Cross-talk between the circadian clock and the cell cycle in cancer

References

• Golombek DA, Rosenstein RE. Physiology of circadian entrainment. Physiol Rev. 2010;90:1063–102.
   PubMed Web of Science ®Google Scholar
• Scheer FA, Hilton MF, Mantzoros CS, Shea SA. Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci U S A. 2009;106:4453–8.
   PubMed Web of Science ®Google Scholar
• Schernhammer ES, Laden F, Speizer FE, Willett WC, Hunter DJ, Kawachi I, et al. Night-shift work and risk of colorectal cancer in the Nurses’ Health Study. J Natl Cancer Inst. 2003;95:825–8.
   PubMed Web of Science ®Google Scholar
• Viswanathan AN, Hankinson SE, Schernhammer ES. Night shift work and the risk of endometrial cancer. Cancer Res. 2007;67:10618–22.
   PubMed Web of Science ®Google Scholar
• Lahti TA, Partonen T, Kyyrönen P, Kauppinen T, Pukkala E. Night-time work predisposes to non-Hodgkin lymphoma. Int J Cancer. 2008; 123:2148–51.
   PubMed Web of Science ®Google Scholar
• Kloog I, Haim A, Stevens RG, Portnov BA. Global co-distribution of light at night (LAN) and cancers of prostate, colon, and lung in men. Chronobiol Int. 2009;26:108–25.
   PubMed Web of Science ®Google Scholar
• Knutsson A, Alfredsson L, Karlsson B, Akerstedt T, Fransson EI, Westerholm P, et al. Breast cancer among shift workers: results of the WOLF longitudinal cohort study. Scand J Work Environ Health. 2013;39:170–7.
   PubMed Web of Science ®Google Scholar
• Flynn-Evans EE, Mucci L, Stevens RG, Lockley SW. Shiftwork and prostate-specific antigen in the National Health and Nutrition Examination Survey. J Natl Cancer Inst. 2013;105:1292–7.
   PubMed Web of Science ®Google Scholar
• Anderson LE, Morris JE, Sasser LB, Stevens RG. Effect of constant light on DMBA mammary tumorigenesis in rats. Cancer Lett. 2000; 148:121–6.
   PubMed Web of Science ®Google Scholar
• Filipski E, King VM, Li X, Granda TG, Mormont MC, Liu X, et al. Host circadian clock as a control point in tumor progression. J Natl Cancer Inst. 2002;94:690–7.
   PubMed Web of Science ®Google Scholar
• Filipski E, Subramanian P, Carrière J, Guettier C, Barbason H, Lévi F. Circadian disruption accelerates liver carcinogenesis in mice. Mutat Res. 2009;680:95–105.
   PubMed Web of Science ®Google Scholar
• Logan RW, Zhang C, Murugan S, O’Connell S, Levitt D, Rosenwasser AM, et al. Chronic shift-lag alters the circadian clock of NK cells and promotes lung cancer growth in rats. J Immunol. 2012;188:2583–91.
   PubMed Web of Science ®Google Scholar
• Wu M, Zeng J, Chen Y, Zeng Z, Zhang J, Cai Y, et al. Experimental chronic jet lag promotes growth and lung metastasis of Lewis lung carcinoma in C57BL/6 mice. Oncol Rep. 2012;27:1417–28.
   PubMed Web of Science ®Google Scholar
• Straif K, Baan R, Grosse Y, Secretan B, El Ghissassi F, Bouvard V, et al. Carcinogenicity of shift-work, painting, and fire-fighting. Lancet Oncol. 2007;8:1065–6.
   PubMed Web of Science ®Google Scholar
• Massagué J. G1 cell-cycle control and cancer. Nature. 2004;432:298–306.
   PubMed Web of Science ®Google Scholar
• Henley SA, Dick FA. The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle. Cell Div. 2012;7:10.
   PubMed Web of Science ®Google Scholar
• Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer. 2009;9:153–66.
   PubMed Web of Science ®Google Scholar
• Bertoli C, Skotheim JM, de Bruin RA. Control of cell cycle transcription during G1 and S phases. Nat Rev Mol Cell Biol. 2013;14:518–28.
   PubMed Web of Science ®Google Scholar
• Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 1999;13:1501–12.
   PubMed Web of Science ®Google Scholar
• Perry JA, Kornbluth S. Cdc25 and Wee1: analogous opposites?. Cell Div. 2007;2:12.
   PubMedGoogle Scholar
• Sancar A, Lindsey-Boltz LA, Unsal-Kaçmaz K, Linn S. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem. 2004;73:39–85.
   PubMed Web of Science ®Google Scholar
• Schibler U, Ripperger J, Brown SA. Peripheral circadian oscillators in mammals: time and food. J Biol Rhythms. 2003;18:250–60.
   PubMed Web of Science ®Google Scholar
• Takahashi JS, Hong HK, Ko CH, McDearmon EL. The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet. 2008;9:764–75.
   PubMed Web of Science ®Google Scholar
• Bae K, Jin X, Maywood ES, Hastings MH, Reppert SM, Weaver DR. Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Neuron. 2001;30:525–36.
   PubMed Web of Science ®Google Scholar
• van der Horst GT, Muijtjens M, Kobayashi K, Takano R, Kanno S, Takao M, et al. Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms. Nature. 1999;398:627–30.
   PubMed Web of Science ®Google Scholar
• Fu L, Lee CC. The circadian clock: pacemaker and tumour suppressor. Nat Rev Cancer. 2003;3:350–61.
   PubMed Web of Science ®Google Scholar
• Reppert SM, Weaver DR. Molecular analysis of mammalian circadian rhythms. Annu Rev Physiol. 2001;63:647–76.
   PubMed Web of Science ®Google Scholar
• Siepka SM, Yoo SH, Park J, Song W, Kumar V, Hu Y, et al. Circadian mutant overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression. Cell. 2007;129:1011–23.
   PubMed Web of Science ®Google Scholar
• Godinho SI, Maywood ES, Shaw L, Tucci V, Barnard AR, Busino L, et al. The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period. Science. 2007;316:897–900.
   PubMed Web of Science ®Google Scholar
• Lee C, Etchegaray JP, Cagampang FR, Loudon AS, Reppert SM. Posttranslational mechanisms regulate the mammalian circadian clock. Cell. 2001;107:855–67.
   PubMed Web of Science ®Google Scholar
• Akashi M, Tsuchiya Y, Yoshino T, Nishida E. Control of intracellular dynamics of mammalian period proteins by casein kinase I ε (CKIε) and CKIδ in cultured cells. Mol Cell Biol. 2002;22:1693–703.
   PubMed Web of Science ®Google Scholar
• Etchegaray JP, Lee C, Wade PA, Reppert SM. Rhythmic histone acetylation underlies transcription in the mammalian circadian clock. Nature. 2003;421:177–82.
   PubMed Web of Science ®Google Scholar
• Preitner N, Damiola F, Lopez-Molina L, Zakany J, Duboule D, Albrecht U, et al. The orphan nuclear receptor REV-ERBα controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell. 2002;110:251–60.
   PubMed Web of Science ®Google Scholar
• Sato TK, Panda S, Miraglia LJ, Reyes TM, Rudic RD, McNamara P, et al. A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron. 2004;43:527–37.
   PubMed Web of Science ®Google Scholar
• Cheng HY, Papp JW, Varlamova O, Dziema H, Russell B, Curfman JP, et al. microRNA modulation of circadian-clock period and entrainment. Neuron. 2007;54:813–29.
   PubMed Web of Science ®Google Scholar
• Ohno T, Onishi Y, Ishida N. The negative transcription factor E4BP4 is associated with circadian clock protein PERIOD2. Biochem Biophys Res Commun. 2007;354:1010–15.
   PubMed Web of Science ®Google Scholar
• Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, et al. Gene ontology: tool for the unification of biology. The gene ontology consortium. Nat Genet. 2000;25:25–9.
   PubMed Web of Science ®Google Scholar
• Yan J, Wang H, Liu Y, Shao C. Analysis of gene regulatory networks in the mammalian circadian rhythm. PLoS Comput Biol. 2008; 4:e1000193.
   Web of Science ®Google Scholar
• Pizarro A, Hayer K, Lahens NF, Hogenesch JB. CircaDB: a database of mammalian circadian gene expression profiles. Nucleic Acids Res. 2013;41(Database issue):D1009–13.
   Google Scholar
• Bjarnason GA, Jordan RC, Sothern RB. Circadian variation in the expression of cell-cycle proteins in human oral epithelium. Am J Pathol. 1999;154:613–22.
   PubMed Web of Science ®Google Scholar
• Bjarnason GA, Jordan RC, Wood PA, Li Q, Lincoln DW, Sothern RB, et al. Circadian expression of clock genes in human oral mucosa and skin: association with specific cell-cycle phases. Am J Pathol. 2001;158:1793–801.
   PubMed Web of Science ®Google Scholar
• Muñoz E, Brewer M, Baler R. Circadian transcription. Thinking outside the E-box. J Biol Chem. 2002;277:36009–17.
   PubMed Web of Science ®Google Scholar
• Brown WR. A review and mathematical analysis of circadian rhythms in cell proliferation in mouse, rat, and human epidermis. J Invest Dermatol. 1991;97:273–80.
   PubMed Web of Science ®Google Scholar
• Scheving LA, Tsai TH, Scheving LE. Effect of thioacetamide on the incorporation of [3H]-thymidine into DNA of 13 tissues and on the mitotic index of the corneal epithelium of BD2F1 in male mice while taking into consideration circadian variation. Chronobiol Int. 1986;3:1–15.
   PubMedGoogle Scholar
• Buchi KN, Moore JG, Hrushesky WJ, Sothern RB, Rubin NH. Circadian rhythm of cellular proliferation in the human rectal mucosa. Gastroenterology. 1991;101:410–15.
   PubMed Web of Science ®Google Scholar
• Smaaland R, Laerum OD, Lote K, Sletvold O, Sothern RB, Bjerknes R. DNA synthesis in human bone marrow is circadian stage dependent. Blood. 1991;77:2603–11.
   PubMed Web of Science ®Google Scholar
• Warnakulasuriya KA, MacDonald DG. Diurnal variation in labelling index in human buccal epithelium. Arch Oral Biol. 1993;38:1107–11.
   PubMed Web of Science ®Google Scholar
• Yeh YC, Scheving LA, Tsai TH, Scheving LE. Circadian stage-dependent effects of epidermal growth factor on deoxyribonucleic acid synthesis in ten different organs of the adult male mouse. Endocrinology. 1981;109:644–51.
   PubMed Web of Science ®Google Scholar
• Brandi G, Calabrese C, Pantaleo MA, Morselli Labate A, Di Febo G, Hakim R, et al. Circadian variations of rectal cell proliferation in patients affected by advanced colorectal cancer. Cancer Lett. 2004;208:193–6.
   PubMed Web of Science ®Google Scholar
• Hrushesky WJ, Lannin D, Haus E. Evidence for an ontogenetic basis for circadian coordination of cancer cell proliferation. J Natl Cancer Inst. 1998;90:1480–4.
   PubMedGoogle Scholar
• Klevecz RR, Shymko RM, Blumenfeld D, Braly PS. Circadian gating of S phase in human ovarian cancer. Cancer Res. 1987;47:6267–71.
   PubMed Web of Science ®Google Scholar
• Tamai TK, Young LC, Cox CA, Whitmore D. Light acts on the zebrafish circadian clock to suppress rhythmic mitosis and cell proliferation. J Biol Rhythms. 2012;27:226–36.
   Web of Science ®Google Scholar
• Taniguchi H, Fernández AF, Setién F, Ropero S, Ballestar E, Villanueva A, et al. Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies. Cancer Res. 2009;69:8447–54.
   PubMed Web of Science ®Google Scholar
• Yang X, Wood PA, Oh EY, Du-Quiton J, Ansell CM, Hrushesky WJ. Down regulation of circadian clock gene Period 2 accelerates breast cancer growth by altering its daily growth rhythm. Breast Cancer Res Treat. 2009;117:423–31.
   PubMed Web of Science ®Google Scholar
• Wood PA, Yang X, Taber A, Oh EY, Ansell C, Ayers SE, et al. Period 2 mutation accelerates ApcMin/+ tumorigenesis. Mol Cancer Res. 2008;6:1786–93.
   PubMed Web of Science ®Google Scholar
• Zhao N, Yang K, Yang G, Chen D, Tang H, Zhao D, et al. Aberrant expression of clock gene period1 and its correlations with the growth, proliferation and metastasis of buccal squamous cell carcinoma. PLoS One. 2013;8:e55894.
   PubMed Web of Science ®Google Scholar
• Geyfman M, Kumar V, Liu Q, Ruiz R, Gordon W, Espitia F, et al. Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis. Proc Natl Acad Sci U S A. 2012;109:11758–63.
   PubMed Web of Science ®Google Scholar
• Miller BH, McDearmon EL, Panda S, Hayes KR, Zhang J, Andrews JL, et al. Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation. Proc Natl Acad Sci U S A. 2007;104:3342–7.
   PubMed Web of Science ®Google Scholar
• Janich P, Pascual G, Merlos-Suárez A, Batlle E, Ripperger J, Albrecht U, et al. The circadian molecular clock creates epidermal stem cell heterogeneity. Nature. 2011;480:209–14.
   PubMed Web of Science ®Google Scholar
• Matsuo T, Yamaguchi S, Mitsui S, Emi A, Shimoda F, Okamura H. Control mechanism of the circadian clock for timing of cell division in vivo. Science. 2003;302:255–9.
   PubMed Web of Science ®Google Scholar
• Fu L, Pelicano H, Liu J, Huang P, Lee C. The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell. 2002;111:41–50.
   PubMed Web of Science ®Google Scholar
• Gu X, Xing L, Shi G, Liu Z, Wang X, Qu Z, et al. The circadian mutation PER2(S662G) is linked to cell cycle progression and tumorigenesis. Cell Death Differ. 2012;19:397–405.
   PubMed Web of Science ®Google Scholar
• Roy PG, Thompson AM. Cyclin D1 and breast cancer. Breast. 2006;15:718–27.
   PubMed Web of Science ®Google Scholar
• Fu L, Patel MS, Bradley A, Wagner EF, Karsenty G. The molecular clock mediates leptin-regulated bone formation. Cell. 2005;122:803–15.
   PubMed Web of Science ®Google Scholar
• Dang CV. MYC on the path to cancer. Cell. 2012;149:22–35.
   PubMed Web of Science ®Google Scholar
• Gery S, Komatsu N, Baldjyan L, Yu A, Koo D, Koeffler HP. The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells. Mol Cell. 2006;22:375–82.
   PubMed Web of Science ®Google Scholar
• Yang X, Wood PA, Ansell CM, Quiton DF, Oh EY, Du-Quiton J, et al. The circadian clock gene Per1 suppresses cancer cell proliferation and tumor growth at specific times of day. Chronobiol Int. 2009; 26:1323–39.
   PubMed Web of Science ®Google Scholar
• Repouskou A, Sourlingas TG, Sekeri-Pataryas KE, Prombona A. The circadian expression of c-MYC is modulated by the histone deacetylase inhibitor trichostatin A in synchronized murine neuroblastoma cells. Chronobiol Int. 2010;27:722–41.
   PubMed Web of Science ®Google Scholar
• Dussault I, Giguère V. Differential regulation of the N-myc proto- oncogene by RORα and RVR, two orphan members of the superfamily of nuclear hormone receptors. Mol Cell Biol. 1997;17:1860–7.
   PubMed Web of Science ®Google Scholar
• Amundson SA, Zhan Q, Penn LZ, Fornace AJ Jr. Myc suppresses induction of the growth arrest genes gadd34, gadd45, and gadd153 by DNA-damaging agents. Oncogene. 1998;17:2149–54.
   PubMed Web of Science ®Google Scholar
• Zeller KI, Jegga AG, Aronow BJ, O’Donnell KA, Dang CV. An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets. Genome Biol. 2003;4:R69.
   PubMed Web of Science ®Google Scholar
• Herkert B, Eilers M. Transcriptional repression: the dark side of myc. Genes Cancer. 2010;1:580–6.
   PubMedGoogle Scholar
• Abbas T, Dutta A. p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer. 2009;9:400–14.
   PubMed Web of Science ®Google Scholar
• Gréchez-Cassiau A, Rayet B, Guillaumond F, Teboul M, Delaunay F. The circadian clock component BMAL1 is a critical regulator of p21WAF1/CIP1 expression and hepatocyte proliferation. J Biol Chem. 2008;283:4535–42.
   PubMed Web of Science ®Google Scholar
• Lin KK, Kumar V, Geyfman M, Chudova D, Ihler AT, Smyth P, et al. Circadian clock genes contribute to the regulation of hair follicle cycling. PLoS Genet. 2009;5:e1000573.
   PubMed Web of Science ®Google Scholar
• Elshazley M, Sato M, Hase T, Yamashita R, Yoshida K, Toyokuni S, et al. The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma. Int J Cancer. 2012; 131:2820–31.
   PubMed Web of Science ®Google Scholar
• Boutros R, Lobjois V, Ducommun B. CDC25 phosphatases in cancer cells: key players? Good targets?. Nat Rev Cancer. 2007;7:495–507.
   PubMed Web of Science ®Google Scholar
• Mullenders J, Fabius AW, Madiredjo M, Bernards R, Beijersbergen RL. A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway. PLoS One. 2009;4:e4798.
   PubMed Web of Science ®Google Scholar
• Tamura RE, de Vasconcellos JF, Sarkar D, Libermann TA, Fisher PB, Zerbini LF. GADD45 proteins: central players in tumorigenesis. Curr Mol Med. 2012;12:634–51.
   PubMed Web of Science ®Google Scholar
• Taneja P, Maglic D, Kai F, Sugiyama T, Kendig RD, Frazier DP, et al. Critical roles of DMP1 in human epidermal growth factor receptor2/neu-Arf-p53 signaling and breast cancer development. Cancer Res. 2010;70:9084–94.
   PubMed Web of Science ®Google Scholar
• Hua H, Wang Y, Wan C, Liu Y, Zhu B, Yang C, et al. Circadian gene mPer2 overexpression induces cancer cell apoptosis. Cancer Sci. 2006;97:589–96.
   PubMed Web of Science ®Google Scholar
• Yang X, He X, Yang Z, Jabbari E. Mammalian PER2 regulates AKT activation and DNA damage response. Biochem Cell Biol. 2012;90:675–82.
   PubMed Web of Science ®Google Scholar
• Unsal-Kaçmaz K, Mullen TE, Kaufmann WK, Sancar A. Coupling of human circadian and cell cycles by the timeless protein. Mol Cell Biol. 2005;25:3109–16.
   PubMed Web of Science ®Google Scholar
• Yang X, Wood PA, Hrushesky WJ. Mammalian TIMELESS is required for ATM-dependent CHK2 activation and G2/M checkpoint control. J Biol Chem. 2010;285:3030–4.
   PubMed Web of Science ®Google Scholar
• Engelen E, Janssens RC, Yagita K, Smits VA, van der Horst GT, Tamanini F. Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock. PLoS One. 2013;8:e56623.
   PubMed Web of Science ®Google Scholar
• Bhattacharya A, Schmitz U, Wolkenhauer O, Schönherr M, Raatz Y, Kunz M. Regulation of cell cycle checkpoint kinase WEE1 by miR-195 in malignant melanoma. Oncogene. 2013;32:3175–83.
   PubMed Web of Science ®Google Scholar
• Yang X, Wood PA, Ansell CM, Ohmori M, Oh EY, Xiong Y, et al. β-Catenin induces β-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice. J Biochem. 2009;145:289–97.
   PubMed Web of Science ®Google Scholar
• Soták M, Polidarová L, Ergang P, Sumová A, Pácha J. An association between clock genes and clock-controlled cell cycle genes in murine colorectal tumors. Int J Cancer. 2013;132:1032–41.
   PubMed Web of Science ®Google Scholar
• Polidarová L, Soták M, Sládek M, Pácha J, Sumová A. Temporal gradient in the clock gene and cell-cycle checkpoint kinase Wee1 expression along the gut. Chronobiol Int. 2009;26:607–20.
   PubMed Web of Science ®Google Scholar
• Polidarová L, Sládek M, Soták M, Pácha J, Sumová A. Hepatic, duodenal, and colonic circadian clocks differ in their persistence under conditions of constant light and in their entrainment by restricted feeding. Chronobiol Int. 2011;28:204–15.
   PubMed Web of Science ®Google Scholar
• Jin S, Antinore MJ, Lung FD, Dong X, Zhao H, Fan F, et al. The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression. J Biol Chem. 2000;275:16602–8.
   PubMed Web of Science ®Google Scholar
• Li HL, Huang DZ, Deng T, Zhou LK, Wang X, Bai M, et al. Overexpression of cyclin L2 inhibits growth and enhances chemosensitivity in human gastric cancer cells. Asian Pac J Cancer Prev. 2012;13:1425–30.
   PubMedGoogle Scholar
• Xu W, Ji JY. Dysregulation of CDK8 and Cyclin C in tumorigenesis. J Genet Genomics. 2011;38:439–52.
   PubMed Web of Science ®Google Scholar
• Redon R, Hussenet T, Bour G, Caulee K, Jost B, Muller D, et al. Amplicon mapping and transcriptional analysis pinpoint cyclin L as a candidate oncogene in head and neck cancer. Cancer Res. 2002; 62:6211–17.
   PubMed Web of Science ®Google Scholar
• Nagano T, Hashimoto T, Nakashima A, Hisanaga S, Kikkawa U, Kamada S. Cyclin I is involved in the regulation of cell cycle progression. Cell Cycle. 2013;12:2617–24.
   PubMed Web of Science ®Google Scholar
• Brinkkoetter PT, Pippin JW, Shankland SJ. Cyclin I-Cdk5 governs survival in post-mitotic cells. Cell Cycle. 2010;9:1729–31.
   PubMed Web of Science ®Google Scholar
• Kwon SH, Park JC, Ramachandran S, Cha SD, Kwon KY, Park JK, et al. Loss of cyclin G1 expression in human uterine leiomyoma cells induces apoptosis. Reprod Sci. 2008;15:400–10.
   PubMed Web of Science ®Google Scholar
• Choi MG, Noh JH, An JY, Hong SK, Park SB, Baik YH, et al. Expression levels of cyclin G2, but not cyclin E, correlate with gastric cancer progression. J Surg Res. 2009;157:168–74.
   PubMed Web of Science ®Google Scholar
• Fu J, Qiu H, Cai M, Pan Y, Cao Y, Liu L, et al. Low cyclin F expression in hepatocellular carcinoma associates with poor differentiation and unfavorable prognosis. Cancer Sci. 2013;104:508–15.
   PubMed Web of Science ®Google Scholar
• Davidson G, Niehrs C. Emerging links between CDK cell cycle regulators and Wnt signaling. Trends Cell Biol. 2010;20:453–60.
   PubMed Web of Science ®Google Scholar
• Guo B, Chatterjee S, Li L, Kim JM, Lee J, Yechoor VK, et al. The clock gene, brain and muscle Arnt-like 1, regulates adipogenesis via Wnt signaling pathway. FASEB J. 2012;26:3453–63.
   PubMed Web of Science ®Google Scholar
• Katoh M. WNT/PCP signaling pathway and human cancer. Oncol Rep. 2005;14:1583–8.
   PubMed Web of Science ®Google Scholar
• Anastas JN, Moon RT. WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer. 2013;13:11–26.
   PubMed Web of Science ®Google Scholar
• Yasuniwa Y, Izumi H, Wang KY, Shimajiri S, Sasaguri Y, Kawai K, et al. Circadian disruption accelerates tumor growth and angio/stromagenesis through a Wnt signaling pathway. PLoS One. 2010;5:e15330.
   Web of Science ®Google Scholar
• Olmeda D, Castel S, Vilaró S, Cano A. β-Catenin regulation during the cell cycle: implications in G2/M and apoptosis. Mol Biol Cell. 2003;14:2844–60.
   PubMed Web of Science ®Google Scholar
• He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, et al. Identification of c-MYC as a target of the APC pathway. Science. 1998;281:1509–12.
   PubMed Web of Science ®Google Scholar
• Tetsu O, McCormick F.. β-Catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature. 1999;398:422–6.
   PubMed Web of Science ®Google Scholar
• Brockschmidt C, Hirner H, Huber N, Eismann T, Hillenbrand A, Giamas G, et al. Anti-apoptotic and growth-stimulatory functions of CK1δ and ε in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo. Gut. 2008;57:799–806.
   PubMed Web of Science ®Google Scholar
• Kim SY, Dunn IF, Firestein R, Gupta P, Wardwell L, Repich K, et al. CK1ε is required for breast cancers dependent on β-catenin activity. PLoS One. 2010;5:e8979.
   Web of Science ®Google Scholar
• Casagolda D, Del Valle-Pérez B, Valls G, Lugilde E, Vinyoles M, Casado-Vela J, et al. A p120-catenin-CK1ε complex regulates Wnt signaling. J Cell Sci. 2010;123:2621–31.
   PubMed Web of Science ®Google Scholar
• Honaker Y, Piwnica-Worms H. Casein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction. Oncogene. 2010;29:3324–34.
   PubMed Web of Science ®Google Scholar
• Tarasewicz E, Jeruss JS. Phospho-specific Smad3 signaling: impact on breast oncogenesis. Cell Cycle. 2012;11:2443–51.
   PubMed Web of Science ®Google Scholar
• Kon N, Hirota T, Kawamoto T, Kato Y, Tsubota T, Fukada Y. Activation of TGFβ/activin signalling resets the circadian clock through rapid induction of Dec1 transcripts. Nat Cell Biol. 2008, 10:1463–9.
   PubMed Web of Science ®Google Scholar
• Sato F, Sato H, Jin D, Bhawal UK, Wu Y, Noshiro M, et al. Smad3 and Snail show circadian expression in human gingival fibroblasts, human mesenchymal stem cell, and in mouse liver. Biochem Biophys Res Commun. 2012;419:441–6.
   PubMed Web of Science ®Google Scholar
• Munshi A, Ramesh R. Mitogen-activated protein kinases and their role in radiation response. Genes Cancer. 2013;4:401–8.
   PubMedGoogle Scholar
• Wada T, Joza N, Cheng HY, Sasaki T, Kozieradzki I, Bachmaier K, et al. MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence. Nat Cell Biol. 2004;6:215–26.
   PubMedGoogle Scholar
• Uchida Y, Osaki T, Yamasaki T, Shimomura T, Hata S, Horikawa K, et al. Involvement of stress kinase mitogen-activated protein kinase kinase 7 in regulation of mammalian circadian clock. J Biol Chem. 2012;287:8318–26.
   PubMed Web of Science ®Google Scholar
• Eto N, Miyagishi M, Inagi R, Fujita T, Nangaku M. Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression. Am J Pathol. 2009; 174:1553–63.
   PubMed Web of Science ®Google Scholar
• Wu CC, Wu X, Han J, Sun P. p38γ regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage. Protein Cell. 2010;1:573–83.
   PubMed Web of Science ®Google Scholar
• Kukkonen-Macchi A, Sicora O, Kaczynska K, Oetken-Lindholm C, Pouwels J, Laine L, et al. Loss of p38γ MAPK induces pleiotropic mitotic defects and massive cell death. J Cell Sci. 2011;124:216–27.
   PubMed Web of Science ®Google Scholar
• Petrzilka S, Taraborrelli C, Cavadini G, Fontana A, Birchler T. Clock gene modulation by TNF-α depends on calcium and p38 MAP kinase signaling. J Biol Rhythms. 2009;24:283–94.
   PubMed Web of Science ®Google Scholar
• Kostenko S, Dumitriu G, Moens U. Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5. J Mol Signal. 2012;7:9.
   PubMedGoogle Scholar
• Hoffman AE, Zheng T, Ba Y, Stevens RG, Yi CH, Leaderer D, et al. Phenotypic effects of the circadian gene Cryptochrome 2 on cancer-related pathways. BMC Cancer. 2010;10:110.
   PubMed Web of Science ®Google Scholar
• Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol. 2007;35:495–516.
   PubMed Web of Science ®Google Scholar
• Cotter TG. Apoptosis and cancer: the genesis of a research field. Nat Rev Cancer. 2009;9:501–7.
   PubMed Web of Science ®Google Scholar
• Granda TG, Liu XH, Smaaland R, Cermakian N, Filipski E, Sassone-Corsi P, et al. Circadian regulation of cell cycle and apoptosis proteins in mouse bone marrow and tumor. FASEB J. 2005;19:304–6.
   PubMed Web of Science ®Google Scholar
• Ozturk N, Lee JH, Gaddameedhi S, Sancar A. Loss of cryptochrome reduces cancer risk in p53 mutant mice. Proc Natl Acad Sci U S A. 2009;106:2841–6.
   PubMed Web of Science ®Google Scholar
• Sato F, Nagata C, Liu Y, Suzuki T, Kondo J, Morohashi S, et al. PERIOD1 is an anti-apoptotic factor in human pancreatic and hepatic cancer cells. J Biochem. 2009;146:833–8.
   PubMed Web of Science ®Google Scholar
• Oda A, Katayose Y, Yabuuchi S, Yamamoto K, Mizuma M, Shirasou S, et al. Clock gene mouse period2 overexpression inhibits growth of human pancreatic cancer cells and has synergistic effect with cisplatin. Anticancer Res. 2009;29:1201–9.
   PubMed Web of Science ®Google Scholar
• Wu Y, Sato F, Bhawal UK, Kawamoto T, Fujimoto K, Noshiro M, et al. Basic helix-loop-helix transcription factors DEC1 and DEC2 regulate the paclitaxel-induced apoptotic pathway of MCF-7 human breast cancer cells. Int J Mol Med. 2011;27:491–5.
   PubMed Web of Science ®Google Scholar
• Liu Y, Sato F, Kawamoto T, Fujimoto K, Morohashi S, Akasaka H, et al. Anti-apoptotic effect of the basic helix-loop-helix (bHLH) transcription factor DEC2 in human breast cancer cells. Genes Cells. 2010;15:315–25.
   PubMed Web of Science ®Google Scholar
• Matsunaga N, Kohno Y, Kakimoto K, Hayashi A, Koyanagi S, Ohdo S. Influence of CLOCK on cytotoxicity induced by diethylnitrosamine in mouse primary hepatocytes. Toxicology. 2011;280:144–51.
   Google Scholar
• Harkin DP, Bean JM, Miklos D, Song YH, Truong VB, Englert C, et al. Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1. Cell. 1999;97:575–86.
   PubMed Web of Science ®Google Scholar