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Original Articles

Impact of variants of the EXT2 gene on Type 2 diabetes and its related traits in the Chinese han population

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Pages 79-82 | Received 18 Dec 2013, Accepted 19 Jul 2014, Published online: 10 Sep 2014

References

  • Yang W, Lu J, Weng J, et al. Prevalence of diabetes among men and women in China. N Engl J Med 2010;362:1090–101
  • Apelqvist A, Ahlgren U, Edlund H. Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Curr Biol 1997;7:801–4
  • Thomas MK, Rastalsky N, Lee JH, Habener JF. Hedgehog signaling regulation of insulin production by pancreatic beta-cells. Diabetes 2000;49:2039–47
  • Sladek R, Rocheleau G, Rung J, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007;445:881–5
  • Horikoshi M, Hara K, Ito C, et al. Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. Diabetologia 2007;50:2461–6
  • Omori S, Tanaka Y, Takahashi A, et al. Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population. Diabetes 2008;57:791–5
  • Cauchi S, Proenca C, Choquet H, et al. Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study. J Mol Med (Berl) 2008;86:341–8
  • Lewis JP, Palmer ND, Hicks PJ, et al. Association analysis in African Americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies. Diabetes 2008;57:2220–5
  • Herder C, Rathmann W, Strassburger K, et al. Variants of the PPARG, IGF2BP2, CDKAL1, HHEX, and TCF7L2 genes confer risk of type 2 diabetes independently of BMI in the German KORA studies. Horm Metab Res 2008;40:722–6
  • Rong R, Hanson RL, Ortiz D, et al. Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians. Diabetes 2009;58:478–88
  • Gutierrez-Vidal R, Rodriguez-Trejo A, Canizales-Quinteros S, et al. LOC387761 polymorphism is associated with type 2 diabetes in the Mexican population. Genet Test Mol Biomarkers 2011;15:79–83
  • Wu Y, Li H, Loos RJ, et al. Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Diabetes 2008;57:2834–42
  • Ma C, Sheng H, Luo J. Association studies of polymorphisms in EXT2(exostoses 2) gene with type 2 diabetes in southern Chinese population. J Jiangsu Univ (Medicine Edition) 2010;20:256–62
  • Moore AF, Jablonski KA, McAteer JB, et al. Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program. Diabetes 2008;57:2503–10
  • DeFronzo RA. Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 1988;37:667–87
  • Bi Y, Zeng L, Zhu D, et al. Association of beta-cell function and insulin sensitivity with fasting and 2-h plasma glucose in a large Chinese population. Diabetes Obes Metab 2012;14:174–80
  • DeFronzo RA, Banerji MA, Bray GA, et al. Determinants of glucose tolerance in impaired glucose tolerance at baseline in the Actos Now for Prevention of Diabetes (ACT NOW) study. Diabetologia 2010;53:435–45
  • Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998;15:539–53
  • Bi Y, Zhu D, Jing Y, et al. Decreased beta cell function and insulin sensitivity contributed to increasing fasting glucose in Chinese. Acta Diabetol 2012;49:S51–8
  • Retnakaran R, Qi Y, Goran MI, Hamilton JK. Evaluation of proposed oral disposition index measures in relation to the actual disposition index. Diabet Med 2009;26:1198–203
  • Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing:comparison with the euglycemic insulin clamp. Diabetes Care 1999;22:1462–70
  • Chen J, Zheng H, Bei JX, et al. Genetic structure of the Han Chinese population revealed by genome-wide SNP variation. Am J Hum Genet 2009;85:775–85
  • Sung KC, Reaven GM, Kim SH. Utility of Homeostasis Model Assessment of beta-Cell Function in Predicting Diabetes in 12 924 Healthy Koreans. Diabetes Care 2010;33:200–2

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