Potential for green microalgae to produce hydrogen, pharmaceuticals and other high value products in a combined process

References

• Abe K, Hattori H, Hirano M. 2007. Accumulation and antioxidant activity of secondary carotenoids in the aerial microalga Coelastrella striolata var. multistriata. Food Chem 100:656–661.
   Web of Science ®Google Scholar
• Abedin RMA, Taha HM. 2008. Antibacterial and antifungal activity of cyanobacteria and green microalgae. Evaluation of medium components by Plackett-Burman design for antimicrobial activity of Spirulina platensis. Glob J Biotech Biochem 3:22–31.
   Google Scholar
• Ahlgren G, Gustafsson IB, Boberg M. 1992. Fatty-acid content and chemical-composition of fresh-water microalgae. J Phycol 28:37–50.
   Web of Science ®Google Scholar
• Ahmad I, Hellebust JA. 1986. The role of glycerol and inorganic ions in osmoregulatory responses of the euryhaline flagellate Chlamydomonas pulsatilla Wollenweber. Plant Physiol 82: 406–410.
   PubMed Web of Science ®Google Scholar
• Albentosa M, Pérez-Camacho A, Labarta U, Fernández-Reiriz MJ. 1997. Evaluation of freeze-dried microalgal diets for the seed culture of Ruditapes decussatus using physiological and biochemical parameters. Aquaculture 154:305–321.
   Web of Science ®Google Scholar
• Alberts DS, Goldman R, Xu MJ, Dorr RT, Quinn J, Welch K, Guillen-Rodriguez J, Aickin M, Peng YM, Loescher L, Gensler H. 1996. Disposition and metabolism of topically administered alpha-tocopherol acetate: a common ingredient of commercially available sunscreens and cosmetics. Nutr Cancer 26: 193–201.
   PubMed Web of Science ®Google Scholar
• Allen EJ, Nelson EW. 1910. On the artificial culture of marine plankton organisms. J Mar Biol Assoc UK 8: 421–474.
   Google Scholar
• Alyabyev AJ, Loseva NL, Gordon LK, Andreyeva IN, Rachimova GG, Tribunskih VI, Ponomareva AA, Kemp RB. 2007. The effect of changes in salinity on the energy yielding processes of Chlorella vulgaris and Dunaliella maritima cells. Thermochim Acta 458: 65–70.
   Web of Science ®Google Scholar
• Antal TK, Krendeleva TE, Laurinavichene TV, Makarova VV, Ghirardi ML, Rubin AB, Tsygankov AA, Seibert M. 2003. The dependence of algal H2 production on Photosystem II and O2 consumption activities in sulfur-deprived Chlamydomonas reinhardtii cells. Biochim Biophys Acta 1607: 153–160.
   PubMed Web of Science ®Google Scholar
• Antal TK, Krendeleva TE, Rubin AB. 2007. Study of photosystem 2 heterogeneity in the sulfur-deficient green alga Chlamydomonas reinhardtii. Photosyn Res 94: 13–22.
   PubMed Web of Science ®Google Scholar
• Antal TK, Volgusheva AA, Kukarskih GP, Krendeleva TE, Rubin AB. 2009. Relationships between H2 photoproduction and different electron transport pathways in sulfur-deprived Chlamydomonas reinhardtii. Int J Hydrogen Energy 34:9087–9094.
   Web of Science ®Google Scholar
• Apt KE, Behrens PW. 1999. Commercial developments in microalgal biotechnology. J Phycol 35:215–226.
   Web of Science ®Google Scholar
• Arisz SA, van Himbergen JA, Musgrave A, van den Ende H, Munnik T. 2000. Polar glycerolipids of Chlamydomonas moewusii. Phytochemistry 53: 265–270.
   Google Scholar
• Azachi M, Sadka A, Fisher M, Goldshlag P, Gokhman I, Zamir A. 2002. Salt induction of fatty acid elongase and membrane lipid modifications in the extreme halotolerant alga Dunaliella salina. Plant Physiol 129: 1320–1329.
   PubMed Web of Science ®Google Scholar
• Babu B, Wu JT. 2008. Production of natural butylated hydroxytoluene as an antioxidant by freshwater phytoplankton. J Phycol 44:1447–1454.
   PubMed Web of Science ®Google Scholar
• Baker RTM, Pfeiffer AM, Schöner FJ, Smith-Lemmon L. 2002. Pigmenting efficacy of astaxanthin and canthaxanthin in fresh-water reared Atlantic salmon, Salmo salar. Anim Feed Sci Technol 99:97–106.
   Web of Science ®Google Scholar
• Barbosa MJ, Janssen M, Ham N, Tramper J, Wijffels RH. 2003. Microalgae cultivation in air-lift reactors: modeling biomass yield and growth rate as a function of mixing frequency. Biotechnol Bioeng 82: 170–179.
   PubMed Web of Science ®Google Scholar
• Barbosa MJ, Zijffers JW, Nisworo A, Vaes W, van Schoonhoven J, Wijffels RH. 2005. Optimization of biomass, vitamins, and carotenoid yield on light energy in a flat-panel reactor using the A-stat technique. Biotechnol Bioeng 89: 233–242.
   PubMed Web of Science ®Google Scholar
• Barclay MC, Irvin SJ, Williams KC, Smith DM. 2006. Comparison of diets for the tropical spiny lobster Panulirus ornatus: astaxanthin-supplemented feeds and mussel flesh. Aquac Nutr 12:117–125.
   Web of Science ®Google Scholar
• Barnhart MC. 2006. Buckets of muckets: A compact system for rearing juvenile freshwater mussels. Aquaculture 254:227–233.
   Web of Science ®Google Scholar
• Baroli I, Melis A. 1998. Photoinhibitory damage is modulated by the rate of photosynthesis and by the photosystem II light-harvesting chlorophyll antenna size. Planta 205: 288–296.
   PubMed Web of Science ®Google Scholar
• Barsanti L, Coltelli P, Evangelista V, Frassanito AM, Passarelli V, Vesentini N, Gualtieri P. 2008. Oddities and curiosities in the algal world, In: Evangelista V, Barsanti L, Frassanito AM, Passarelli V, Gualtieri P. (Eds.), Algal toxins: nature, occurrence, effect and detection, Springer, Dordrecht. pp. 353–391.
   Google Scholar
• Becker EW. 2007. Micro-algae as a source of protein. Biotechnol Adv 25: 207–210.
   PubMed Web of Science ®Google Scholar
• Becker W. 2004a. Microalgae for aquaculture - The nutritional value of microalgae for aquaculture, In: Richmond A (Ed.), Handbook of microalgal culture: Biotechnology and applied phycology, Blackwell Science Ltd, Oxford. pp. 380–391.
   Google Scholar
• Becker W. 2004b. Microalgae in human and animal nutrition, In: Richmond A (Ed.), Handbook of microalgal culture: Biotechnology and applied phycology, Blackwell Science Ltd, Oxford. pp. 312–351.
   Google Scholar
• Beer LL, Boyd ES, Peters JW, Posewitz MC. 2009. Engineering algae for biohydrogen and biofuel production. Curr Opin Biotechnol 20: 264–271.
   PubMed Web of Science ®Google Scholar
• Belgis C, Guido P. 2003. Cyst-based toxicity tests. XI. Influence of the type of food on the intrinsic growth rate of the rotifer Brachionus calyciflorus in short-chronic toxicity tests. Chemosphere 50: 365–372.
   PubMed Web of Science ®Google Scholar
• Bell JG, McEvoy LA, Estevez A, Shields RJ, Sargent JR. 2003. Optimising lipid nutrition in first-feeding flatfish larvae. Aquaculture 227: 211–220.
   Web of Science ®Google Scholar
• Ben-Amotz A. 2004. Industrial production of microalgal cell-mass and secondary products - Major industrial species - Dunaliella, In: Richmond A. (Ed.) Handbook of microalgal culture: Biotechnology and applied phycology, Blackwell Science Ltd, Oxford. pp. 273–280.
   Google Scholar
• Ben-Amotz A, Avron M. 1983. On the factors which determine massive beta-carotene accumulation in the halotolerant alga Dunaliella bardawil. Plant Physiol 72: 593–597.
   PubMed Web of Science ®Google Scholar
• Ben-Amotz A, Tornabene TG, Thomas WH. 1985. Chemical profile of selected species of microalgae with emphasis on lipids. J Phycol 21:72–81.
   Web of Science ®Google Scholar
• Bethmann B, Schönknecht G. 2009. pH regulation in an acidophilic green alga - a quantitative analysis. New Phytol 183: 327–339.
   PubMed Web of Science ®Google Scholar
• Bhosale P, Bernstein PS. 2005. Microbial xanthophylls. Appl Microbiol Biotechnol 68: 445–455.
   PubMed Web of Science ®Google Scholar
• Bhosale SH, Pant A, Khan MI. 2009. Purification and characterization of putative alkaline [Ni-Fe] hydrogenase from unicellular marine green alga, Tetraselmis kochinensis NCIM 1605. Microbiol Res 164: 131–137.
   PubMed Web of Science ®Google Scholar
• Bigogno C, Khozin-Goldberg I, Cohen Z. 2002. Accumulation of arachidonic acid-rich triacylglycerols in the microalga Parietochloris incisa (Trebuxiophyceae, Chlorophyta). Phytochemistry 60: 135–143.
   PubMed Web of Science ®Google Scholar
• Bishop NI, Frick M, Jones LW. 1977. Photohydrogen production in green algae: Water serves as the primary substrate for hydrogen and oxygen production. Academic Press Inc, New York - San Fransisco - London.
   Google Scholar
• Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. 2007. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 297: 842–857.
   PubMed Web of Science ®Google Scholar
• Blackwell JR, Gilmour DJ. 1991. Determination of intracellular volume and internal solute concentrations of the green alga Chlorococcum submarinum. Arch Microbiol 157:80–85.
   Web of Science ®Google Scholar
• Blanco AM, Moreno J, Del Campo JA, Rivas J, Guerrero MG. 2007. Outdoor cultivation of lutein-rich cells of Muriellopsis sp. in open ponds. Appl Microbiol Biotechnol 73: 1259–1266.
   PubMed Web of Science ®Google Scholar
• Blunden G. 1993. Marine algae as sources of biologically active compounds. Interdiscip Sci Rev 18:73–80.
   Web of Science ®Google Scholar
• Blunt JW, Copp BR, Hu WP, Munro MH, Northcote PT, Prinsep MR. 2007. Marine natural products. Nat Prod Rep 24: 31–86.
   PubMed Web of Science ®Google Scholar
• Blunt JW, Copp BR, Hu WP, Munro MH, Northcote PT, Prinsep MR. 2008. Marine natural products. Nat Prod Rep 25: 35–94.
   PubMed Web of Science ®Google Scholar
• Blunt JW, Copp BR, Hu WP, Munro MH, Northcote PT, Prinsep MR. 2009. Marine natural products. Nat Prod Rep 26: 170–244.
   PubMed Web of Science ®Google Scholar
• Blunt JW, Copp BR, Munro MH, Northcote PT, Prinsep MR. 2003. Marine natural products. Nat Prod Rep 20: 1–48.
   PubMed Web of Science ®Google Scholar
• Blunt JW, Copp BR, Munro MH, Northcote PT, Prinsep MR. 2004. Marine natural products. Nat Prod Rep 21: 1–49.
   PubMed Web of Science ®Google Scholar
• Blunt JW, Copp BR, Munro MH, Northcote PT, Prinsep MR. 2005. Marine natural products. Nat Prod Rep 22: 15–61.
   PubMed Web of Science ®Google Scholar
• Blunt JW, Copp BR, Munro MH, Northcote PT, Prinsep MR. 2006. Marine natural products. Nat Prod Rep 23: 26–78.
   PubMed Web of Science ®Google Scholar
• Boichenko VA, Hoffmann P. 1994. Photosynthetic hydrogen-production in prokaryotes and eukaryotes - occurrence, mechanism, and functions. Photosynth 30:527–552.
   Web of Science ®Google Scholar
• Boichenko VA, Wiessner W, Klimov VV, Mende D, Demeter S. 1992. Hydrogen photoevolution indicates an increase in the antenna size of Photosystem I in Chlamydobotrys stellata during transition from autotrophic to photoheterotrophic nutrition. Plant Physiol 100: 518–524.
   PubMed Web of Science ®Google Scholar
• Bölling C, Fiehn O. 2005. Metabolite profiling of Chlamydomonas reinhardtii under nutrient deprivation. Plant Physiol 139: 1995–2005.
   PubMed Web of Science ®Google Scholar
• Borowitzka MA. 1988. Vitamins and fine chemicals from micro-algae, In: Borowitzka MA,Borowitzka LJ (Eds.), Micro-algal Biotechnology, Cambridge University Press, Cambridge pp. 153–196.
   Google Scholar
• Borowitzka MA. 1995. Microalgae as sources of pharmaceuticals and other biologically-active compounds. J Appl Phycol 7:3–15.
   Web of Science ®Google Scholar
• Brand JJ, Wright JN, Lien S. 1989. Hydrogen production by eukaryotic algae. Biotechnol Bioeng 33: 1482–1488.
   PubMed Web of Science ®Google Scholar
• Brown MR, Jeffrey SW, Volkman JK, Dunstan GA. 1997. Nutritional properties of microalgae for mariculture. Aquaculture 151:315–331.
   Web of Science ®Google Scholar
• Brown MR, Mular M, Miller I, Farmer C, Trenerry C. 1999. The vitamin content of microalgae used in aquaculture. J Appl Phycol 11:247–255.
   Web of Science ®Google Scholar
• Cao HM, Zhang LP, Melis A. 2001. Bioenergetic and metabolic processes for the survival of sulfur-deprived Dunaliella salina (Chlorophyta). J Appl Phycol 13:25–34.
   Web of Science ®Google Scholar
• Capitani CD, Carvalho ACL, Rivelli DP, Barros SBM, Castro IA. 2009. Evaluation of natural and synthetic compounds according to their antioxidant activity using a multivariate approach. Eur J Lipid Sci Technol 111:1090–1099.
   Web of Science ®Google Scholar
• Capon JF, Gloaguen F, Pétillon FY, Schollhammer P, Talarmin J. 2009. Electron and proton transfers at diiron dithiolate sites relevant to the catalysis of proton reduction by the [FeFe]-hydrogenases. Coord Chem Rev 253:1476–1494.
   Web of Science ®Google Scholar
• Carballo-Cárdenas EC, Tuan PM, Janssen M, Wijffels RH. 2003. Vitamin E (alpha-tocopherol) production by the marine microalgae Dunaliella tertiolecta and Tetraselmis suecica in batch cultivation. Biomol Eng 20: 139–147.
   PubMedGoogle Scholar
• Cardozo KH, Guaratini T, Barros MP, Falcão VR, Tonon AP, Lopes NP, Campos S, Torres MA, Souza AO, Colepicolo P, Pinto E. 2007. Metabolites from algae with economical impact. Comp Biochem Physiol C Toxicol Pharmacol 146: 60–78.
   PubMed Web of Science ®Google Scholar
• Carvalho AP, Meireles LA, Malcata FX. 2006. Microalgal reactors: a review of enclosed system designs and performances. Biotechnol Prog 22: 1490–1506.
   PubMed Web of Science ®Google Scholar
• Cerón MC, Campos I, Sánchez JF, Acién FG, Molina E, Fernández-Sevilla JM. 2008. Recovery of lutein from microalgae biomass: development of a process for Scenedesmus almeriensis biomass. J Agric Food Chem 56: 11761–11766.
   PubMed Web of Science ®Google Scholar
• Cerón MC, García-Malea MC, Rivas J, Acien FG, Fernandez JM, Del Río E, Guerrero MG, Molina E. 2007. Antioxidant activity of Haematococcus pluvialis cells grown in continuous culture as a function of their carotenoid and fatty acid content. Appl Microbiol Biotechnol 74: 1112–1119.
   PubMed Web of Science ®Google Scholar
• Cha KH, Koo SY, Lee DU. 2008. Antiproliferative effects of carotenoids extracted from Chlorella ellipsoidea and Chlorella vulgaris on human colon cancer cells. J Agric Food Chem 56: 10521–10526.
   PubMed Web of Science ®Google Scholar
• Chader S, Hacene H, Agathos SN. 2009. Study of hydrogen production by three strains of Chlorella isolated from the soil in the Algerian Sahara. Int J Hydrogen Energy 34:4941–4946.
   Web of Science ®Google Scholar
• Chan KC, Mong MC, Yin MC. 2009. Antioxidative and anti-inflammatory neuroprotective effects of astaxanthin and canthaxanthin in nerve growth factor differentiated PC12 cells. J Food Sci 74: H225–H231.
   Web of Science ®Google Scholar
• Chattopadhyay P, Chatterjee S, Sen SK. 2008. Biotechnological potential of natural food grade biocolorants. Afr J Biotechnol 7:2972–2985.
   Google Scholar
• Chen F. 1998. Bioreactor technology for production of valuable algal products. Chin J Oceanol Limnol 16 Suppl.
   Google Scholar
• Chen GQ, Jiang Y, Chen F. 2008. Salt-induced alterations in lipid composition of diatom Nitzschia laevis (Bacillariophyceae) under heterotrophic culture condition. J Phycol 44:1309–1314.
   PubMed Web of Science ®Google Scholar
• Chen H, Jiang JG. 2009. Osmotic responses of Dunaliella to the changes of salinity. J Cell Physiol 219: 251–258.
   PubMed Web of Science ®Google Scholar
• Chen HC, Newton AJ, Melis A. 2005. Role of SulP, a nuclear-encoded chloroplast sulfate permease, in sulfate transport and H2 evolution in Chlamydomonas reinhardtii. Photosyn Res 84: 289–296.
   PubMed Web of Science ®Google Scholar
• Chiang IZ, Huang WY, Wu JT. 2004. Allelochemicals of Botryococcus braunii (Chlorophyceae). J Phycol 40:474–480.
   Web of Science ®Google Scholar
• Cho SH, Ji SC, Hur SB, Bae J, Park IS, Song YC. 2007. Optimum temperature and salinity conditions for growth of green algae Chlorella ellipsoidea and Nannochloris oculata. Fish Sci 73:1050–1056.
   Web of Science ®Google Scholar
• Chochois V, Dauvillée D, Beyly A, Tolleter D, Cuiné S, Timpano H, Ball S, Cournac L, Peltier G. 2009. Hydrogen production in Chlamydomonas: photosystem II-dependent and -independent pathways differ in their requirement for starch metabolism. Plant Physiol 151: 631–640.
   PubMed Web of Science ®Google Scholar
• Chou YC, Prakash E, Huang CF, Lien TW, Chen X, Su IJ, Chao YS, Hsieh HP, Hsu JT. 2008. Bioassay-guided purification and identification of PPARalpha/gamma agonists from Chlorella sorokiniana. Phytother Res 22: 605–613.
   PubMed Web of Science ®Google Scholar
• Choubert G. 2010. Response of rainbow trout (Oncorhynchus mykiss) to varying dietary astaxanthin/canthaxanthin ratio: colour and carotenoid retention of the muscle. Aquac Nutr 16:528–535.
   Web of Science ®Google Scholar
• Choubert G, Mendes-Pinto MM, Morais R. 2006. Pigmenting efficacy of astaxanthin fed to rainbow trout Oncorhynchus mykiss: Effect of dietary astaxanthin and lipid sources. Aquaculture 257: 429–436.
   Web of Science ®Google Scholar
• Chow WS, Lee HY, Park YI, Park YM, Hong YN, Anderson JM. 2002. The role of inactive photosystem-II-mediated quenching in a last-ditch community defence against high light stress in vivo. Philos Trans R Soc Lond, B, Biol Sci 357: 1441–49; discussion 1449.
   PubMed Web of Science ®Google Scholar
• Christner BC. 2010. Bioprospecting for microbial products that affect ice crystal formation and growth. Appl Microbiol Biotechnol 85: 481–489.
   PubMed Web of Science ®Google Scholar
• Chu CY, Liao WR, Huang R, Lin LP. 2004. Haemagglutinating and antibiotic activities of freshwater microalgae. World J Microbiol Biotechnol 20:817–825.
   Web of Science ®Google Scholar
• Coesel SN, Baumgartner AC, Teles LM, Ramos AA, Henriques NM, Cancela L, Varela JC. 2008. Nutrient limitation is the main regulatory factor for carotenoid accumulation and for Psy and Pds steady state transcript levels in Dunaliella salina (Chlorophyta) exposed to high light and salt stress. Mar Biotechnol 10: 602–611.
   PubMed Web of Science ®Google Scholar
• Conceicão LEC, Yufera M, Makridis P, Morais S, Dinis MT. 2010. Live feeds for early stages of fish rearing. Aquac Res 41:613–640.
   Web of Science ®Google Scholar
• Croft MT, Lawrence AD, Raux-Deery E, Warren MJ, Smith AG. 2005. Algae acquire vitamin B12 through a symbiotic relationship with bacteria. Nature 438: 90–93.
   PubMed Web of Science ®Google Scholar
• Cuaresma M, Janssen M, Vílchez C, Wijffels RH. 2009. Productivity of Chlorella sorokiniana in a short light-path (SLP) panel photobioreactor under high irradiance. Biotechnol Bioeng 104: 352–359.
   PubMed Web of Science ®Google Scholar
• Cunha L, Mascaro M, Chiapa X, Costa A, Simoes N. 2008. Experimental studies on the effect of food in early larvae of the cleaner shrimp Lysmata amboinensis (De Mann, 1888) (Decapoda: Caridea: Hippolytidae). Aquaculture 277:117–123.
   Web of Science ®Google Scholar
• D’Souza FML, Kelly GJ. 2000. Effects of a diet of a nitrogen-limited alga (Tetraselmis suecica) on growth, survival and biochemical composition of tiger prawn (Penaeus semisulcatus) larvae. Aquaculture 181:311–329.
   Web of Science ®Google Scholar
• D’Souza FML, Loneragan NR. 1999. Effects of monospecific and mixed-algae diets on survival, development and fatty acid composition of penaeid prawn (Penaeus spp.) larvae. Mar Biol 133:621–633.
   Web of Science ®Google Scholar
• Dahl U, Lind CR, Gorokhova E, Eklund B, Breitholtz M. 2009. Food quality effects on copepod growth and development: implications for bioassays in ecotoxicological testing. Ecotoxicol Environ Saf 72: 351–357.
   PubMed Web of Science ®Google Scholar
• Daligault F, Nugier-Chauvin C, Patin H. 2006. Microalga Chlorella sorokiniana: a new sulfoxidation biocatalyst. Org Biomol Chem 4: 1474–1477.
   PubMed Web of Science ®Google Scholar
• Dasgupta CN, Gilbert J, Lindblad P, Heidorn T, Borgvang SA, Skjånes K, Das D. 2010. Recent trends on the development of photo-biological processes and photobioreactors for the improvement of hydrogen production. Int J Hydrogen Energy 35:10218–10238.
   Web of Science ®Google Scholar
• Day AG, Brinkmann D, Franklin S, Espina K, Rudenko G, Roberts A, Howse KS. 2009. Safety evaluation of a high-lipid algal biomass from Chlorella protothecoides. Regul Toxicol Pharmacol 55: 166–180.
   PubMed Web of Science ®Google Scholar
• de-Bashan LE, Trejo A, Huss VA, Hernandez JP, Bashan Y. 2008. Chlorella sorokiniana UTEX 2805, a heat and intense, sunlight-tolerant microalga with potential for removing ammonium from wastewater. Bioresour Technol 99: 4980–4989.
   PubMed Web of Science ®Google Scholar
• de la Coba F, Aguilera J, de Gálvez MV, Álvarez M, Gallego E, Figueroa FL, Herrera E. 2009. Prevention of the ultraviolet effects on clinical and histopathological changes, as well as the heat shock protein-70 expression in mouse skin by topical application of algal UV-absorbing compounds. J Dermatol Sci 55:161–169.
   PubMed Web of Science ®Google Scholar
• de la Noue J, de Pauw N. 1988. The potential of microalgal biotechnology – A review of production and uses of microalgae. Biotechnol Adv 6:725–770.
   PubMed Web of Science ®Google Scholar
• de Pauw N, Persoone G. 1988. Micro-algae for aquaculture, In: Borowitzka MA,Borowitzka LJ. (Eds.) Micro-algal Biotechnology, Cambridge University Press, Cambridge pp. 197–221.
   Google Scholar
• Del Campo JA, García-González M, Guerrero MG. 2007. Outdoor cultivation of microalgae for carotenoid production: current state and perspectives. Appl Microbiol Biotechnol 74: 1163–1174.
   PubMed Web of Science ®Google Scholar
• Del Campo JA, Moreno J, Rodríguez H, Vargas MA, Rivas J, Guerrero MG. 2000. Carotenoid content of chlorophycean microalgae: factors determining lutein accumulation in Muriellopsis sp. (Chlorophyta). J Biotechnol 76: 51–59.
   PubMed Web of Science ®Google Scholar
• Del Campo JA, Rodríguez H, Moreno J, Vargas MA, Rivas J, Guerrero MG. 2004. Accumulation of astaxanthin and lutein in Chlorella zofingiensis (Chlorophyta). Appl Microbiol Biotechnol 64: 848–854.
   PubMed Web of Science ®Google Scholar
• Dembitsky VM. 2006. Anticancer activity of natural and synthetic acetylenic lipids. Lipids 41: 883–924.
   PubMed Web of Science ®Google Scholar
• Demeter S, Janda T, Kovacs L, Mende D, Wiessner W. 1995. Effects of in-vivo CO2 depletion on electron-transport and photoinhibition in the green algae, Chlamydobotrys stellata and Chlamydomonas reinhardtii. Biochim Biophys Acta - Bioenergetics 1229:166–174.
   Web of Science ®Google Scholar
• Devos N, Ingouff M, Loppes R, Matagne RF. 1998. Rubisco adaptation to low temperatures: A comparative study in psychrophilic and mesophilic unicellular algae. J Phycol 34:655–660.
   Web of Science ®Google Scholar
• Domínguez-Bocanegra AR, Guerrero Legarreta I, Martinez Jeronimo F, Tomasini Campocosio A. 2004. Influence of environmental and nutritional factors in the production of astaxanthin from Haematococcus pluvialis. Bioresour Technol 92: 209–214.
   PubMed Web of Science ®Google Scholar
• Duerr EO, Molnar A, Sato V. 1998. Cultured microalgae as aquaculture feeds. J Mar Biotechnol 6:65–70.
   Google Scholar
• Dufossé L, Galaup P, Yaron A, Arad SM. 2005. Microorganisms and microalgae as sources of pigments for food use: a scientific oddity or an industrial reality? Trends Food Sci Technol 16:389–406.
   Web of Science ®Google Scholar
• Durmaz Y. 2007. Vitamin E (alpha-tocopherol) production by the marine microalgae Nannochloropsis oculata (Eustigmatophyceae) in nitrogen limitation. Aquaculture 272:717–722.
   Web of Science ®Google Scholar
• Duval B, Shetty K, Thomas WH. 2000. Phenolic compounds and antioxidant properties in the snow alga Chlamydomonas nivalis after exposure to UV light. J Appl Phycol 11:559–566.
   Web of Science ®Google Scholar
• Egeland ES, Eikrem W, Throndsen J, Wilhelm C, Zapata M, Liaaen-Jensen S. 1995. Carotenoids from further prasinophytes. Biochem Syst Ecol 23:747–755.
   Web of Science ®Google Scholar
• Egeland ES, Guillard RRL, Liaaen-Jensen S. 1997. Additional carotenoid prototype representatives and a general chemosystematic evaluation of carotenoids in Prasinophyceae (Chlorophyta). Phytochemistry 44:1087–1097.
   Web of Science ®Google Scholar
• Elliott P, Aldridge DC, Moggridge GD. 2008. Zebra mussel filtration and its potential uses in industrial water treatment. Water Res 42: 1664–1674.
   PubMed Web of Science ®Google Scholar
• Eriksen NT. 2008. The technology of microalgal culturing. Biotechnol Lett 30: 1525–1536.
   PubMed Web of Science ®Google Scholar
• Fedorov AS, Kosourov S, Ghirardi ML, Seibert M. 2005. Continuous hydrogen photoproduction by Chlamydomonas reinhardtii: using a novel two-stage, sulfate-limited chemostat system. Appl Biochem Biotechnol 121–124: 403–412.
   PubMed Web of Science ®Google Scholar
• Fernandes BD, Dragone GM, Teixeira JA, Vicente AA. 2010. Light regime characterization in an airlift photobioreactor for production of microalgae with high starch content. Appl Biochem Biotechnol 161: 218–226.
   PubMed Web of Science ®Google Scholar
• Finney KF, Pomeranz Y, Bruinsma BL. 1984. Use of algae Dunaliella as a protein supplement in bread. Cereal Chem 61:402–406.
   Web of Science ®Google Scholar
• Flynn T, Ghirardi ML, Seibert M. 2002. Accumulation of O2 tolerant phenotypes in H2 producing strains of Chlamydomonas reinhardtii by sequential applications of chemical mutagenesis and selection. Int J Hydrogen Energy 27:1421–1430.
   Web of Science ®Google Scholar
• Fouchard S, Pruvost J, Degrenne B, Legrand J. 2008. Investigation of H2 production using the green microalga Chlamydomonas reinhardtii in a fully controlled photobioreactor fitted with on-line gas analysis. Int J Hydrogen Energy 33:3302–3310.
   Web of Science ®Google Scholar
• Fried A, Tietz A, Benamotz A, Eichenberger W. 1982. Lipid-composition of the halotolerant alga, Dunaliella bardawil. Biochim Biophys Acta 713:419–426.
   Google Scholar
• Fujii K, Nakajima H, Anno Y. 2008. Potential of Monoraphidium sp GK12 for energy-saving astaxanthin production. J Chem Technol Biotechnol 83:1578–1584.
   Web of Science ®Google Scholar
• Fujii Y, Sakamoto S, Ben-Amotz A, Nagasawa H. 1993. Effects of beta-carotene-rich algae Dunaliella bardawil on the dynamic changes of normal and neoplastic mammary cells and general metabolism in mice. Anticancer Res 13: 389–393.
   PubMed Web of Science ®Google Scholar
• Gerloff-Elias A, Barua D, Mölich A, Spijkerman E. 2006. Temperature- and pH-dependent accumulation of heat-shock proteins in the acidophilic green alga Chlamydomonas acidophila. FEMS Microbiol Ecol 56: 345–354.
   PubMed Web of Science ®Google Scholar
• Garbayo I, Cuaresma M, Vilchez C, Vega JM. 2008. Effect of abiotic stress on the production of lutein and beta-carotene by Chlamydomonas acidophila. Process Biochem 43:1158–1161.
   Web of Science ®Google Scholar
• Garcia-Malea MC, Brindley C, Del Rio E, Acien FG, Fernandez JM, Molina E. 2005. Modelling of growth and accumulation of carotenoids in Haematococcus pluvialis as a function of irradiance and nutrients supply. Biochem Eng J 26:107–114.
   Web of Science ®Google Scholar
• Gatenby CM, Orcutt DM, Kreeger DA, Parker BC, Jones VA, Neves RJ. 2003. Biochemical composition of three algal species proposed as food for captive freshwater mussels. J Appl Phycol 15:1–11.
   Web of Science ®Google Scholar
• Gerloff-Elias A, Barua D, Mölich A, Spijkerman E. 2006. Temperature- and pH-dependent accumulation of heat-shock proteins in the acidophilic green alga Chlamydomonas acidophila. FEMS Microbiol Ecol 56: 345–354.
   PubMed Web of Science ®Google Scholar
• Gerloff-Elias A, Spijkerman E, Proschold T. 2005. Effect of external pH on the growth, photosynthesis and photosynthetic electron transport of Chlamydomonas acidophila Negoro, isolated from an extremely acidic lake (pH 2.6). Plant Cell Environ 28:1218–1229.
   Web of Science ®Google Scholar
• Ghazala B, Shameel M, Choudhary MI, Shahzad S, Leghari SM. 2004. Phycochemistry and bioactivity of Tetraspora(Volvocophyta) from Sindh. Pak J Bot 36:531–547.
   Web of Science ®Google Scholar
• Ghirardi ML, Dubini A, Yu J, Maness PC. 2009. Photobiological hydrogen-producing systems. Chem Soc Rev 38: 52–61.
   PubMed Web of Science ®Google Scholar
• Ghirardi ML, King P, Kosourov S, Forestier M, Zhang L, Seibert M. 2006. Development of algal systems for hydrogen photoproduction: Addressing the hydrogenase oxygen-sensitivity problem, In: Collings AF,Critchley C. (Eds.) Artificial photosynthesis: From basic biology to industrial application, WILEY-VCH Verlag GmbH & Co, Weinheim. pp. 213–227.
   Google Scholar
• Ghirardi ML, Zhang L, Lee JW, Flynn T, Seibert M, Greenbaum E, Melis A. 2000. Microalgae: a green source of renewable H(2). Trends Biotechnol 18: 506–511.
   PubMed Web of Science ®Google Scholar
• Glaser KB, Mayer AM. 2009. A renaissance in marine pharmacology: from preclinical curiosity to clinical reality. Biochem Pharmacol 78: 440–448.
   PubMed Web of Science ®Google Scholar
• Goes JI, Handa N, Taguchi S, Hama T. 1994. Effect of UV-B radiation on the fatty-acid composition of the marine-phytoplankton Tetraselmis sp – relationship to cellular pigments. Mar Ecol-Prog Ser 114:259–274.
   Web of Science ®Google Scholar
• Gouveia L, Choubert G, Pereira N, Santinha J, Empis J, Gomes E. 2002. Pigmentation of gilthead seabream, Sparus aurata (L. 1875), using Chlorella vulgaris (Chlorophyta, Volvocales) microalga. Aquac Res 33:987–993.
   Web of Science ®Google Scholar
• Gouveia L, Empis J. 2003. Relative stabilities of microalgal carotenoids in microalgal extracts, biomass and fish feed: Effect of storage conditions. Innov Food Sci Emerg Technol 4:227–233.
   Google Scholar
• Gouveia L, Oliveira AC. 2009. Microalgae as a raw material for biofuels production. J Ind Microbiol Biotechnol 36: 269–274.
   PubMed Web of Science ®Google Scholar
• Gouveia L, Raymundo A, Batista AP, Sousa I, Empis J. 2006. Chlorella vulgaris and Haematococcus pluvialis biomass as colouring and antioxidant in food emulsions. Eur Food Res Technol 222: 362–367.
   Web of Science ®Google Scholar
• Gouveia L, Veloso V, Reis A, Fernandes H, Novais J, Empis J. 1996. Evolution of pigment composition in Chlorella vulgaris. Bioresour Technol 57:157.
   Web of Science ®Google Scholar
• Goyal A. 2007. Osmoregulation in Dunaliella, Part II: Photosynthesis and starch contribute carbon for glycerol synthesis during a salt stress in Dunaliella tertiolecta. Plant Physiol Biochem 45: 705–710.
   PubMed Web of Science ®Google Scholar
• Granot E, Kohen R. 2004. Oxidative stress in childhood–in health and disease states. Clin Nutr 23: 3–11.
   PubMed Web of Science ®Google Scholar
• Greenbaum E, Guillard RRL, Sunda WG. 1983. Hydrogen and oxygen photoproduction by marine algae. Photochem Photobiol 37:649–655.
   Web of Science ®Google Scholar
• Griesbeck C, Kobl I, Heitzer M. 2006. Chlamydomonas reinhardtii: a protein expression system for pharmaceutical and biotechnological proteins. Mol Biotechnol 34: 213–223.
   PubMed Web of Science ®Google Scholar
• Griffiths MJ, Harrison STL. 2009. Lipid productivity as a key characteristic for choosing algal species for biodiesel production. J Appl Phycol 21:493–507.
   Web of Science ®Google Scholar
• Grossman A. 2000. Acclimation of Chlamydomonas reinhardtii to its nutrient environment. Protist 151: 201–224.
   PubMed Web of Science ®Google Scholar
• Guan YF, Deng MC, Yu XJ, Zhang W. 2004. Two-stage photo-biological production of hydrogen by marine green alga Platymonas subcordiformis. Biochem Eng J 19:69–73.
   Web of Science ®Google Scholar
• Guerin M, Huntley ME, Olaizola M. 2003. Haematococcus astaxanthin: applications for human health and nutrition. Trends Biotechnol 21: 210–216.
   PubMed Web of Science ®Google Scholar
• Guiry MD, Guiry GM. 2012. AlgaeBase. World-wide electronic publication, National University of Ireland, Galway. Available at: http://wwwalgaebaseorg.
   Google Scholar
• Guschina IA, Harwood JL. 2006. Lipids and lipid metabolism in eukaryotic algae. Prog Lipid Res 45: 160–186.
   PubMed Web of Science ®Google Scholar
• Guzmán S, Gato A, Lamela M, Freire-Garabal M, Calleja JM. 2003. Anti-inflammatory and immunomodulatory activities of polysaccharide from Chlorella stigmatophora and Phaeodactylum tricornutum. Phytother Res 17: 665–670.
   PubMed Web of Science ®Google Scholar
• Hadi MR, Shariati M, Afsharzadeh S. 2008. Microalgal biotechnology: carotenoid and glycerol production by the green algae Dunaliella isolated from the Gave-Khooni salt marsh, Iran, Biotechnol Bioprocess Eng 13:540–544.
   Web of Science ®Google Scholar
• Hahn JJ, Ghirardi ML, Jacoby WA. 2004. Effect of process variables on photosynthetic algal hydrogen production. Biotechnol Prog 20: 989–991.
   PubMed Web of Science ®Google Scholar
• Hankamer B, Lehr F, Rupprecht J, Mussgnug JH, Posten C, Kruse O. 2007. Photosynthetic biomass and H2 production by green algae: from bioengineering to bioreactor scale-up. Physiol Plant 131: 10–21.
   PubMed Web of Science ®Google Scholar
• Harker M, Tsavalos AJ, Young AJ. 1996. Factors responsible for astaxanthin formation in the chlorophyte Haematococcus pluvialis. Bioresour Technol 55:207–214.
   Web of Science ®Google Scholar
• Harrigan GG, Goetz G. 2002. Symbiotic and dietary marine microalgae as a source of bioactive molecules-experience from natural products research. J Appl Phycol 14:103–108.
   Web of Science ®Google Scholar
• Hasegawa T, Matsuguchi T, Noda K, Tanaka K, Kumamoto S, Shoyama Y, Yoshikai Y. 2002. Toll-like receptor 2 is at least partly involved in the antitumor activity of glycoprotein from Chlorella vulgaris. Int Immunopharmacol 2: 579–589.
   PubMed Web of Science ®Google Scholar
• Havaux M, Dall’osto L, Bassi R. 2007. Zeaxanthin has enhanced antioxidant capacity with respect to all other xanthophylls in Arabidopsis leaves and functions independent of binding to PSII antennae. Plant Physiol 145: 1506–1520.
   PubMed Web of Science ®Google Scholar
• He P, Duncan J, Barber J. 2007. Astaxanthin accumulation in the green alga Haematococcus pluvialis: Effects of cultivation parameters. J Integr Plant Biol 49:447–451.
   Web of Science ®Google Scholar
• Healey FP. 1970. Hydrogen evolution by several algae. Planta 91:220–226.
   PubMed Web of Science ®Google Scholar
• Heinrich U, Gärtner C, Wiebusch M, Eichler O, Sies H, Tronnier H, Stahl W. 2003. Supplementation with beta-carotene or a similar amount of mixed carotenoids protects humans from UV-induced erythema. J Nutr 133: 98–101.
   PubMed Web of Science ®Google Scholar
• Hejazi MA, Wijffels RH. 2003. Effect of light intensity on beta-carotene production and extraction by Dunaliella salina in two-phase bioreactors. Biomol Eng 20: 171–175.
   PubMedGoogle Scholar
• Hellebust JA, Lin YH. 1989. Regulation of glycerol and starch metabolism in Chlamydomonas pulsatilla in response to changes in salinity. Plant Cell Environ 12:621–627.
   Web of Science ®Google Scholar
• Hemschemeier A, Fouchard S, Cournac L, Peltier G, Happe T. 2008. Hydrogen production by Chlamydomonas reinhardtii: an elaborate interplay of electron sources and sinks. Planta 227: 397–407.
   PubMed Web of Science ®Google Scholar
• Herrero M, Ibáñez E, Cifuentes A, Reglero G, Santoyo S. 2006. Dunaliella salina microalga pressurized liquid extracts as potential antimicrobials. J Food Prot 69: 2471–2477.
   PubMed Web of Science ®Google Scholar
• Hessen DO, De Lange HJ, Van Donk E. 1997. UV-induced changes in phytoplankton cells and its effects on grazers. Freshw Biol 38:513–524.
   Web of Science ®Google Scholar
• Hu HH, Ll HY, Xu XD. 2008a. Alternative cold response modes in Chlorella (Chlorophyta, Trebouxiophyceae) from Antarctica. Phycologia 47:28–34.
   Web of Science ®Google Scholar
• Hu Q. 2004. Environmental effects on cell composition, In: Richmond A. (Ed.) Handbook of microalgal culture: Biotechnology and applied phycology, Blackwell Science Ltd, Oxford. pp. 83–93.
   Google Scholar
• Hu Q, Sommerfeld M, Jarvis E, Ghirardi M, Posewitz M, Seibert M, Darzins A. 2008b. Microalgal triacylglycerols as feedstocks for biofuel production: perspectives and advances. Plant J 54: 621–639.
   PubMed Web of Science ®Google Scholar
• Hu ZY, Li YT, Sommerfeld M, Chen F, Hu Q. 2008c. Enhanced protection against oxidative stress in an astaxanthin-overproduction Haematococcus mutant (Chlorophyceae). Eur J Phycol 43:365–376.
   Web of Science ®Google Scholar
• Huner NPA, Öquist G, Sarhan F. 1998. Energy balance and acclimation to light and cold. Trends Plant Sci 3:224–230.
   Web of Science ®Google Scholar
• Hunt B, Vincent AC. 2006. Scale and sustainability of marine bioprospecting for pharmaceuticals. Ambio 35: 57–64.
   PubMed Web of Science ®Google Scholar
• Ikawa M. 2004. Algal polyunsaturated fatty acids and effects on plankton ecology and other organisms. UNH Center Freshwat Biol Res 6:17–44.
   Google Scholar
• Ikeuchi M, Koyama T, Takahashi J, Yazawa K. 2007. Effects of astaxanthin in obese mice fed a high-fat diet. Biosci Biotechnol Biochem 71: 893–899.
   PubMed Web of Science ®Google Scholar
• Illman AM, Scragg AH, Shales SW. 2000. Increase in Chlorella strains calorific values when grown in low nitrogen medium. Enzyme Microb Technol 27: 631–635.
   PubMed Web of Science ®Google Scholar
• Imamoglu E, Dalay MC, Sukan FV. 2009. Influences of different stress media and high light intensities on accumulation of astaxanthin in the green alga Haematococcus pluvialis. N Biotechnol 26: 199–204.
   PubMed Web of Science ®Google Scholar
• Ip PF, Chen F. 2005. Employment of reactive oxygen species to enhance astaxanthin formation in Chlorella zofingiensis in heterotrophic culture. Process Biochem 40:3491–3496.
   Web of Science ®Google Scholar
• Iwamoto H. 2004. Industrial production of microalgal cell-mass and secondary products - Major industrial species - Chlorella, In: Richmond A. (Ed.) Handbook of microalgal culture: Biotechnology and applied phycology, Blackwell Science Ltd, Oxford. pp. 255–263.
   Google Scholar
• Jahns P, Latowski D, Strzalka K. 2009. Mechanism and regulation of the violaxanthin cycle: the role of antenna proteins and membrane lipids. Biochim Biophys Acta 1787: 3–14.
   PubMed Web of Science ®Google Scholar
• Janczyk P, Franke H, Souffrant WB. 2007. Nutritional value of Chlorella vulgaris: Effects of ultrasonication and electroporation on digestibility in rats. Anim Feed Sci Technol 132:163–169.
   Web of Science ®Google Scholar
• Janczyk P, Halle B, Souffrant WB. 2009. Microbial community composition of the crop and ceca contents of laying hens fed diets supplemented with Chlorella vulgaris. Poult Sci 88: 2324–2332.
   PubMed Web of Science ®Google Scholar
• Jin E, Lee CG, Polle JEW. 2006. Secondary carotenoid accumulation in Haematococcus (Chlorophyceae): Biosynthesis, regulation, and biotechnology. J Microbiol Biotechnol 16:821–831.
   Web of Science ®Google Scholar
• Jin E, Polle JEW, Lee HK, Hyun SM, Chang M. 2003. Xanthophylls in microalgae: From biosynthesis to biotechnological mass production and application. J Microbiol Biotechnol 13:165–174.
   Web of Science ®Google Scholar
• Jo JH, Lee DS, Park JM. 2006. Modeling and optimization of photosynthetic hydrogen gas production by green alga Chlamydomonas reinhardtii in sulfur-deprived circumstance. Biotechnol Prog 22: 431–437.
   PubMed Web of Science ®Google Scholar
• Johnson DT, Taconi KA. 2007. The glycerin glut: Options for the value-added conversion of crude glycerol resulting from biodiesel production. Environ Prog 26:338–348.
   Google Scholar
• Jyonouchi H, Sun S, Iijima K, Gross MD. 2000. Antitumor activity of astaxanthin and its mode of action. Nutr Cancer 36: 59–65.
   PubMed Web of Science ®Google Scholar
• Jyonouchi H, Sun S, Gross M. 1995. Effect of carotenoids on in vitro immunoglobulin production by human peripheral blood mononuclear cells: astaxanthin, a carotenoid without vitamin A activity, enhances in vitro immunoglobulin production in response to a T-dependent stimulant and antigen. Nutr Cancer 23: 171–183.
   PubMed Web of Science ®Google Scholar
• Kaçka A, Dönmez G. 2008. Isolation of Dunaliella spp. from a hypersaline lake and their ability to accumulate glycerol. Bioresour Technol 99: 8348–8352.
   PubMed Web of Science ®Google Scholar
• Kamath BS, Srikanta BM, Dharmesh SM, Sarada R, Ravishankar GA. 2008. Ulcer preventive and antioxidative properties of astaxanthin from Haematococcus pluvialis. Eur J Pharmacol 590: 387–395.
   PubMed Web of Science ®Google Scholar
• Kamp C, Silakov A, Winkler M, Reijerse EJ, Lubitz W, Happe T. 2008. Isolation and first EPR characterization of the [FeFe]-hydrogenases from green algae. Biochim Biophys Acta 1777: 410–416.
   PubMed Web of Science ®Google Scholar
• Kang CD, Lee JS, Park TH, Sim SJ. 2005. Comparison of heterotrophic and photoautotrophic induction on astaxanthin production by Haematococcus pluvialis. Appl Microbiol Biotechnol 68: 237–241.
   PubMed Web of Science ®Google Scholar
• Kang JS, Raymond JA. 2004. Reduction of freeze-thaw-induced hemolysis of red blood cells by an algal ice-binding protein. Cryo Letters 25: 307–310.
   PubMed Web of Science ®Google Scholar
• Kaplan A, Schreiber U, Avron M. 1980. Salt-induced metabolic changes in Dunaliella salina. Plant Physiol 65: 810–813.
   PubMed Web of Science ®Google Scholar
• Karsten U, Lembcke S, Schumann R. 2007. The effects of ultraviolet radiation on photosynthetic performance, growth and sunscreen compounds in aeroterrestrial biofilm algae isolated from building facades. Planta 225: 991–1000.
   PubMed Web of Science ®Google Scholar
• Kessler E. 1973. Effect of anaerobiosis on photosynthetic reactions and nitrogen metabolism of algae with and without hydrogenase. Arch Mikrobiol 93: 91–100.
   PubMedGoogle Scholar
• Kessler E. 1974. Hydrogenase, photoreduction and anaerobic growth, In: Stewart WDP. (Ed.) Algal physiology and biochemistry, Blackwell Sci., Oxford. pp. 456–473.
   Google Scholar
• Khan SA, Rashmi, Hussain MZ, Prasad S, Banerjee UC. 2009. Prospects of biodiesel production from microalgae in India. Renew Sust Energy Rev 13:2361–2372.
   Web of Science ®Google Scholar
• Khozin-Goldberg I, Bigogno C, Shrestha P, Cohen Z. 2002. Nitrogen starvation induces the accumulation of arachidonic acid in the freshwater green alga Parietochloris incisa (Trebuxiophyceae). J Phycol 38:991–994.
   Web of Science ®Google Scholar
• Khozin-Goldberg I, Cohen Z, Pimenta-Leibowitz M, Nechev J, Zilberg D. 2006. Feeding with arachidonic acid-rich triacylglycerols from the microalga Parietochloris incisa improved recovery of guppies from infection with Tetrahymena sp. Aquaculture 255:142–150.
   Web of Science ®Google Scholar
• Kim HK, Li L, Lee HS, Park MO, Bilehal D, Li W, Kim YH. 2009a. Protective effects of Chlorella vulgaris extract on carbon tetrachloride induced acute liver injury in mice. Food Sci Biotechnol 18:1186–1192.
   Web of Science ®Google Scholar
• Kim JP, Kang CD, Park TH, Kim MS, Sim SJ. 2006a. Enhanced hydrogen production by controlling light intensity in sulfur-deprived Chlamydomonas reinhardtii culture. Int J Hydrogen Energy 31:1585–1590.
   Web of Science ®Google Scholar
• Kim JP, Kang CD, Sim SJ, Kim MS, Park TH, Lee D, Kim D, Kim JH, Lee YK, Pak D. 2005. Cell age optimization for hydrogen production induced by sulfur deprivation using a green alga Chlamydomonas reinhardtii UTEX 90. J Microbiol Biotechnol 15:131–135.
   Web of Science ®Google Scholar
• Kim JP, Kim KR, Choi SP, Han SJ, Kim MS, Sim SJ. 2010. Repeated production of hydrogen by sulfate re-addition in sulfur deprived culture of Chlamydomonas reinhardtii. Int J Hydrogen Energy doi:10.1016/j.ijhydene.2009.11.113.
   PubMed Web of Science ®Google Scholar
• Kim MK, Park JW, Park CS, Kim SJ, Jeune KH, Chang MU, Acreman J. 2007. Enhanced production of Scenedesmus spp. (green microalgae) using a new medium containing fermented swine wastewater. Bioresour Technol 98: 2220–2228.
   PubMed Web of Science ®Google Scholar
• Kim MS, Baek JS, Yun YS, Sim SJ, Park S, Kim SC. 2006b. Hydrogen production from Chlamydomonas reinhardtii biomass using a two-step conversion process: Anaerobic conversion and photosynthetic fermentation. Int J Hydrogen Energy 31:812–816.
   Web of Science ®Google Scholar
• Kim SH, Jean DI, Lim YP, Lee C, An G. 2009b. Weight gain limitation and liver protection by long-term feeding of astaxanthin in murines. J Korean Soc Appl Biol Chem 52:180–185.
   Google Scholar
• Kim SK, Ravichandran YD, Khan SB, Kim YT. 2008. Prospective of the cosmeceuticals derived from marine organisms. Biotechnol Bioprocess Eng 13:511–523.
   Web of Science ®Google Scholar
• Kirst GO. 1989. Salinity tolerance of eukaryotic marine algae. Annu Rev Plant Physiol Plant Molec Biol 41:21–53.
   Web of Science ®Google Scholar
• Kosourov S, Makarova V, Fedorov AS, Tsygankov A, Seibert M, Ghirardi ML. 2005. The effect of sulfur re-addition on H(2) photoproduction by sulfur-deprived green algae. Photosyn Res 85: 295–305.
   PubMed Web of Science ®Google Scholar
• Kosourov S, Seibert M, Ghirardi ML. 2003. Effects of extracellular pH on the metabolic pathways in sulfur-deprived, H2-producing Chlamydomonas reinhardtii cultures. Plant Cell Physiol 44: 146–155.
   PubMed Web of Science ®Google Scholar
• Kosourov S, Tsygankov A, Seibert M, Ghirardi ML. 2002. Sustained hydrogen photoproduction by Chlamydomonas reinhardtii: Effects of culture parameters. Biotechnol Bioeng 78: 731–740.
   PubMed Web of Science ®Google Scholar
• Kosourov SN, Seibert M. 2009. Hydrogen photoproduction by nutrient-deprived Chlamydomonas reinhardtii cells immobilized within thin alginate films under aerobic and anaerobic conditions. Biotechnol Bioeng 102: 50–58.
   PubMed Web of Science ®Google Scholar
• Kreuzberg K. 1984. Starch fermentation via a formate producing pathway in Chlamydomonas reinhardii, Chlorogonium elongatum and Chlorella fusca. Physiol Plant 61:87–94.
   Web of Science ®Google Scholar
• Krinsky NI, Landrum JT, Bone RA. 2003. Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye. Annu Rev Nutr 23: 171–201.
   PubMed Web of Science ®Google Scholar
• Kruse O, Rupprecht J, Bader KP, Thomas-Hall S, Schenk PM, Finazzi G, Hankamer B. 2005. Improved photobiological H2 production in engineered green algal cells. J Biol Chem 280: 34170–34177.
   PubMed Web of Science ®Google Scholar
• Laguna MR, Villar R, Calleja JM, Cadavid I. 1993. Effects of Chlorella stigmatophora extract on the central nervous system. Planta Med 59: 125–130.
   PubMed Web of Science ®Google Scholar
• Lakeh AAB, Ahmadi MR, Safi S, Ytrestøyl T, Bjerkeng B. 2010. Growth performance, mortality and carotenoid pigmentation of fry offspring as affected by dietary supplementation of astaxanthin to female rainbow trout (Oncorhynchus mykiss) broodstock. J Appl Ichthyol 26:35–39.
   Web of Science ®Google Scholar
• Lall SP, Lewis-McCrea LM. 2007. Role of nutrients in skeletal metabolism and pathology in fish - An overview. Aquaculture 267:3–19.
   Web of Science ®Google Scholar
• Lamers PP, Janssen M, De Vos RC, Bino RJ, Wijffels RH. 2008. Exploring and exploiting carotenoid accumulation in Dunaliella salina for cell-factory applications. Trends Biotechnol 26: 631–638.
   PubMed Web of Science ®Google Scholar
• Langner U, Jakob T, Stehfest K, Wilhelm C. 2009. An energy balance from absorbed photons to new biomass for Chlamydomonas reinhardtii and Chlamydomonas acidophila under neutral and extremely acidic growth conditions. Plant Cell Environ 32: 250–258.
   PubMed Web of Science ®Google Scholar
• Latasa M, Scharek R, Le Gall F, Guillou L. 2004. Pigment suites and taxonomic groups in Prasinophyceae. J Phycol 40:1149–1155.
   Web of Science ®Google Scholar
• Laurinavichene T, Tolstygina I, Tsygankov A. 2004. The effect of light intensity on hydrogen production by sulfur-deprived Chlamydomonas reinhardtii. J Biotechnol 114: 143–151.
   PubMed Web of Science ®Google Scholar
• Laurinavichene TV, Fedorov AS, Ghirardi ML, Seibert M, Tsygankov AA. 2006. Demonstration of sustained hydrogen photoproduction by immobilized, sulfur-deprived Chlamydomonas reinhardtii cells. Int J Hydrogen Energy 31:659–667.
   Web of Science ®Google Scholar
• Laurinavichene TV, Tolstygina IV, Galiulina RR, Ghirardi ML, Seibert M, Tsygankov AA. 2002. Dilution methods to deprive Chlamydomonas reinhardtii cultures of sulfur for subsequent hydrogen photoproduction. Int J Hydrogen Energy 27:1245–1249.
   Web of Science ®Google Scholar
• Lavens P, Sorgeloos P. 1996. Manual on the production and use of live food for aquaculture. Food and Agriculture Organization of the United Nations, Rome.
   Google Scholar
• León-Bañares R, González-Ballester D, Galván A, Fernández E. 2004. Transgenic microalgae as green cell-factories. Trends Biotechnol 22: 45–52.
   PubMed Web of Science ®Google Scholar
• León R, Galván F. 1994. Halotolerance studies on Chlamydomonas reinhardtii – glycerol excretion by free and immobilized cells. J Appl Phycol 6:13–20.
   Web of Science ®Google Scholar
• León R, Galván F. 1999. Interaction between saline stress and photoinhibition of photosynthesis in the freshwater green algae Chlamydomonas reinhardtii. Implications for glycerol photoproduction. Plant Physiol Biochem 37:623–628.
   Web of Science ®Google Scholar
• Lewis LA, McCourt RM. 2004. Green algae and the origin of land plants. Am J Bot 91: 1535–1556.
   PubMed Web of Science ®Google Scholar
• Leya T, Rahn A, Lütz C, Remias D. 2009. Response of arctic snow and permafrost algae to high light and nitrogen stress by changes in pigment composition and applied aspects for biotechnology. FEMS Microbiol Ecol 67: 432–443.
   PubMed Web of Science ®Google Scholar
• Li SS, Tsai HJ. 2009a. Transgenic microalgae as a non-antibiotic bactericide producer to defend against bacterial pathogen infection in the fish digestive tract. Fish Shellfish Immunol 26: 316–325.
   PubMed Web of Science ®Google Scholar
• Li Y, Wei G, Chen J. 2004. Glutathione: a review on biotechnological production. Appl Microbiol Biotechnol 66: 233–242.
   PubMed Web of Science ®Google Scholar
• Li YT, Huang JC, Sandmann G, Chen F. 2009b. High light and sodium chloride stress differentially regulate the biosynthesis of astaxanthin in Chlorella zofingiensis (chlorophyceae). J Phycol 45:635–641.
   PubMed Web of Science ®Google Scholar
• Liang Y, Sarkany N, Cui Y. 2009. Biomass and lipid productivities of Chlorella vulgaris under autotrophic, heterotrophic and mixotrophic growth conditions. Biotechnol Lett 31: 1043–1049.
   PubMed Web of Science ®Google Scholar
• Liao WR, Lin JY, Shieh WY, Jeng WL, Huang R. 2003. Antibiotic activity of lectins from marine algae against marine vibrios. J Ind Microbiol Biotechnol 30: 433–439.
   PubMed Web of Science ®Google Scholar
• Libessart N, Maddelein ML, Koornhuyse N, Decq A, Delrue B, Mouille G, D’Hulst C, Ball S. 1995. Storage, photosynthesis, and growth: The conditional nature of mutations affecting starch synthesis and structure in Chlamydomonas. Plant Cell 7: 1117–1127.
   PubMed Web of Science ®Google Scholar
• Lindberg P, Melis A. 2008. The chloroplast sulfate transport system in the green alga Chlamydomonas reinhardtii. Planta 228: 951–961.
   PubMed Web of Science ®Google Scholar
• Liu BH, Lee YK. 2000. Secondary carotenoids formation by the green alga Chlorococcum sp. J Appl Phycol 12:301–307.
   Web of Science ®Google Scholar
• Logan BA, Kornyeyev D, Hardison J, Holaday AS. 2006. The role of antioxidant enzymes in photoprotection. Photosyn Res 88: 119–132.
   PubMed Web of Science ®Google Scholar
• Long H, Chang CH, King PW, Ghirardi ML, Kim K. 2008. Brownian dynamics and molecular dynamics study of the association between hydrogenase and ferredoxin from Chlamydomonas reinhardtii. Biophys J 95: 3753–3766.
   PubMed Web of Science ®Google Scholar
• Lorenz RT, Cysewski GR. 2000. Commercial potential for Haematococcus microalgae as a natural source of astaxanthin. Trends Biotechnol 18: 160–167.
   PubMed Web of Science ®Google Scholar
• Luiten EE, Akkerman I, Koulman A, Kamermans P, Reith H, Barbosa MJ, Sipkema D, Wijffels RH. 2003. Realizing the promises of marine biotechnology. Biomol Eng 20: 429–439.
   PubMedGoogle Scholar
• Lustigman B. 1988. Comparison of antibiotic production from four ecotypes of the marine alga, Dunaliella. Bull Environ Contam Toxicol 40: 18–22.
   PubMed Web of Science ®Google Scholar
• Maliga P. 2003. Progress towards commercialization of plastid transformation technology. Trends Biotechnol 21: 20–28.
   PubMed Web of Science ®Google Scholar
• Maneeruttanarungroj C, Lindblad P, Incharoensakdi A. 2010. A newly isolated green alga, Tetraspora sp. CU2551, from Thailand with efficient hydrogen production. Int J Hydrogen Energy 35:13193–13199.
   Web of Science ®Google Scholar
• Martinez-Fernandez E, Acosta-Salmon H, Southgate PC. 2006. The nutritional value of seven species of tropical microalgae for black-lip pearl oyster (Pinctada margaritifera, L.) larvae. Aquaculture 257:491–503.
   Web of Science ®Google Scholar
• Martinez-Fernandez E, Southgate PC. 2007. Use of tropical microalgae as food for larvae of the black-lip pearl oyster Pinctada margaritifera. Aquaculture 263:220–226.
   Web of Science ®Google Scholar
• Mata TM, Martins AA, Caetano NS. 2010. Microalgae for biodiesel production and other applications: A review. Renew Sust Energy Rev 14:217–232.
   Web of Science ®Google Scholar
• Matagne RF, Loppes R, Deltour R. 1976. Phosphatase of Chlamydomonas reinhardtii: biochemical and cytochemical approach with specific mutants. J Bacteriol 126: 937–950.
   PubMed Web of Science ®Google Scholar
• Matsukawa R, Hotta M, Masuda Y, Chihara M, Karube I. 2000. Antioxidants from carbon dioxide fixing Chlorella sorokiniana. J Appl Phycol 12:263–267.
   Web of Science ®Google Scholar
• Mayer AM, Gustafson KR. 2003. Marine pharmacology in 2000: antitumor and cytotoxic compounds. Int J Cancer 105: 291–299.
   PubMed Web of Science ®Google Scholar
• Mayer AM, Gustafson KR. 2008. Marine pharmacology in 2005–2006: antitumour and cytotoxic compounds. Eur J Cancer 44: 2357–2387.
   PubMed Web of Science ®Google Scholar
• McCord JM. 2000. The evolution of free radicals and oxidative stress. Am J Med 108: 652–659.
   PubMed Web of Science ®Google Scholar
• McCracken MD, Middaugh RE, Middaugh RS. 1980. A chemical characterization of an algal inhibitor obtained from Chlamydomonas. Hydrobiologia 70:271–276.
   Web of Science ®Google Scholar
• Melis A. 1999. Photosystem II damage and repair cycle in chloroplasts: what modulates the rate of photodamage in vivo? Trends Plant Sci 4:130–135.
   PubMed Web of Science ®Google Scholar
• Melis A. 2002. Green alga hydrogen production: progress, challenges and prospects. Int J Hydrogen Energy 27:1217–1228.
   Web of Science ®Google Scholar
• Melis A. 2007. Photosynthetic H2 metabolism in Chlamydomonas reinhardtii (unicellular green algae). Planta 226: 1075–1086.
   PubMed Web of Science ®Google Scholar
• Melis A. 2009. Solar energy conversion efficiencies in photosynthesis: Minimizing the chlorophyll antennae to maximize efficiency. Plant Sci 177:272–280.
   Web of Science ®Google Scholar
• Melis A, Happe T. 2001. Hydrogen production. Green algae as a source of energy. Plant Physiol 127: 740–748.
   PubMed Web of Science ®Google Scholar
• Melis A, Zhang L, Forestier M, Ghirardi ML, Seibert M. 2000. Sustained photobiological hydrogen gas production upon reversible inactivation of oxygen evolution in the green alga Chlamydomonas reinhardtii. Plant Physiol 122: 127–136.
   PubMed Web of Science ®Google Scholar
• Mendes RL, Nobre BP, Cardoso MT, Pereira AP, Palavra AF. 2003. Supercritical carbon dioxide extraction of compounds with pharmaceutical importance from microalgae. Inorg Chim Acta 356:328–334.
   Web of Science ®Google Scholar
• Meuser JE, Ananyev G, Wittig LE, Kosourov S, Ghirardi ML, Seibert M, Dismukes GC, Posewitz MC. 2009. Phenotypic diversity of hydrogen production in chlorophycean algae reflects distinct anaerobic metabolisms. J Biotechnol 142: 21–30.
   PubMed Web of Science ®Google Scholar
• Mignone LI, Giovannucci E, Newcomb PA, Titus-Ernstoff L, Trentham-Dietz A, Hampton JM, Willett WC, Egan KM. 2009. Dietary carotenoids and the risk of invasive breast cancer. Int J Cancer 124: 2929–2937.
   PubMed Web of Science ®Google Scholar
• Miura Y, Akano T, Fukatsu K, Miyasaka H, Mizoguchi T, Yagi K, Maeda I, Ikuta Y, Matsumoto H. 1997. Stably sustained hydrogen production by biophotolysis in natural day/night cycle. Energy Conv Manag 38:S533–S537.
   Web of Science ®Google Scholar
• Miyasaka H, Ohnishi Y, Akano T, Fukatsu K, Mizoguchi T, Yagi K, Maeda I, Ikuta Y, Matsumoto H, Shioji N, Miura Y. 1998. Excretion of glycerol by the marine Chlamydomonas sp. strain W-80 in high CO2 cultures. J Ferment Bioeng 85:122–124.
   Google Scholar
• Mohamed ZA. 2008. Polysaccharides as a protective response against microcystin-induced oxidative stress in Chlorella vulgaris and Scenedesmus quadricauda and their possible significance in the aquatic ecosystem. Ecotoxicology 17: 504–516.
   PubMed Web of Science ®Google Scholar
• Mokady S, Abramovici A, Cogan U. 1989. The safety evaluation of Dunaliella bardawil as a potential food supplement. Food Chem Toxicol 27: 221–226.
   PubMed Web of Science ®Google Scholar
• Momirlan M, Veziroglu TN. 2002. Current status of hydrogen energy. Renew Sust Energy Rev 6:141–179.
   Web of Science ®Google Scholar
• Morgan-Kiss RM, Priscu JC, Pocock T, Gudynaite-Savitch L, Huner NP. 2006. Adaptation and acclimation of photosynthetic microorganisms to permanently cold environments. Microbiol Mol Biol Rev 70: 222–252.
   PubMed Web of Science ®Google Scholar
• Morita M, Watanabe Y, Saiki H. 2000. High photosynthetic productivity of green microalga Chlorella sorokiniana. Appl Biochem Biotechnol 87: 203–218.
   PubMed Web of Science ®Google Scholar
• Myrand B, de la Noüe J. 1983. Ingestion and assimilation rates of Oocystis sp. by Daphnia magna in treated wastewaters. Environ Poll (Series A) – Ecol Biol 31:77–95.
   Web of Science ®Google Scholar
• Nagy LE, Meuser JE, Plummer S, Seibert M, Ghirardi ML, King PW, Ahmann D, Posewitz MC. 2007. Application of gene-shuffling for the rapid generation of novel [FeFe]-hydrogenase libraries. Biotechnol Lett 29: 421–430.
   PubMed Web of Science ®Google Scholar
• Nakano S, Noguchi T, Takekoshi H, Suzuki G, Nakano M. 2005. Maternal–fetal distribution and transfer of dioxins in pregnant women in Japan, and attempts to reduce maternal transfer with Chlorella (Chlorella pyrenoidosa) supplements. Chemosphere 61: 1244–1255.
   PubMed Web of Science ®Google Scholar
• Napolitano MJ, Shain DH. 2005. Distinctions in adenylate metabolism among organisms inhabiting temperature extremes. Extremophiles 9: 93–98.
   PubMed Web of Science ®Google Scholar
• Neale PJ, Melis A. 1989. Salinity stress enhances photoinhibition of photosynthesis in Chlamydomonas reinhardtii. J Plant Physiol 134:619–622.
   Web of Science ®Google Scholar
• Neori A. 2011. “Green water” microalgae: the leading sector in world aquaculture. J Appl Phycol 23:143–149.
   Web of Science ®Google Scholar
• Nield J, Redding K, Hippler M. 2004. Remodeling of light-harvesting protein complexes in Chlamydomonas in response to environmental changes. Eukaryotic Cell 3: 1370–1380.
   PubMedGoogle Scholar
• Nishiyama Y, Allakhverdiev SI, Murata N. 2006. A new paradigm for the action of reactive oxygen species in the photoinhibition of photosystem II. Biochim Biophys Acta 1757: 742–749.
   PubMed Web of Science ®Google Scholar
• Nishiyama Y, Allakhverdiev SI, Murata N. 2011. Protein synthesis is the primary target of reactive oxygen species in the photoinhibition of photosystem II. Physiol Plant 142: 35–46.
   PubMed Web of Science ®Google Scholar
• Niu J, Tian LX, Liu YJ, Yang HJ, Ye CX, Gao W, Mai KS. 2009. Effect of dietary astaxanthin on growth, survival, and stress tolerance of postlarval shrimp, Litopenaeus vannamei. J World Aquacult Soc 40:795–802.
   Web of Science ®Google Scholar
• Niyogi KK. 2000. Safety valves for photosynthesis. Curr Opin Plant Biol 3: 455–460.
   PubMed Web of Science ®Google Scholar
• Oguchi R, Terashima I, Kou J, Chow WS. 2011. Operation of dual mechanisms that both lead to photoinactivation of Photosystem II in leaves by visible light. Physiol Plant 142: 47–55.
   PubMed Web of Science ®Google Scholar
• Ohta S, Shiomi Y, Kawashima A, Aozasa O, Nakao T, Nagate T, Kitamura K, Miyata H. 1995. Antibiotic effect of linolenic acid from Chlorococcum strain HS-101 and Dunaliella primolecta on methicillin resistant Staphylococcus aureus. J Appl Phycol 7:121–127.
   Web of Science ®Google Scholar
• Olaizola M. 2005. The health benefits of Haematococcus astaxanthin: cardiovascular health. Agro Food Ind Hi-Tech 16:35–37.
   Google Scholar
• Olsen Y, Knutsen G, Lien T. 1983. Characteristics of phosphorus limitation in Chlamydomonas reinhardtii (Chlorophyceae) and its palmelloids. J Phycol 19:313–319.
   Web of Science ®Google Scholar
• Opuszynski K. 1981. Comparison of the usefulness of the Silver Carp and the Bighead Carp as additional fish in carp ponds. Aquaculture 25:223–233.
   Web of Science ®Google Scholar
• Ördög V, Stirk WA, Lenobel R, Bancírová M, Strnad M, van Staden J, Szigeti J, Néřmeth L. 2004. Screening microalgae for some potentially useful agricultural and pharmaceutical secondary metabolites. J Appl Phycol 16:309–314.
   Web of Science ®Google Scholar
• Oren A. 2007. Diversity of organic osmotic compounds and osmotic adaptation in cyanobacteria and algae, In: Seckbach J. (Ed.) Algae and cyanobacteria in extreme environments, Springer, Dordrecht, Netherlands. pp. 641–660.
   Google Scholar
• Oren A, Ionescu D, Hindiyeh M, Malkawi H. 2008. Microalgae and cyanobacteria of the Dead Sea and its surrounding springs. Isr J Plant Sci 56:1–13.
   Web of Science ®Google Scholar
• Orosa M, Valero JF, Herrero C, Abalde J. 2001. Comparison of the accumulation of astaxanthin in Haematococcus pluvialis and other green microalgae under N-starvation and high light conditions. Biotechnol Lett 23:1079–1085.
   Web of Science ®Google Scholar
• Palozza P, Torelli C, Boninsegna A, Simone R, Catalano A, Mele MC, Picci N. 2009. Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells. Cancer Lett 283: 108–117.
   PubMed Web of Science ®Google Scholar
• Park JS, Chyun JH, Kim YK, Line LL, Chew BP. 2010. Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. Nutr Metab (Lond) 7: 18.
   PubMed Web of Science ®Google Scholar
• Patil V, Källqvist T, Olsen E, Vogt G, Gislerød HR. 2007. Fatty acid composition of 12 microalgae for possible use in aquaculture feed. Aquac Int 15:1–9.
   Web of Science ®Google Scholar
• Pelah D, Sintov A, Cohen E. 2004. The effect of salt stress on the production of canthaxanthin and astaxanthin by Chlorella zofingiensis grown under limited light intensity. World J Microbiol Biotechnol 20:483–486.
   Web of Science ®Google Scholar
• Pham-Huy LA, He H, Pham-Huy C. 2008. Free radicals, antioxidants in disease and health. Int J Biomed Sci 4:89–96.
   PubMedGoogle Scholar
• Picataggio S. 2009. Potential impact of synthetic biology on the development of microbial systems for the production of renewable fuels and chemicals. Curr Opin Biotechnol 20: 325–329.
   PubMed Web of Science ®Google Scholar
• Piorreck M, Baasch KH, Pohl P. 1984. Biomass production, total protein, chlorophylls, lipids and fatty acids of freshwater green and blue-green algae under different nitrogen regimes. Phytochemistry 23:207–216.
   Web of Science ®Google Scholar
• Plaza M, Herrero M, Cifuentes A, Ibáñez E. 2009. Innovative natural functional ingredients from microalgae. J Agric Food Chem 57: 7159–7170.
   PubMed Web of Science ®Google Scholar
• Poerschmann J, Spijkerman E, Langer U. 2004. Fatty acid patterns in Chlamydomonas sp. as a marker for nutritional regimes and temperature under extremely acidic conditions. Microb Ecol 48: 78–89.
   PubMed Web of Science ®Google Scholar
• Pollock SV, Pootakham W, Shibagaki N, Moseley JL, Grossman AR. 2005. Insights into the acclimation of Chlamydomonas reinhardtii to sulfur deprivation. Photosyn Res 86: 475–489.
   PubMed Web of Science ®Google Scholar
• Ponomarenko LP, Stonik IV, Aizdaicher NA, Orlova TY, Popovskaya GI, Pomazkina GV, Stonik VA. 2004. Sterols of marine microalgae Pyramimonas cf. cordata (Prasinophyta), Attheya ussurensis sp. nov. (Bacillariophyta) and a spring diatom bloom from Lake Baikal. Comp Biochem Physiol B, Biochem Mol Biol 138: 65–70.
   PubMed Web of Science ®Google Scholar
• Posewitz MC, Smolinski SL, Kanakagiri S, Melis A, Seibert M, Ghirardi ML. 2004. Hydrogen photoproduction is attenuated by disruption of an isoamylase gene in Chlamydomonas reinhardtii. Plant Cell 16: 2151–2163.
   PubMed Web of Science ®Google Scholar
• Posten C.. 2009. Design principles of photo-bioreactors for cultivation of microalgae. Eng Life Sci 9:165–177.
   Web of Science ®Google Scholar
• Posten C, Schaub G. 2009. Microalgae and terrestrial biomass as source for fuels–a process view. J Biotechnol 142: 64–69.
   PubMed Web of Science ®Google Scholar
• Proksch P, Edrada RA, Ebel R. 2002. Drugs from the seas – current status and microbiological implications. Appl Microbiol Biotechnol 59: 125–134.
   PubMed Web of Science ®Google Scholar
• Puello-Cruz AC, Mezo-Villalobos S, Gonzalez-Rodriguez B, Voltolina D. 2009. Culture of the calanoid copepod Pseudodiaptomus euryhalinus (Johnson 1939) with different microalgal diets. Aquaculture 290:317–319.
   Web of Science ®Google Scholar
• Pugh N, Ross SA, ElSohly HN, ElSohly MA, Pasco DS. 2001. Isolation of three high molecular weight polysaccharide preparations with potent immunostimulatory activity from Spirulina platensis, aphanizomenon flos-aquae and Chlorella pyrenoidosa. Planta Med 67: 737–742.
   PubMed Web of Science ®Google Scholar
• Pulz O. 2001. Photobioreactors: production systems for phototrophic microorganisms. Appl Microbiol Biotechnol 57: 287–293.
   PubMed Web of Science ®Google Scholar
• Pulz O, Gross W. 2004. Valuable products from biotechnology of microalgae. Appl Microbiol Biotechnol 65: 635–648.
   PubMed Web of Science ®Google Scholar
• Qiao HJ, Wang G. 2009. Effect of carbon source on growth and lipid accumulation in Chlorella sorokiniana GXNN01. Chin J Oceanol Limnol 27:762–768.
   Web of Science ®Google Scholar
• Qin S, Liu GX, Hu ZY. 2008. The accumulation and metabolism of astaxanthin in Scenedesmus obliquus (Chlorophyceae). Process Biochem 43:795–802.
   Web of Science ®Google Scholar
• Rabbani S, Beyer P, Lintig J, Hugueney P, Kleinig H. 1998. Induced beta-carotene synthesis driven by triacylglycerol deposition in the unicellular alga Dunaliella bardawil. Plant Physiol 116: 1239–1248.
   PubMed Web of Science ®Google Scholar
• Rainuzzo JR, Reitan KI, Olsen Y. 1997. The significance of lipids at early stages of marine fish: a review. Aquaculture 155:103–115.
   Web of Science ®Google Scholar
• Raja R, Hemaiswarya S, Balasubramanyam D, Rengasamy R. 2007. Protective effect of Dunaliella salina (Volvocales, Chlorophyta) against experimentally induced fibrosarcoma on wistar rats. Microbiol Res 162: 177–184.
   PubMed Web of Science ®Google Scholar
• Raja R, Hemaiswarya S, Kumar NA, Sridhar S, Rengasamy R. 2008. A perspective on the biotechnological potential of microalgae. Crit Rev Microbiol 34: 77–88.
   PubMed Web of Science ®Google Scholar
• Rao AR, Dayananda C, Sarada R, Shamala TR, Ravishankar GA. 2007. Effect of salinity on growth of green alga Botryococcus braunii and its constituents. Bioresour Technol 98: 560–564.
   PubMed Web of Science ®Google Scholar
• Rao AR, Sarada R, Baskaran V, Ravishankar GA. 2006. Antioxidant activity of Botryococcus braunii extract elucidated in vitro models. J Agric Food Chem 54: 4593–4599.
   PubMed Web of Science ®Google Scholar
• Reitan KI, Rainuzzo JR, Olsen Y. 1994. Effect of nutrient limitation on fatty acid and lipid content of marine microalgae. J Phycol 30:972–979.
   Web of Science ®Google Scholar
• Reitan KI, Rainuzzo JR, Øie G, Olsen Y. 1997. A review of the nutritional effects of algae in marine fish larvae. Aquaculture 155:207–221.
   Web of Science ®Google Scholar
• Remias D, Holzinger A, Lutz C. 2009. Physiology, ultrastructure and habitat of the ice alga Mesotaenium berggrenii (Zygnemaphyceae, Chlorophyta) from glaciers in the European Alps. Phycologia 48:302–312.
   Web of Science ®Google Scholar
• Remias D, Lütz-Meindl U, Lütz C. 2005. Photosynthesis, pigments and ultrastructure of the alpine snow alga Chlamydomonas nivalis. Eur J Phycol 40:259–268.
   Web of Science ®Google Scholar
• Richmond A. 2003. Growth characteristics of ultrahigh-density microalgal cultures. Biotechnol Bioprocess Eng 8:349–353.
   Web of Science ®Google Scholar
• Richmond A, Soeder CJ. 1986. Microalgaculture. Crit Rev Biotechnol 4:369–438.
   Web of Science ®Google Scholar
• Riediger ND, Othman RA, Suh M, Moghadasian MH. 2009. A systemic review of the roles of n-3 fatty acids in health and disease. J Am Diet Assoc 109: 668–679.
   PubMed Web of Science ®Google Scholar
• Rigano VD, Vona V, Carfagna S, Esposito S, Carillo P, Rigano C. 2000. Effects of sulfate-starvation and re-supply on growth, NH4+ uptake and starch metabolism in Chlorella sorokiniana. Aust J Plant Physiol 27:335–342.
   Google Scholar
• Rodolfi L, Chini Zittelli G, Bassi N, Padovani G, Biondi N, Bonini G, Tredici MR. 2009. Microalgae for oil: strain selection, induction of lipid synthesis and outdoor mass cultivation in a low-cost photobioreactor. Biotechnol Bioeng 102: 100–112.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Garcia I, Guil-Guerrero JL. 2008. Evaluation of the antioxidant activity of three microalgal species for use as dietary supplements and in the preservation of foods. Food Chem 108:1023–1026.
   PubMed Web of Science ®Google Scholar
• Running JA, Severson DK, Schneider KJ. 2002. Extracellular production of L-ascorbic acid by Chlorella protothecoides, Prototheca species, and mutants of P. moriformis during aerobic culturing at low pH. J Ind Microbiol Biotechnol 29: 93–98.
   PubMed Web of Science ®Google Scholar
• Russo GL. 2009. Dietary n-6 and n-3 polyunsaturated fatty acids: from biochemistry to clinical implications in cardiovascular prevention. Biochem Pharmacol 77: 937–946.
   PubMed Web of Science ®Google Scholar
• Sakai N, Sakamoto Y, Kishimoto N, Chihara M, Karube I. 1995. Chlorella strains from hot springs tolerant to high temperature and high CO2. Energy Conv Manag 36:693.
   Web of Science ®Google Scholar
• Salguero A, de la Morena B, Vigara J, Vega JM, Vilchez C, León R. 2003. Carotenoids as protective response against oxidative damage in Dunaliella bardawil. Biomol Eng 20: 249–253.
   PubMedGoogle Scholar
• Sánchez JF, Fernández-Sevilla JM, Acién FG, Cerón MC, Pérez-Parra J, Molina-Grima E. 2008. Biomass and lutein productivity of Scenedesmus almeriensis: influence of irradiance, dilution rate and temperature. Appl Microbiol Biotechnol 79: 719–729.
   PubMed Web of Science ®Google Scholar
• Sargent J, McEvoy L, Estevez A, Bell G, Bell M, Henderson J, Tocher D. 1999. Lipid nutrition of marine fish during early development: current status and future directions. Aquaculture 179:217–229.
   Web of Science ®Google Scholar
• Sato N, Sonoike K, Kawaguchi A, Tsuzuki M. 1996. Contribution of lowered unsaturation levels of chloroplast lipids to high temperature tolerance of photosynthesis in Chlamydomonas reinhardtii. J Photochem Photobiol B-Biol 36:333–337.
   Web of Science ®Google Scholar
• Sato N, Sonoike K, Tsuzuki M, Kawaguchi A. 1995. Impaired photosystem II in a mutant of Chlamydomonas reinhardtii defective in sulfoquinovosyl diacylglycerol. Eur J Biochem 234: 16–23.
   PubMedGoogle Scholar
• Satoh A, Tsuji S, Okada Y, Murakami N, Urami M, Nakagawa K, Ishikura M, Katagiri M, Koga Y, Shirasawa T. 2009. Preliminary clinical evaluation of toxicity and efficacy of a new astaxanthin-rich Haematococcus pluvialis extract. J Clin Biochem Nutr 44: 280–284.
   PubMed Web of Science ®Google Scholar
• Satoh K, Smith CM, Fork DC. 1983. Effects of salinity on primary processes of photosynthesis in the red alga Porphyra perforata. Plant Physiol 73: 643–647.
   PubMed Web of Science ®Google Scholar
• Schenk PM, Thomas-Hall SR, Stephens E, Marx UC, Mussgnug JH, Posten C, Kruse O, Hankamer B. 2008. Second generation biofuels: High-efficiency microalgae for biodiesel production. Bioenerg Res 1:20–43.
   Web of Science ®Google Scholar
• Schmid D, Schürch C, Zülli F. 2006. Mycosporine-like amino acids from red algae protect against premature skin-aging. Euro Cosmetics 9:1–4.
   Google Scholar
• Schreiner O, Lien T, Knutsen G. 1975. The capacity for arylsulfatase synthesis in synchronous and synchronized cultures of Chlamydomonas reinhardtii. Biochim Biophys Acta 384: 180–193.
   Google Scholar
• Scott KJ, Rodriquez-Amaya D. 2000. Pro-vitamin A carotenoid conversion factors: retinol equivalents – fact or fiction? Food Chem 69:125–127.
   Google Scholar
• Seckbach J. 2007. Algae and cyanobacteria in extreme environments. Springer, Dordrecht, Netherlands.
   Google Scholar
• Seixas P, Rey-Méndez M, Valente LMP, Otero A. 2008. Producing juvenile Artemia as prey for Octopus vulgaris paralarvae with different microalgal species of controlled biochemical composition. Aquaculture 283:83–91.
   Google Scholar
• Seto A, Wang HL, Hesseltine CW. 1984. Culture conditions affect eicosapentaenoic acid content of Chlorella minutissima. J Am Oil Chem Soc 61:892–894.
   Web of Science ®Google Scholar
• Seymour EH, Murray L, Fernandes R. 2008. Key challenges to the introduction of hydrogen – European stakeholder views. Int J Hydrogen Energy 33:3015–3020.
   Web of Science ®Google Scholar
• Sheng JC, Yu F, Xin ZH, Zhao LY, Zhu XJ, Hu QH. 2007. Preparation, identification and their antitumor activities in vitro of polysaccharides from Chlorella pyrenoidosa. Food Chem 105:533–539.
   Web of Science ®Google Scholar
• Shi X, Wu Z, Chen F. 2006. Kinetic modeling of lutein production by heterotrophic Chlorella at various pH and temperatures. Mol Nutr Food Res 50: 763–768.
   PubMed Web of Science ®Google Scholar
• Shon YH, Nam KS, Kim MK. 2004. Cancer chemopreventive potential of Scenedesmus spp. cultured in medium containing bioreacted swine urine. J Microbiol Biotechnol 14:158–161.
   Web of Science ®Google Scholar
• Shpigel M, Schlosser SC, Ben-Amotz A, Lawrence AL, Lawrence JM. 2006. Effects of dietary carotenoid on the gut and the gonad of the sea urchin Paracentrotus lividus. Aquaculture 261:1269–1280.
   Web of Science ®Google Scholar
• Sies H. 1999. Glutathione and its role in cellular functions. Free Radic Biol Med 27: 916–921.
   PubMed Web of Science ®Google Scholar
• Simopoulos AP. 1999. Essential fatty acids in health and chronic disease. Am J Clin Nutr 70: 560S–569S.
   PubMed Web of Science ®Google Scholar
• Sinha RP, Singh SP, Häder DP. 2007. Database on mycosporines and mycosporine-like amino acids (MAAs) in fungi, cyanobacteria, macroalgae, phytoplankton and animals. J Photochem Photobiol B, Biol 89: 29–35.
   PubMed Web of Science ®Google Scholar
• Skjånes K, Knutsen G, Källqvist T, Lindblad P. 2008. H2 production from marine and freshwater species of green algae during sulfur starvation and considerations for bioreactor design. Int J Hydrogen Energy 33:511–521.
   Web of Science ®Google Scholar
• Skjånes K, Lindblad P, Muller J. 2007. BioCO2 – a multidisciplinary, biological approach using solar energy to capture CO2 while producing H2 and high value products. Biomol Eng 24: 405–413.
   PubMedGoogle Scholar
• Soeder CJ, Hegewald E. 1988. Scenedesmus, In: Borowitzka MA,Borowitzka LJ. (Eds.) Micro-algal biotechnology, Cambridge University Press, Cambridge pp. 59–84.
   Google Scholar
• Solovchenko AE, Khozin-Goldberg I, Cohen Z, Merzlyak MN. 2009. Carotenoid-to-chlorophyll ratio as a proxy for assay of total fatty acids and arachidonic acid content in the green microalga Parietochloris incisa. J Appl Phycol 21:361–366.
   Web of Science ®Google Scholar
• Solovchenko AE, Khozin-Goldberg I, Didi-Cohen S, Cohen Z, Merzlyak MN. 2008. Effects of light intensity and nitrogen starvation on growth, total fatty acids and arachidonic acid in the green microalga Parietochloris incisa. J Appl Phycol 20:245–251.
   Web of Science ®Google Scholar
• Souto M, Saavedra M, Pousão-Ferreira P, Herrero C. 2008. Riboflavin enrichment throughout the food chain from the marine microalga Tetraselmis suecica to the rotifer Brachionus plicatilis and to White Sea Bream (Diplodus sargus) and Gilthead Sea bream (Sparus aurata) larvae. Aquaculture 283:128–133.
   Web of Science ®Google Scholar
• Spoehr HA, Milner HW. 1949. The chemical composition of Chlorella; effect of environmental conditions. Plant Physiol 24: 120–149.
   PubMed Web of Science ®Google Scholar
• Spolaore P, Joannis-Cassan C, Duran E, Isambert A. 2006. Commercial applications of microalgae. J Biosci Bioeng 101: 87–96.
   PubMed Web of Science ®Google Scholar
• Spruell JA. 1984. Response of algae and zooplankton to C18 fatty acids of Chlamydomonas reinhardtii. Hydrobiologia 114:9–12.
   Web of Science ®Google Scholar
• Stephens E, Ross IL, King Z, Mussgnug JH, Kruse O, Posten C, Borowitzka MA, Hankamer B. 2010. An economic and technical evaluation of microalgal biofuels. Nat Biotechnol 28: 126–128.
   PubMed Web of Science ®Google Scholar
• Stiller C, Bünger U, Møller-Holst S, Svensson AM, Espegren KA, Nowak M. 2010. Pathways to a hydrogen fuel infrastructure in Norway. Int J Hydrogen Energy 35:2597–2601 sp. iss.
   Web of Science ®Google Scholar
• Stoynova-Bakalova E, Toncheva-Panova T. 2003. Subcellular adaptation to salinity and irradiance in Dunaliella salina. Biol Plantarum 47:233–236.
   Web of Science ®Google Scholar
• Strizh IG, Popova LG, Balnokin YV. 2004. Physiological aspects of adaptation of the marine microalga Tetraselmis (Platymonas) viridis to various medium salinity. Russ J Plant Physiol 51:176–182.
   Web of Science ®Google Scholar
• Subhadra BG. 2010. Sustainability of algal biofuel production using integrated renewable energy park (IREP) and algal biorefinery approach. Energy Policy 38:5892–5901.
   Web of Science ®Google Scholar
• Sugimoto K, Sato N, Tsuzuki M. 2007. Utilization of a chloroplast membrane sulfolipid as a major internal sulfur source for protein synthesis in the early phase of sulfur starvation in Chlamydomonas reinhardtii. FEBS Lett 581: 4519–4522.
   PubMed Web of Science ®Google Scholar
• Sugimoto K, Sato N, Watanabe A, Tsuzuki M. 2005. Effects of sulfur deprivation on sulfolipid metabolism in Chlamydomonas reinhardtii, In: Saito K. (Ed.), Sulfur transport and assimilation in plants in the postgenomic era, Backhuys Publishers, Leiden, The Netherlands. pp. 133–135.
   Google Scholar
• Surai AP, Surai PF, Steinberg W, Wakeman WG, Speake BK, Sparks NH. 2003. Effect of canthaxanthin content of the maternal diet on the antioxidant system of the developing chick. Br Poult Sci 44: 612–619.
   PubMed Web of Science ®Google Scholar
• Surzycki R, Greenham K, Kitayama K, Dibal F, Wagner R, Rochaix JD, Ajam T, Surzycki S. 2009. Factors effecting expression of vaccines in microalgae. Biologicals 37: 133–138.
   PubMed Web of Science ®Google Scholar
• Sushchik NN, Kalacheva GS, Zhila NO, Gladyshev MI, Volova TG. 2003. A temperature dependence of the intra- and extracellular fatty acid composition of green algae and cyanobacterium. Russ J Plant Physiol 50:374–380.
   Web of Science ®Google Scholar
• Szyszka B, Ivanov AG, Hüner NP. 2007. Psychrophily is associated with differential energy partitioning, photosystem stoichiometry and polypeptide phosphorylation in Chlamydomonas raudensis. Biochim Biophys Acta 1767: 789–800.
   PubMed Web of Science ®Google Scholar
• Takahashi S, Badger MR. 2011. Photoprotection in plants: a new light on photosystem II damage. Trends Plant Sci 16: 53–60.
   PubMed Web of Science ®Google Scholar
• Takahashi S, Milward SE, Yamori W, Evans JR, Hillier W, Badger MR. 2010. The solar action spectrum of photosystem II damage. Plant Physiol 153: 988–993.
   PubMed Web of Science ®Google Scholar
• Tanaka K, Yamada A, Noda K, Hasegawa T, Okuda M, Shoyama Y, Nomoto K. 1998. A novel glycoprotein obtained from Chlorella vulgaris strain CK22 shows antimetastatic immunopotentiation. Cancer Immunol Immunother 45: 313–320.
   PubMed Web of Science ®Google Scholar
• Tang BJ, Liu BZ, Wang GD, Zhang T, Xiang JH. 2006. Effects of various algal diets and starvation on larval growth and survival of Meretrix meretrix. Aquaculture 254:526–533.
   Web of Science ®Google Scholar
• Tatsuzawa H, Takizawa E, Wada M, Yamamoto Y. 1996. Fatty acid and lipid composition of the acidophilic green alga Chlamydomonas sp. J Phycol 32:598–601.
   Web of Science ®Google Scholar
• Tejera N, Cejas JR, Rodriguez C, Bjerkeng B, Jerez S, Bolanos A, Lorenzo A. 2007. Pigmentation, carotenoids, lipid peroxides and lipid composition of skin of red porgy (Pagrus pagrus) fed diets supplemented with different astaxanthin sources. Aquaculture 270:218–230.
   Web of Science ®Google Scholar
• Thaipratum R, Melis A, Svasti J, Yokthongwattana K. 2009. Analysis of non-photochemical energy dissipating processes in wild type Dunaliella salina (green algae) and in zea1, a mutant constitutively accumulating zeaxanthin. J Plant Res 122: 465–476.
   PubMed Web of Science ®Google Scholar
• Timmins M, Thomas-Hall SR, Darling A, Zhang E, Hankamer B, Marx UC, Schenk PM. 2009. Phylogenetic and molecular analysis of hydrogen-producing green algae. J Exp Bot 60: 1691–1702.
   PubMed Web of Science ®Google Scholar
• Timmins M, Zhou WX, Rupprecht J, Lim L, Thomas-Hall SR, Doebbe A, Kruse O, Hankamer B, Marx UC, Smith SM, Schenk PM. 2009b. The metabolome of Chlamydomonas reinhardtii following induction of anaerobic H2 production by sulfur depletion. J Biol Chem 284:23415–23425.
   PubMed Web of Science ®Google Scholar
• Tjahjono AE, Hayama Y, Kakizono T, Terada Y, Nishio N, Nagai S. 1994. Hyper accumulation of astaxanthin in a green alga Haematococcus pluvialis at elevated temperatures. Biotechnol Lett 16:133–138.
   Web of Science ®Google Scholar
• Tolstygina IV, Antal TK, Kosourov SN, Krendeleva TE, Rubin AB, Tsygankov AA. 2009. Hydrogen production by photoautotrophic sulfur-deprived Chlamydomonas reinhardtii pre-grown and incubated under high light. Biotechnol Bioeng 102: 1055–1061.
   PubMed Web of Science ®Google Scholar
• Tsygankov A, Kosourov S, Seibert M, Ghirardi ML. 2002. Hydrogen photoproduction under continuous illumination by sulfur-deprived, synchronous Chlamydomonas reinhardtii cultures. Int J Hydrogen Energy 27:1239–1244.
   Web of Science ®Google Scholar
• Tsygankov AA. 2001. Laboratory scale photobioreactors. Appl Biochem Microbiol 37:333–341.
   Web of Science ®Google Scholar
• Tsygankov AA, Kosourov SN, Tolstygina IV, Ghirardi ML, Seibert M. 2006. Hydrogen production by sulfur-deprived Chlamydomonas reinhardtii under photoautotrophic conditions. Int J Hydrogen Energy 31:1574–1584.
   Web of Science ®Google Scholar
• Tukaj Z, Matusiak-Mikulin K, Lewandowska J, Szurkowski J. 2003. Changes in the pigment patterns and the photosynthetic activity during a light-induced cell cycle of the green alga Scenedesmus armatus. Plant Physiol Biochem 41:337–344.
   Web of Science ®Google Scholar
• Turker H, Eversole AG, Brune DE. 2003. Filtration of green algae and cyanobacteria by Nile tilapia, Oreochromis niloticus, in the Partitioned Aquaculture System. Aquaculture 215:93–101.
   Web of Science ®Google Scholar
• Tyystjärvi E. 2008. Photoinhibition of Photosystem II and photodamage of the oxygen evolving manganese cluster. Coord Chem Rev 252:361–376.
   Web of Science ®Google Scholar
• Tzovenis I, De Pauw N, Sorgeloos P. 2003. Optimisation of T-ISO biomass production rich in essential fatty acids: I. Effect of different light regimes on growth and biomass production. Aquaculture 216:203–222.
   Web of Science ®Google Scholar
• Tzovenis I, Fountoulaki E, Dolapsakis N, Kotzamanis I, Nengas I, Bitis I, Cladas Y, Economou-Amilli A. 2009. Screening for marine nanoplanktic microalgae from Greek coastal lagoons (Ionian Sea) for use in mariculture. J Appl Phycol 21:457–469.
   Web of Science ®Google Scholar
• Ueno Y, Kurano N, Miyachi S. 1998. Ethanol production by dark fermentation in the marine green alga, Chlorococcum littorale. J Ferment Bioeng 86:38–43.
   Google Scholar
• Ueno Y, Kurano N, Miyachi S. 1999. Purification and characterization of hydrogenase from the marine green alga, Chlorococcum littorale. FEBS Lett 443: 144–148.
   PubMed Web of Science ®Google Scholar
• Ugwu CU, Aoyagi H. 2008. Influence of shading inclined tubular photobioreactor surfaces on biomass productivity of C. sorokiniana. Photosynthetica 46: 283–285.
   Web of Science ®Google Scholar
• Uhlik DJ, Gowans CS. 1974. Synthesis of nicotinic acid in Chlamydomonas eugametos. Int J Biochem 5:79–84.
   Google Scholar
• Ukeles R. 1961. The effect of temperature on the growth and survival of several marine algal species. Biol Bull 120:255–264.
   Web of Science ®Google Scholar
• van Eykelenburg C. 1980. Spirulina platensis – Morphology & Ultrastructure, PhD Thesis, Technische Hogeschool Delft, Delft. pp. 118.
   Google Scholar
• Vasilikiotis C, Melis A. 1994. Photosystem II reaction center damage and repair cycle: chloroplast acclimation strategy to irradiance stress. Proc Natl Acad Sci USA 91: 7222–7226.
   PubMed Web of Science ®Google Scholar
• Vasudevan PT, Briggs M. 2008. Biodiesel production–current state of the art and challenges. J Ind Microbiol Biotechnol 35: 421–430.
   PubMed Web of Science ®Google Scholar
• Vilchez C, Garbayo I, Lobato MV, Vega JM. 1997. Microalgae-mediated chemicals production and wastes removal. Enz Microb Technol 20:562–572.
   Web of Science ®Google Scholar
• Villar R, Laguna MR, Calleja JM, Cadavid I. 1992. Effects of Phaeodactylum tricornutum and Dunaliella tertiolecta extracts on the central nervous system. Planta Med 58: 405–409.
   PubMed Web of Science ®Google Scholar
• Visviki I, Santikul D. 2000. The pH tolerance of Chlamydomonas applanata (Volvocales, Chlorophyta). Arch Environ Contam Toxicol 38: 147–151.
   PubMed Web of Science ®Google Scholar
• Wang ZT, Ullrich N, Joo S, Waffenschmidt S, Goodenough U. 2009. Algal lipid bodies: stress induction, purification, and biochemical characterization in wild-type and starchless Chlamydomonas reinhardtii. Eukaryotic Cell 8: 1856–1868.
   PubMed Web of Science ®Google Scholar
• Wang ZX, Zhuge J, Fang H, Prior BA. 2001. Glycerol production by microbial fermentation: a review. Biotechnol Adv 19: 201–223.
   PubMed Web of Science ®Google Scholar
• Warburg O. 1919. Über die Geschwindigkeit der photochemischen Kohlensaurezersetzung in lebenden Zellen. Biochem Z 100:230.
   Google Scholar
• Watanabe T, Kitajima C, Fujita S. 1983. Nutritional values of live organisms used in Japan for mass propagation of fish – A review. Aquaculture 34:115–143.
   Web of Science ®Google Scholar
• Wei Z, Cady CW, Brudvig GW, Hou HJ. 2011. Photodamage of a Mn(III/IV)-oxo mixed-valence compound and photosystem II: evidence that a high-valent manganese species is responsible for UV-induced photodamage of the oxygen-evolving complex in photosystem II. J Photochem Photobiol B, Biol 104: 118–125.
   PubMed Web of Science ®Google Scholar
• Winkler M, Hemschemeier A, Gotor C, Melis A, Happe T. 2002. [Fe]-hydrogenases in green algae: photo-fermentation and hydrogen evolution under sulfur deprivation. Int J Hydrogen Energy 27:1431–1439.
   Web of Science ®Google Scholar
• Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. 2004. Glutathione metabolism and its implications for health. J Nutr 134: 489–492.
   PubMed Web of Science ®Google Scholar
• Wu ZY, Wu SM, Shi XM. 2007. Supercritical fluid extraction and determination of lutein in heterotrophically cultivated Chlorella pyrenoidosa. J Food Process Eng 30:174–185.
   Web of Science ®Google Scholar
• Wünschiers R, Lindblad P. 2002. Hydrogen in education – a biological approach. Int J Hydrogen Energy 27:1131–1140.
   Web of Science ®Google Scholar
• Wykoff DD, Davies JP, Melis A, Grossman AR. 1998. The regulation of photosynthetic electron transport during nutrient deprivation in Chlamydomonas reinhardtii. Plant Physiol 117: 129–139.
   PubMed Web of Science ®Google Scholar
• Xiong FS, Kopecky J, Nedbal L. 1999. The occurrence of UV-B absorbing mycosporine-like amino acids in freshwater and terrestrial microalgae (Chlorophyta). Aquat Bot 63:37–49.
   Web of Science ®Google Scholar
• Xu L, Weathers PJ, Xiong XR, Liu CZ. 2009. Microalgal bioreactors: Challenges and opportunities. Eng Life Sci 9:178–189.
   Web of Science ®Google Scholar
• Yamaguchi K. 1997. Recent advances in microalgal bioscience in Japan, with special reference to utilization of biomass and metabolites: A review. J Appl Phycol 8:487–502.
   Web of Science ®Google Scholar
• Yang FM, Shi Y, Sheng JC, Hu QH. 2006. In vivo immunomodulatory activity of polysaccharides derived from Chlorella pyrenoidosa. Eur Food Res Technol 224:225–228.
   Web of Science ®Google Scholar
• Yeum KJ, Russell RM. 2002. Carotenoid bioavailability and bioconversion. Annu Rev Nutr 22: 483–504.
   PubMed Web of Science ®Google Scholar
• Yildiz FH, Davies JP, Grossman AR. 1994. Characterization of sulfate transport in Chlamydomonas reinhardtii during sulfur-limited and sulfur-sufficient growth. Plant Physiol 104: 981–987.
   PubMed Web of Science ®Google Scholar
• Yongmanitchai WC, Ward OP. 1989. Omega-3 fatty acids – Alternative sources of production. Process Biochem 24:117–125.
   Web of Science ®Google Scholar
• Yuan JP, Chen F, Liu X, Li XZ. 2002. Carotenoid composition in the green microalga Chlorococcum. Food Chem 76:319–325.
   Web of Science ®Google Scholar
• Zhang CW, Cohen Z, Khozin-Goldberg I, Richmond A. 2002a. Characterization of growth and arachidonic acid production of Parietochloris incisa comb. nov (Trebouxiophyceae, Chlorophyta). J Appl Phycol 14:453–460.
   Web of Science ®Google Scholar
• Zhang L, Happe T, Melis A. 2002. Biochemical and morphological characterization of sulfur-deprived and H2-producing Chlamydomonas reinhardtii (green alga). Planta 214: 552–561.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Shrager J, Jain M, Chang CW, Vallon O, Grossman AR. 2004. Insights into the survival of Chlamydomonas reinhardtii during sulfur starvation based on microarray analysis of gene expression. Eukaryotic Cell 3: 1331–1348.
   PubMed Web of Science ®Google Scholar
• Zhekisheva M, Boussiba S, Khozin-Goldberg I, Zarka A, Cohen Z. 2002. Accumulation of oleic acid in Haematococcus pluvialis (Chlorophyceae) under nitrogen starvation or high light is correlated with that of astaxanthin esters. J Phycol 38:325–331.
   Web of Science ®Google Scholar
• Zhekisheva M, Zarka A, Khozin-Goldberg I, Cohen Z, Boussiba S. 2005. Inhibition of astaxanthin synthesis under high irradiance does not abolish triacylglycerol accumulation in the green alga Haematococcus pluvialis (Chlorophyceae). J Phycol 41:819–826.
   Web of Science ®Google Scholar
• Zmora O, Findiesen A, Stubblefield J, Frenkel V, Zohar Y. 2005. Large-scale juvenile production of the blue crab Callinectes sapidus. Aquaculture 244:129–139.
   Web of Science ®Google Scholar
• Zuppini A, Gerotto C, Moscatiello R, Bergantino E, Baldan B. 2009. Chlorella saccharophila cytochrome f and its involvement in the heat shock response. J Exp Bot 60: 4189–4200.
   PubMed Web of Science ®Google Scholar