No association of the neuropeptide Y (Leu7Pro) and ghrelin gene (Arg51Gln, Leu72Met, Gln90Leu) single nucleotide polymorphisms with eating disorders

References

• American Psychiatric Association (APA). Practice guideline for the treatment of patients with eating disorders, 3rd. Washington, DC: American Psychiatric Association (APA); 2006.
   Google Scholar
• Sullivan PF. Mortality in anorexia nervosa. Am J Psychiatry 1995;152:1073–4.
   PubMed Web of Science ®Google Scholar
• Mercader JM, Saus E, Agüera Z, Bayés M, Boni C, Carreras A, . Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders. Hum Mol Genet 2008;17:1234–44.
   PubMedGoogle Scholar
• Javaras KN, Laird NM, Reichborn-Kjennerud T, Bulik CM, Pope HG, Hudson JI. Familiality and heritability of binge eating disorder: Results of a case–control family study and a twin study. Int J Eat Disord 2008;41:174–9.
   PubMed Web of Science ®Google Scholar
• Ando T, Komaki G, Naruo T, Okabe K, Takii M, Kawai K, . Possible role of preproghrelin gene polymorphisms in susceptibility to bulimia nervosa. Am J Med Genet Part B (Neuropsychiatric Genetics) 2006;141:929–34.
   Web of Science ®Google Scholar
• Dardennes RM, Zizzari P, Tolle V, Foulon C, Kipman A, Romo L, . Family trios analysis of common polymorphisms in the obestatin/ghrelin, BDNF and AGRP genes in patients with anorexia nervosa: Association with subtype, body mass index, severity and age of onset. Psychoneuroendocrinology 2007;32:106–13.
   PubMed Web of Science ®Google Scholar
• Monteleone P, Tortorella A, Castaldo E, DiFilippo C, Maj M. No association of the Arg51Gln and Leu72Met polymorphisms of the ghrelin gene with anorexia nervosa or bulimia nervosa. Neurosci Lett 2006;398:325–7.
   PubMed Web of Science ®Google Scholar
• Kishi T, Elmquist JK. Body weight is regulated by the brain: A link between feeding and emotion. Mol Psychiatry 2005;10:132–46.
   PubMed Web of Science ®Google Scholar
• Seim I, Collet CC, Herington AC, Chopin LK. Revised genomic structure of the human ghrelin gene and identification of novel exons, alternative splice variants and natural antisense transcripts. BMC Genomics 2007;8:298.
   PubMedGoogle Scholar
• Lee HM, Wang G, Englander EW, Kojima M, Greeley GH Jr. Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: Enteric distribution, ontogeny, influence of endocrine and dietary manipulations. Endocrinology 2002;143:185–90.
   PubMed Web of Science ®Google Scholar
• Shiiya T, Nakazato M, Mizuta M, Date Y, Mondal MS, Tanaka M, . Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab 2002;87:240–4.
   PubMed Web of Science ®Google Scholar
• Shintani M, Ogawa Y, Ebihara K, Aizawa-Abe M, Miyanaga F, Takaya K, . Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 2001;50:227–32.
   PubMed Web of Science ®Google Scholar
• Ukkola O, Ravussin E, Jacobson P, Snyder EE, Chagnon M, Sjöström L, Bouchard C. Mutations in the preproghrelin/ghrelin gene associated with obesity in humans. J Clin Endocrinol Metab 2001;86:3996–9.
   Google Scholar
• Garcia MC, Lopez M, Alvarez CV, Casanueva F, Tena-Sempere M, Dieguez C. Role of ghrelin in reproduction. Reproduction 2007;133:531–40.
   PubMed Web of Science ®Google Scholar
• Hinney A, Hoch A, Geller F, Schafer H, Siegfried W, Goldschmidt H, Remschmidt H, Hebebrand J. Ghrelin gene: Identification of missense variants and a frameshift mutation in extremely obese children and adolescents and healthy normal weight students. J Clin Endocrinol Metab 2002;87:2716.
   PubMed Web of Science ®Google Scholar
• Steinle NI, Pollin TI, O'Connell JR, Mitchell BD, Shuldiner AR. Variants in the ghrelin gene are associated with metabolic syndrome in the Old Order Amish. J Clin Endocrinol Metab 2005;90:6672–7.
   PubMed Web of Science ®Google Scholar
• Landgren S, Jerlhag E, Zetterberg H, Gonzalez-Quintela A, Campos J, Olofsson U, . Association of pro-ghrelin and GHS-R1A gene polymorphisms and haplotypes with heavy alcohol use and body mass. Alcohol Clin Exp Res 2008;32:2054–61.
   PubMedGoogle Scholar
• Monteleone P, Tortorella A, Castaldo E, DiFilippo C, Maj M. The Leu72Met polymorphism of the ghrelin gene is significantly associated with binge eating disorder. Psychiatr Genet 2007;17:13–6.
   PubMed Web of Science ®Google Scholar
• Cellini E, Nacmias B, Anderluh MB, Badia-Casanovas A, Bellodi L, Boni C, . Case–control and combined family trios analysis of three polymorphisms in the ghrelin gene in European patients with anorexia and bulimia nervosa. Psychiatr Genet 2006;16:51–2.
   PubMed Web of Science ®Google Scholar
• Baker E, Hort YJ, Ball H, Sutherland GR, Shine J, Herzog H. Assignment of the human neuropeptide Y gene to chromosome 7p15.1 by nonisotopic in situ hybridization. Genomics 1995;26:163–4.
   PubMedGoogle Scholar
• Kaye WH, Berrettini W, Gwirtsman H, George DT. Altered cerebrospinal fluid neuropeptide Y and peptide YY immunoreactivity in anorexia and bulimia nervosa. Arch Gen Psychiatry 1990;47:548–56.
   PubMed Web of Science ®Google Scholar
• Karvonen MK, Pesonen U, Koulu M, Niskanen L, Laakso M, Rissanen A, . Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels. Nat Med 1998;4:1434–7.
   PubMed Web of Science ®Google Scholar
• Pettersson Fernholm K, Karvonen MK, Kallio J, Forsblom CM, Koulu M, Pesonen U, ; FinnDiane Study Group. Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with proteinuria, coronary heart disease, and glycemic control in type 1 diabetic patients. Diabetes Care 2004;27:503–9.
   PubMedGoogle Scholar
• Jaakkola U, Kuusela T, Jartti T, Pesonen U, Koulu M, Vahlberg T, . The Leu7Pro polymorphism of preproNPY is associated with decreased insulin secretion, delayed ghrelin suppression, and increased cardiovascular responsiveness to norepinephrine during oral glucose tolerance test. J Clin Endocrinol Metab 2005;90:3646–52.
   PubMedGoogle Scholar
• Lappalainen J, Kranzler HR, Malison R, Price LH, Van Dyck C, Rosenheck RA, . A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States. Arch Gen Psychiatry 2002;59:825–31.
   PubMedGoogle Scholar
• American Psychiatric Association, Diagnostic and statistical manual of mental disorders, 4th (DSM-IV). Washington, DC: American Psychiatric Association; 1994.
   Google Scholar
• Wittchen HU, Zaudig M, Fydrich T. SKID. Strukturiertes Klinisches Interview für DSM-IV. Göttingen, Germany, Hogrefe, Verlag für Psychologie; 1997.
   Google Scholar
• Hamajima N, Saito T, Matsuo K, Tajima K. Competitive amplification and unspecific amplification in polymerase chain reaction with confronting two-pair primers. J Mol Diagn 2002;4:103–7.
   PubMed Web of Science ®Google Scholar
• Nergårdh R, Ammar A, Brodin U, Bergström J, Scheurink A, Södersten P. Neuropeptide Y facilitates activity-based-anorexia. Psychoneuroendocrinology 2007;32:493–502.
   PubMedGoogle Scholar