Visceral adiposity as a target for the management of the metabolic syndrome

References

• Kannel WB, Dawber TR, Friedman GD, Glennon WE, Mcnamara PM. Risk factors in coronary heart disease. An evaluation of several serum lipid as predictors of coronary heart disease; The Framingham Study. Ann Intern Med. 1964;61:888–99.
   PubMed Web of Science ®Google Scholar
• Stamler J, Wentworth D, Neaton JD. Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT). JAMA. 1986;256:2823–8.
   PubMed Web of Science ®Google Scholar
• Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, .; INTERHEART Study Investigators. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet. 2004;364:937–52.
   PubMed Web of Science ®Google Scholar
• Cullen P, Schulte H, Assmann G. Smoking, lipoproteins and coronary heart disease risk. Data from the Münster Heart Study (PROCAM). Eur Heart J. 1998;19:1632–41.
   Google Scholar
• Despres JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature. 2006;444:881–7.
   PubMed Web of Science ®Google Scholar
• Vitale C, Marazzi G, Volterrani M, Aloisio A, Rosano G, Fini M. Metabolic syndrome. Minerva Med. 2006;97:219–29.
   PubMedGoogle Scholar
• Grundy SM. Metabolic syndrome pandemic. Arterioscler Thromb Vasc Biol. 2008;28:629–36.
   PubMed Web of Science ®Google Scholar
• Misra A, Khurana L. Obesity and the metabolic syndrome in developing countries. J Clin Endocrinol Metab. 2008; 93:S9–30.
   PubMed Web of Science ®Google Scholar
• Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, Bales VS, . Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA. 2003;289:76–9.
   PubMed Web of Science ®Google Scholar
• Galassi A, Reynolds K, He J. Metabolic syndrome and risk of cardiovascular disease: a meta-analysis. Am J Med. 2006; 119:812–9.
   PubMed Web of Science ®Google Scholar
• Després JP, Arsenault BJ, Côté M, Cartier A, Lemieux I. Abdominal obesity: the cholesterol of the 21st century? Can J Cardiol. 2008;24:7D–12D.
   PubMedGoogle Scholar
• Mottillo S, Filion KB, Genest J, Joseph L, Pilote L, Poirier P, . The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. J Am Coll Cardiol. 2010;56:1113–32.
   PubMed Web of Science ®Google Scholar
• Fujimoto WY, Bergstrom RW, Boyko EJ, Chen KW, Leonetti DL, Newell-Morris L, . Visceral adiposity and incident coronary heart disease in Japanese-American men. The 10-year follow-up results of the Seattle Japanese-American Community Diabetes Study. Diabetes Care. 1999; 22:1808–12.
   PubMed Web of Science ®Google Scholar
• Fujimoto WY, Bergstrom RW, Boyko EJ, Chen K, Kahn SE, Leonetti DL, . Type 2 diabetes and the metabolic syndrome in Japanese Americans. Diabetes Res Clin Pract. 2000;50:S73–6.
   Web of Science ®Google Scholar
• Fujimoto WY, Bergstrom RW, Boyko EJ, Leonetti DL, Newell-Morris LL, Wahl PW. Susceptibility to development of central adiposity among populations. Obes Res. 1995;3: 179S–186S.
   Google Scholar
• Hayashi T, Boyko EJ, McNeely MJ, Leonetti DL, Kahn SE, Fujimoto WY. Minimum waist and visceral fat values for identifying Japanese Americans at risk for the metabolic syndrome. Diabetes Care. 2007;30:120–7.
   PubMedGoogle Scholar
• Tong J, Boyko EJ, Utzschneider KM, McNeely MJ, Hayashi T, Carr DB, . Intra-abdominal fat accumulation predicts the development of the metabolic syndrome in non-diabetic Japanese-Americans. Diabetologia. 2007;50: 1156–60.
   PubMedGoogle Scholar
• Lovejoy JC, de la Bretonne JA, Klemperer M, Tulley R. Abdominal fat distribution and metabolic risk factors: effects of race. Metabolism. 1996;45:1119–24.
   PubMed Web of Science ®Google Scholar
• Després JP, Couillard C, Gagnon J, Bergeron J, Leon AS, Rao DC, . Race, visceral adipose tissue, plasma lipids, and lipoprotein lipase activity in men and women: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) family study. Arterioscler Thromb Vasc Biol. 2000; 20:1932–8.
   PubMed Web of Science ®Google Scholar
• Gill TP. Cardiovascular risk in the Asia-Pacific region from a nutrition and metabolic point of view: abdominal obesity. Asia Pac J Clin Nutr. 2001;10:85–9.
   Google Scholar
• WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004 Jan 10;363:157–63. Review. Erratum in: Lancet. 2004;363:902.
   PubMed Web of Science ®Google Scholar
• Kadowaki T, Sekikawa A, Murata K, Maegawa H, Takamiya T, Okamura T, . Japanese men have larger areas of visceral adipose tissue than Caucasian men in the same levels of waist circumference in a population-based study. Int J Obes (Lond). 2006;30:1163–5.
   PubMed Web of Science ®Google Scholar
• Huxley R, James WP, Barzi F, Patel JV, Lear SA, Suriyawongpaisal P, . Ethnic comparisons of the cross-sectional relationships between measures of body size with diabetes and hypertension. Obesity in Asia Collaboration. Obes Rev. 2008;9:53–61.
   Web of Science ®Google Scholar
• Low S, Chin MC, Ma S, Heng D, Deurenberg-Yap M. Rationale for redefining obesity in Asians. Ann Acad Med Singapore. 2009;38:66–9.
   PubMed Web of Science ®Google Scholar
• Després JP, Moorjani S, Lupien PJ, Tremblay A, Nadeau A, Bouchard C. Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease. Arteriosclerosis. 1990;10:497–511.
   PubMedGoogle Scholar
• Després JP, Lemieux I, Bergeron J, Pibarot P, Mathieu P, Larose E, . Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arterioscler Thromb Vasc Biol. 2008;28:1039–49.
   PubMed Web of Science ®Google Scholar
• Després JP. Is visceral obesity the cause of the metabolic syndrome? Ann Med. 2006;38:52–63.
   PubMed Web of Science ®Google Scholar
• Ylä-Herttuala S, Palinski W, Rosenfeld ME, Parthasarathy S, Carew TE, Butler S, . Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J Clin Invest. 1989;84: 1086–95.
   PubMed Web of Science ®Google Scholar
• Brown BG, Zhao XQ, Sacco DE, Albers JJ. Lipid lowering and plaque regression. New insights into prevention of plaque disruption and clinical events in coronary disease. Circulation. 1993;87:1781–91.
   PubMed Web of Science ®Google Scholar
• Sacks FM, Pfeffer MA, Moye LA, Rouleau JL, Rutherford JD, Cole TG, . The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators. N Engl J Med. 1996;335: 1001–9.
   PubMed Web of Science ®Google Scholar
• Assmann G, Schulte H, Cullen P. Pravastatin and coronary heart disease. Circulation. 1998;98:2933–4.
   Google Scholar
• Archbold RA, Timmis AD. Cholesterol lowering and coronary artery disease: mechanisms of risk reduction. Heart. 1998;80:543–7.
   Google Scholar
• Austin MA. Plasma triglyceride as a risk factor for coronary heart disease. The epidemiologic evidence and beyond. Am J Epidemiol. 1989;129:249–59.
   PubMed Web of Science ®Google Scholar
• Nesto RW. Beyond low-density lipoprotein: addressing the atherogenic lipid triad in type 2 diabetes mellitus and the metabolic syndrome. Am J Cardiovasc Drugs. 2005;5: 379–87.
   PubMedGoogle Scholar
• Björntorp P. Classification of obese patients and complications related to the distribution of surplus fat. Am J Clin Nutr. 1987;45:112–25.
   Google Scholar
• Kissebah AH, Vydelingum N, Murray R, Evans DJ, Hartz AJ, Kalkhoff RK, . Relation of body fat distribution to metabolic complications of obesity. J Clin Endocrinol Metab. 1982;54:254–60.
   PubMed Web of Science ®Google Scholar
• Kaplan NM. The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch Intern Med. 1989;149:1514–20.
   PubMed Web of Science ®Google Scholar
• Vague J. La differenciation sexuelle, feateur determinant des formes de l'obesite. Presse Med. 1947;55:339–40.
   PubMed Web of Science ®Google Scholar
• Tokunaga K, Matsuzawa Y, Ishikawa K, Tarui S. A novel technique for the determination of body fat by computed tomography. Int J Obes. 1983;7:437–45.
   PubMed Web of Science ®Google Scholar
• Hiuge-Shimizu A, Kishida K, Funahashi T, Ishizaka Y, Oka R, . Absolute value of visceral fat area measured on computed tomography scans and obesity-related cardiovascular risk factors in large-scale Japanese general population (the VACATION-J study). 2010 Oct 22 Ann Med 2010.
   Google Scholar
• Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P, Liu CY, . Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation. 2007;116:39–48.
   PubMed Web of Science ®Google Scholar
• Porter SA, Massaro JM, Hoffmann U, Vasan RS, O'Donnel CJ, Fox CS. Abdominal subcutaneous adipose tissue: a protective fat depot? Diabetes Care. 2009;32:1068–75.
   PubMed Web of Science ®Google Scholar
• Oka R, Miura K, Sakurai M, Nakamura K, Yagi K, Miyamoto S, . Impacts of visceral adipose tissue and subcutaneous adipose tissue on metabolic risk factors in middle-aged Japanese. Obesity (Silver Spring). 2010;18: 153–60.
   PubMed Web of Science ®Google Scholar
• Fujioka S, Matsuzawa Y, Tokunaga K, Tarui S. Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism. 1987;36:54–9.
   PubMed Web of Science ®Google Scholar
• Kanai H, Matsuzawa Y, Kotani K, Keno Y, Kobatake T, Nagai Y, . Close correlation of intra-abdominal fat accumulation to hypertension in obese women. Hypertension. 1990;16:484–90.
   PubMed Web of Science ®Google Scholar
• Zamboni M, Armellini F, Sheiban I, De Marchi M, Todesco T, Bergamo-Andreis IA, . Relation of body fat distribution in men and degree of coronary narrowings in coronary artery disease. Am J Cardiol. 1992;70:1135–8.
   PubMedGoogle Scholar
• Nakamura T, Tokunaga K, Shimomura I, Nishida M, Yoshida S, Kotani K, . Contribution of visceral fat accumulation to the development of coronary artery disease in non-obese men. Atherosclerosis. 1994;107:239–46.
   PubMed Web of Science ®Google Scholar
• Matsuzawa Y, Shimomura I, Nakamura T, Keno Y, Kotani K, Tokunaga K. Pathophysiology and pathogenesis of visceral fat obesity. Obes Res. 1995;3:187S–94S.
   PubMedGoogle Scholar
• Matsuzawa Y. Pathophysiology and molecular mechanisms of visceral fat syndrome: the Japanese experience. Diabetes Metab Rev. 1997;13:3–13.
   PubMed Web of Science ®Google Scholar
• Fujioka S, Matsuzawa Y, Tokunaga K, Kawamoto T, Kobatake T, Keno Y, . Improvement of glucose and lipid metabolism associated with selective reduction of intra-abdominal visceral fat in premenopausal women with visceral fat obesity. Int J Obes. 1991;15:853–9.
   PubMed Web of Science ®Google Scholar
• Kanai H, Tokunaga K, Fujioka S, Yamashita S, Kameda-Takemura KK, Matsuzawa Y. Decrease in intra-abdominal visceral fat may reduce blood pressure in obese hypertensive women. Hypertension. 1996;27:125–9.
   PubMed Web of Science ®Google Scholar
• Alberti KG, Zimmet P, Shaw J. Metabolic syndrome—a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med. 2006;23: 469–80.
   PubMed Web of Science ®Google Scholar
• Isomaa B, Almgren P, Tuomi T, Forsén B, Lahti K, Nissén M, . Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care. 2001;24:683–9.
   PubMed Web of Science ®Google Scholar
• Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, . The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA. 2002;288:2709–16.
   PubMed Web of Science ®Google Scholar
• Takeuchi H, Saitoh S, Takagi S, Ohnishi H, Ohhata J, Isobe T, . Metabolic syndrome and cardiac disease in Japanese men: applicability of the concept of metabolic syndrome defined by the National Cholesterol Education Program-Adult Treatment Panel III to Japanese men—the Tanno and Sobetsu Study. Hypertens Res. 2005;28: 203–8.
   PubMed Web of Science ®Google Scholar
• Ninomiya T, Kubo M, Doi Y, Yonemoto K, Tanizaki Y, Rahman M, . Impact of metabolic syndrome on the development of cardiovascular disease in a general Japanese population: the Hisayama study. Stroke. 2007;38: 2063–9.
   PubMed Web of Science ®Google Scholar
• Kokubo Y, Okamura T, Yoshimasa Y, Miyamoto Y, Kawanishi K, Kotani Y, . Impact of metabolic syndrome components on the incidence of cardiovascular disease in a general urban Japanese population: the suita study. Hypertens Res. 2008;31:2027–35.
   PubMed Web of Science ®Google Scholar
• Gami AS, Witt BJ, Howard DE, Erwin PJ, Gami LA, Somers VK, . Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol. 2007;49:403–14.
   PubMed Web of Science ®Google Scholar
• Iso H, Sato S, Kitamura A, Imano H, Kiyama M, Yamagishi K, . Metabolic syndrome and the risk of ischemic heart disease and stroke among Japanese men and women. Stroke. 2007;38:1744–51.
   PubMed Web of Science ®Google Scholar
• Wu SH, Liu Z, Ho SC. Metabolic syndrome and all-cause mortality: a meta-analysis of prospective cohort studies. Eur J Epidemiol. 2010;25:375–84.
   PubMed Web of Science ®Google Scholar
• Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15:539–53.
   PubMed Web of Science ®Google Scholar
• Balkau B, Charles MA. Comment on the provisional report from the WHO consultation. European Group for the Study of Insulin Resistance (EGIR). Diabet Med. 1999;16: 442–3.
   PubMed Web of Science ®Google Scholar
• Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001;285:2486–97.
   PubMed Web of Science ®Google Scholar
• Einhorn D, Reaven GM, Cobin RH, Ford E, Ganda OP, Handelsman Y, . American College of Endocrinology position statement on the insulin resistance syndrome. Endocr Pract. 2003;9:237–52.
   PubMedGoogle Scholar
• Ford ES. Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S. Diabetes Care. 2005;28:2745–9.
   PubMed Web of Science ®Google Scholar
• The Examination Committee of the Criteria for Metabolic Syndrome in Japan. Definition and criteria of the metabolic syndrome in Japan. J Jpn Society Intern Med. 2005;94: 188–201 (in Japanese).
   Google Scholar
• Teramoto T, Sasaki J, Ueshima H, Egusa G, Kinoshita M, Shimamoto K, . Metabolic syndrome. J Atheroscler Thromb. 2008;15:1–5.
   PubMed Web of Science ®Google Scholar
• Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, .; International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; International Association for the Study of Obesity. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120:1640–5.
   PubMed Web of Science ®Google Scholar
• Ramsay TG. Fat cells. Endocrinol Metab Clin North Am. 1996;25:847–70.
   PubMed Web of Science ®Google Scholar
• Després JP. Abdominal obesity as important component of insulin-resistance syndrome. Nutrition. 1993;9:452–9.
   PubMed Web of Science ®Google Scholar
• Kelley DE, Thaete FL, Troost F, Huwe T, Goodpaster BH. Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance. Am J Physiol Endocrinol Metab. 2000; 278:E941–8.
   PubMed Web of Science ®Google Scholar
• Ross R, Aru J, Freeman J, Hudson R, Janssen I. Abdominal adiposity and insulin resistance in obese men. Am J Physiol Endocrinol Metab. 2002;282:E657–63.
   PubMed Web of Science ®Google Scholar
• Ross R, Freeman J, Hudson R, Janssen I. Abdominal obesity, muscle composition, and insulin resistance in premenopausal women. J Clin Endocrinol Metab. 2002;87:5044–51.
   PubMed Web of Science ®Google Scholar
• Smith U, Hammersten J, Björntorp P, Kral JG. Regional differences and effect of weight reduction on human fat cell metabolism. Eur J Clin Invest. 1979;9:327–32.
   PubMed Web of Science ®Google Scholar
• Mittelman SD, Van Citters GW, Kirkman EL, Bergman RN. Extreme insulin resistance of the central adipose depot in vivo. Diabetes. 2002;51:755–61.
   PubMed Web of Science ®Google Scholar
• Londos C, Brasaemle DL, Schultz CJ, Adler-Wailes DC, Levin DM, Kimmel AR, . On the control of lipolysis in adipocytes. Ann N Y Acad Sci. 1999;892:155–68.
   PubMed Web of Science ®Google Scholar
• Kuriyama H, Yamashita S, Shimomura I, Funahashi T, Ishigami M, Aragane K, . Enhanced expression of hepatic acyl-coenzyme A synthetase and microsomal triglyceride transfer protein messenger RNAs in the obese and hypertriglyceridemic rat with visceral fat accumulation. Hepatology. 1998;27:557–62.
   Google Scholar
• White DA, Bennett AJ, Billett MA, Salter AM. The assembly of triacylglycerol-rich lipoproteins: an essential role for the microsomal triacylglycerol transfer protein. Br J Nutr. 1998; 80:219–29.
   PubMedGoogle Scholar
• Adeli K, Taghibiglou C, Van Iderstine SC, Lewis GF. Mechanisms of hepatic very low-density lipoprotein overproduction in insulin resistance. Trends Cardiovasc Med. 2001;11:170–6.
   PubMed Web of Science ®Google Scholar
• Kuriyama H, Shimomura I, Kishida K, Kondo H, Furuyama N, Nishizawa H, . Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9. Diabetes. 2002;51:2915–21.
   PubMed Web of Science ®Google Scholar
• Maeda N, Funahashi T, Shimomura I. Metabolic impact of adipose and hepatic glycerol channels aquaporin 7 and aquaporin 9. Nat Clin Pract Endocrinol Metab. 2008;4:627–34.
   PubMedGoogle Scholar
• Unger RH. Lipid overload and overflow: metabolic trauma and the metabolic syndrome. Trends Endocrinol Metab. 2003;14:398–403.
   PubMed Web of Science ®Google Scholar
• Klein S. The case of visceral fat: argument for the defense. J Clin Invest. 2004;113:1530–2.
   PubMed Web of Science ®Google Scholar
• van Herpen NA, Schrauwen-Hinderling VB. Lipid accumulation in non-adipose tissue and lipotoxicity. Physiol Behav. 2008;94:231–41.
   PubMed Web of Science ®Google Scholar
• Lettner A, Roden M. Ectopic fat and insulin resistance. Curr Diab Rep. 2008;8:185–91.
   Google Scholar
• Szendroedi J, Roden M. Ectopic lipids and organ function. Curr Opin Lipidol. 2009;20:50–6.
   Google Scholar
• Samuel VT, Petersen KF, Shulman GI. Lipid-induced insulin resistance: unravelling the mechanism. Lancet. 2010;375: 2267–77.
   PubMed Web of Science ®Google Scholar
• Maeda K, Okubo K, Shimomura I, Mizuno K, Matsuzawa Y, Matsubara K. Analysis of an expression profile of genes in the human adipose tissue. Gene. 1997;190:227–35.
   PubMed Web of Science ®Google Scholar
• Funahashi T, Nakamura T, Shimomura I, Maeda K, Kuriyama H, Takahashi M, . Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity. Intern Med. 1999;38:202–6.
   PubMed Web of Science ®Google Scholar
• Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem Biophys Res Commun. 1996;22:286–9.
   Google Scholar
• Matsuzawa Y. Establishment of a concept of visceral fat syndrome and discovery of adiponectin. Proc Jpn Acad Ser B Phys Biol Sci. 2010;86:131–41.
   PubMed Web of Science ®Google Scholar
• Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem. 1995;270:26746–9.
   PubMed Web of Science ®Google Scholar
• Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem. 1996; 271:10697–703.
   PubMed Web of Science ®Google Scholar
• Nakano Y, Tobe T, Choi-Miura NH, Mazda T, Tomita M. Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. J Biochem. 1996;120:803–12.
   PubMed Web of Science ®Google Scholar
• Funahashi T, Matsuzawa Y. Metabolic syndrome: clinical concept and molecular basis. Ann Med. 2007;39:482–94.
   PubMed Web of Science ®Google Scholar
• Lukaski HC, Johnson PE, Bolonchuk WW, Lykken GI. Assessment of fat-free mass using bioeletrical impedance measurements of the human body. Am J Clin Nutr. 1985; 41:810–7.
   PubMed Web of Science ®Google Scholar
• Lukaski HC, Bolonchuk WW, Hall CB, Siders A. Validation of tetrapolar bioelectrical impedance method to assess human body composition. J Appl Physiol. 1986;60: 1327–32.
   PubMed Web of Science ®Google Scholar
• Scharfetter H, Schlager T, Stollberger R, Felsberger R, Hutten H, Hinghofer-Szalkay H. Assessing abdominal fatness with local bioimpedance analysis: basics and experimental findings. Int J Obes. 2001;25:502–11.
   Google Scholar
• Ryo M, Maeda K, Onda T, Katashima M, Okumiya A, Nishida M, . A new simple method for the measurement of visceral fat accumulation by bioelectrical impedance. Diabetes Care. 2005;28:451–3.
   PubMed Web of Science ®Google Scholar
• Okauchi Y, Nishizawa H, Funahashi T, Ogawa T, Noguchi M, Ryo M, . Reduction of visceral fat is associated with decrease in the number of metabolic risk factors in Japanese men. Diabetes Care. 2007;30:2392–4.
   PubMed Web of Science ®Google Scholar
• Tamba S, Nishizawa H, Funahashi T, Okauchi Y, Ogawa T, Noguchi M, . Relationship between the serum uric acid level, visceral fat accumulation and serum adiponectin concentration in Japanese men. Intern Med. 2008;47: 1175–80.
   PubMed Web of Science ®Google Scholar
• Okauchi Y, Kishida K, Funahashi T, Noguchi M, Ogawa T, Ryo M, . Changes in serum adiponectin concentrations correlate with changes in BMI, waist circumference, and estimated visceral fat area in middle-aged general population. Diabetes Care. 2009;32:e122.
   Google Scholar
• Tamba S, Nakatsuji H, Kishida K, Noguchi M, Ogawa T, Okauchi Y, . Relationship between visceral fat accumulation and urinary albumin-creatinine ratio in middle-aged Japanese men. Atherosclerosis. 2010;211:601–5.
   Google Scholar
• Nakatsuji H, Kishida K, Funahashi T, Noguchi M, Ogawa T, Okauchi Y, . One-year reductions in body weight and blood pressure, but not in visceral fat accumulation and adiponectin, improve urinary albumin-to-creatinine ratio in middle-aged Japanese men. Diabetes Care. 2010; 33:e110–1.
   Google Scholar
• Okauchi Y, Kishida K, Funahashi T, Noguchi M, Morita S, Ogawa T, . 4-year follow-up of cardiovascular events and changes in visceral fat accumulation after health promotion program in the Amagasaki Visceral Fat Study. Atherosclerosis. 2010;212:698–700.
   Google Scholar
• Okauchi Y, Kishida K, Funahashi T, Noguchi M, Ogawa T, Ryo M, . Absolute value of bioelectrical impedance analysis-measured visceral fat area with obesity-related cardiovascular risk factors in Japanese workers. J Atheroscler Thromb. 2010;17:1237–45.
   Google Scholar
• Katsuya T, Ishikawa K, Sugimoto K, Rakugi H, Ogihara T. Salt sensitivity of Japanese from the viewpoint of gene polymorphism. Hypertens Res. 2003;26:521–5.
   PubMed Web of Science ®Google Scholar
• Flack JM, Ensrud KE, Mascioli S, Launer CA, Svendsen K, Elmer PJ, . Racial and ethnic modifiers of the salt-blood pressure response. Hypertension. 1991;17:I115–21.
   PubMed Web of Science ®Google Scholar
• Douglas JG, Thibonnier M, Wright JT Jr. Essential hypertension: racial/ethnic differences in pathophysiology. J Assoc Acad Minor Phys. 1996;7:16–21.
   Google Scholar
• Brownley KA, Hurwitz BE, Schneiderman N. Ethnic variations in the pharmacological and nonpharmacological treatment of hypertension: biopsychosocial perspective. Hum Biol. 1999;71:607–39.
   PubMed Web of Science ®Google Scholar
• Fujimoto WY, Akanuma Y, Kanazawa Y, Mashiko S, Leonetti D, Wahl P. Plasma insulin levels in Japanese and Japanese-American men with type 2 diabetes may be related to the occurrence of cardiovascular disease. Diabetes Res Clin Pract. 1989;6:121–7.
   Google Scholar
• Ramachandran A. Genetic epidemiology of NIDDM among Asian Indians. Ann Med. 1992;24:499–503.
   PubMed Web of Science ®Google Scholar
• Chen KW, Boyko EJ, Bergstrom RW, Leonetti DL, Newell-Morris L, Wahl PW, . Earlier appearance of impaired insulin secretion than of visceral adiposity in the pathogenesis of NIDDM. 5-Year follow-up of initially nondiabetic Japanese-American men. Diabetes Care. 1995; 18:747–53.
   PubMed Web of Science ®Google Scholar
• Fujimoto WY. Overview of non-insulin-dependent diabetes mellitus (NIDDM) in different population groups. Diabet Med. 1996;13:S7–10.
   PubMed Web of Science ®Google Scholar
• Hoang KC, Le TV, Wong ND. The metabolic syndrome in East Asians. J Cardiometab Syndr. 2007;2:276–82.
   Google Scholar
• Singh V, Deedwania P. Dyslipidemia in special populations: Asian Indians, African Americans, and Hispanics. Curr Atheroscler Rep. 2006;8:32–40.
   Google Scholar
• Goff DC Jr, Bertoni AG, Kramer H, Bonds D, Blumenthal RS, Tsai MY, . Dyslipidemia prevalence, treatment, and control in the Multi-Ethnic Study of Atherosclerosis (MESA): gender, ethnicity, and coronary artery calcium. Circulation. 2006;113:647–56.
   PubMed Web of Science ®Google Scholar