Rodent models in depression research: Classical strategies and new directions

References

• Murray CJL, Lopez AD. The global burden of disease: a comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020. Cambridge: Harvard University Press; 1996.
   Google Scholar
• Blazer DG, Kessler RC, McGonagle KA, Swartz MS. The prevalence and distribution of major depression in a national community sample: the National Comorbidity Survey. Am J Psychiatry. 1994;151:979–86.
   PubMed Web of Science ®Google Scholar
• Wong ML, Licinio J. Research and treatment approaches to depression. Nat Rev Neurosci. 2001;2:343–51.
   PubMed Web of Science ®Google Scholar
• Sheps DS, Sheffield D. Depression, anxiety, and the cardiovascular system: the cardiologist's perspective. J Clin Psychiatry. 2001;62 Suppl 8:12–6; discussion 17–8.
   PubMed Web of Science ®Google Scholar
• Rumsfeld JS, Ho PM. Depression and cardiovascular disease: a call for recognition. Circulation. 2005;111:250–3.
   PubMed Web of Science ®Google Scholar
• Baker CB, Johnsrud MT, Crismon ML, Rosenheck RA, Woods SW. Quantitative analysis of sponsorship bias in economic studies of antidepressants. Br J Psychiatry. 2003;183: 498–506.
   PubMed Web of Science ®Google Scholar
• Meijer WE, Heerdink ER, Nolen WA, Herings RM, Leufkens HG, Egberts AC. Association of risk of abnormal bleeding with degree of serotonin reuptake inhibition by antidepressants. Arch Intern Med. 2004;164:2367–70.
   PubMedGoogle Scholar
• Porsolt RD, Bertin A, Jalfre M. Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther. 1977;229:327–36.
   PubMedGoogle Scholar
• Cryan JF, Mombereau C, Vassout A. The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neurosci Biobehav Rev. 2005;29:571–625.
   PubMed Web of Science ®Google Scholar
• Dulawa SC, Hen R. Recent advances in animal models of chronic antidepressant effects: the novelty-induced hypophagia test. Neurosci Biobehav Rev. 2005;29:771–83.
   PubMed Web of Science ®Google Scholar
• Dunn AJ, Swiergiel AH, de Beaurepaire R. Cytokines as mediators of depression: what can we learn from animal studies? Neurosci Biobehav Rev. 2005;29:891–909.
   PubMed Web of Science ®Google Scholar
• Feder A, Nestler EJ, Charney DS. Psychobiology and molecular genetics of resilience. Nat Rev Neurosci. 2009;10: 446–57.
   PubMed Web of Science ®Google Scholar
• Forbes NF, Stewart CA, Matthews K, Reid IC. Chronic mild stress and sucrose consumption: validity as a model of depression. Physiol Behav. 1996;60:1481–4.
   PubMed Web of Science ®Google Scholar
• Francis DD, Szegda K, Campbell G, Martin WD, Insel TR. Epigenetic sources of behavioral differences in mice. Nat Neurosci. 2003;6:445–6.
   PubMed Web of Science ®Google Scholar
• Millstein RA, Holmes A. Effects of repeated maternal separation on anxiety- and depression-related phenotypes in different mouse strains. Neurosci Biobehav Rev. 2007;31:3–17.
   PubMed Web of Science ®Google Scholar
• Newport DJ, Stowe ZN, Nemeroff CB. Parental depression: animal models of an adverse life event. Am J Psychiatry. 2002;159:1265–83.
   PubMed Web of Science ®Google Scholar
• Song C, Leonard BE. The olfactory bulbectomised rat as a model of depression. Neurosci Biobehav Rev. 2005;29: 627–47.
   PubMed Web of Science ®Google Scholar
• Vollmayr B, Henn FA. Learned helplessness in the rat: improvements in validity and reliability. Brain Res Brain Res Protoc. 2001;8:1–7.
   PubMedGoogle Scholar
• Willner P, Muscat R, Papp M. Chronic mild stress-induced anhedonia: a realistic animal model of depression. Neurosci Biobehav Rev. 1992;16:525–34.
   PubMed Web of Science ®Google Scholar
• Yadid G, Nakash R, Deri I, Tamar G, Kinor N, Gispan I, . Elucidation of the neurobiology of depression: insights from a novel genetic animal model. Prog Neurobiol. 2000;62:353–78.
   PubMed Web of Science ®Google Scholar
• Cryan JF, Slattery DA. Animal models of mood disorders: Recent developments. Curr Opin Psychiatry. 2007;20:1–7.
   PubMed Web of Science ®Google Scholar
• Willner P. Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. Psychopharmacology (Berl). 1997;134:319–29.
   PubMed Web of Science ®Google Scholar
• van der Staay FJ, Arndt SS, Nordquist RE. Evaluation of animal models of neurobehavioral disorders. Behav Brain Funct. 2009;5:11.
   PubMed Web of Science ®Google Scholar
• Crabbe JC, Wahlsten D, Dudek BC. Genetics of mouse behavior: interactions with laboratory environment. Science. 1999;284:1670–2.
   PubMed Web of Science ®Google Scholar
• Wahlsten D, Metten P, Phillips TJ, Boehm SL 2nd, Burkhart-Kasch S, Dorow J, . Different data from different labs: lessons from studies of gene-environment interaction. J Neurobiol. 2003;54:283–311.
   PubMedGoogle Scholar
• Cryan JF, Markou A, Lucki I. Assessing antidepressant activity in rodents: recent developments and future needs. Trends in pharmacological sciences. 2002;23:238–45.
   PubMed Web of Science ®Google Scholar
• Cryan JF, Mombereau C. In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice. Mol Psychiatry. 2004;9:326–57.
   PubMed Web of Science ®Google Scholar
• Pollak DD, Monje FJ, Zuckerman L, Denny CA, Drew MR, Kandel ER. An animal model of a behavioral intervention for depression. Neuron. 2008;60:149–61.
   PubMedGoogle Scholar
• Castagne V, Porsolt RD, Moser P. Use of latency to immobility improves detection of antidepressant-like activity in the behavioral despair test in the mouse. Eur J Pharmacol. 2009; 616:128–33.
   PubMed Web of Science ®Google Scholar
• Popoli M. Agomelatine: innovative pharmacological approach in depression. CNS Drugs. 2009;23 Suppl 2:27–34.
   PubMedGoogle Scholar
• Rupniak NM. Animal models of depression: challenges from a drug development perspective. Behav Pharmacol. 2003;14: 385–90.
   PubMed Web of Science ®Google Scholar
• Steru L, Chermat R, Thierry B, Mico JA, Lenegre A, Steru M, . The automated Tail Suspension Test: a computerized device which differentiates psychotropic drugs. Prog Neuropsychopharmacol Biol Psychiatry. 1987;11:659–71.
   PubMedGoogle Scholar
• Steru L, Chermat R, Thierry B, Simon P. The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology (Berl). 1985;85:367–70.
   PubMed Web of Science ®Google Scholar
• Perrault G, Morel E, Zivkovic B, Sanger DJ. Activity of litoxetine and other serotonin uptake inhibitors in the tail suspension test in mice. Pharmacol Biochem Behav. 1992;42:45–7.
   PubMed Web of Science ®Google Scholar
• Dulawa SC, Holick KA, Gundersen B, Hen R. Effects of chronic fluoxetine in animal models of anxiety and depression. Neuropsychopharmacology. 2004;29:1321–30.
   PubMed Web of Science ®Google Scholar
• Kalueff AV, Wheaton M, Murphy DL. What's wrong with my mouse model? Advances and strategies in animal modeling of anxiety and depression. Behav Brain Res. 2007;179:1–18.
   PubMed Web of Science ®Google Scholar
• Reus V. Mental disorders. Fauci A. Harrison's Principles of Internal Medicine. Columbus: McGraw-Hill Medical; 2006.
   Google Scholar
• Argyropoulos SV, Nutt DJ. Anhedonia and chronic mild stress model in depression. Psychopharmacology (Berl). 1997;134:333–6; discussion 371–7.
   PubMed Web of Science ®Google Scholar
• Markou A, Kosten TR, Koob GF. Neurobiological similarities in depression and drug dependence: a self-medication hypothesis. Neuropsychopharmacology. 1998;18:135–74.
   PubMed Web of Science ®Google Scholar
• Jayatissa MN, Bisgaard C, Tingstrom A, Papp M, Wiborg O. Hippocampal cytogenesis correlates to escitalopram-mediated recovery in a chronic mild stress rat model of depression. Neuropsychopharmacology. 2006;31:2395–404.
   PubMedGoogle Scholar
• Strekalova T, Gorenkova N, Schunk E, Dolgov O, Bartsch D. Selective effects of citalopram in a mouse model of stress-induced anhedonia with a control for chronic stress. Behav Pharmacol. 2006;17:271–87.
   PubMedGoogle Scholar
• Casarotto PC, Andreatini R. Repeated paroxetine treatment reverses anhedonia induced in rats by chronic mild stress or dexamethasone. Eur Neuropsychopharmacol. 2007;17: 735–42.
   PubMed Web of Science ®Google Scholar
• Wise RA. Addictive drugs and brain stimulation reward. Annu Rev Neurosci. 1996;19:319–40.
   PubMed Web of Science ®Google Scholar
• Slattery DA, Markou A, Cryan JF. Evaluation of reward processes in an animal model of depression. Psychopharmacology (Berl). 2007;190:555–68.
   PubMed Web of Science ®Google Scholar
• Cryan JF, Hoyer D, Markou A. Withdrawal from chronic amphetamine induces depressive-like behavioral effects in rodents. Biol Psychiatry. 2003;54:49–58.
   PubMed Web of Science ®Google Scholar
• Romeas T, Morissette MC, Mnie-Filali O, Pineyro G, Boye SM. Simultaneous anhedonia and exaggerated locomotor activation in an animal model of depression. Psychopharmacology (Berl). 2009;205:293–303.
   PubMed Web of Science ®Google Scholar
• Moreau JL, Jenck F, Martin JR, Mortas P, Haefely WE. Antidepressant treatment prevents chronic unpredictable mild stress-induced anhedonia as assessed by ventral tegmentum self-stimulation behavior in rats. Eur Neuropsychopharmacol. 1992;2:43–9.
   PubMedGoogle Scholar
• Tsankova NM, Berton O, Renthal W, Kumar A, Neve RL, Nestler EJ. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci. 2006;9:519–25.
   PubMed Web of Science ®Google Scholar
• Anderson IM, Nutt DJ, Deakin JF. Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 1993 British Association for Psychopharmacology guidelines. British Association for Psychopharmacology. J Psychopharmacol. 2000;14:3–20.
   PubMed Web of Science ®Google Scholar
• Berton O, McClung CA, Dileone RJ, Krishnan V, Renthal W, Russo SJ, . Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science. 2006; 311:864–8.
   PubMed Web of Science ®Google Scholar
• Kuipers SD, Trentani A, Westenbroek C, Bramham CR, Korf J, Kema IP, . Unique patterns of FOS, phospho-CREB and BrdU immunoreactivity in the female rat brain following chronic stress and citalopram treatment. Neuropharmacology. 2006;50:428–40.
   PubMedGoogle Scholar
• Swiergiel AH, Leskov IL, Dunn AJ. Effects of chronic and acute stressors and CRF on depression-like behavior in mice. Behav Brain Res. 2008;186:32–40.
   PubMedGoogle Scholar
• Haenisch B, Bilkei-Gorzo A, Caron MG, Bonisch H. Knockout of the norepinephrine transporter and pharmacologically diverse antidepressants prevent behavioral and brain neurotrophin alterations in two chronic stress models of depression. J Neurochem. 2009;111:403–16.
   PubMed Web of Science ®Google Scholar
• Bravo JA, Diaz-Veliz G, Mora S, Ulloa JL, Berthoud VM, Morales P, . Desipramine prevents stress-induced changes in depressive-like behavior and hippocampal markers of neuroprotection. Behav Pharmacol. 2009;20:273–85.
   PubMedGoogle Scholar
• Veena J, Srikumar BN, Raju TR, Shankaranarayana Rao BS. Exposure to enriched environment restores the survival and differentiation of new born cells in the hippocampus and ameliorates depressive symptoms in chronically stressed rats. Neurosci Lett. 2009;455:178–82.
   PubMed Web of Science ®Google Scholar
• Parihar VK, Hattiangady B, Kuruba R, Shuai B, Shetty AK. Predictable chronic mild stress improves mood, hippocampal neurogenesis and memory. Mol Psychiatry. 2009 Dec 15 (Epub ahead of print).
   PubMedGoogle Scholar
• Ito H, Nagano M, Suzuki H, Murakoshi T. Chronic stress enhances synaptic plasticity due to disinhibition in the anterior cingulate cortex and induces hyper-locomotion in mice. Neuropharmacology. 2010;58:746–57.
   PubMedGoogle Scholar
• Finamore TL, Port RL. Developmental stress disrupts habituation but spares prepulse inhibition in young rats. Physiol Behav. 2000;69:527–30.
   PubMedGoogle Scholar
• Eklund MB, Johansson LM, Uvnas-Moberg K, Arborelius L. Differential effects of repeated long and brief maternal separation on behaviour and neuroendocrine parameters in Wistar dams. Behav Brain Res. 2009;203:69–75.
   PubMed Web of Science ®Google Scholar
• Pihoker C, Owens MJ, Kuhn CM, Schanberg SM, Nemeroff CB. Maternal separation in neonatal rats elicits activation of the hypothalamic-pituitary-adrenocortical axis: a putative role for corticotropin-releasing factor. Psychoneuroendocrinology. 1993;18:485–93.
   PubMedGoogle Scholar
• Dent GW, Smith MA, Levine S. Stress-induced alterations in locus coeruleus gene expression during ontogeny. Brain Res Dev Brain Res. 2001;127:23–30.
   PubMedGoogle Scholar
• Kehoe P, Blass EM. Behaviorally functional opioid systems in infant rats: II. Evidence for pharmacological, physiological, and psychological mediation of pain and stress. Behav Neurosci. 1986;100:624–30.
   PubMed Web of Science ®Google Scholar
• Fabricius K, Wortwein G, Pakkenberg B. The impact of maternal separation on adult mouse behaviour and on the total neuron number in the mouse hippocampus. Brain Struct Funct. 2008;212:403–16.
   PubMedGoogle Scholar
• Mirescu C, Peters JD, Gould E. Early life experience alters response of adult neurogenesis to stress. Nat Neurosci. 2004;7:841–6.
   PubMed Web of Science ®Google Scholar
• Weinberg J, Krahn EA, Levine S. Differential effects of handling on exploration in male and female rats. Dev Psychobiol. 1978;11:251–9.
   PubMed Web of Science ®Google Scholar
• Abraham IM, Kovacs KJ. Postnatal handling alters the activation of stress-related neuronal circuitries. Eur J Neurosci. 2000;12:3003–14.
   PubMed Web of Science ®Google Scholar
• Lovic V, Gonzalez A, Fleming AS. Maternally separated rats show deficits in maternal care in adulthood. Dev Psychobiol. 2001;39:19–33.
   PubMed Web of Science ®Google Scholar
• Fride E, Weinstock M. The effects of prenatal exposure to predictable or unpredictable stress on early development in the rat. Dev Psychobiol. 1984;17:651–60.
   PubMed Web of Science ®Google Scholar
• Drago F, Di Leo F, Giardina L. Prenatal stress induces body weight deficit and behavioural alterations in rats: the effect of diazepam. Eur Neuropsychopharmacol. 1999;9:239–45.
   PubMed Web of Science ®Google Scholar
• Vallee M, Mayo W, Dellu F, Le Moal M, Simon H, Maccari S. Prenatal stress induces high anxiety and postnatal handling induces low anxiety in adult offspring: correlation with stress-induced corticosterone secretion. J Neurosci. 1997;17: 2626–36.
   PubMed Web of Science ®Google Scholar
• Henry C, Kabbaj M, Simon H, Le Moal M, Maccari S. Prenatal stress increases the hypothalamo-pituitary-adrenal axis response in young and adult rats. J Neuroendocrinol. 1994;6:341–5.
   PubMed Web of Science ®Google Scholar
• Peters DA. Prenatal stress: effect on development of rat brain adrenergic receptors. Pharmacol Biochem Behav. 1984;21: 417–22.
   PubMed Web of Science ®Google Scholar
• Maccari S, Morley-Fletcher S. Effects of prenatal restraint stress on the hypothalamus-pituitary-adrenal axis and related behavioural and neurobiological alterations. Psychoneuroendocrinology. 2007;32 Suppl 1:S10–5.
   PubMed Web of Science ®Google Scholar
• Abe H, Hidaka N, Kawagoe C, Odagiri K, Watanabe Y, Ikeda T, . Prenatal psychological stress causes higher emotionality, depression-like behavior, and elevated activity in the hypothalamo-pituitary-adrenal axis. Neurosci Res. 2007;59: 145–51.
   PubMed Web of Science ®Google Scholar
• Maccari S, Darnaudery M, Morley-Fletcher S, Zuena AR, Cinque C, Van Reeth O. Prenatal stress and long-term consequences: implications of glucocorticoid hormones. Neurosci Biobehav Rev. 2003;27:119–27.
   PubMed Web of Science ®Google Scholar
• Roche M, Shanahan E, Harkin A, Kelly JP. Trans-species assessment of antidepressant activity in a rodent model of depression. Pharmacol Rep. 2008;60:404–8.
   PubMedGoogle Scholar
• Roche M, Harkin A, Kelly JP. Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomized rat. Neuropsychopharmacology. 2007;32:1312–20.
   PubMed Web of Science ®Google Scholar
• Bauer M, Whybrow PC, Angst J, Versiani M, Moller HJ. World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Unipolar Depressive Disorders, Part 2: Maintenance treatment of major depressive disorder and treatment of chronic depressive disorders and subthreshold depressions. World J Biol Psychiatry. 2002;3:69–86.
   PubMedGoogle Scholar
• Sherman AD, Sacquitne JL, Petty F. Specificity of the learned helplessness model of depression. Pharmacol Biochem Behav. 1982;16:449–54.
   PubMed Web of Science ®Google Scholar
• Hitzemann R. Animal models of psychiatric disorders and their relevance to alcoholism. Alcohol Res Health. 2000;24: 149–58.
   PubMedGoogle Scholar
• Gardier AM, Guiard BP, Guilloux JP, Reperant C, Coudore F, David DJ. Interest of using genetically manipulated mice as models of depression to evaluate antidepressant drugs activity: a review. Fundam Clin Pharmacol. 2009;23:23–42.
   PubMedGoogle Scholar
• Cryan JF, Holmes A. The ascent of mouse: advances in modelling human depression and anxiety. Nat Rev Drug Discov. 2005;4:775–90.
   PubMed Web of Science ®Google Scholar
• Alexandre C, Popa D, Fabre V, Bouali S, Venault P, Lesch KP, . Early life blockade of 5-hydroxytryptamine 1A receptors normalizes sleep and depression-like behavior in adult knock-out mice lacking the serotonin transporter. J Neurosci. 2006;26:5554–64.
   PubMedGoogle Scholar
• Fox MA, Andrews AM, Wendland JR, Lesch KP, Holmes A, Murphy DL. A pharmacological analysis of mice with a targeted disruption of the serotonin transporter. Psychopharmacology (Berl). 2007;195:147–66.
   PubMedGoogle Scholar
• Groenink L, van Bogaert MJ, van der Gugten J, Oosting RS, Olivier B. 5-HT1A receptor and 5-HT1B receptor knockout mice in stress and anxiety paradigms. Behav Pharmacol. 2003;14:369–83.
   PubMed Web of Science ®Google Scholar
• Guilloux JP, David DJ, Guiard BP, Chenu F, Reperant C, Toth M, . Blockade of 5-HT1A receptors by (+/-)-pindolol potentiates cortical 5-HT outflow, but not antidepressant-like activity of paroxetine: microdialysis and behavioral approaches in 5-HT1A receptor knockout mice. Neuropsychopharmacology. 2006;31:2162–72.
   PubMed Web of Science ®Google Scholar
• Canli T, Lesch KP. Long story short: the serotonin transporter in emotion regulation and social cognition. Nat Neurosci. 2007;10:1103–9.
   PubMed Web of Science ®Google Scholar
• Murphy DL, Lesch KP. Targeting the murine serotonin transporter: insights into human neurobiology. Nat Rev Neurosci. 2008;9:85–96.
   PubMed Web of Science ®Google Scholar
• Muigg P, Hoelzl U, Palfrader K, Neumann I, Wigger A, Landgraf R, . Altered brain activation pattern associated with drug-induced attenuation of enhanced depression-like behavior in rats bred for high anxiety. Biol Psychiatry. 2007;61:782–96.
   PubMedGoogle Scholar
• Kohen R, Neumaier JF, Hamblin MW, Edwards E. Congenitally learned helpless rats show abnormalities in intracellular signaling. Biol Psychiatry. 2003;53:520–9.
   PubMedGoogle Scholar
• Touma C, Bunck M, Glasl L, Nussbaumer M, Palme R, Stein H, . Mice selected for high versus low stress reactivity: a new animal model for affective disorders. Psychoneuroendocrinology. 2008;33:839–62.
   PubMed Web of Science ®Google Scholar
• Overstreet DH, Russell RW, Helps SC, Messenger M. Selective breeding for sensitivity to the anticholinesterase DFP. Psychopharmacology (Berl). 1979;65:15–20.
   PubMedGoogle Scholar
• Janowsky DS, Overstreet DH, Nurnberger JI Jr. Is cholinergic sensitivity a genetic marker for the affective disorders? Am J Med Genet. 1994;54:335–44.
   PubMed Web of Science ®Google Scholar
• Overstreet DH, Griebel G. Antidepressant-like effects of the vasopressin V1b receptor antagonist SSR149415 in the Flinders Sensitive Line rat. Pharmacol Biochem Behav. 2005; 82:223–7.
   PubMed Web of Science ®Google Scholar
• Landgraf R, Wigger A. Born to be anxious: neuroendocrine and genetic correlates of trait anxiety in HAB rats. Stress. 2003;6:111–9.
   PubMed Web of Science ®Google Scholar
• Keck ME, Sartori SB, Welt T, Muller MB, Ohl F, Holsboer F, . Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment. J Neurochem. 2005;92:1170–9.
   PubMedGoogle Scholar
• Frank E, Novick D, Kupfer DJ. Antidepressants and psychotherapy: a clinical research review. Dialogues Clin Neurosci. 2005;7:263–72.
   PubMedGoogle Scholar
• Keller MB, McCullough JP, Klein DN, Arnow B, Dunner DL, Gelenberg AJ, . A comparison of nefazodone, the cognitive behavioral-analysis system of psychotherapy, and their combination for the treatment of chronic depression. N Engl J Med. 2000;342:1462–70.
   PubMed Web of Science ®Google Scholar
• van Praag H, Kempermann G, Gage FH. Neural consequences of environmental enrichment. Nat Rev Neurosci. 2000;1:191–8.
   PubMed Web of Science ®Google Scholar
• Nithianantharajah J, Hannan AJ. Enriched environments, experience-dependent plasticity and disorders of the nervous system. Nat Rev Neurosci. 2006;7:697–709.
   PubMed Web of Science ®Google Scholar
• Sahay A, Hen R. Adult hippocampal neurogenesis in depression. Nat Neurosci. 2007;10:1110–5.
   PubMed Web of Science ®Google Scholar
• Bruel-Jungerman E, Laroche S, Rampon C. New neurons in the dentate gyrus are involved in the expression of enhanced long-term memory following environmental enrichment. Eur J Neurosci. 2005;21:513–21.
   PubMed Web of Science ®Google Scholar
• Koh S, Magid R, Chung H, Stine CD, Wilson DN. Depressive behavior and selective down-regulation of serotonin receptor expression after early-life seizures: reversal by environmental enrichment. Epilepsy Behav. 2007;10:26–31.
   PubMed Web of Science ®Google Scholar
• Meshi D, Drew MR, Saxe M, Ansorge MS, David D, Santarelli L, . Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment. Nat Neurosci. 2006;9:729–31.
   PubMed Web of Science ®Google Scholar
• Neeper SA, Gomez-Pinilla F, Choi J, Cotman C. Exercise and brain neurotrophins. Nature. 1995;373:109.
   PubMed Web of Science ®Google Scholar
• Gomez-Pinilla F, Dao L, So V. Physical exercise induces FGF-2 and its mRNA in the hippocampus. Brain Res. 1997;764:1–8.
   PubMed Web of Science ®Google Scholar
• Naylor AS, Bull C, Nilsson MK, Zhu C, Bjork-Eriksson T, Eriksson PS, . Voluntary running rescues adult hippocampal neurogenesis after irradiation of the young mouse brain. Proc Natl Acad Sci USA. 2008;105:14632–7.
   PubMed Web of Science ®Google Scholar
• Russo-Neustadt A, Ha T, Ramirez R, Kesslak JP. Physical activity-antidepressant treatment combination: impact on brain-derived neurotrophic factor and behavior in an animal model. Behav Brain Res. 2001;120:87–95.
   PubMed Web of Science ®Google Scholar
• Greenwood BN, Strong PV, Brooks L, Fleshner M. Anxiety-like behaviors produced by acute fluoxetine administration in male Fischer 344 rats are prevented by prior exercise. Psychopharmacology (Berl). 2008;199:209–22.
   PubMed Web of Science ®Google Scholar
• Chambliss HO, Van Hoomissen JD, Holmes PV, Bunnell BN, Dishman RK. Effects of chronic activity wheel running and imipramine on masculine copulatory behavior after olfactory bulbectomy. Physiol Behav. 2004;82:593–600.
   PubMed Web of Science ®Google Scholar
• Souetre E, Salvati E, Belugou JL, Pringuey D, Candito M, Krebs B, . Circadian rhythms in depression and recovery: evidence for blunted amplitude as the main chronobiological abnormality. Psychiatry Res. 1989;28:263–78.
   PubMed Web of Science ®Google Scholar
• Partonen T, Treutlein J, Alpman A, Frank J, Johansson C, Depner M, . Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression. Ann Med. 2007;39:229–38.
   PubMed Web of Science ®Google Scholar
• Johansson C, Willeit M, Smedh C, Ekholm J, Paunio T, Kieseppa T, . Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference. Neuropsychopharmacology. 2003;28:734–9.
   PubMed Web of Science ®Google Scholar
• Gonzalez MM, Aston-Jones G. Light deprivation damages monoamine neurons and produces a depressive behavioral phenotype in rats. Proc Natl Acad Sci USA. 2008;105: 4898–903.
   PubMed Web of Science ®Google Scholar
• Yirmiya R. Depression in medical illness: the role of the immune system. West J Med. 2000;173:333–6.
   PubMedGoogle Scholar
• Schaefer M, Winterer J, Sarkar R, Uebelhack R, Franke L, Heinz A, . Three cases of successful tryptophan add-on or monotherapy of hepatitis C and IFNalpha-associated mood disorders. Psychosomatics. 2008;49:442–6.
   PubMedGoogle Scholar
• O'Connor JC, Lawson MA, Andre C, Moreau M, Lestage J, Castanon N, . Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice. Mol Psychiatry. 2009;14:511–22.
   PubMed Web of Science ®Google Scholar
• Miller AH, Maletic V, Raison CL. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry. 2009;65:732–41.
   PubMed Web of Science ®Google Scholar
• Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci. 2008;9:46–56.
   PubMed Web of Science ®Google Scholar
• Brown GW, Craig TK, Harris TO. Parental maltreatment and proximal risk factors using the Childhood Experience of Care & Abuse (CECA) instrument: a life-course study of adult chronic depression—5. J Affect Disord. 2008;110:222–33.
   PubMed Web of Science ®Google Scholar
• Uher R. The implications of gene-environment interactions in depression: will cause inform cure? Mol Psychiatry. 2008; 13:1070–8.
   PubMed Web of Science ®Google Scholar
• Renthal W, Nestler EJ. Chromatin regulation in drug addiction and depression. Dialogues Clin Neurosci. 2009;11: 257–68.
   PubMedGoogle Scholar
• Tsankova N, Renthal W, Kumar A, Nestler EJ. Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci. 2007; 8:355–67.
   PubMed Web of Science ®Google Scholar
• Grayson DR, Kundakovic M, Sharma RP. Is there a future for histone deacetylase inhibitors in the pharmacotherapy of psychiatric disorders? Mol Pharmacol. 2010;77:126–35.
   PubMed Web of Science ®Google Scholar
• Crowley JJ, Blendy JA, Lucki I. Strain-dependent antidepressant-like effects of citalopram in the mouse tail suspension test. Psychopharmacology (Berl). 2005;183:257–64.
   PubMed Web of Science ®Google Scholar
• Lucki I, Dalvi A, Mayorga AJ. Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice. Psychopharmacology (Berl). 2001;155: 315–22.
   PubMed Web of Science ®Google Scholar
• Stock HS, Ford K, Wilson MA. Gender and gonadal hormone effects in the olfactory bulbectomy animal model of depression. Pharmacol Biochem Behav. 2000;67:183–91.
   PubMed Web of Science ®Google Scholar
• Delgado MR, Nearing KI, Ledoux JE, Phelps EA. Neural circuitry underlying the regulation of conditioned fear and its relation to extinction. Neuron. 2008;59:829–38.
   PubMed Web of Science ®Google Scholar
• Pollak DD, Rogan MT, Egner T, Perez DL, Yanagihara TK, Hirsch J. A translational bridge between mouse and human models of learned safety. Ann Med. 2010;42:115–22.
   PubMedGoogle Scholar
• Ressler KJ, Mayberg HS. Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic. Nat Neurosci. 2007;10:1116–24.
   PubMed Web of Science ®Google Scholar