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Articles

Administration-Time Differences in Effects of Hypertension Medications on Ambulatory Blood Pressure Regulation

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Pages 280-314 | Received 14 Mar 2011, Accepted 17 Apr 2012, Published online: 19 Oct 2012

REFERENCES

  • Acelajado MC, Pisoni R, Dudenbostel T, Oparil S, Calhoun DA, Glasser SP. (2012). Both morning and evening dosing of nebivolol reduces trough mean blood pressure surge in hypertensive patients. J. Am. Soc. Hypertens. 6:66–72.
  • Almirall J, Comas L, Martínez-Ocaña JC, Roca S, Arnau A. (2012). Effects of chronotherapy on blood pressure control in non-dipper patients with refractory hypertension. Nephrol. Dial. Transplant. 27:1855–1859.
  • Angeli A, Gatti G, Masera R. (1992). Chronobiology of the hypothalamic-pituitary-adrenal and renin-angiotensin-aldosterone systems. In Touitou Y, Haus E (Eds.). Biologic rhythms in clinical and laboratory medicine. Berlin: Springer Verlag, 292–314.
  • Arangino S, Cagnacci A, Angiolucci M, Vacca AMB, Longu G, Volpe A, Melis G. (1999). Effect of melatonin on vascular reactivity, catecholamine levels, and blood pressure in healthy men. Am. J. Cardiol. 83:1417–1419.
  • Arendt J. (1997). The pineal gland, circadian rhythms and photoperiodism. In Redfern PH, Lemmer B (Eds.). Physiology and pharmacology of biological rhythms. Berlin: Springer Verlag, 375–414.
  • Arendt J, Skene DJ, Middelton B, Lockley SW, Deacon S. (1997). Efficacy of melatonin treatment in jet lag, shift work and blindness. J Biol. Rhythms 12:604–617.
  • Ashizawa N, Seto S, Shibata Y, Yano K. (2007). Bedtime administration of cilnidipine controls morning hypertension. Int. Heart J. 48:597–603.
  • Asmar R, Gosse P, Queré S, Achouba A. (2011). Efficacy of morning and evening dosing of amlodipine/valsartan combination in hypertensive patients uncontrolled by 5 mg of amlodipine. Blood Press. Monit. 16:80–86.
  • Astrup AS, Nielsen FS, Rossing P, Ali S, Kastrup J, Smidt UM, Parving HH. (2007). Predictors of mortality in patients with type 2 diabetes with or without diabetic nephropathy: a follow-up study. J. Hypertens. 25:2479–2485.
  • Ayala DE, Hermida RC. (2010). Sex differences in the administration-time-dependent effects of low-dose aspirin on ambulatory blood pressure in hypertensive subjects. Chronobiol. Int. 27:345–362.
  • Ayala DE, Hermida RC, Portaluppi F, Smolensky MH, on behalf of the Hygia Project Investigators. (2011). Bedtime hypertension treatment increases ambulatory blood pressure control and reduces cardiovascular risk in resistant hypertension. Hypertension 58:e26.
  • Ayala DE, Hermida RC, Mojón A, Fernández JR. (2013a). Cardiovascular risk of resistant hypertension: dependence on treatment-time regimen of blood pressure-lowering medications. Chronobiol. Int. 30: 340–352.
  • Ayala DE, Moyá A, Crespo JJ, Castiñeira C, Domínguez-Sardiña M, Gomara S, Sineiro E, Mojón A, Fontao MJ, Hermida RC, on behalf of the Hygia Project Investigators. (2013b). Circadian pattern of ambulatory blood pressure in hypertensive patients with and without type 2 diabetes. Chronobiol. Int. 30: 99–115.
  • Ayala DE, Ucieda R, Hermida RC. (2013c). Chronotherapy with low-dose aspirin for prevention of complications in pregrancy. Chronobiol. Int. 30: 260–279.
  • Balan H, Popescu E, Angelescu G. (2011). Comparing different treatment schedules of Zomen (zofenopril). Rom. J. Intern. Med. 49:75–84.
  • Bartter FC, Chan JCM, Simpson HW. (1979). Chronobiological aspect of plasma renin activity, plasma aldosterone and urinary electrolytes. In Krieger DT (Ed.). Endocrine rhythms. New York: Raven Press, 49–132.
  • Bélanger PM, Bruguerolle B, Labrecque G. (1997). Rhythms in pharmacokinetics: absorption, distribution, metabolism. In Redfern PH, Lemmer B (Eds.). Physiology and pharmacology of biological rhythms. Handbook of experimental pharmacology series, Vol. 125. Berlin, New York: Springer Verlag, 177–204.
  • Ben-Dov IZ, Kark JD, Ben-Ishay D, Mekler J, Ben-Arie L, Bursztyn M. (2007). Predictors of all-cause mortality in clinical ambulatory monitoring. Unique aspects of blood pressure during sleep. Hypertension 49:1235–1241.
  • Black HR, Elliott WJ, Grandits G, Grambsch P, Lucente T, White WB, Neaton JD, Grimm RH , Hansson L, Lacourciere Y, Muller J, Sleight P, Weber MA, Williams G, Wittes J, Zanchetti A, Anders RJ, CONVINCE Research Group. (2003). Principal results of the Controlled Onset Verapamil Investigation of Cardiovascular End Points (CONVINCE) trial. JAMA 289:2073–2082.
  • Boggia J, Li Y, Thijs L, Hansen TW, Kikuya M, Björklund-Bodegård K, Richart T, Ohkubo T, Kuznetsova T, Torp-Pedersen CH, Lind L, Ibsen H, Imai Y, Wang J, Sandoya E, O'Brien E, Staessen JA. (2007). Prognostic accuracy of day versus night ambulatory blood pressure: a cohort study. Lancet 370:1219–1229.
  • Bouhanick B, Bongard V, Amar J, Bousquel S, Chamontin B. (2008). Prognostic value of nocturnal blood pressure and reverse-dipping status on the occurrence of cardiovascular events in hypertensive diabetic patients. Diabetes Metab. 34:560–567.
  • Brotman DJ, Davidson MB, Boumitri M, Vidt DG. (2008). Impaired diurnal blood pressure variation and all-cause mortality. Am. J. Hypertens. 21:92–97.
  • Bruguerolle B, Lemmer B. (1993). Recent advances in chronopharmacokinetics: methodological problems. Life Sci. 52:1809–1824.
  • Cabezas-Cerrato J, Hermida RC, Cabezas-Agrícola JM, Ayala DE. (2009). Cardiac autonomic neuropathy, estimated cardiovascular risk, and circadian blood pressure pattern in diabetes mellitus. Chronobiol. Int. 26:942–957.
  • Cagnacci A, Arangino S, Angiolucci M, Maschio E, Melis GB. (1998). Influences of melatonin administration on the circulation of women. Am. J. Physiol. 274:R335–R338.
  • Cagnacci A, Arangino S, Angiolucci M, Melis GB, Facchinetti F, Malmusi S, Volpe A. (2001). Effect of exogenous melatonin on vascular reactivity and nitric oxide in post menopausal women: role of hormone replacement therapy. Clin. Endocrinol. 54:26–266.
  • Cagnacci A, Cannoletta M, Renzi A, Baldassari F, Arangino S, Volpe A. (2005). Prolonged melatonin administration decreases nocturnal blood pressure in women. Am. J. Hypertens. 18:1614–1618.
  • Calhoun DA, Jones D, Textor S, Goff DC, Murphy TP, Toto RD, White A, Cushman WC, White W, Sica D, Ferdinand K, Giles TD, Falkner B, Carey RM. (2008). Resistant hypertension: diagnosis, evaluation, and treatment. A scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Hypertension 51:1403–1419.
  • Casetta I, Granieri E, Portaluppi F, Manfredini R. (2002). Circadian variability in hemorrhagic stroke. JAMA 287:1266–1267.
  • Cavallo A, Daniels SR, Dolan LM, Bean JA, Khoury JC. (2004). Blood pressure-lowering effect of melatonin in type 1 diabetes. J. Pineal Res. 36:262–266.
  • Chasen C, Muller JE. (1998). Cardiovascular triggers and morning events. Blood Press. Monit. 3:35–42.
  • Chau NP, Bauduceau B, Chanudet X, Larroque P, Gautier D. (1994). Ambulatory blood pressure in diabetic subjects. Am. J. Hypertens. 7:487–491.
  • Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jones DW, Materson BJ, Oparil S, Wright JT, Rocella EJ. (2003). Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 42:1206–1252.
  • Cohen MC, Rohtla KM, Lavery CE, Muller JE, Middleman MA. (1997). Meta analysis of the morning excess of acute myocardial infarction and sudden cardiac death. Am. J. Cardiol. 79:1512–1516.
  • Cornélissen G, Halberg F, Prikryl P, Dankova E, Siegelova J, Dusek J, International Womb-To-Tomb Chronome Study Group. (1991). Prophylactic aspirin treatment: the merits of timing. JAMA 266:3128–3129.
  • Crespo C, Aboy M, Fernández JR, Mojón A. (2012). Automatic identification of activity-rest periods based on actigraphy. Med. Biol. Eng. Comput. 50:329–340.
  • Crespo C, Fernández JR, Aboy M, Mojón A. (2013). Clinical application of a novel automatic algorithm for actigraphy-based activity and rest period identification to accurately determine awake and asleep ambulatory blood pressure parameters and cardiovascular risk. Chronobiol. Int. 30: 43–54.
  • Crespo JJ, Piñeiro L, Otero A, Castiñeira C, Ríos MT, Regueiro A, Mojón A, Lorenzo S, Ayala DE, Hermida RC, on behalf of the Hygia Project Investigators. (2013). Administration-time-dependent effects of hypertension treatment on ambulatory blood pressure in patients with chronic kidney disease. Chronobiol. Int. 30: 159–175.
  • Cugini P. (1996). The treatability of refractory or resistant hypertension by personalized antihypertensive chronotherapy based on ambulatory monitoring of the arterial pressure. Recenti Prog. Med. 87:51–57
  • Cugini P. (1997). Compliance and the chronotherapy of refractory arterial hypertension. Recenti Prog. Med. 88:463–469.
  • Cugini P, Manconi E, Serdoz N, Mancini A, Meucci R, Scavo D. (1980). Rhythm characteristics of plasma renin, aldosterone and cortisol in five types of mesor-hypertension. J. Endocrinol. Invest. 3:143–149.
  • Cugini P, Letizia C, Scavo D. (1988). The circadian rhythmicity of serum angiotensin converting enzyme: its phasic relation with the circadian cycle of plasma renin and aldosterone. Chronobiologia 15:229–232.
  • Cuspidi C, Macca G, Sampieri L, Michev I, Salerno M, Fusi V, Severgnini B, Meani S, Magrini F, Zanchetti A. (2001). High prevalence of cardiac and extracardiac target organ damage in refractory hypertension. J. Hypertens. 19:2063–2070.
  • Cuspidi C, Meani S, Lonati L, Fusi V, Valerio C, Sala C, Magnaghi G, Maisaidi M, Zanchetti A. (2006). Short-term reproducibility of a non-dipping pattern in type 2 diabetic hypertensive patients. J. Hypertens. 24:647–653.
  • Dahlöf B. (2009). Management of cardiovascular risk with RAS inhibitor/CCB combination therapy. J. Hum. Hypertens. 23:77–85.
  • Deedwania PC (Ed.). (1997). Circadian rhythms of cardiovascular disorders. Armonk, NY: Futura Publishing.
  • Deedwania PC, Nelson J. (1990). Pathophysiology of silent ischemia during daily life. Circulation. 82:1296–1304.
  • Defina LF, Bookstaver DA, Goldfinger MP, Coffey TA. (1997). Nifedipine gastrointestinal therapeutic system versus nifedipine coat-core: comparison of efficacy via 24-hour ambulatory blood pressure monitoring. Ann. Pharmacother. 31:819–822.
  • de la Sierra A, Redon J, Banegas JR, Segura J, Parati G, Gorostidi M, de la Cruz JJ, Sobrino J, Llisterri JL, Alonso J, Vinyoles E, Pallarés V, Sarría A, Aranda P, Ruilope LM, for the Spanish Society of Hypertension Ambulatory Blood Pressure Monitoring Registry Investigators. (2009). Prevalence and factors associated with circadian blood pressure patterns in hypertensive patients. Hypertension 53:466–472.
  • de Leeuw PW, Falke HE, Kho TL, Vandongen R, Wester A, Birkenhäger H (1977). Effects of beta-agrenergic blockade on diurnal variability of blood pressure and plasma noradrenaline levels. Acta Med. Scand. 202:389–392.
  • Dolan E, Stanton A, Thijs L, Hinedi K, Atkins N, McClory S, Den Hond E, McCormack P, Staessen JA, O'Brien E. (2005). Superiority of ambulatory over clinic blood pressure measurement in predicting mortality: the Dublin outcome study. Hypertension 46:156–161.
  • Duguay D, Cermakian N. (2009). The crosstalk between physiology and circadian clock proteins. Chronobiol. Int. 26:1479–1513.
  • Eguchi K, Pickering TG, Hoshide S, Ishikawa J, Ishikawa S, Schwartz J, Shimada K, Kario K. (2008). Ambulatory blood pressure is a better marker than clinic blood pressure in predicting cardiovascular events in patients with/without type 2 diabetes. Am. J. Hypertens. 21:443–450.
  • Ekmekcioglu C, Thalhammer T, Mehrabi M, Glogar H, Holzenbein T, Markovic O, Leibetseder VJ, Strauss-Blasche G, Marktl W. (2003). The melatonin receptor subtype MT2 is present in the human cardiovascular system. J. Pineal Res. 35:40–44.
  • Elliot WJ. (1998). Circadian variation in the timing of stroke onset. A meta-analysis. Stroke 29:992–996.
  • Equiluz-Bruck S, Schnack C, Kopp HP, Schernthaner G. (1996). Nondipping of nocturnal blood pressure is related to urinary albumin excretion rate in patients with type 2 diabetes mellitus. Am. J. Hypertens. 9:1139–1143.
  • Ernst ME, Carter BL, Goerdt CJ, Steffensmeier JJG, Phillips BB, Zimmerman MB, Bergus BR. (2006). Comparative antihypertensive effects of hydrochlorothiazide and chlorthalidone on ambulatory and office blood pressure. Hypertension 47:352–358.
  • Fagard RH. (2012). Resistant hypertension. Heart 98:254–161.
  • Fagard RH, Celis H, Thijs L, Staessen JA, Clement DL, De Buyzere ML, De Bacquer DA. (2008). Daytime and nighttime blood pressure as predictors of death and cause-specific cardiovascular events in hypertension. Hypertension 51:55–61.
  • Fan HQ, Li Y, Thijs L, Hansen TW, Boggia J, Kikuya M, Björklund-Bodegard K, Richart T, Ohkubo T, Jeppesen J, Torp-Pedersen C, Dolan E, Kuznetsova T, Stolarz-Skrzypek K, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Lind L, Sandoya E, Kawecka-Jaszcz K, Imai Y, Ibsen H, O'Brien E, Wang J, Staessen JA. (2010). Prognostic value of isolated nocturnal hypertension on ambulatory measurement in 8711 individuals from 10 populations. J. Hypertens. 28:2036–2045.
  • Fogari R, Malacco E, Tettamanti F, Gnemmi AE, Milani M. (1993a). Evening vs. morning isradipine sustained release in essential hypertension: a double-blind study with 24 h ambulatory monitoring. Br. J. Clin. Pharmacol. 35:51–54.
  • Fogari R, Zoppi A, Malamani GD, Lazzari P, Destro M, Corradi L. (1993b). Ambulatory blood pressure monitoring in normotensive and hypertensive type 2 diabetes. Prevalence of impaired diurnal blood pressure patterns. Am. J. Hypertens. 6:1–7.
  • Fujimura A, Ebihara A, Shiigai T, Shimada K, Tagawa H, Gomi T, Nakamura Y, Suzuki M, Yokozuka H. (1999). Amelioration of enalapril-induced dry cough by changing dosing time from morning to evening: a preliminary trial. Jpn. J. Clin. Pharmacol. Ther. 30:741–744.
  • Furlan R, Guzzetti S, Crivellaro W, Dassi S, Tinelli M, Baselli G, Cerutti S, Lombardi F, Pagani M, Malliani A. (1990). Continuous 24-hour assessment of the neural regulation of systemic arterial pressure and RR variabilities in ambulant subjects. Circulation 81:537–547.
  • Gallerani M, Portaluppi F, Grandi E, Manfredini R. (1997). Circadian rhythmicity in the occurrence of spontaneous acute dissection and rupture of thoracic aorta. J. Thorac. Cardiovasc. Surg. 113:603–604.
  • Giles TD. (2003). Rationale for combination therapy as initial treatment for hypertension. J. Clin. Hypertens. 5(4 Suppl 3):4–11.
  • Gordon RD, Wolfe LK, Island DP, Liddle GW. (1966). A diurnal rhythm in plasma renin activity in man. J. Clin. Invest. 45:1587–1592.
  • Greminger P, Suter PM, Holm D, Kobelt R, Vetter W. (1994). Morning versus evening administration of nifedipine gastrointestinal therapeutic system in the management of essential hypertension. Clin. Invest. 72:864–869.
  • Grosser N, Schroder H. (2003). Aspirin protects endothelial cells from oxidant damage via the nitric-oxide-cGMP pathway. Arterioscler. Thromb. Vasc. Biol. 23:1345–1351.
  • Grossman E, Laudon M, Yalcin R, Zengil H, Peleg E, Sharabi Y, Kamari Y, Shen-Orr Z, Zisapel N. (2006). Melatonin reduces night blood pressure in patients with nocturnal hypertension. Am. J. Med. 119:898–902.
  • Grossman E, Laudon M, Zisapel N. (2011). Effect of melatonin on nocturnal blood pressure: meta-analysis of randomized controlled trials. Vasc. Health Risk Manag. 7:577–584.
  • Grundy JS, Foster RT. (1996). The nifedipine gastrointestinal and therapeutic system (GITS): evaluation of pharmaceutical, pharmacokinetic and pharmacological properties. J. Clin. Pharmacokinet. 30:28–51.
  • Gupta SK, Yih BM, Atkinson L, Longstreth J. (1995). The effect of food, time of dosing and body composition on the pharmacokinetics and pharmacodynamics of verapamil and norverapamil. J. Clin. Pharmacol. 35:1083–1093.
  • Hermida RC. (2007). Ambulatory blood pressure monitoring in the prediction of cardiovascular events and effects of chronotherapy: rationale and design of the MAPEC study. Chronobiol. Int. 24:749–775.
  • Hermida RC, Ayala DE. (2009). Chronotherapy with the angiotensin-converting enzyme inhibitor ramipril in essential hypertension: improved blood pressure control with bedtime dosing. Hypertension 54:40–46.
  • Hermida RC, Smolensky MH. (2004). Chronotherapy of hypertension. Curr. Opin. Nephrol. Hypertens. 13:501–505.
  • Hermida RC, Ayala DE, Iglesias M, Mojón A, Silva I, Ucieda R, Fernández JR. (1997). Time-dependent effects of low-dose aspirin administration on blood pressure in pregnant women. Hypertension 30:589–595.
  • Hermida RC, Ayala DE, Fernández JR, Mojón A, Alonso I, Silva I, Ucieda R, Codesido J, Iglesias M. (1999). Administration time-dependent effects of aspirin in women at differing risk for preeclampsia. Hypertension 34:1016–1023.
  • Hermida RC, Calvo C, Ayala DE, Mojón A, López JE. (2002). Relationship between physical activity and blood pressure in dipper and nondipper hypertensive patients. J. Hypertens. 20:1097–1104.
  • Hermida RC, Ayala DE, Calvo C, López JE, Fernández JR, Mojón A, Domínguez MJ, Covelo M. (2003a). Administration-time dependent effects of aspirin on blood pressure in untreated hypertensive patients. Hypertension 41:1259–1267.
  • Hermida RC, Ayala DE, Iglesias M. (2003b). Administration-time dependent influence of aspirin on blood pressure in pregnant women. Hypertension 41:651–656.
  • Hermida RC, Calvo C, Ayala DE, Domínguez MJ, Covelo M, Fernández JR, Mojón A, López JE. (2003c). Administration-time-dependent effects of valsartan on ambulatory blood pressure in hypertensive subjects. Hypertension 42:283–290.
  • Hermida RC, Calvo C, Ayala DE, Domínguez MJ, Covelo M, Fernández JR, Fontao MJ, López JE. (2004). Administration-time-dependent effects of doxazosin GITS on ambulatory blood pressure of hypertensive subjects. Chronobiol. Int. 21:277–296.
  • Hermida RC, Ayala DE, Calvo C. (2005a). Administration time-dependent effects of antihypertensive treatment on the circadian pattern of blood pressure. Curr. Opin. Nephrol. Hypertens. 14:453–459
  • Hermida RC, Ayala DE, Calvo C, López JE. (2005b). Aspirin administered at bedtime, but not on awakening, has an effect on ambulatory blood pressure in hypertensive patients. J. Am. Coll. Cardiol. 46:975–983.
  • Hermida RC, Calvo C, Ayala DE, Fernández JR, Covelo M, Mojón A, López JE. (2005c). Treatment of non-dipper hypertension with bedtime administration of valsartan. J. Hypertens. 23:1913–1922.
  • Hermida RC, Calvo C, Ayala DE, López JE. (2005d). Decrease in urinary albumin excretion associated to the normalization of nocturnal blood pressure in hypertensive subjects. Hypertension 46:960–968.
  • Hermida RC, Ayala DE, Calvo C, López JE, Mojón A, Fontao MJ, Soler R, Fernández JR. (2005e). Effects of the time of day of antihypertensive treatment on the ambulatory blood pressure pattern of patients with resistant hypertension. Hypertension 46:1053–1059.
  • Hermida RC, Calvo C, Ayala DE, López JE, Rodríguez M, Covelo M. (2005f). Administration time-dependent effects of amlodipine on ambulatory blood pressure in patients with essential hypertension. Am. J. Hypertens. 18(5 Pt 2):61A.
  • Hermida RC, Calvo C, Ayala DE, Mojón A, Rodríguez M, Chayán L, López JE, Fontao MJ, Soler R, Fernández JR. (2005g). Administration time-dependent effects of valsartan on ambulatory blood pressure in elderly hypertensive subjects. Chronobiol. Int. 22:755–776.
  • Hermida RC, Calvo C, Ayala DE, Rodríguez M, Chayán L, López JE. (2006). Administration time-dependent effects of nebivolol on the diurnal/nocturnal blood pressure ratio in hypertensive patients. J. Hypertens. 24( Suppl 4):S89.
  • Hermida RC, Ayala DE, Calvo C. (2007a). Optimal timing of antihypertensive dosing: focus on valsartan. Ther. Clin. Risk Manag. 3:119–131.
  • Hermida RC, Ayala DE, Calvo C, Portaluppi F, Smolensky MH. (2007b). Chronotherapy of hypertension: administration-time dependent effects of treatment on the circadian pattern of blood pressure. Adv. Drug Deliv. Rev. 59:923–939.
  • Hermida RC, Ayala DE, Fernández JR, Calvo C. (2007c). Comparison of the efficacy of morning versus evening administration of telmisartan in essential hypertension. Hypertension 50:715–722.
  • Hermida RC, Ayala DE, Portaluppi F. (2007d). Circadian variation of blood pressure: the basis for the chronotherapy of hypertension. Adv. Drug Deliv. Rev. 59:904–922.
  • Hermida RC, Calvo C, Ayala DE, Lopez JE, Rodriguez M, Chayan L, Mojon A, Fontao MJ. Fernandez JR. (2007e). Dose- and administration-time-dependent effects of nifedipine GITS on ambulatory blood pressure in hypertensive subjects. Chronobiol. Int. 24:471–493.
  • Hermida RC, Ayala DE, Chayán L, Mojón A, Fernández JR. (2008a). Comparison of the efficacy of morning versus bedtime administration of 40 mg/day olmesartan in essential hypertension. 23rd Annual Scientific Meeting and Exposition of the American Society of Hypertension New Orleans (Louisiana, USA), May 14–17, 2008. J. Clin. Hypertens. 10( Suppl A):A22.
  • Hermida RC, Ayala DE, Fernández JR, Calvo C. (2008b). Chronotherapy improves blood pressure control and reverts the nondipper pattern in patients with resistant hypertension. Hypertension 51:69–76.
  • Hermida RC, Ayala DE, Mojón A, Chayán L, Domínguez MJ, Fontao MJ, Soler R, Alonso I, Fernández JR. (2008c). Comparison of the effects on ambulatory blood pressure of awakening versus bedtime administration of torasemide in essential hypertension. Chronobiol. Int. 25:950–970.
  • Hermida RC, Ayala DE, Mojon A, Fernandez JR. (2008d). Chronotherapy with nifedipine GITS in hypertensive patients: improved efficacy and safety with bedtime dosing. Am. J. Hypertens. 21:948–954.
  • Hermida RC, Ayala DE, Chayán L, Mojón A, Fernández JR. (2009a). Administration-time-dependent effects of olmesartan on the ambulatory blood pressure of essential hypertension patients. Chronobiol. Int. 26:61–79.
  • Hermida RC, Ayala DE, Mojon A, Alonso I, Fernandez JR. (2009b). Reduction of morning blood pressure surge after treatment with nifedipine GITS at bedtime, but not upon awakening, in essential hypertension. Blood Press. Monit. 14:152–159.
  • Hermida RC, Ayala DE, Mojón A, Fernández JR. (2009c). Ambulatory blood pressure control with bedtime aspirin administration in subjects with prehypertension. Am. J. Hypertens. 22:896–903.
  • Hermida RC, Ayala DE, Fontao MJ, Mojón A, Alonso I, Fernández JR. (2010a). Administration-time-dependent effects of spirapril on ambulatory blood pressure in uncomplicated essential hypertension. Chronobiol. Int. 27:560–574.
  • Hermida RC, Ayala DE, Fontao MJ, Mojón A, Fernández JR. (2010b). Chronotherapy with valsartan/amlodipine combination in essential hypertension: improved blood pressure control with bedtime dosing. Chronobiol. Int. 27:1287–1303.
  • Hermida RC, Ayala DE, Mojón A, Fernández JR. (2010c). Influence of circadian time of hypertension treatment on cardiovascular risk: results of the MAPEC study. Chronobiol. Int. 27:1629–1651.
  • Hermida RC, Ayala DE, Mojón A, Fernández JR. (2010d). Effects of time of antihypertensive treatment on ambulatory blood pressure and clinical characteristics of subjects with resistant hypertension. Am. J. Hypertens. 23:432–439.
  • Hermida RC, Ayala DE, Fernández JR, Portaluppi F, Fabbian F, Smolensky MH. (2011a). Circadian rhythms in blood pressure regulation and optimization of hypertension treatment with ACE inhibitor and ARB medications. Am. J. Hypertens. 24:383–391.
  • Hermida RC, Ayala DE, Mojón A, Fernández JR. (2011b). Decreasing sleep-time blood pressure determined by ambulatory monitoring reduces cardiovascular risk. J. Am. Coll. Cardiol. 58:1165–1173.
  • Hermida RC, Ayala DE, Mojón A, Fernández JR. (2011c). Influence of time of day of blood pressure-lowering treatment on cardiovascular risk in hypertensive patients with type 2 diabetes. Diabetes Care 34:1270–1276.
  • Hermida RC, Ayala DE, Mojón A, Fernández JR. (2011d). Bedtime dosing of antihypertensive medications reduces cardiovascular risk in CKD. J. Am. Soc. Nephrol. 22:2313–2321.
  • Hermida RC, Ayala DE, Mojón A, Fontao MJ, Fernández JR. (2011e). Chronotherapy with valsartan/hydrochlorothiazide combination in essential hypertension: improved sleep-time blood pressure control with bedtime dosing. Chronobiol. Int. 28:601–610.
  • Hermida RC, Ayala DE, Mojón A, Fernández JR. (2012a). Sleep-time blood pressure as a therapeutic target for cardiovascular risk reduction in type 2 diabetes. Am. J. Hypertens. 25:325–334.
  • Hermida RC, Ayala DE, Mojón A, Fernández JR. (2012b). Sleep-time blood pressure and the prognostic value of isolated-office and masked hypertension. Am. J. Hypertens. 25:297–305.
  • Hermida RC, Ayala DE, Crespo JJ, Mojón A, Chayán L, Fontao MJ, Fernández JR. (2013a). Influence of age and hypertension treatment-time on ambulatory blood pressure in hypertensive patients. Chronobiol. Int. 30: 176–191.
  • Hermida RC, Ayala DE, Fernández JR, Mojón A. (2013b). Sleep-time blood pressure: prognostic value and relevance as a therapeutic target for cardiovascular risk reduction. Chronobiol. Int. 30: 68–86.
  • Hermida RC, Ayala DE, Mojón A, Fernández JR. (2013c). Blunted sleep-time relative blood pressure decline increases cardiovascular risk independent of blood pressure level—the “normotensive non-dipper” paradox. Chronobiol. Int. 30: 87–98.
  • Hermida RC, Ayala DE, Mojón A, Fernández JR. (2013d). Role of time-of-day of hypertension treatment on the J-shaped relationship between blood pressure and cardiovascular risk. Chronobiol. Int. 30: 328–339.
  • Hermida RC, Ayala DE, Mojón A, Fernández JR. (2013e). Cardiovascular risk of essential hypertension: influence of class, number, and treatment-time regimen of hypertension medications. Chronobiol. Int. 30: 315–327.
  • Hermida RC, Ríos MT, Crespo JJ, Moya A, Domínguez-Sardiña M, Otero A, Sánchez JJ, Mojón A, Fernández JR, Ayala DE, on behalf on the Hygia Project Investigators. (2013f). Treatment-time regimen of hypertension medications significantly affects ambulatory blood pressure and clinical characteristics of patients with resistant hypertension. Chronobiol. Int. 30: 192–206.
  • Hoshino A, Nakamura T, Matsubara H. (2010). The bedtime administration ameliorates blood pressure variability and reduces urinary albumin excretion in amlodipine-olmesartan combination therapy. Clin. Exp. Hypertens. 32:416–422.
  • Ikeda T, Matsubara T, Sato Y, Sakamoto N. (1993). Circadian blood pressure variation in diabetic patients with autonomic neuropathy. J. Hypertens. 11:581–587.
  • Inaba M, Noguchi Y, Yamamoto T, Imai T, Hatano M, Yagi S, Katayama S. (2004). Effects of a low dose of indapamide, a diuretic, given daily or every-other-day on blood pressure and metabolic parameters. Hypertens. Res. 27:141–145.
  • Ingelsson E, Bjorklund-Bodegard K, Lind L, Arnlov J, Sundstrom J. (2006). Diurnal blood pressure pattern and risk of congestive heart failure. JAMA 295:2859–2866.
  • Jonas M, Garfinkel D, Zisapel N, Laudon M, Grossman E. (2003). Impaired nocturnal melatonin secretion in non-dipper hypertensive patients. Blood Press. 12:19–24.
  • Jumabay M, Ozawa Y, Kawamura H, Saito S, Izumi Y, Mitsubayashi H, Kawasaki Y, Nakayama T, Mahumut M, Cheng Z, Wang S, Kammatsuse K. (2002). Ambulatory blood pressure monitoring in Uygur centenarians. Circ. J. 66:75–79.
  • Kanabrocki EL, George M, Hermida RC, Messmore HL, Ryan MD, Ayala DE, Hoppensteadt DA, Fareed J, Bremmer FW, Third JLHC, Shirazi P, Nemchausky BA. (2001). Day-night variations in blood levels of nitric oxide, T-TFPI and E-selectin. Clin. Appl. Thromb. Hemost. 7:339–345.
  • Kaneko Y, Sasaki Y, Aizaka R, Shimisu T. (2001). The effects of oral melatonin on the automatic function in healthy subjects. Psychiatry Clin. Neurosci. 55:299–300.
  • Kanzik I, Cakici I, Ersoy S, Ark M, Abacioglu N, Zengil H. (1992). Effects of cyclooxygenase and lipoxygenase inhibitors on digoxin-induced arrhythmias and haemodynamics in guinea-pigs. Pharmacol. Res. 26:305–316.
  • Kario K, Pickering TG, Matsuo T, Hoshide S, Schwartz JE, Shimada K. (2001). Stroke prognosis and abnormal nocturnal blood pressure falls in older hypertensives. Hypertension 38:852–857.
  • Kario K, Pickering TG, Umeda Y, Hoshide S, Hoshide Y, Morinari M, Murata M, Kuroda T, Schwartz JE, Shimada K. (2003). Morning surge in blood pressure as a predictor of silent and clinical cerebrovascular disease in elderly hypertensives: a prospective study. Circulation 107:1401–1406.
  • Katz F, Romfh P, Smith JA. (1975). Diurnal variation of plasma aldosterone, cortisol and renin activity in supine man. J. Clin. Endocrinol. Metab. 40:125–134.
  • Kawano Y, Tochikubo O, Minamisawa K, Miyajima E, Ishii M. (1994). Circadian variation of hemodynamics in patients with essential hypertension: comparison between early morning and evening. J. Hypertens. 12:1405–1412.
  • Kawashima K, Miwa Y, Fujimoto K, Oohata H, Nishino H, Koike H. (1987). Antihypertensive action of melatonin in the spontaneously hypertensive rat. Clin. Exp. Hypertens. A9:1121–1131.
  • Kikuya M, Ohkubo T, Asayama K, Metoki H, Obara T, Saito S, Hashimoto J, Totsune K, Hoshi H, Satoh H, Imai Y. (2005). Ambulatory blood pressure and 10-year risk of cardiovascular and noncardiovascular mortality. The Ohasama Study. Hypertension 45:240–245.
  • Kitahara Y, Saito F, Akao M, Fujita H, Takahashi A, Taguchi H, Hino T, Otsuka Y, Kushiro T, Kanmatsuse K. (2004). Effect of morning and bedtime dosing with cilnidipine on blood pressure, heart rate, and sympathetic nervous activity in essential hypertensive patients. J. Cardiovasc. Pharmacol. 43:68–73.
  • Koga H, Hayashi J, Yamamoto M, Kitamoto K. (2005). Prevention of morning surge of hypertension by the evening administration of carvedilol. Jap. Med. Assoc. J. 48:398–403.
  • Kohno I, Iwasaki H, Okutani M, Mochizuki Y, Sano S, Satoh Y, Ishihara T, Ishii H, Mukaiyama S, Ijiri H, Komori S, Tamura K. (1997). Administration-time-dependent effects of diltiazem on the 24-hour blood pressure profile of essential hypertension patients. Chronobiol. Int. 14:71–84.
  • Kohno I, Ijiri H, Takusagawa M, Yin DF, Sano S, Ishihara T, Sawanobori T, Komori S, Tamura K. (2000). Effect of imidapril in dipper and nondipper hypertensive patients: comparison between morning and evening administration. Chronobiol. Int. 17:209–219.
  • Koopman MG, Koomen GC, Krediet RT, de Moor EA, Hoek FJ, Arisz L. (1989). Circadian rhythm of glomerular filtration rate in normal individuals. Clin. Sci. (Lond.) 77:105–111.
  • Kuroda T, Kario K, Hoshide S, Hashimoto T, Nomura Y, Saito Y, Mito H, Shimada K. (2004). Effects of bedtime vs. morning administration of the long-acting lipophilic angiotensin-converting enzyme inhibitor trandolapril on morning blood pressure in hypertensive patients. Hypertens. Res. 27:15–20.
  • Laflamme A, Wu L, Foucart S, de Chamlain J. (1998). Impaired basal sympathetic tone and alpha 1-adrenergic responsiveness in association with the hypotensive effect of melatonin in spontaneously hypertensive rats. Am. J. Hypertens. 11:219–229.
  • Lakatua DJ, Haus E, Halberg F, Halberg E, Wendt HW, Sackett-Lundeen LL, Berg HG, Kawasaki T, Ueno M, Uezono K, Matsuoka M, Omae T. (1986). Circadian characteristics of urinary epinephrine and norepinephrine from healthy young women in Japan and U.S.A. Chronobiol. Int. 3:189–195.
  • Labrecque G, Beauchamp D. (2003). Rhythms and pharmacokinetics. In Redfern P (Ed.). Chronotherapeutics. London: Pharmaceutical Press, 75–110.
  • Langner B, Lemmer B. (1988). Circadian changes in the pharmacokinetics and cardiovascular effects of oral propranolol in healthy subjects. Eur. J. Clin. Pharmacol. 33:619–624.
  • Lasko BH, Laplante A, Hebert D, Bonnefis-Boyer S. (2001). Canadian valsartan study in patients with mild-to-moderate hypertension. Blood Press. Monit. 6:91–99.
  • Leenen FHH. (1996). Clinical relevance of 24 h blood pressure control by 1,4-dihydropyridines. Am. J. Hypertens. 9:97S–104S.
  • Lemmer B. (1999). Chronopharmacokinetics—implications for drug treatment. J. Pharm. Pharmacol. 51:887–890.
  • Lemmer B. (2000). Cardiovascular chronobiology and chronopharmacology. Importance of timing of dosing. In White WB (Ed.). Blood pressure monitoring in cardiovascular medicine and therapeutics. Totowa, NJ: Humana Press, 255–271.
  • Lemmer B, Nold G. (2003). Effect of doxazosin GITS on 24-hour blood pressure profile in patients with stage 1 to atage 2 primary hypertension. Blood Press. Monit. 8:119–125.
  • Lemmer B, Portaluppi F. (1997). Chronopharmacology of cardiovascular diseases. In Redfern P, Lemmer B (Eds.). Physiology and pharmacology of biological rhythms. Handbook of experimental pharmacology, Vol. 125. Heidelberg, Germany: Springer Verlag, 251–297.
  • Lemmer B, Nold G, Behne S, Kaiser R. (1991). Chronopharmacokinetics and cardiovascular effects of nifedipine. Chronobiol. Int. 8:485–494.
  • Liebson PR. (2006). Calcium channel blockers in the spectrum of antihypertensive agents. Exp. Opin. Pharmacother. 7:2385–2401.
  • Linsell CR, Lightman SL, Mullen PE, Brown MJ, Causon RC. (1985). Circadian rhythms of epinephrine and norepinephrine in man. J. Clin. Endocrinol. Metab. 60:1210–1215.
  • Lusardi P, Preti P, Savino S, Piazza E, Zoppi A, Fogari R. (1997). Effect of bedtime melatonin ingestion on blood pressure of normotensive subjects. Blood Press Monit. 2:99–103.
  • Lusardi P, Piazza E, Fogari R. (2000). Cardiovascular effects of melatonin in hypertensive patients well controlled by nifedipine: a 24-hour study. Br. J. Clin. Pharmacol. 49:423–427.
  • Macchiarulo C, Pieri R, Mitolo DC, Pirrelli A. (1999). Management of antihypertensive treatment with lisinopril: a chronotherapeutic approach. Eur. Rev. Med. Pharmacol. Sci. 3:269–275.
  • Mancia G, Omboni S, Parati G, on behalf of the investigators of the INSIGHT ABPM substudy. (2002). Twenty-four hours ambulatory blood pressure in the International Nifedipine GITS Study Intervention as a Goal in Hypertension Treatment (INSIGHT). J. Hypertens. 20:545–553.
  • Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, Grassi G, Heagerty AM, Kjeldsen SE, Laurent S, Narkiewicz K, Ruilope L, Rynkiewicz A, Schmieder RE, Struijker HAJ, Zanchetti A. (2007). 2007 guidelines for the management of arterial hypertension. The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J. Hypertens. 25:1105–1187.
  • Manfredini R, Portaluppi F, Grandi E, Fersini C, Gallerani M. (1996). Out-of-hospital sudden death referring to an emergency department. J. Clin. Epidemiol. 49:865–868.
  • Manfredini R, Gallerani M, Portaluppi F, Salmi R, Fersini C. (1997). Chronobiological patterns of onset of acute cerebrovascular diseases. Thromb. Res. 88:451–463.
  • Manfredini R, Boari B, Portaluppi F. (2003). Morning surge in blood pressure as a predictor of silent and clinical cerebrovascular disease in elderly hypertensives [letter]. Circulation 108:e72–e73.
  • Manfredini R, Boari B, Bressan S, Gallerani M, Salmi R, Portaluppi F, Mehta RH. (2004). Influence of circadian rhythm on mortality after myocardial infarction: data from a prospective cohort of emergency calls. Am. J. Emerg. Med. 22:555–559.
  • Manfredini R, Boari B, Salmi R, Fabbian F, Pala M, Tiseo R, Portaluppi F. (2013). Twenty-four-hour patterns in occurrence and pathophysiology of acute cardiovascular events and ischemic heart disease. Chronobiol. Int. 30: 6–16.
  • Mehta HR, Manfredini R, Hassan F, Sechtem U, Bossone E, Oh JK, Cooper JV, Smith DE, Portaluppi F, Penn M, Hutchison S, Nienaber CA, Isselbacher EM, Eagle KA. (2002). Chronobiological patterns of acute aortic dissection. Circulation 106:1110–1115.
  • Meilhac B, Mallion JM, Carre A, Chanudet X, Poggi L, Gosse P, Dallocchio M. (1992). Study of the influence of the time of administration on the antihypertensive effect and nitrendipine tolerance in mild to moderate essential hypertensive patients. Value of ambulatory recording of blood pressure on 24 hours. Therapie 47:205–210.
  • Meng Y, Zhang Z, Liang X, Wu C, Qi G. (2010). Effects of combination therapy with amlodipine and fosinopril administered at different times on blood pressure and circadian blood pressure pattern in patients with essential hypertension. Acta Cardiol. 65:309–314.
  • Mengden T, Binswanger B, Spühler T, Weisser B, Vetter W. (1993). The use of self-measured blood pressure determinations in assessing dynamics of drug compliance in a study with amlodipine once a day, morning versus evening. J. Hypertens. 11:1403–1411.
  • Middeke M, Kluglich M, Holzgreve H. (1991). Chronopharmacology of captopril plus hydrochlorothiazide in hypertension: morning versus evening dosing. Chronobiol. Int. 8:506–510.
  • Milani RV. (2005). Reaching for aggressive blood pressure goals: role of angiotensin receptor blockade in combination therapy. Am. J. Manag. Care 11( Suppl 7):S220–S227.
  • Minutolo R, Gabbai FB, Borrelli S, Scigliano R, Trucillo P, Baldanza D, Laurino S, Mascia S, Conte G, De Nicola L. (2007). Changing the timing of antihypertensive therapy to reduce nocturnal blood pressure in CKD: an 8-week uncontrolled trial. Am. J. Kidney Dis. 50:908–917.
  • Minutolo R, Agarwal R, Borrelli S, Chiodini P, Bellizzi V, Nappi F, Cianciaruso B, Zamboni P, Conte G, Gabbai FB, De Nicola L. (2011). Prognostic role of ambulatory blood pressure measurement in patients with nondialysis chronic kidney disease. Arch. Intern. Med. 171:1090–1098.
  • Mojón A, Ayala DE, Piñeiro L, Otero A, Crespo JJ, Moyá A, Bóveda J, Pérez de Lis J, Fernández JR, Hermida RC, on behalf of the Hygia Project Investigators. (2013). Comparison of ambulatory blood pressure parameters of hypertensive patients with and without chronic kidney disease. Chronobiol. Int. 30: 145–158.
  • Morgan TO. (2009). Does it matter when drugs are taken? Hypertension 54:23–24.
  • Morgan T, Anderson A, Jones E. (1997). The effect on 24 h blood pressure control of an angiotensin converting enzyme inhibitor (perindopril) administered in the morning or at night. J. Hypertens. 15:205–211.
  • Moyá A, Crespo JJ, Ayala DE, Ríos MT, Pousa L, Callejas PA, Salgado JL, Mojón A, Fernández JR, Hermida RC, on behalf on the Hygia Project Investigators. (2013). Effects of time-of-day of hypertension treatment on ambulatory blood pressure and clinical characteristics of patients with type 2 diabetes. Chronobiol. Int. 30: 116–131.
  • Muxfeldt ES, Bloch KV, Nogueira AR, Salles GF. (2003). Twenty-four hour ambulatory blood pressure monitoring pattern of resistant hypertension. Blood Press. Monit. 8:181–185.
  • Myburgh DP, Verho M, Botes JH, Erasmus ThP, Luus HG. (1995). 24-Hour pressure control with ramipril: comparison of once-daily morning and evening administration. Curr. Ther. Res. 56:1298–1306.
  • Nakano S, Fukuda M, Hotta F, Ito T, Ishii T, Kitazawa M, Nishizawa M, Kigoshi T, Uchida K. (1998). Reversed circadian blood pressure rhythm is associated with occurrences of both fatal and nonfatal events in NIDDM subjects. Diabetes 47:1501–1506.
  • Neutel JM, Smith DHG. (2003). Evaluation of angiotensin II receptor blockers for 24-hour blood pressure control: meta-analysis of a clinical database. J. Clin. Hypertens. 1:58–63.
  • Neutel J, Weber M, Pool J, Smith D, Fitzsimmons S, Chiang YT, Gatlin M. (1997). Valsartan, a new angiotensin II antagonist: antihypertensive effects over 24 hours. Clin. Ther. 19:447–458.
  • Niegowska J, Niegowska M, Jasinski B. (2005). Telmisartan in monotherapy of essential hypertension in young men—time of drug administration and 24-hours blood pressure and heart rate. Pol. Arch. Med. Wewn. 114:868–873.
  • Nold G, Strobel G, Lemmer B. (1998). Morning vs evening amlodipine treatment: effect on circadian blood pressure profile in essential hypertensive patients. Blood Press. Monit. 3:17–25.
  • O'Brien E, Sheridan J, O'Malley K. (1988). Dippers and non-dippers [letter]. Lancet 13:397.
  • Ocón J, Mora J. (1990). Twenty-four-hour blood pressure monitoring and effects of indapamide. Am. J. Cardiol. 65:p58H–61H.
  • Ohkubo T, Hozawa A, Yamaguchi J, Kikuya M, Ohmori K, Michimata M, Matsubara M, Hashimoto J, Hoshi H, Araki T, Tsuji I, Satoh H, Hisamichi S, Imai Y. (2002). Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure: the Ohasama study. J. Hypertens. 20:2183–2189.
  • Ohmori M, Fujimura A. ACE inhibitors and chronotherapy. (2005). Clin. Exp. Hypertens. 2–3:179–185
  • Okyar A, Dressler C, Hanafy A, Baktir G, Lemmer B, Spahn-Langguth H. (2012). Circadian variations in exsorptive transport: in-situ intestinal perfusion data and in-vivo relevance. Chronobiol. Int. 29:443–453.
  • O'Sullivan C, Duggan J, Atkins N, ÓBrien E. (2003). Twenty-four-hour ambulatory blood pressure in community-dwelling elderly men and women aged 60–102 years. J. Hypertens. 21:1641–1647.
  • Palatini P. (1992). Can an angiotensin-converting enzyme inhibitor with a short half-life effectively lower blood pressure for 24 hours? Am. Heart J. 123:1421–1425.
  • Palatini P, Racioppa A, Raule G, Zaninotto M, Penzo M, Pessina AC. (1992). Effect of timing of administration on the plasma ACE inhibitory activity and the antihypertensive effect of quinapril. Clin. Pharmacol. Ther. 52:378–383.
  • Palatini P, Mos L, Motolese M, Mormino P, Del Torre M, Varotto L, Pavan E, Pessina AC. (1993). Effect of evening versus morning benazepril on 24-hour blood pressure: a comparative study with continuous intraarterial monitoring. Int. J. Clin. Pharmacol. Ther. Toxicol. 31:295–300.
  • Palmas W, Pickering T, Teresi J, Schwartz JE, Eguchi K, Field L, Weinstock RS, Shea S. (2008). Nocturnal blood pressure elevation predicts progression of albuminuria in elderly people with type 2 diabetes. J. Clin. Hypertens. (Greenwich) 10:12–20.
  • Panza JA, Epstein SE, Quyyumi AA. (1991). Circadian variation in vascular tone and its relation to alpha-sympathetic vasoconstrictor activity. N. Engl. J. Med. 325:986–990.
  • Parati G, Bilo G. (2010). Evening administration of antihypertensive drugs: filling a knowledge gap. J. Hypertens. 28:1390–1392.
  • Patrono C, Ciabattoni G, Patrignani P, Pugliese F, Filabozzi P, Catella F, Dave G, Forni L. (1985). Clinical pharmacology of platelet cyclo-oxygenase inhibition. Circulation 72:1177–1184.
  • Pechère-Bertschi A, Nussberger J, Decosterd L, Armagnac C, Sissmann J, Bouroudian M, Brunner HR, Burnier M. (1998). Renal response to the angiotensin II receptor subtype 1 antagonist irbesartan versus enalapril in hypertensive patients. J. Hypertens. 16:385–393.
  • Petrie K, Dawson AG, Thompson L, Brook R. (1993). A double blind trial of melatonin as a treatment for jet-lag in international cabin crew. Biol. Psychiatry 33:526–530.
  • Pickering TG, Levenstein M, Walmsley P, for the Hypertension and Lipid Trial Study Group. (1994). Night-time dosing of doxazosin has peak effect on morning ambulatory blood pressure. Results of the HALT study. Am. J. Hypertens. 7:844–847.
  • Pistrosch F, Reissmann E, Wildbrett J, Koehler C, Hanefeld M. (2007). Relationship between diurnal blood pressure variation and diurnal blood glucose levels in type 2 diabetic patients. Am. J. Hypertens. 20:541–545.
  • Portaluppi F, Hermida RC. (2007). Circadian rhythms in cardiac arrhythmias and opportunities for their chronotherapy. Adv. Drug Deliv. Rev. 59:940–951.
  • Portaluppi F, Smolensky MH. (2000). Circadian rhythm and environmental determinants of blood pressure regulation in normal and hypertensive conditions. In White WB (Ed.). Blood pressure monitoring in cardiovascular medicine and therapeutics. Totowa, NJ: Humana Press, pp.79–118.
  • Portaluppi F, Smolensky MH. (2010). Perspectives on the chronotherapy of hypertension based on the results of the MAPEC study. Chronobiol. Int. 27:1652–1667.
  • Portaluppi F, Montanari L, Ferlini M, Gilli P. (1990). Altered circadian rhythms of blood pressure and heart rate in non-hemodialysis chronic renal failure. Chronobiol. Int. 7:321–327.
  • Portaluppi F, Trasforini G, Margutti A, Vergnani L, Ambrosio MR, Rossi R, Bagni B, Pansini R, degli Uberti EC. (1992). Circadian rhythm of calcitonin gene-related peptide in uncomplicated essential hypertension. J. Hypertens. 10:1227–1234.
  • Portaluppi F, Cortelli P, Avoni P, Vergnani L, Maltoni P, Pavani A, Sforza E, degli Uberti EC, Gambetti P, Lugaresi E. (1994). Progressive disruption of the circadian rhythm of melatonin in fatal familial insomnia. J. Clin. Endocrinol. Metab. 78:1075–1078.
  • Portaluppi F, Vergnani L, Manfredini R, degli Uberti EC, Fersini C. (1995). Time-dependent effect of isradipine on the nocturnal hypertension in chronic renal failure. Am. J. Hypertens. 8:719–726.
  • Portaluppi F, Vergnani L, Manfredini R, Fersini C. (1996). Endocrine mechanisms of blood pressure rhythms. Ann. N. Y. Acad. Sci. 783:113–131.
  • Portaluppi F, Manfredini R, Fersini C. (1999). From a static to a dynamic concept of risk: the circadian epidemiology of cardiovascular events. Chronobiol. Int. 16:33–49.
  • Portaluppi F, Boari B, Manfredini R. (2004). Oxidative stress in essential hypertension. Curr. Pharm. Des. 10:1695–1698.
  • Portaluppi F, Tiseo R, Smolensky MH, Hermida RC, Ayala DE, Fabbian F. (2012). Circadian rhythms and cardiovascular health. Sleep Med. Rev. 16:151–166.
  • Qiu YG, Chen JZ, Zhu JH, Yao XY. (2003). Differential effects of morning or evening dosing of amlodipine on circadian blood pressure and heart rate. Cardiovasc. Drugs Ther. 17:335–341.
  • Qiu YG, Zhu JH, Tao QM, Zheng P, Chen JZ, Hu SJ, Zhang FR, Zheng LR, Zhao LL, Yao XY. (2005). Captopril administered at night restores the diurnal blood pressure rhythm in adequately controlled, nondipping hypertensives. Cardiovasc. Drugs Ther. 19:189–195.
  • Raftery EB, Melville DI, Gould BA, Mann S, Whittington JR. (1981). A study of the antihypertensive action of xipadime using ambulatory intra-arterial monitoring. Br. J. Clin. Pharmacol. 12:381–385.
  • Ray CA. (2003). Melatonin attenuates sympathetic nerve response to orthostatic stress in humans. J. Physiol. 551:1043–1048.
  • Rechcinski T, Kurpesa M, Trzos E, Krzeminska-Pakula M. (2006). The influence of melatonin supplementation on circadian pattern of blood pressure in patients with coronary artery disease—preliminary report. Pol. Arch. Med. Wewn. 115:520–528.
  • Rechcinski T, Trzos E, Wierzbowska-Drabik K, Krzeminska-Pakula M, Kurpesa M. (2010). Melatonin for nondippers with coronary artery disease: assessment of blood pressure profile and heart rate variability. Hypertens. Res. 33:56–61.
  • Reinberg A, Smolensky MH. (1982). Circadian changes of drug disposition in man. Clin. Pharmacokinet. 7:401–420.
  • Ríos MT, Domínguez-Sardiña M, Ayala DE, Gomara S, Sineiro E, Pousa L, Callejas PA, Fontao MJ, Fernández JR, Hermida RC, on behalf of the Hygia Project Investigators. (2013). Prevalence and clinical characteristics of isolated-office and true resistant hypertension determined by ambulatory blood pressure monitoring. Chronobiol. Int. 30: 207–220.
  • Rutter MK, McComb JM, Forster J, Brady S, Marshall SM. (2000). Increased left ventricular mass index and nocturnal systolic blood pressure in patients with Type 2 diabetes mellitus and microalbuminuria. Diabet. Med. 17:321–325.
  • Salles GF, Cardoso CR, Muxfeldt ES. (2008). Prognostic influence of office and ambulatory blood pressures in resistant hypertension. Arch. Intern. Med. 168:2340–2346.
  • Scheer FA, Van Montfrans GA, van Someren EJ, Mairuhu G, Buijs RM. (2004). Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Hypertension 43:192–197.
  • Seki S, Taniguchi M, Ohsawa S, Koga A, Ito T, Kunoh M, Imamoto S, Miyazaki H, Takeda S, Iwano K, Satoh C, Kanae K, Mochizuki S. (2005). Chronobiological analysis by ambulatory blood pressure monitoring of the hyperbaric and hypobaric indexes for evaluation of the antihypertensive effect of long-acting nifedipine. Circ. J. 69:1249–1255.
  • Sharpe M, Jarvis B, Goa KL. (2001). Telmisartan: a review of its use in hypertension. Drugs 61:1501–1529.
  • Skene DJ, Lockley SW, Arendt J. (1999). Use of melatonin in the treatment of phase shift and sleep disorders. Adv. Exp. Med. Biol. 467:79–84.
  • Smith DH, Neutel JM, Lacourciere Y, Kempthorne-Rawson J. (2003). Prospective, randomized, open-label, blinded-endpoint (PROBE) designed trials yield the same results as double-blind, placebo-controlled trials with respect to ABPM measurements. J. Hypertens. 21:1291–1298.
  • Smolensky MH, Haus E. (2001). Circadian rhythms in clinical medicine with applications to hypertension. Am. J. Hypertens. 14(9 Pt 2):280S–290S.
  • Smolensky MH, Portaluppi F. (1999). Chronopharmacology and chronotherapy of cardiovascular medications: relevance to prevention and treatment of coronary heart disease. Am. Heart J. 137(4 Pt 2):S14–S24.
  • Smolensky MH, Hermida R, Portaluppi F, Haus E, Reinberg A. (2005). Chronotherapeutics in the treatment of hypertersion. In Oparil S, Weber MA (Eds.). Hypertension: a companion to Brenner and Rector's The Kidney. 2nd ed. Philadelphia: Elsevier Saunders, pp.530–542.
  • Smolensky MH, Hermida RC, Castriotta RJ, Portaluppi F. (2007a). Role of sleep-wake cycle on blood pressure circadian rhythms and hypertension. Sleep Med. 8:668–680.
  • Smolensky MH, Hermida RC, Portaluppi F. (2007b). Comparison of the efficacy of morning versus evening administration of olmesartan in uncomplicated essential hypertension. Chronobiol. Int. 24:171–181.
  • Smolensky MH, Hermida RC, Ayala DE, Tiseo R, Portaluppi F. (2010). Administration-time-dependent effect of blood pressure-lowering medications: basis for the chronotherapy of hypertension. Blood Press. Monit. 15:173–180.
  • Smolensky MH, Siegel RA, Haus E, Hermida R, Portaluppi F. (2012). Biological rhythms, drug delivery, and chronotherapeutics. In Siepmann J, Siegel RA, Rathbone MJ (Eds.). Fundamentals and applications of controlled release drug delivery. Heidelberg: Springer Verlag, pp.359–443.
  • Snoep JD, Hovens MMC, Pasha SM, Frölich M, Pijl H, Tamsma JT, Huisman MV. (2009). Time-dependent effects of low-dose aspirin on plasma renin activity, aldosterone, cortisol, and catecholamines. Hypertension 54:1136–1142.
  • Somers VK, Dyken ME, Mark AL, Abboud FM. (1993). Sympathetic-nerve activity during sleep in normal subjects. N. Engl. J. Med. 328:303–307.
  • Sothern RB, Vesely DL, Kanabrocki EL, Hermida RC, Bremner FW, Third JLHC, Boles MA, Nemchausky BM, Olwin JH, Scheving LE. (1995). Temporal (circadian) and functional relationship between atrial natriuretic peptides and blood pressure. Chronobiol. Int. 12:106–120.
  • Sowers JR, Vlachakis N. (1984). Circadian variation in plasma dopamine levels in man. J. Endocrinol. Invest. 7:341–345.
  • Spallone V, Maiello MR, Cicconetti E, Pannone A, Barini A, Gambardella S, Menzinger G. (2001). Factors determining the 24-h blood pressure profile in normotensive patients with type 1 and type 2 diabetes. J. Hum. Hypertens. 15:239–246.
  • Staessen JA, Fagard R, Thijs L, Celis H, Arabidze GG, Birkenhager WH, Bulpitt CJ, de Leeuw PW, Dollery CT, Fletcher AE, Forette F, Leonetti G, Nachev C, ÓBrien ET, Rosenfeld J, Rodicio JL, Tuomilehto J, Zanchetti A. (1997). Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. Lancet 350:757–764.
  • Staessen JA, Thijs L, Fagard R, ÓBrien ET, Clement D, de Leeuw PW, Mancia G, Nachev C, Palatini P, Parati G, Tuomilehto J, Webster J, for the Systolic Hypertension in Europe (Syst-Eur) trial investigators. (1999). Predicting cardiovascular risk using conventional vs ambulatory blood pressure in older patients with systolic hypertension. JAMA 282:539–546.
  • Stanton A, O'Brien E. (1994). Auswirkungen der Therapie auf das zirkadiane Blutdruckprofil. Kar-dio 3:1–8.
  • Sturrock NDC, George E, Pound N, Stevenson J, Peck GM, Sowter H. (2000). Non-dipping circadian blood pressure and renal impairment are associated with increased mortality in diabetes mellitus. Diabet. Med. 17:360–364.
  • Sunaga K, Fujimura A, Shiga T, Ebihara A. (1995). Chronopharmacology of enalapril in hypertensive patients. Eur. J. Clin. Pharmacol. 48:441–445.
  • Suzuki K, Aizawa Y. (2011). Evaluation of dosing time-related anti-hypertensive efficacy of valsartan in patients with type 2 diabetes. Clin. Exp. Hypertens. 33:56–62.
  • Svensson P, de Faire U, Sleight P, Yusuf S, Östergren J. (2001). Comparative effects of ramipril on ambulatory and office blood pressures. A HOPE substudy. Hypertension 38:e28–e32.
  • Taubert D, Berkels R, Grosser N, Schroder H, Grundemann D, Schomig E. (2004). Aspirin induces nitric oxide release from vascular endothelium: a novel mechanism of action. Br. J. Pharmacol. 143:159–165.
  • Tofé S, García B. (2009). 24-hour and nighttime blood pressures in type 2 diabetic hypertensive patients following morning or evening administration of olmesartan. J. Clin. Hypertens. (Greenwhich) 11:426–431.
  • Umeda T, Naomi S, Iwaoka T, Inoue J, Sasaki M, Ideguchi Y, Sato T. (1994). Timing for administration of an antihypertensive drug in the treatment of essential hypertension. Hypertension 23( Suppl 1):I211–I214.
  • Uzu T, Kimura G. (1999). Diuretics shift circadian rhythm of blood pressure from nondipper to dipper in essential hypertension. Circulation 100:1635–1638.
  • Uzu T, Ishikawa K, Fujii T, Nakamura S, Inenaga T, Kimura G. (1997). Sodium restriction shifts circadian rhythm of blood pressure from nondipper to dipper in essential hypertension. Circulation 96:1859–1862.
  • van de Borne P, Nguyen H, Biston P, Linkowski P, Degaute JP. (1994). Effects of wake and sleep stages on the 24-h autonomic control of blood pressure and heart rate in recumbent men. Am. J. Physiol. 266(2 Pt 2):H548–H554.
  • Varani K, Gessi S, Caiazza A, Rastelli G, Portaluppi F, Borea PA. (1999a). Platelet alpha2-adrenoceptor alterations in patients with essential hypertension. Br. J. Clin. Pharmacol. 47:167–172.
  • Varani K, Portaluppi F, Merighi S, Ongini E, Belardinelli L, Borea PA. (1999b). Caffeine alters A2A adenosine receptors and their function in human platelets. Circulation 99:2499–2502.
  • Varani K, Portaluppi F, Gessi S, Merighi S, Ongini E, Belardinelli L, Borea PA. (2000). Dose and time effects of caffeine intake on human platelet adenosine A(2A) receptors: functional and biochemical aspects. Circulation 102:285–289.
  • Verdecchia P, Porcellati C, Schillaci G, Borgioni C, Ciucci A, Battistell M, Guerrieri M, Gatteschi C, Zampi I, Santucci A, Santucci C, Reboldi G. (1994). Ambulatory blood pressure: an independent predictor of prognosis in essential hypertension. Hypertension 24:793–801.
  • Weekley LB. (1993). Effects of melatonin on pulmonary and coronary vessels are exerted through perivascular nerves. Clin. Auton. Res. 3:45–47.
  • White WB, Mansoor GA, Pickering TG, Vidt DG, Hutchinson HG, Johnson RB, Noveck R. (1999). Differential effects of morning and evening dosing of nisoldipine ER on circadian blood pressure and heart rate. Am. J. Hypertens. 12:806–814.
  • Winters CJ, Sallman AL, Vesely DL. (1988). Circadian rhythm of prohormone atrial natriuretic peptides 1–30, 31–67 and 99–126 in man. Chronobiol. Int. 5:403–409.
  • Witte K, Lemmer B. (2003). Rhythms and pharmacodynamics. In Redfern P (ed.). Chronotherapeutics. London: Pharmaceutical Press, pp.111–126.
  • Witte K, Weisser K, Neubeck M, Mutschler E, Lehmann K, Hopf R, Lemmer B. (1993). Cardiovascular effects, pharmacokinetics and converting enzyme inhibition of enalapril after morning versus evening administration. Clin. Pharmacol. Ther. 54:177–186.
  • Wu R, Lamontagne D, de Champlain J. (2002). Antioxidative properties of acetylsalicylic acid on vascular tissues from normotensive and spontaneously hypertensive rats. Circulation 105:387–392.
  • Wu R, Laplante MA, de Champlain J. (2004). Prevention of angiotensin II-induced hypertension, cardiovascular hypertrophy and oxidative stress by acetylsalicylic acid in rats. J. Hypertens. 22:793–801.
  • Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G. (2000). Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients: the Heart Outcomes Prevention Evaluation Study Investigators. N. Engl. J. Med. 342:145–153.
  • Zanchetti A, Bianchi L, Bozza M, and the Italian Nifedipine GITS Study Group. (1994). Antihypertensive effects of nifedipine GITS on clinic and ambulatory blood pressures in essential hypertensives. High Blood Pressure 3:45–56.
  • Zaslavskaia RM, Narmanova OZ, Teiblium MM, Kalimurzina BS. (1999). Time-dependent effects of ramipril in patients with hypertension of 2 stage. Klin. Mad. (Mosk.) 77:41–44.
  • Zaslavskaia RM, Komarov FI, Makarova LA, Shakirova AN, Narmanova OZh, Biiasilov N. (2000). Time-dependent effects of antihypertensive agents and chronocorrecting action of melatonin in patients with arterial hypertension. Vestn. Ross. Akad. Med. Nauk. 8:36–41.
  • Zaslavskaia RM, Lilitsa GV, Dilmagambetova GS, Halberg F, Cornélissen G, Otsuka K, Singh R B, Stoynev A, Ikonomov O, Tarquini R, Perfetto F, Schwartzkopff O, Bakken EE. (2004). Melatonin, refractory hypertension, myocardial ischemia and other challenges in nightly blood pressure lowering. Biomed. Pharmacotherapy 58:S129–S134.
  • Zaslavskaia RM, Shcherban' EA, Logvinenko SI. (2008). Melatonin in combined therapy of patients with stable angina and arterial hypertension. Klin. Med. (Mosk.) 86:64–67.
  • Zeman M, Dulková K, Bada V, Herichová I. (2005). Plasma melatonin concentrations in hypertensive patients with the dipping and non-dipping blood pressure profile. Life Sci. 76:1795–1803.
  • Zeng J, Jia M, Ran H, Zhang Y, Zhang J, Wang X, Wang H, Yang C, Zeng C. (2011). Fixed-combination of amlodipine and diuretic chronotherapy in the treatment of essential hypertension: improved blood pressure control with bedtime dosing—a multicenter, open-label randomized study. Hypertens. Res. 34:767–772.

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