otta Y, Ando A, Nagata Y. 2001. A lectin from an ascomycete mushroom, Melastiza chateri: No synthesis of the lectin in mycelial isolate. Biosci Biotechnol Biochem 65: 686–689.
  • Oguri S, Ando A, Nagata Y. 1996. A novel developmental stage-specific lectin of the basidiomycete. Pleurotus cornucopiae. J Bacteriol 178: 5692–5698.
  • Olausson J, Tibell L, Jonsson BH, Påhlsson P. 2008. Detection of a high affinity binding site in recombinant Aleuria aurantia lectin. Glycoconj J 25: 753–762.
  • Otta, Y, Amano, K, Nishiyama, K, Ando, A, Ogawa, S, Nagata, Y. 2002. Purification and properties of a lectin from Ascomycete mushroom, Ciborinia camelliae. Carbohydr. Res, 340: 1973–1982.
  • Panchak LV, Antoniuk VO. 2007. Purification of lectin from fruiting bodies of Lactarius rufus (Scop.: Fr.)Fr. and its carbohydrate specificity. Ukr Biokhim Zh 79: 123–128.
  • Pardoe GI, Uhlenbruck G, Anstee DJ, Reifenberg U. 1969. On the specificity of broad spectrum agglutinins. 3. Heterophile agglutinins associated with anti-B-like specificity. Z Immunitatsforsch Allerg Klin Immunol 139: 468–485.
  • Park JH, Ryu CS, Kim HN, Na YJ, Park HJ, Kim H. 2004. A sialic acid-specific lectin from the mushroom Paecilomyces japonica that exhibits hemagglutination activity and cytotoxicity. Protein Pept Lett 11: 563–569.
  • Parslew R, Jones KT, Rhodes JM, Sharpe GR. 1999. The antiproliferative effect of lectin from the edible mushroom (Agaricus bisporus) on human keratinocytes: Preliminary studies on its use in psoriasis. Br J Dermatol 140: 56–60.
  • Pemberton RT. 1994. Agglutinins (lectins) from some British higher fungi. Mycological Res 98: 277–290.
  • Petit P. 1978. Phytolectins from the nitrogen-fixing lichen Peltigera horizontalis: The binding pattern of primary protein extract. New Phytol, 91: 705–710.
  • Petit P, Lallemant R, Savoye D. 1983. Purified phytolectin from the lichen Peltigera canina var canina which binds to the phycobiont cell walls and its use as cytochemical marker in situ. New Phytol 94: 103–110.
  • Pohleven J, Obermajer N, Sabotic J, Anzlovar S, Sepcic K, Kos J, Kralj B, Strukelj B, Brzin J. 2009. Purification, characterization and cloning of a ricin B-like lectin from mushroom Clitocybe nebularis with antiproliferative activity against human leukemic T cells. Biochim Biophys Acta 1790: 173–181.
  • Prassanti A, Hart GW. 1988. Cell surface sialylation and tumor metastasis. J Biol Chem 263: 7591–7603.
  • Rempel BP, Winter HC, Goldstein IJ, Hindsgaul O. 2002. Characterization of the recognition of blood group B trisaccharide derivatives by the lectin from Marasmius oreades using frontal affinity chromatography-mass spectrometry. Glycoconj J 19: 175–180.
  • Rosén S, Ek B, Rask L, Tunlid A. 1992. Purification and characterization of a surface lectin from the nematode-trapping fungus Arthrobotrys oligospora. J Gen Microbiol 138: 2663–2672.
  • Rosenzweig WD, Ackroyd D. 1983. Binding characteristics of lectins involved in the trapping of nematodes by fungi. Appl Environ Microbiol 46: 1093–1096.
  • Roth-Walter F, Schöll I, Untersmayr E, Fuchs R, Boltz-Nitulescu G, Weissenböck A, Scheiner O, Gabor F, Jensen-Jarolim E. 2004. M cell targeting with Aleuria aurantia lectin as a novel approach for oral allergen immunotherapy. J Allergy Clin Immunol 114: 1362–1368.
  • Roth-Walter F, Schöll I, Untersmayr E, Ellinger A, Boltz-Nitulescu G, Scheiner O, Gabor F, Jensen-Jarolim E. 2005. Mucosal targeting of allergen-loaded microspheres by Aleuria aurantia lectin. Vaccine 23: 2703–2710.
  • Sage HJ, Connett SL. 1969. Studies on a hemagglutinin from the meadow mushroom. II. Purification, composition, and structure of Agaricus campestris hemagglutinin. J Biol Chem 244: 4713–4719.
  • Sage HJ, Vazquez JJ. 1967. Studies on a hemagglutinin from the mushroom Agaricus campestris. J Biol Chem 242: 120–125.
  • Sansonetti PJ, Phalipon A. 1999. M cells as ports of entry for enteroinvasive pathogens: mMechanisms of interaction, consequences for the disease process. Semin Immunol 11: 193–203.
  • Schauer R. 1982. Chemistry, metabolism, and biological functions of sialic acids. Adv Carbohydr Chem Biochem 40: 131–234.
  • Sharon N, Lis H. 1972. Lectins: Cell-agglutinating and sugar-specific proteins. Science 177: 949–959.
  • Sharon N, Lis H. 1989. Lectins as cell recognition molecules. Science 246: 227–234.
  • She QB, Ng TB, Liu WK. 1998. A novel lectin with potent immunomodulatory activity isolated from both fruiting bodies and cultured mycelia of the edible mushroom Volvariella volvacea. Biochem Biophys Res Commun 247: 106–111.
  • Singh RS, Sharma S, Kaur G, Bhari R. 2009a. Screening of Penicillium species for occurrence of lectins and their characterization. J Basic Microbiol 49: 471–476.
  • Singh RS, Thakur G, Bhari R. 2009b. Optimization of culture conditions and characterization of a new lectin from Aspergillus niger. Indian J Microbiol 49: 219–222.
  • Singh RS, Tiwary AK, Bhari R. 2008. Screening of Aspergillus species for occurrence of lectins and their characterization. J Basic Microbiol 48: 112–117.
  • Singh RS, Tiwary AK, Kennedy JF. 1999. Lectins: Sources, activities, and applications. Crit Rev Biotechnol 19: 145–178.
  • Speert DP, Wright SD, Silverstein SC, Mah B. 1988. Functional characterization of macrophage receptors for in vitro phagocytosis of unopsonized Pseudomonas aeruginosa. J Clin Invest 82: 872–879.
  • Springer GF. 1997. Immunoreactive T and Tn epitopes in cancer diagnosis, prognosis, and immunotherapy. J Mol Med 75: 594–602.
  • Stepanova LV, Burygin GL, Matora LYu, Bogatyrev VA, Sokolova MK, Nikitina VE. 2009. Localization and immunochemical characteristics of Basidiomycete Grifola frondosa (Fr.) S.F. Gray lectin]. Microbiology 78: 202–207.
  • Stepanova LV, Nikitina VE, Boiko AS. 2007. Isolation and characterization of lectin from the surface of Grifola frondosa (Fr.) S.F. Gray mycelium. Mikrobiologiia 76: 429–434.
  • Stepanova LV, Nikitina VE, Tsivileva OM, Loshchinina EA, Garibova LV, Tyuryukina EV. 2006. Hemagglutinating activity of some basidial xylotrophs at the stage of dikaryotic mycelium. Mikol Fitopatol 40: 307–313.
  • Stillmark H. 1888. Ricin, a toxic enzyme from seeds of Ricinus communis L. and some other Euphorbiaceae. Dissertation, Medical School of Dorpat, Estonia.
  • Sueyoshi S, Tsuji T, Osawa T. 1985. Purification and characterization of four isolectins of mushroom (Agaricus bisporus). Biol Chem Hoppe-Seyler 366: 213–221.
  • Sumisa F, Iijima N, Ando A, Shiga M, Kondo K, Amano K, Nagata Y. 2004. Properties of mycelial aggregate-specific lectin of Pleurotus cornucopiae produced in Pichia pastoris. Biosci Biotechnol Biochem 68: 959–960.
  • Sun H, Zhao CG, Tong X, Qi YP. 2003. A lectin with mycelia differentiation and antiphytovirus activities from the edible mushroom Agrocybe aegerita. J Biochem Mol Biol 36: 214–222.
  • Suzuki T, Amano Y, Fujita M, Kobayashi Y, Dohra H, Hirai H, Murata T, Usui T, Morita T, Kawagishi H. 2009. Purification, characterization, and cDNA cloning of a lectin from the mushroom Pleurocybella porrigens. Biosci Biotechnol Biochem 73: 702–709.
  • Sychrova H, Tichá M, Kocourek J. 1985. Studies on lectins. LIX. Isolation and properties of lectins from fruiting bodies of Xerocomus chrysenteron and Lactarius lignyotus. Can J Biochem Cell Biol 63: 700–704.
  • Sze SC, Ho JC, Liu WK. 2004. Volvariella volvacea lectin activates mouse T lymphocytes by a calcium dependent pathway. J Cell Biochem 92: 1193–1202.
  • Tateno H, Goldstein IJ. 2003. Molecular cloning, expression, and characterization of novel hemolytic lectins from the mushroom Laetiporus sulphureus, which show homology to bacterial toxins. J Biol Chem 278: 40455–40463.
  • Tateno H, Goldstein IJ. 2004. Partial identification of carbohydrate-binding sites of a Galalpha1,3Galbeta1,4GlcNAc-specific lectin from the mushroom Marasmius oreades by site-directed mutagenesis. Arch Biochem Biophys 427: 101–109.
  • Tateno H, Winter HC, Goldstein IJ. 2004. Cloning, expression in Escherichia coli and characterization of the recombinant Neu5Acalpha2,6Galbeta1,4GlcNAc-specific high-affinity lectin and its mutants from the mushroom Polyporus squamosus. Biochem J 382: 667–675.
  • Teneberg S, Lönnroth I, Torres López JF, Galili U, Halvarsson MO, Angström J, Karlsson KA. 1996. Molecular mimicry in the recognition of glycosphingolipids by Gal alpha 3 Gal beta 4 GlcNAc beta-binding Clostridium difficile toxin A, human natural anti alpha-galactosyl IgG and the monoclonal antibody Gal-13: Characterization of a binding-active human glycosphingolipid, non-identical with the animal receptor. Glycobiology 6: 599–609.
  • Tetry A, Sutton E, Moullec J. 1954. Presence of specific phytoagglutinin anti-O in fungus ascomycete Xylaria polymorpha (Pearson) Grev.. C R Hebd Seances Acad Sci 238: 277–278.
  • Thakur A, Rana M, Lakhanpal TN, Ahmad A, Khan MI. 2007a. Purification and characterization of lectin from fruiting body of Ganoderma lucidum. Biochim. Biophys Acta 1770: 1404–1412.
  • Thakur A, Pal L, Ahmad A, Khan MI. 2007. Complex carbohydrate specificity of lectin from fruiting body of Ganoderma lucidum. A surface plasmon resonance study. IUBMB Life 59: 758–764.
  • Ticha M, Dudova V, Kocourek J, Volc J. 1985. Studies on lectins LXII. A non-specific erythroagglutinating lectin and a blood group A specific lectin in the mushroom Agrocybe aegerita (Brig.) Sing. In: Bog-Hansen CT, Breborowicz J, eds., Biology, Biochemistry, Clinical Biochemistry (Vol. 4. pp. 505–514 ). Berlin, Germany: Walter de Gruyter.
  • Ticha M, Sychrova H, Kocourek J. 1988. Saccharide binding properties of lectins of higher fungi. In: Bog-Hansen CT, Freed DLJ, eds., Lectins (Vol. 6. pp. 383–391 ). St Louis, USA: Sigma Chemical Co.
  • Tiwary AK, Singh RS. 1999. Lectins: Novel drug targeting molecules. Ind J Pharm Sci 61: 259–267.
  • Toma V, Zuber C, Winter HC, Goldstein IJ, Roth J. 2001. Application of a lectin from the mushroom Polysporus squamosus for the histochemical detection of the NeuAcalpha2,6Galbeta1,4Glc/GlcNAc sequence of N-linked oligosaccharides: A comparison with the Sambucus nigra lectin. Histochem Cell Biol 116: 183–193.
  • Trigueros V, Lougarre A, Ali-Ahmed D, Rahbé Y, Guillot J, Chavant L, Fournier D, Paquereau L. 2003. Xerocomus chrysenteron lectin: identification of a new pesticidal protein. Biochim Biophys Acta 1621: 292–298.
  • Tronchin G, Esnault K, Sanchez M, Larcher G, Marot-Leblond A, Bouchara JP. 2002. Purification and partial characterization of a 32-kilodalton sialic acid-specific lectin from Aspergillus fumigatus. Infect Immun 70: 6891–6895.
  • Tsivileva OM, Nikitina VE, Garibova LV. 2005. Effect of culture medium composition on the activity of extracellular lectins of Lentinus edodes. Appl Biochem Microbiol 41: 174–176.
  • Tsivileva OM, Nikitina VE, Garibova LV, Zav’yalova LA, Ignatov VV. 2000. Hemagglutinating activity of the fungus Lentinus edodes (Berk.) Sing [Lentinus edodes (Berk.) Pegler]. Microbiology 69: 30–35.
  • Tsuchiya N, Endo T, Matsuta K, Yoshinoya S, Takeuchi F, Nagano Y, Shiota M, Furukawa K, Kochibe N, Ito K. 1993. Detection of glycosylation abnormality in rheumatoid IgG using N-acetylglucosamine-specific Psathyrella velutina lectin. J Immunol 151: 1137–1146.
  • Tsuda M. 1979. Purification and characterization of a lectin from the mushroom, Flammulina veltipes. J Biochem 86: 1463–1468.
  • Ueda H, Kojima K, Saitoh T, Ogawa H. 1999a. Interaction of a lectin from Psathyrella velutina mushroom with N-acetylneuraminic acid. FEBS Lett 448: 75–80.
  • Ueda H, Saitoh T, Kojima K, Ogawa H. 1999. Multi-specificity of a Psathyrella velutina mushroom lectin: heparin/pectin binding occurs at a site different from the N-acetylglucosamine/N-acetylneuraminic acid-specific site. J Biochem 126: 530–537.
  • Ueda H, Matsumoto H, Takahashi N, Ogawa H. 2002. Psathyrella velutina mushroom lectin exhibits high affinity toward sialoglycoproteins possessing terminal N-acetylneuraminic acid α2,3-linked to penultimate galactose residues of trisiayl N-glycans. Comparison with other sialic acid specific lectins. J Biol Chem 277: 24916–24925.
  • Veau B, Guillot J, Damez M, Dusser M, Konska G, Botton B. 1999. Purification and characterization of an anti-(A+B) specific lectin from the mushroom Hygrophorus hypothejus. Biochim Biophys Acta 1428: 39–44.
  • Vetchinkina EP, Nikitina VE, Tsivileva OM, Garibova LV. 2008a. Activity of Lentinus edodes intracellular lectins at various developmental stages of the fungus. Appl Biochem Microbiol 44: 66–72.
  • Vetchinkina EP, Pozdnyakova NN, Nikitina VE. 2008. Laccase and lectin activities of intracellular proteins produced in a submerged culture of the xylotrophic basidiomycete Lentinus edodes. Curr Microbiol 57: 381–385.
  • Vranken AM, Van Damme ELM, Allen AK, Pneumans WJ. 1987. Purification and properties of an N-acetylgalactosamine specific lectin from the plant pathogenic fungus Rhizoctonia solani. FEBS Lett, 216: 67–72.
  • Wang F-L, Cui S-X, Sun L-P, Qu X-J, Xie Y-Y, Zhou L, Mu Y-L, Tang W, Wang Y-S. 2009. High expression of α 2,3-linked sialic acid residues is associated with the metastatic potential of human gastric cancer. Cancer Epidemiol 32: 437–443.
  • Wang H, Ng TB. 2005. First report of an arabinose-specific fungal lectin. Biochem Biophys Res Commun 337: 621–625.
  • Wang H, Gao J, Ng TB. 2000. A new lectin with highly potent antihepatoma and antisarcoma activities from the oyster mushroom Pleurotus ostreatus. Biochem Biophys Res Commun 275: 810–816.
  • Wang H, Ng TB, Liu Q. 2002a. Isolation of a new heterodimeric lectin with mitogenic activity from fruiting bodies of the mushroom Agrocybe cylindracea. Life Sci 70: 877–885.
  • Wang M, Triguéros V, Paquereau L, Chavant L, Fournier D. 2002b. Proteins as active compounds involved in insecticidal activity of mushroom fruitbodies. J Econ Entomol 95: 603–607.
  • Wang H, Ng TB, Liu Q. 2003. A novel lectin from the wild mushroom Polyporus adusta. Biochem Biophys Res Commun 307: 535–539.
  • Wang H, Ng TB, Ooi VE. 1998a. Lectins from mushrooms. Mycological Res 102: 897–906.
  • Wang HX, Ng TB, Ooi VE. 1998b. Lectin activity in fruiting bodies of the edible mushroom Tricholoma mongolicum. Biochem Mol Biol Int 44: 135–141.
  • Wang HX, Ng TB. 2001. Examination of lectins, polysaccharopeptide, polysaccharide, alkaloid, coumarin and trypsin inhibitors for inhibitory activity against human immunodeficiency virus reverse transcriptase and glycohydrolases. Planta Med 67: 669–672.
  • Wang H, Ng TB. 2003. Isolation of a novel N-acetylglucosamine-specific lectin from fresh sclerotia of the edible mushroom Pleurotus tuber-regium. Protein Expr Purif 29: 156–160.
  • Wang HX, Liu WK, Ng TB, Ooi VE, Chang ST. 1996a. The immunomodulatory and antitumor activities of lectins from the mushroom Tricholoma mongolicum. Immunopharmacology 31: 205–211.
  • Wang HX, Ooi VE, Ng TB, Chiu KW, Chang ST. 1996b. Hypotensive and vasorelaxing activities of a lectin from the edible mushroom Tricholoma mongolicum. Pharmacol Toxicol 79: 318–323.
  • Wang HX, Ng TB, Ooi VEC. 1999. Studies on the purification of a lectin from fruiting bodies of the edible shiitake mushroom Lentinus edodes. Int J Biochem Cell Biol 31: 595–599.
  • Wang HX, Ng TB, Liu WK, Ooi VE, Chang ST. 1995. Isolation and characterization of two distinct lectins with antiproliferative activity from the cultured mycelium of the edible mushroom Tricholoma mongolicum. Int J Pept Protein Res 46: 508–513.
  • Wang HX, Ng TB, Ooi VE, Liu WK, Chang ST. 1997. Actions of lectins from the mushroom Tricholoma mongolicum on macrophages, splenocytes and life-span in sarcoma-bearing mice. Anticancer Res 17: 419–424.
  • Wang PH, Hsu CI, Tang SC, Huang YL, Lin JY, Ko JL. 2004. Fungal immunomodulatory protein from Flammulina velutipes induces interferon-gamma production through p38 mitogen-activated protein kinase signaling pathway. J Agric Food Chem 52: 2721–2725.
  • Wimmerova M, Mitchell E, Sanchez JF, Gautier C, Imberty A. 2003. Crystal structure of fungal lectin: six-bladed beta-propeller fold and novel fucose recognition mode for Aleuria aurantia lectin. J Biol Chem 278: 27059–27067.
  • Winter HC, Mostafapour K, Goldstein IJ. 2002. The mushroom Marasmius oreades lectin is a blood group type B agglutinin that recognizes the Galalpha 1,3Gal and Galalpha 1,3Galbeta 1,4GlcNAc porcine xenotransplantation epitopes with high affinity. J Biol Chem 277: 14996–15001.
  • Wong JH, Wang H, Ng TB. 2008. A hemagglutinin from the medicinal fungus Cordyceps militaris. Biosci Reports 29: 321–327.
  • Wu AM, Wu JH, Tsai MS, Hedge GV, Inamdar SR, Swamy BM, Herp A. 2001. Carbohydrate specificity of a lectin isolated from the fungus Sclerotium rolfsii. Life Sci 69: 2039–2050.
  • Yagi F, Tadera K. 1988. Purification and characterization of lectin from Auricularia polytricha. Agric Biol Chem 52: 2077–2079.
  • Yagi F, Hiroyama H, Kodama S. 2001. Agrocybe cylindracea lectin is a member of the galectin family. Glycoconj J 18: 745–749.
  • Yagi F, Miyamoto M, Abe T, Minami Y, Tadera K, Goldstein IJ. 1997. Purification and carbohydrate-binding specificity of Agrocybe cylindracea lectin. Glycoconj J 14: 281–288.
  • Yagi F, Sakai T, Shiraishi N, Yotsumoto M, Mukoyoshi R. 2000. Hemagglutinins (lectins) in fruit bodies of Japanese higher fungi. Myoscience 41: 323–330.
  • Yang N, Tong X, Xiang Y, Zhang Y, Sun H, Wang DC. 2005a. Crystallization and preliminary crystallographic studies of the recombinant antitumour lectin from the edible mushroomAgrocybe aegerita. Biochim Biophys Acta 1751: 209–212.
  • Yang N, Tong X, Xiang Y, Zhang Y, Liang Y, Sun H, Wang DC. 2005b. Molecular character of the recombinant antitumor lectin from the edible mushroom Agrocybe aegerita. J Biochem 138: 145–150.
  • Yatohgo T, Nakata M, Tsumuraya Y, Hashimoto Y, Yamamoto S. 1988. Purification and properties of a lectin from the fruitbodies of Flammulina velutipes. Agric Biol Chem 52: 1485–1493.
  • Yoshida M, Kato S, Oguri S, Nagata Y. 1994. Purification and properties of lectins from a mushroom Pleurotus cornucopiae. Biosci Biotechnol Biochem 58: 498–501.
  • Yu L, Fernig DG, Smith JA, Milton JD, Rhodes JM. 1993. Reversible inhibition of proliferation of epithelial cell lines by Agaricus bisporus (edible mushroom) lectin. Cancer Res 53: 4627–4632.
  • Yu LG, Fernig DG, Rhodes JM. 2000. Intracellular trafficking and release of intact edible mushroom lectin from HT29 human colon cancer cells. Eur J Biochem 267: 2122–2126.
  • Yu LG, Fernig DG, White MR, Spiller DG, Appleton P, Evans RC, Grierson I, Smith JA, Davies H, Gerasimenko OV, Petersen OH, Milton JD, Rhodes JM. 1999. Edible mushroom (Agaricus bisporus) lectin, which reversibly inhibits epithelial cell proliferation, blocks nuclear localization sequence-dependent nuclear protein import. J Biol Chem 274: 4890–4899.
  • Zhang B, Palcic MM, Mo H, Goldstein IJ, Hindsgaul O. 2001. Rapid determination of the binding affinity and specificity of the mushroom Polyporus squamosus lectin using frontal affinity chromatography coupled to electrospray mass spectrometry. Glycobiology 11: 141–147.
  • Zhao C, Sun H, Tong X, Qi Y. 2003. An antitumour lectin from the edible mushroom Agrocybe aegerita. Biochem J 374: 321–327.
  • Zhao JK, Wang HX, Ng TB. 2009a. Purification and characterization of a novel lectin from the toxic wild mushroom Inocybe umbrinella. Toxicon 53: 360–366.
  • Zhao S, Guo YX, Liu QH, Wang HX, Ng TB. 2009b. Lectins but not the anti-fungal proteins exhibit antinematode activity. Env Toxicol Pharmacol 48: 265–268.
  • Zheng S, Li C, Ng TB, Wang HX. 2007. A lectin with mitogenic activity from the edible wild mushroom Boletus edulis. Process Biochem 42: 1620–1624.
  • Zhuang C, Murata T, Usui T, Kawagishi H, Kobayashi K. 1996. Purification and characterization of a lectin from the toxic mushroom Amanita pantherina. Biochim Biophys Acta 1291: 40–44.

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